ライフサイエンスコーパス: substoichiometric

1 n for every 40-50 molecules of free protein (substoichiometric).

2 PSII complex, whereas PsbP is significantly substoichiometric.

3 ng in the proteins as isolated varies and is substoichiometric.

4 th ubiquinol-2 (UQ2H2) was carried out using substoichiometric (0.5 equiv) amounts of substrate.

5 Protection is afforded at substoichiometric (1:100) TTR:Abeta molar ratios, and th

6 Gdown1, the substoichiometric 13th subunit of RNA polymerase II (pol

7 d betaE(199)V/Y(345)W subcomplexes hydrolyze substoichiometric [(3)H]ATP, whereas it is not retained

8 ype and double-mutant subcomplexes hydrolyze substoichiometric [(3)H]ATP.

9 etaG(156)C/E(199)V/Y(345)W mutants hydrolyze substoichiometric [(3)H]ATP.

10 ion of the APC requires its association with substoichiometric activating subunits termed Cdc20 and H

11 The ligand could be used in a substoichiometric amount (0.25 equiv) without significan

12 However, a substoichiometric amount (33 mol%) of potassium metal tr

13 concluded that although cyt cy is present in substoichiometric amount compared to the RCs, it support

14 a fluorinated aluminum salph complex with a substoichiometric amount of a nucleophilic cocatalyst.

15 Only a substoichiometric amount of AcOH is required as an addit

16 reaction of alkyl azides and ketones using a substoichiometric amount of catalyst is reported.

17 ents in conjunction with a stoichiometric or substoichiometric amount of chiral controller to deliver

18 everse gyrase can efficiently mediate with a substoichiometric amount of enzyme.

19 Metal analysis indicated that a substoichiometric amount of iron, predominately Fe (3+),

20 ET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putat

21 Additionally, only a substoichiometric amount of nickel (5-10 mol %) is requi

22 formation is catalytic in electrons; i.e., a substoichiometric amount of reduced species can isomeriz

23 A substoichiometric amount of reverse gyrase can insert po

24 ids, very good results were obtained using a substoichiometric amount of SiO(2)-Pip as the base.

25 coupling (CDC) reaction with aldehydes using substoichiometric amount of TBAB (tetrabutylammonium bro

26 "activated" through mono demethylation by a substoichiometric amount of the borate, [PhNMe(2)H][B(C(

27 rination alternative using Selectfluor and a substoichiometric amount of triethylborane--an establish

28 ruthenium photocatalyst in the presence of a substoichiometric amount of triphenylphosphine upon irra

29 ase (EcPhr), the MTHF cofactor is present in substoichiometric amounts after purification, while in V

30 type, suggesting that Cox11p is required in substoichiometric amounts for its role in oxidase assemb

31 ons in both 16S and 23S rRNA were present in substoichiometric amounts in the preribosomal particles.

32 ow temperature (-78 degrees C), and requires substoichiometric amounts of a simple copper(I) or coppe

33 Moreover, substoichiometric amounts of alpha-SynDeltaC enhance the

34 When crystallized with substoichiometric amounts of an NSAID, both monomers are

35 magnetic resonance, we provide evidence that substoichiometric amounts of annexin A5 inhibit h-IAPP a

36 The addition of substoichiometric amounts of Ca(2+) is sufficient to sta

37 by dithiothreitol (DTT), the enzyme contains substoichiometric amounts of calcium and zinc but little

38 The addition of substoichiometric amounts of chloride is essential, and

39 It is also of interest that substoichiometric amounts of Co(2)(CO)(8), in DME and in

40 ts in complete inhibition of the protease at substoichiometric amounts of compound.

41 ipoprotein/lipopeptide nonresponsive; and 2) substoichiometric amounts of deacylated LPS that block L

42 Relative to fibrinogen, substoichiometric amounts of decorin core protein modula

43 Importantly, addition of substoichiometric amounts of either LBP or sCD14 signifi

44 nation for complete inactivation of RNR with substoichiometric amounts of F2CDP.

45 nt of 402.1 +/- 35.1 nM, and that binding of substoichiometric amounts of FAD triggers a transition i

46 DvFtn) and its E130A variant was loaded with substoichiometric amounts of Fe(2+), and the products we

47 uced to H2O2 in a reaction that is driven by substoichiometric amounts of Fe(II) or Cu(I).

48 Substoichiometric amounts of ferric heme bound to GAPDH

49 urface-immobilized fibronectin, we show that substoichiometric amounts of heparin exposed cryptic VEG

50 We have demonstrated that substoichiometric amounts of human HspB1 (Hsp27) abolish

51 he vast excess of insulin over IAPP in vivo, substoichiometric amounts of insulin inhibit seeded and

52 r equivalents of calcium and zinc along with substoichiometric amounts of iron and functions as a ure

53 D, purified from Escherichia coli, contained substoichiometric amounts of iron and had an absorption

54 Addition of substoichiometric amounts of naphthol at higher quinone

55 Addition of substoichiometric amounts of NC results in significant b

56 r(CO)(2)I(3)(COMe)](-), 6, is accelerated by substoichiometric amounts of neutral promoter species (e

57 s obligate heteropolymers requiring NF-L and substoichiometric amounts of NF-M and/or NF-H, NF invest

58 Identical experiments with Arg produced substoichiometric amounts of NOHA or citrulline even whe

59 l complex of variable length, perhaps due to substoichiometric amounts of other CASCADE components.

60 assembly/disassembly reactions revealed that substoichiometric amounts of PrABP80 can nucleate actin

61 amethyldisilazide), Mg(HMDS)(2), reacts with substoichiometric amounts of propiophenone in toluene so

62 n between PrP(C) and Abeta and discover that substoichiometric amounts of PrP(C), as little as 1/20,

63 In vitro, substoichiometric amounts of RecX strongly inhibited bot

64 n of Tet-v2.0-protein reacts in cellulo with substoichiometric amounts of sTCO-label fast enough to r

65 ated A subunit association with membranes at substoichiometric amounts of the B subunit or the 16-kD

66 The revertants contained substoichiometric amounts of the Fe-S protein subunit an

67 In addition, they contained substoichiometric amounts of the Fe-S protein with respe

68 ed functional bc(1) complexes, but contained substoichiometric amounts of the Fe-S subunit.

69 pentamers on a T=7 icosahedral lattice, with substoichiometric amounts of the minor capsid protein, L

70 lysis as well as poisoning experiments using substoichiometric amounts of various poisoning agents.

71 strength polymerization-promoting F-buffer, substoichiometric amounts of VT accelerate the polymeriz

72 lopropylmagnesium bromide in the presence of substoichiometric amounts of zinc bromide produces cyclo

73 w that, under near-physiological conditions, substoichiometric amounts of Zn(2+) effectively retard t

74 Substoichiometric amounts of ZnCl(2) promote the room te

75 subunits ABCDEFGH (with subunit C present at substoichiometric amounts) as determined by matrix-assis

76 ntrast SEK can activate SAPK when present in substoichiometric amounts, but this activation is slow,

77 identified a Mg(2+)-labile factor present in substoichiometric amounts.

78 Our data indicate that even at substoichiometric antibody binding an overall increase i

79 (either free base or metalated) to E287Q is substoichiometric, as this variant retains bound porphyr

80 Paradoxically, substoichiometric, ATM-independent, phosphorylation of t

81 The reduced double mutant hydrolyzed substoichiometric ATP 100-fold more rapidly than the enz

82 en the wild-type TF(1) subcomplex hydrolyzes substoichiometric ATP.

83 ns increase the final anisotropy of actin at substoichiometric binding densities, indicating long-ran

84 Substoichiometric binding of taxol to tubulin in microtu

85 All titrations showed substoichiometric binding of the equilibrium mixtures to

86 with a KI of 45 +/- 7 microM, also exhibited substoichiometric binding to 3 +/- 1 sites per hexamer,

87 Neither the binding affinity nor the substoichiometric binding was significantly affected by

88 elated AAV1 and AAV6, a common Fab exhibited substoichiometric binding, with one Fab bound, on averag

89 ressive complex 2 (PRC2), to form a distinct substoichiometric biochemical complex, Pcl2-PRC2.

90 dissociation of RT dimer is responsible for substoichiometric burst amplitudes with normal substrate

91 -dihydroguanine (8-oxoGua) moieties in which substoichiometric bursts (2-35%) were observed even afte

92 verse transcriptase (HIV-1 RT) have reported substoichiometric bursts (30-50%) of product formation i

93 in normal nucleotide incorporation and that substoichiometric bursts with modified systems are well-

94 roximately 190-kD subunits per molecule plus substoichiometric calmodulin.

95 w-abundance proteins that are susceptible to substoichiometric carbonylation during oxidative stress.

96 e is a helical filamentous assembly in which substoichiometric CARMA1 nucleates Bcl10 filaments.

97 azapyrenium-based metallacycle as a reusable substoichiometric catalyst for the SNAr reaction between

98 a binding-induced rate enhancement, enables substoichiometric chirality transfer from the receptor t

99 The substoichiometric CO could be delivered to the reaction

100 bor cooperative interactions and saturate at substoichiometric cofilin binding densities.

101 e activity) that, when purified, contained a substoichiometric complement of Zn.

102 ith Ltv1, a protein recently identified as a substoichiometric component of a 43S preribosomal partic

103 CyanoP is a substoichiometric component of the isolated cyanobacteri

104 l for rapidly identifying stoichiometric and substoichiometric components of large protein assemblies

105 Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive

106 o sCD14 was very slow but was accelerated by substoichiometric concentration of LBP, and the rate of

107 tituted in the proteoliposome, although at a substoichiometric concentration relative to Drs2p.

108 TP4 inhibits Tau aggregation at substoichiometric concentration, demonstrating that it i

109 ril formation of beta2-microglobulin even at substoichiometric concentration.

110 bly of each corresponding polypeptide at low substoichiometric concentrations (1:10 gammabody:monomer

111 y and that these chaperones are effective at substoichiometric concentrations (approximately 1:50).

112 ro, CsgC inhibited CsgA amyloid formation at substoichiometric concentrations and maintained CsgA in

113 hibits the aggregation of alpha-synuclein at substoichiometric concentrations and that binding occurs

114 N744 at substoichiometric concentrations did not inhibit Abeta a

115 We show here that substoichiometric concentrations of 3,4-dihydroxyphenyla

116 inhibited at center P and preincubated with substoichiometric concentrations of antimycin showed a r

117 hat CaM binding to the MLCK enzyme begins at substoichiometric concentrations of Ca2+ (< or = 2 mol o

118 , with the same technology, we observed that substoichiometric concentrations of clusterin prevent ol

119 Substoichiometric concentrations of CsgB induce a change

120 We show that substoichiometric concentrations of Hsp31 can abrogate a

121 hen dealing with tight-binding inhibitors if substoichiometric concentrations of inhibitor are preinc

122 f lithium diisopropylamide (LDA) solvated by substoichiometric concentrations of oxetane, THF, Et(2)O

123 Substoichiometric concentrations of purified anti-A beta

124 vitro assembly was efficiently inhibited by substoichiometric concentrations of purified Hsp70 in th

125 embly in the presence of both saturating and substoichiometric concentrations of the 44/62 protein.

126 We now show that substoichiometric concentrations of TTR tetramers suppre

127 nds selectively inhibited oligomerization at substoichiometric concentrations relative to amyloid bet

128 ) stimulates Rad51-mediated recombination at substoichiometric concentrations relative to Rad51.

129 blue inhibited oligomerization when used at substoichiometric concentrations relative to that of the

130 n of full-length, four-repeat tau protein at substoichiometric concentrations relative to total tau a

131 At substoichiometric concentrations, LBP facilitates delive

132 n the electron donor formate was supplied at substoichiometric concentrations, the interactions betwe

133 tions and substantially delay aggregation at substoichiometric concentrations, while homodivalent lin

134 that HNG inhibits IAPP misfolding at highly substoichiometric concentrations.

135 monomers), we achieved fibril inhibition at substoichiometric concentrations.

136 e to native state stabilization and requires substoichiometric concentrations.

137 toward SH-SY5Y neuroblastoma cells, even at substoichiometric concentrations.

138 that LptE can disrupt LPS aggregates even at substoichiometric concentrations.

139 ring of actin filaments, most efficiently at substoichiometric concentrations.

140 unable to prevent fibrillization at the same substoichiometric concentrations.

141 The effects are most dramatic at substoichiometric conditions (most relevant for in vivo

142 tween the QB-depleted enzyme and UQ2H2 under substoichiometric conditions, there was no observable ch

143 l ions; this component is also detected as a substoichiometric consitutent of the purified T4MOH.

144 Substoichiometric Cu(2+) drastically perturbs Abeta(11-4

145 not burn, while CuO/RF composites, even with substoichiometric CuO, sustain combustion, burning compl

146 lly suppresses the aggregation of Abeta at a substoichiometric dose.

147 Reduction with substoichiometric equivalents of Ti(III) citrate afforde

148 The semiquinone is substoichiometric, even with conditions optimized for it

149 Compound binding to ClpP in a substoichiometric fashion triggers the formation of comp

150 tightly associated with the proteasome in a substoichiometric fashion, e.g., the deubiquitinating en

151 nation of single-molecule photobleaching and substoichiometric fluorescent labeling to determine the

152 ults in a 1000- to 2000-fold change, so that substoichiometric forms are estimated at less than one c

153 Oxidation also leads to the appearance of a substoichiometric free radical EPR signal with an averag

154 ned when the wild-type subcomplex hydrolyzes substoichiometric [gamma-(32)P]ATP.

155 C52A and C52S mutations lead to protein with substoichiometric heme (19% with respect to wild type);

156 We report the crystal structure of a substoichiometric, HMPA-trisolvated lithium pinacolone e

157 umber in approximately 10% of the lines, but substoichiometric in all others.

158 in(-1) mg(-1)) establishes that F(2)CDP is a substoichiometric inactivator of RNR.

159 r affinity, spanned the spectrum from strong substoichiometric inhibition (TKB) to stoichiometric inh

160 various drugs identified the need for strong substoichiometric inhibition of a carbonyl group on ring

161 nding reveals an unprecedented mechanism for substoichiometric inhibition of a gene-regulatory protei

162 nd (iii) highlight potential implications of substoichiometric inhibition of the viral protease in de

163 The mechanism of the stoichiometric and substoichiometric inhibitions of tubulin self-assembly b

164 ly to tubulin (Kb = 3.5 x 10(2) M(-1)), is a substoichiometric inhibitor.

165 t this single modification has a notable and substoichiometric inhibitory effect on alpha-synuclein a

166 chemical quench analysis has demonstrated a substoichiometric initial burst of ADP formation by free

167 We identify a novel substoichiometric interactor of the complex, transcripti

168 Substoichiometric kinetic bursts were observed in the pr

169 thod exists for controlled stoichiometric or substoichiometric labeling of proteins in live cells.

170 ne consumption, but only accumulated at low, substoichiometric levels ( approximately 10% yield) rela

171 tor of in vitro amyloid formation by IAPP at substoichiometric levels and protects cultured rat INS-1

172 Freshly purified IDI contained substoichiometric levels of a single metal ion, presumab

173 d is increased when the reaction is run with substoichiometric levels of AdoMet or with the defective

174 0 mol of bound ATP per dimer equivalent, and substoichiometric levels of bound ADP (0.08-0.58 mol/dim

175 he formation of Sc237 prions is inhibited by substoichiometric levels of hamster unglycosylated PrPC

176 of the tyrosyl radicals was evident even at substoichiometric levels of nimesulide.

177 itination of Med3 offers a rationale for the substoichiometric levels of the tail module that are fou

178 ATP or ADP binding to FtsA* and occurred at substoichiometric levels relative to FtsZ, similar to ce

179 transcriptional repression by PLZF, even at substoichiometric levels relative to PLZF.

180 assays and microscopy, we show that MciZ, at substoichiometric levels to FtsZ, causes shortening of p

181 Second, streptavidin protein was added at substoichiometric levels to prepare a series of complexe

182 Rpb4 and Rpb7 are present at substoichiometric levels, form a dissociable subcomplex,

183 ence was identified in Phaseolus glabelus in substoichiometric levels, suggesting that the present-da

184 dicated that the Sip1 protein was present in substoichiometric levels.

185 mma-Li2B12H12 polymorph then decomposes to a substoichiometric Li2B12H(12-x) composition.

186 the beta- and gamma-Li2B12H12 polymorphs and substoichiometric Li2B12H(12-x).

187 anhydrous Li2B12H12 begins to decompose to a substoichiometric Li2B12H12-x composition, which display

188 (3)H]-F2CDP have established that F2CDP is a substoichiometric mechanism based inhibitor (0.5 eq F2CD

189 t ring C contains the ability to induce both substoichiometric microtubule inhibition and GTPase acti

190 um that ranges from stoichiometric to strong substoichiometric modes of microtubule inhibition.

191 unassigned spectra arise from peptides with substoichiometric modifications.

192 al, convergent route for the introduction of substoichiometric numbers of latent surface sites into d

193 ed appears to be greater than 12, suggesting substoichiometric occupancy at any given site.

194 ardation and final immunochemical profile at substoichiometric phosphorylation of most sites.

195 to the low abundance of phosphoproteins and substoichiometric phosphorylation.

196 Introduction of substoichiometric quantities of converted Sup35p greatly

197 Substoichiometric quantities of Hunig's base are used to

198 stituted biaryl azides at 60 degrees C using substoichiometric quantities of Rh(2)(O(2)CC(3)F(7))(4)

199 Substoichiometric quantities of scandium and ytterbium t

200 subunits Rpd3 and RbAp48/p46 [8] as well as substoichiometric quantities of the deacetylase-associat

201 The purified protein was associated with substoichiometric quantities of tightly bound NADP+ and

202 s and the ability to use these organotins in substoichiometric quantities, the hazards and purificati

203 re fully functional and are bound to VhuD in substoichiometric quantities.

204 e Fukuzumi acridinium photooxidant (1) and a substoichiometric quantity of a hydrogen-atom donor.

205 optimization, it has been determined that a substoichiometric quantity of piperidine (secondary amin

206 Metal saturation occurs at a substoichiometric ratio of 0.8-0.85 metal/monomer, and t

207 The collapse occurs with a substoichiometric ratio of coat protein subunits and is

208 rmodynamically coupled and suggests that the substoichiometric ratio of CypA in the HIV-1 virion resu

209 beta-tubulin toxicity requires a minimal but substoichiometric ratio of Rbl2p to beta-tubulin.

210 Substoichiometric ratios of bound taxol in microtubules

211 the strong stabilizing effects on plus ends, substoichiometric ratios of Taxol bound to tubulin in mi

212 itivity to taxol, we measured the effects of substoichiometric ratios of taxol bound to tubulin in mi

213 illation of Alzheimer Abeta(1-40) peptide at substoichiometric ratios, albeit some more effectively t

214 rapid aggregation of full-length protein at substoichiometric ratios.

215 2)A; it also shows significant inhibition at substoichiometric ratios.

216 uired for polymerization, but instead caused substoichiometric reductions in the amount of tubulin th

217 POT1-TPP1 increased processivity even when substoichiometric relative to the DNA, providing evidenc

218 ratio of 1:1, our data indicate that FADD is substoichiometric relative to TRAIL-Rs or DED-only prote

219 ow that Eha is nevertheless essential, and a substoichiometric requirement for H(2) suggests that its

220 a nuclear gene that regulates mitochondrial substoichiometric shifting in Arabidopsis.

221 We postulate that the process of substoichiometric shifting in plants may be a consequenc

222 lectrically biasing thin films of amorphous, substoichiometric silicon oxide drives surprisingly larg

223 tein, most phosphoproteins contain multiple, substoichiometric sites of phosphorylation.

224 Gdown1 is a substoichiometric subunit of RNA polymerase II (Pol II)

225 that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated wi

226 Substoichiometric ThT (1 mol % relative to hydrogelator)

227 The REM consists of a porous substoichiometric titanium dioxide (Ti4O7) tubular, cera

228 nd strand exchange requires amounts of Rad52 substoichiometric to Rad51 and involves a stable, equimo

229 lecular chaperone Hsp110, in a concentration substoichiometric to the mutant SOD1 protein, completely

230 factors, with a copy number per cell that is substoichiometric to the ribosome and similar to the abu

231 ) at concentrations of RecA protein that are substoichiometric to the ssDNA, arguing that LexA repres

232 ted tubulin polymerization at concentrations substoichiometric to the tubulin concentration.

233 This substoichiometric uptake of protons could be due to a pK

234 stern signal strengths, Cox16p appears to be substoichiometric with Cox1p and Cox4p, which could indi

235 Interestingly, when E(C) concentrations were substoichiometric with respect to the N-terminal splicin

236 To determine if the substoichiometric Y (*) level was associated with apo be

237 nantly expressed AztD purifies with slightly substoichiometric zinc from the periplasm of Escherichia

238 is unstable and only partially populated at substoichiometric Zn(II); a slight molar excess of zinc