ライフサイエンスコーパス: substitution reaction

1 neously activated to effect a stereospecific substitution reaction.

2 ted to the morpholino group through a simple substitution reaction.

3 diastereoselective palladium-catalyzed azide substitution reaction.

4 olabeling was accomplished by a nucleophilic substitution reaction.

5 ified as an "inverse-electron-demand" ligand-substitution reaction.

6 sky reaction followed by a nucleophilic acyl substitution reaction.

7 e OH- + CH3F --> CH3OH + F- SN2 nucleophilic substitution reaction.

8 e the possibility of a nucleophilic aromatic substitution reaction.

9 ate with the proposed electrophilic aromatic substitution reaction.

10 bifunctional catalyst in the intramolecular substitution reaction.

11 -exo-trig cyclization/electrophilic aromatic substitution reaction.

12 the superiority of organocuprates in allylic substitution reactions.

13 oup in COP-catalyzed enantioselective S(N)2' substitution reactions.

14 of nucleophiles with applications in allylic substitution reactions.

15 itutions at boron and electrophilic aromatic substitution reactions.

16 o found to undergo very facile electrophilic substitution reactions.

17 zene reactivity gave access to oxidation and substitution reactions.

18 vity in iridium-catalyzed asymmetric allylic substitution reactions.

19 ent for substrate activation in nucleophilic substitution reactions.

20 remely reactive with respect to nucleophilic substitution reactions.

21 astereoselectivity results from nucleophilic substitution reactions.

22 ich are notoriously poor substrates in other substitution reactions.

23 and the regioselectivities observed in model substitution reactions.

24 s rate-limiting in the nucleophilic aromatic substitution reactions.

25 ave on the stereoselectivity of nucleophilic substitution reactions.

26 tion enthalpies of the carbonyl to phosphine substitution reactions.

27 uch as reductions and vicarious nucleophilic substitution reactions.

28 nd evaluated for regioselectivity in ammonia substitution reactions.

29 capable of catalyzing nucleophilic aromatic substitution reactions.

30 rate of the enzyme for nucleophilic aromatic substitution reactions.

31 e of the different mechanisms of the allylic substitution reactions.

32 des popular starting materials in many photo-substitution reactions.

33 es in Ir-catalyzed, enantioselective allylic substitution reactions.

34 ibing the stereochemical outcome in suchlike substitution reactions.

35 e reactivity and selectivity of nucleophilic substitution reactions.

36 ic understanding of cuprate-mediated allylic substitution reactions.

37 equence of one-electron reduction and ligand substitution reactions.

38 sunobu, oxidation, reduction, acylation, and substitution reactions.

39 kinetically controlled nucleophilic aromatic substitution reactions.

40 ic base precursors (F, Cl, Br, and I) or via substitution reactions after the synthesis of the carboc

41 azoles and after intramolecular nucleophilic substitution reaction and electrooxidative disulfide bon

42 lted in an intramolecular radical [1,5]-ipso substitution reaction and migration of the pyrimidinyl r

43 red nucleophiles using nucleophilic aromatic substitution reactions and palladium-catalyzed reactions

44 iranes provide opportunities for bis-allylic substitution reactions and the generation of new vicinal

45 opure aminocyclopentenols, a Pd(0)-catalyzed substitution reaction, and a mild reduction of an alpha-

46 luence on catalysis of nucleophilic aromatic substitution reactions, and a H107S substitution account

47 Palladium-catalyzed allylic substitution reactions are among the most efficient meth

48 d by organic chemists, that radical aromatic substitution reactions are inherently unselective.

49 regioselective and enantioselective allylic substitution reactions are presented.

50 Most substitution reactions are thought to proceed through ra

51 Copper-mediated allylic substitution reactions are widely used in organic synthe

52 assemblies that is capable of catalyzing the substitution reaction at a secondary benzylic carbon cen

53 which relies on a successive 2-fold SN'-type substitution reaction at methoxy-substituted propargylic

54 The nucleophilic substitution reaction at sulfur follows the addition-eli

55 ich undergoes an ipso electrophilic aromatic substitution reaction at the carboxylic acid-bound carbo

56 nctional theory calculations of model alkene-substitution reactions at a diimine-palladium(0) center

57 A series of gas-phase nucleophilic substitution reactions at sulfur of methanesulfinyl deri

58 The first step involves a nucleophilic substitution reaction between aryl-BF3K salts (aryl = me

59 he synthesis is a new vicarious nucleophilic substitution reaction between p-nitroanisole and a C-sil

60 ype I (PGGTase-I) catalyzes the nucleophilic substitution reaction between the C(20) geranylgeranyl d

61 he prodrug synthesis involves a nucleophilic substitution reaction between the parent tertiary amine

62 Ligand substitution reactions between five-coordinate oxorheniu

63 large changes in the emission though ligand substitution reactions between the solid complex and sol

64 Each enzyme catalyzes a nucleophilic substitution reaction, but IS and SS are uniquely able t

65 ge has much in common with familiar chemical substitution reactions, but differs in some respects: no

66 are not met during iridium catalyzed allylic substitution reactions by eta(3)-eta(1)-eta(3) interconv

67 This study shows that the substitution reaction can be described as a concerted as

68 The reversible nucleophilic substitution reaction catalyzed by the vaccinia virus ty

69 t an unusual concerted nucleophilic aromatic substitution reaction (CSNAr) that is not limited to ele

70 n is provided, as are data from nucleophilic substitution reactions demonstrating that products are f

71 genase that involves a nucleophilic aromatic substitution reaction, either via an S(N)Ar mechanism or

72 Palladium (0)-catalyzed allylic substitution reactions employing triorganoindium reagent

73 ydroxyisocaproate dehydrogenase, and for the substitution reaction, employing cystathionine beta-lyas

74 The highly exoergic nucleophilic substitution reaction F(-) + CH3I shows reaction dynamic

75 ubjected to sequential nucleophilic aromatic substitution reactions, first at one or both of the more

76 The substitution reactions follow an addition-elimination pa

77 ures an intramolecular aromatic nucleophilic substitution reaction for formation of the diaryl ether

78 ted a room-temperature aromatic nucleophilic substitution reaction for formation of the remaining dia

79 ng system enlisting an aromatic nucleophilic substitution reaction for macrocyclization with biaryl e

80 f a versatile hemiacetal hydroxyl activation/substitution reaction for the formation of anomeric link

81 ough application to a classical nucleophilic substitution reaction for the study of solvent effects,

82 approach relied on two aromatic nucleophilic substitution reactions for formation of the 16-membered

83 port a significant expansion to the scope of substitution reactions for the dodecaborate ion, whereby

84 amic quantities for isomerization and ligand substitution reactions, gas-phase proton affinities, and

85 The vicarious nucleophilic substitution reaction has also been extended to six-memb

86 phospha-Mannich/intramolecular nucleophilic substitution reaction has been developed for the constru

87 phospha-Michael/intramolecular nucleophilic substitution reaction has been developed.

88 the palladium-catalyzed Tsuji-Trost allylic substitution reaction has been intensively studied, ther

89 this process and the regiochemistry of their substitution reactions has been studied.

90 e factors influencing the selectivity of the substitution reaction have been examined thoroughly.

91 de products that readily participate in acyl substitution reactions (hence, they are convertible).

92 plex catalytically promotes the nucleophilic substitution reaction (here after alpha-amidoalkylation

93 r of iodide > bromide > trifluoroacetate for substitution reactions; however, the basicities of bromi

94 arenes occurs via an electrophilic aromatic substitution reaction in which the coordinated arene pro

95 portance of including electrophilic aromatic substitution reactions in atmospheric models.

96 )Et > monoester 3-CO(2)()Et) and may lead to substitution reactions in cellular systems.

97 emarkably lower reactivities in nucleophilic substitution reactions in protic solvents than in aproti

98 enable alcohols to be used as nucleofuges in substitution reactions in the future.

99 picture contrasts that of traditional ligand-substitution reactions, in which the incoming ligand don

100 Redox potentials and substitution reactions indicate that the carbene is the

101 dence for a stepwise, S(N)1 mechanism in the substitution reaction induced by anion binding to the ca

102 ing as expected but rather undergoes ethynyl substitution reactions instead.

103 structural motifs that undergo a reversible substitution reaction involving the concerted and spatia

104 The first instances of catalytic allylic substitution reactions involving a propargylic nucleophi

105 s employing catalytic electrophilic aromatic substitution reactions involving bromination.

106 In solution, nucleophilic vinylic substitution reactions involving electron-withdrawing gr

107 A series of nucleophilic substitution reactions involving simple species (chlorid

108 ite nucleophile involved in catalysis of the substitution reaction is located between Pro79 and Thr17

109 The palladium-catalysed allylic substitution reaction is one of the most important react

110 The substitution reaction is performed under ammonia flow by

111 sion of gem-diesters to chiral esters by the substitution reaction is the equivalent of an asymmetric

112 the stereochemical outcome of a nucleophilic substitution reaction is unprecedented in the field of s

113 hat the diastereoselectivity of nucleophilic substitution reactions is attenuated at the limits of di

114 ies of 9H-carbazoles by photostimulated SRN1 substitution reactions is presented.

115 le played by the axial region in many ligand substitution reactions is therefore intimately connected

116 d by an intramolecular nucleophilic aromatic substitution reaction, is described.

117 fluorescence measurements indicate that the substitution reaction leading to compounds 4 can be util

118 ity of anilines in the aromatic nucleophilic substitution reaction leading to the formation of the TA

119 ,5- and then the 2,6-positions; nucleophilic substitution reactions occur first at the 8- followed by

120 omoted intramolecular electrophilic aromatic substitution reaction of 1-[2-(3,4-dimethoxyphenyl)ethyl

121 nucleophilic vinylic "addition-elimination" substitution reaction of 3 beta-acetoxy-17-chloro-16-for

122 The intramolecular nucleophilic substitution reaction of 3-oxo-2-(2'-pyridyl)-(2-halophe

123 nucleophilic vinylic "addition-elimination" substitution reaction of 3beta-acetoxy-17-chloro-16-form

124 The metal-catalyzed allylic substitution reaction of 5a,b and 6a was examined.

125 ated via base-induced vicarious nucleophilic substitution reaction of alkyl dichloroacetates with nit

126 nine may substitute for l-serine in the beta-substitution reaction of an engineered subunit of trypto

127 ivity based on a regioselective nucleophilic substitution reaction of Br4-NDI with arylamines, follow

128 in strong contrast to the previously studied substitution reaction of Cl(-) + CH3I at all but the low

129 emonstrated on the basis of the nucleophilic substitution reaction of CN(-) on (5F)LOH.

130 The nucleophilic substitution reaction of Cys-SeH on (NO2)L has been clea

131 al to study the dynamics of the nucleophilic substitution reaction of dichloroethane by a carboxylate

132 nthesis involved a new nucleophilic aromatic substitution reaction of methacrylamide anion.

133 The substitution reaction of phosphono allylic carbonate 10a

134 We have developed a copper-catalyzed substitution reaction of propargylic ammonium salts with

135 TFE) or hexafluoropropan-2-ol (HFP) mediated substitution reaction of the bay-region C10 acetoxy grou

136 cess is followed by FeBr3-mediated SN2'-type substitution reaction of the formed homoallenic bromohyd

137 monitoring the kinetics of the nucleophilic substitution reaction of the imidazole moiety by amines.

138 Aromatic nucleophilic substitution reaction of the nitro group of meso-nitropo

139 n the sequential intramolecular nucleophilic substitution reaction of the phosphonylation.

140 ion, followed by an intramolecular aromatic substitution reaction of the resultant cation (i.e., a d

141 The rate of the nucleophilic substitution reaction of tributylamine with methyl p-nit

142 The substitution reactions of 2 with 9-ethylguanine at vario

143 Nucleophilic substitution reactions of 2-deoxyglycosyl donors indicat

144 A systematic study of the N-substitution reactions of 3-substituted pyrazoles under

145 Nucleophilic substitution reactions of 4-substituted cyclohexanone ac

146 Other substitution reactions of [NiFe(3)S(4)](+) clusters and

147 inc complexes can either be formed by ligand substitution reactions of [Zn(2)(eta(5)-Cp*)(2)] or by r

148 Nucleophilic substitution reactions of acetals having benzyloxy group

149 mplished by photochemically promoted allylic substitution reactions of allylic alcohols and ethers wi

150 Here, we use this approach to study the substitution reactions of arsenic(III) compounds with th

151 Nucleophilic substitution reactions of C-4 sulfur-substituted tetrahy

152 S(N)2, and syn and anti S(N)2' nucleophilic substitution reactions of chloride anion with allyl chlo

153 n assessing the stereoselective nucleophilic substitution reactions of cyclic oxocarbenium ions at hi

154 t has been proposed to take place in related substitution reactions of cyclopentadienyl-metal complex

155 The photoinduced substitution reactions of halogenated alkanes (1-haloada

156 stituents were used in nucleophilic aromatic substitution reactions of halogens.

157 n dynamics strikingly different from that of substitution reactions of larger halogen anions.

158 substituted zirconacycles allowed for facile substitution reactions of MesC[triple bond]CPh or PrC[tr

159 The gas-phase substitution reactions of methyl chloride and 1,3-dimeth

160 Asymmetric lithiation-substitution reactions of N-Boc-pyrrolidine and N,N-diis

161 Nucleophilic substitution reactions of small rings incorporating sele

162 , is used to study the nucleophilic aromatic substitution reactions of SNAr and VNS (vicarious nucleo

163 Lewis acid-mediated nucleophilic substitution reactions of substituted tetrahydropyran ac

164 Nucleophilic aromatic substitution reactions of suitably activated (electron-d

165 addition to reductive coupling with alkenes, substitution reactions of tertiary radicals with allylic

166 Substitution reactions of the chemically and photochemic

167 yields and with high anomeric purities by S-substitution reactions of the sulfide anion or sulfur-ce

168 , was prepared and characterized, and olefin-substitution reactions of these complexes were found to

169 Partial substitution reactions of these W(6)S(8) complexes by ph

170 promoted intramolecular direct nucleophilic substitution reactions of unsaturated alcohols with hete

171 atalyzed regio- and enantioselective allylic substitution reactions of unstabilized silyl dienolates

172 eport Ir-catalyzed, enantioselective allylic substitution reactions of unstabilized silyl enolates de

173 as created from an unsaturated aldehyde by a substitution reaction on a derived allylic tosylate.

174 es have been shown to catalyze electrophilic substitution reactions on activated substrates.

175 for regio- and stereocontrolled bis-allylic substitution reactions on both electron-rich and electro

176 redict the outcome of electrophilic aromatic substitution reactions on different heterocyclic compoun

177 of "ylide" structures in Lewis acid induced substitution reactions on the boron vertices of carboran

178 l such conversions are based on axial-ligand substitution reactions on the molecular octahedron.

179 hotoinduced base-promoted homolytic aromatic substitution reaction (photo-BHAS) have remained elusive

180 The Tsuji-Trost allylic substitution reaction provides a useful and efficient ap

181 This newly developed substitution reaction provides an attractive alternative

182 nt, they were good catalysts for the allylic substitution reaction, providing branched allylic esters

183 to contribute about one-half of the overall substitution reaction rate at both low and high collisio

184 the alkenyl migration/electrophilic aromatic substitution reactions recently reported by Oshima and c

185 d regioselectivity in cyanidecarbon monoxide substitution reactions, relate to the enzyme active site

186 leophiles and alkyl electrophiles, many such substitution reactions remain out of reach.

187 io for the competing proton transfer and the substitution reactions results from the competition betw

188 he "element effect" in nucleophilic aromatic substitution reactions (S(N)Ar) is characterized by the

189 ne-pot tandem 1,4-addition-nucleophilic acyl substitution reaction sequence to afford 3-substituted 4

190 s the study of the competing elimination and substitution reactions simultaneously.

191 merize via a series of nucleophilic aromatic substitution reactions (SNAr), in which aromatic enolate

192 cal cascades, including unimolecular radical substitution reactions (SRN1-type chemistry), base-promo

193 reoselective (>/=15:1) aromatic nucleophilic substitution reaction that benefits from substrate preor

194 DTT likely functions in a ligand substitution reaction that generates a [2Fe-2S]-DTT spec

195 ze the transition state of the in-line S(N)2 substitution reaction that is peroxidation.

196 not sufficiently activated for nucleophilic substitution reactions that are generally required for t

197 amples of catalytic enantioselective allylic substitution reactions that involve alkyne-based nucleop

198 play a dominant role in nucleophilic vinylic substitution reactions that proceed so readily in the co

199 port puts forward the first cases of allylic substitution reactions that result in the generation of

200 es as a "textbook example" of a nucleophilic substitution reaction, the selective mono-alkylation of

201 Through nucleophilic substitution reactions, the chlorides are useful precurs

202 have been employed in asymmetric lithiation-substitution reactions, the limited conformational flexi

203 In these copper-mediated allylic substitution reactions, the Z-isomer 4a displayed comple

204 )R) can be induced to undergo solvolysis and substitution reactions through an elimination-addition m

205 per configuration, and (d) an intramolecular substitution reaction to form the sensitive bridging lac

206 nt must be a stable cation precursor for the substitution reaction to proceed under these conditions.

207 Progress has been made for directed aromatic substitution reactions to achieve ortho and meta selecti

208 OCl(2)(bdt)](1-) (2), which undergoes ligand substitution reactions to form other monodithiolene comp

209 The avoidance of electrophilic aromatic substitution reactions to make the isoquinoline allows d

210 lcohol and subsequently employs nucleophilic substitution reactions to prepare various derivatives.

211 ones 7-10 undergo stereoselective lithiation-substitution reactions to provide cis-18-27 and cis-31-3

212 (RBO) monomers in the gas phase by a radical substitution reaction under single-collision conditions

213 ives undergo the intramolecular nucleophilic substitution reaction upon treatment with a strong base,

214 The direct allylic substitution reaction using allylic alcohols in 1,1,1,3,

215 atropisomer-selective electrophilic aromatic substitution reaction using simple bromination reagents.

216 er, we report the effect of ionic liquids on substitution reactions using a variety of anionic nucleo

217 ene sulfide to the salen complex in a ligand substitution reaction was established by isolation of [R

218 In some cases the allylic substitution reaction was found to be accompanied by a k

219 omponent Mannich-type electrophilic aromatic substitution reaction was previously developed to target

220 ular nitrile-activated nucleophilic aromatic substitution reaction was used for the key macrocyclizat

221 competent to be intermediates in the allylic substitution reactions was prepared and characterized by

222 In a DFT study of the substitution reaction, we identified a six-membered clos

223 Rate constants, kArO, for these substitution reactions were determined in 50% MeCN-50% w

224 ct, the activation parameters for the ligand substitution reactions were determined, and single-cryst

225 Finally, dynamic substitution reactions were employed toward the facile p

226 experiments confirmed that all nucleophilic substitution reactions were performed under kinetic cont

227 tively, the oxirane undergoes a nucleophilic substitution reaction where the conjugate base of Pro-1

228 substituted benzenes is capable of inducing substitution reactions where no reaction takes place the

229 lytic enantioselective nucleophilic aromatic substitution reaction which yields axially chiral biaryl

230 we perform an abiotic electrophilic aromatic substitution reaction, which is directed precisely throu

231 highly regioselective electrophilic aromatic substitution reaction, while metalation and alkylation p

232 T7/9 is a typical in-line S(N)2 nucleophilic substitution reaction with a transition state of 70% dis

233 derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in th

234 >99%) after recrystallization and (b) S(N)2 substitution reaction with methylamine to provide diamin

235 onate wafers using an electrophilic aromatic substitution reaction with nitric acid to insert aromati

236 of the diol followed by double nucleophilic substitution reaction with primary amines led to the syn

237 The first example of Ir-catalyzed asymmetric substitution reaction with vinyl trifluoroborates is des

238 propose a general mechanism for the allylic substitution reactions with 1 which involves dissociatio

239 also describe high yielding and C6-selective substitution reactions with 6-bromonucleosides using alc

240 Surprisingly facile direct substitution reactions with acetyl-protected 6-bromopuri

241 with electron-deficient alkenes and radical substitution reactions with allylic and vinylic bromides

242 en atom undergo smooth nucleophilic aromatic substitution reactions with anionic sulfur nucleophiles

243 l equivalent then undergoes nickel-catalyzed substitution reactions with aryl halides and triflates a

244 Substitution reactions with carbon, nitrogen, oxygen and

245 that are crosslinked in situ by nucleophilic substitution reactions with carboxylates.

246 ope effects operating through four bonds for substitution reactions with dimethylallyl derivatives be

247 iments, undergoes gas-phase enantioselective substitution reactions with other amino acids.

248 from the parent borane dipp-Imd-BH(3) by (1) substitution reactions with R-X (X = halide or sulfonate

249 ewis acids to mediate electrophilic aromatic substitution reactions with super-stoichiometric equival

250 Nucleophilic aromatic substitution reactions with the hydroxide and hydrosulfi

251 o- and enantioselective Ir-catalyzed allylic substitution reactions with the proper choice of enolate

252 tom, were prepared and subjected to SN1-type substitution reactions with various silyl nucleophiles e

253 sis, including the following: transamination substitution reactions with virtually any primary amine,

254 The nucleotide product of this substitution reaction would be N2-hydroxyguanosine 5'-mo

255 n prototypical identity nucleophilic vinylic substitution reactions, X(-) + ViX --> XVi + X(-) (Vi =