ライフサイエンスコーパス: substrain

1 ceptible RED strain and the resistant MOYO-R substrain.

2 ia major infection depending on the parasite substrain.

3 te a highly conserved branch of the HTLV-IIB substrain.

4 em cell line derived from a related C57BL/6N substrain.

5 tated Nnt(C57BL/6J) allele from the C57BL/6J substrain.

6 C57BL/6N substrains, but not in the C57BL/6J substrain.

7 une arthritis, unlike the wild-type B10.Q/Ai substrain.

8 red in its entirety within a single congenic substrain.

9 y stimuli compared with the related C57BL/6N substrain.

10 -deficient 6J mice and NNT-competent C57BL/6 substrains.

11 gence of behavioral performance in these 129 substrains.

12 was present on epithelial structures in both substrains.

13 infiltrating lacrimal gland lesions in both substrains.

14 susceptible wild-type and initial resistant substrains.

15 c orchitis (EAO) exists among various BALB/c substrains.

16 an disease, makes extensive use of 129 mouse substrains.

17 pic and phenotypic differences between these substrains.

18 ignificantly, and similarly with age in both substrains.

19 d mice and was not different between the two substrains.

20 NOD/ShiLtJ (CHORI-29), two commonly used NOD substrains.

21 etabolic disease is similar in the 6J and 6N substrains.

22 only in BALB/cJ mice and not in other BALB/c substrains.

23 sceptible to infection as other C3H (H-2(k)) substrains.

24 J mice to those of TLR4-sufficient C3H mouse substrains.

25 thand C57BL/6 is often used to describe both substrains.

26 d MRL/lpr (mean difference 33.6%, P < 0.001) substrains.

27 esponses similar to those of other C3H mouse substrains.

28 Mp-lpr/lpr strains to generate C1q-deficient substrains.

29 of all groups tested, suggesting that linked substrain 129 alleles, not the absence of D2 receptors p

30 an induced severe arthritis in the C3H/HeJCr substrain (95-100% incidence), whereas the original pare

31 sal agenesis and behavior in the 129/SvEvTac substrain and compared their behavior to that of C57BL/6

32 wering effect demonstrated by the S.R(ET3x5) substrain and the BP lowering effect retained by the S.R

33 or characterizing sequence variants in these substrains and demonstrate their use in quantitative ana

34 lead to extensive genetic variability among substrains and embryonic stem cells derived from them.

35 This review will describe these two substrains and highlight the importance of separate cons

36 inge eating in closely related C57BL/6 mouse substrains and in an F2 cross to identify quantitative t

37 strate their use in quantitative analysis of substrains and sequence variations in mixed virus cultur

38 Studies in rodent substrains and subpopulations are providing new insights

39 rt weight comparisons between these congenic substrains and their S control localized the BP QTL to a

40 etic relationship between four C57BL-derived substrains and used the panel to map two N-ethyl-N-nitro

41 The dacryoadenitis in both substrains appears to be Th2 in nature, with little IFN-

42 died primarily in C57BL/6 mice, however, 129 substrains are commonly used in gene-targeting experimen

43 e distinguishing features of the SAMP1/YitFc substrain at the University of Virginia, compared with t

44 in IL-12-dependent IFN-gamma responses in a substrain (B10.Q-H2-(q)/SgJ) of B10.Q mice that manifest

45 entials and PPI in these two closely related substrains based on the hypothesis that any observed end

46 d 129, we document that outcrossing of these substrains, both deliberate and accidental, has lead to

47 mutation in homozygous form in all C57BL/6N substrains, but not in the C57BL/6J substrain.

48 during the critical period, whereas another substrain, C57BL/6J (6J), exhibits both plasticity proce

49 dominant screening for obesity using C57BL/6 substrains, C57BL/6J and C57BL/6N, with the routine use

50 In this study, two common substrains, C57BL/6J and C57BL/6NHsd, exhibited differen

51 ell response to MCMV infection in novel BALB substrains congenic for different MHC (or H-2 in mice) h

52 ed glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is not affect

53 cle bacilli tested and was deleted only from substrains derived from the original BCG Pasteur strain

54 ility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 an

55 and IL-4Ralpha-/- mice infected with either substrain displayed reduced Th2 responses.

56 We found that DBA/2Hsd substrain exhibited reduced inhibition of evoked potenti

57 C3H/He substrains exhibited a modest incidence (average of 19 S

58 The SAMP1/YitFc substrain exhibits unique characteristics when compared

59 hus, the authors decided to test several 129 substrains for their behavioral characteristics.

60 hil migration, induced by the other L. major substrain, Friedlin, was unaffected, and the initial par

61 Sisa1, a congenic substrain from the SHR.WKY-Sa animals carrying an introg

62 ial protein was found in the M. tuberculosis substrains H37Rv, H37Ra, Erdman, and "C" strain, as well

63 Five of the six congenic substrains had significantly lower BP compared to the pa

64 The inbred 129 substrains have been characterized as poor learners that

65 ross onto highly fibrosis-susceptible BALB/c substrain, identified in inbred mouse strain screening.

66 studies suggest that regardless of parasite substrain, IL-10 is as important as IL-4/IL-13 in promot

67 ferences between C3H/HeJ and other C3H mouse substrains in response to M. tuberculosis infection.

68 es associated with development of CP in both substrains, including RIKEN cDNA 1810009J06 gene (trypsi

69 t for IL-4R alpha-chain (IL-4R alpha), while substrain IR173 was highly controlled.

70 mmonly used CD45.1(+) congenic C57BL/6 mouse substrain is characterized by selective deficiency in Vg

71 function, these findings suggest that the 6N substrain is the more logical and representative genetic

72 ypically contain at least two distinct viral substrains, JL1 and JL2, which have been characterized b

73 Because many of the C3H substrains lost arthritis susceptibility or acquired res

74 In previous studies the L. major substrain LV39 caused progressive, nonhealing lesions in

75 d website dedicated to Escherichia coli K-12 substrain MG1655 that is revised daily using information

76 sistance but not in virus-susceptible DBA/2J substrain mice.

77 The differences between the substrains might reflect genetic drift.

78 Several strains and substrains mirrored the high and low responses of B6 and

79 genetic heterogeneity among inbred C3H mouse substrains modifies resistance to infection.

80 MRL/MpJ mice of substrains MRL/MpJ-fas(+)/fas(+) (MRL/+) and MRL/MpJ-fas

81 th this idea, we found that an often-studied substrain of C57BL/6 mice, C57BL/6JOlaHsd (6JOla), lacks

82 pic MuLVs identified in mice infected with a substrain of Friend MuLV (F-MuLV57) are reactive with Hy

83 The moderate seizure severity substrain of genetically epilepsy-prone rats (GEPR-3s) e

84 ing generalized AGS in the moderate severity substrain of genetically epilepsy-prone rats (GEPR-3s).

85 seizure (AGS) ('AGS kindling') in the severe substrain of genetically epilepsy-prone rats (GEPR-9s) r

86 When the substrain of L. major, LV39, was infected, lack of galec

87 Here we describe an FVB substrain of mice in which this repertoire was uniquely

88 titative morphology in eyes of the DBA/2NNia substrain of mouse (DBA) with inherited angle-closure gl

89 F-11A cells are a substrain of murine neuroblastoma F-11 cells that contai

90 sed echocardiographic selection to develop a substrain of myosin light chain (MLC)-Ras (RAS) transgen

91 ons of the GEPR-3 (moderate seizure severity substrain of the GEPR).

92 Interestingly, two substrains of 129 mice were resistant to high-dose Y. pe

93 Rather, the changes suggest that substrains of an established infecting strain are shuffl

94 electroencephalography (EEG) in C3H/He mice, substrains of C3H mice were evaluated by EEG and sensiti

95 Finally, embryos from two substrains of C57BL mice that differ in susceptibility t

96 Two substrains of GEPRs exist, GEPR-9s, exhibiting tonic AGS

97 We report that females of some substrains of inbred mouse strain 129 are resistant to s

98 The M. bovis type strain, five substrains of M. bovis BCG (Copenhagen, Glaxo, Japanese,

99 deletion mutations in the chromosomes of two substrains of M. bovis BCG and M. tuberculosis H37Rv.

100 C57BL/6J and 129 substrains of mice are known to differ in their basal le

101 as(lpr)/fas(lpr) (MRL/lpr) mice are congenic substrains of mice that have spontaneously developing la

102 is considered an inherent property of LICs, substrains of NOD/SCID mice that possess additional dele

103 We previously reported that multiple substrains of the 129 mouse background are resistant to

104 atients with recurrent infections, different substrains of the established clone dominate in an appar

105 n in DBA/2J mice, using genetically modified substrains of this inbred line.

106 be necessary to determine whether particular substrains of viruses confer an elevated risk of asthma

107 ll nonarthritic animals, regardless of their substrain origin.

108 in, whereas, in its absence, the susceptible substrain outgrew its resistant counterpart.

109 nds but different CP phenotypes of these two substrains presents a unique opportunity to discover gen

110 Comparison of seven congenic substrains refined QTL1 to a 1.17 Mb segment flanked by

111 y or resistance in the C3H/HeJCr and C3H/HeJ substrains, respectively, significant differences were f

112 n because few persist between separate mouse substrains, rodents, or primates.

113 Two nonoverlapping substrains, S.R(ET3x1) and S.R(ET3x6), had significantly

114 The WKY More Immobile (WMI) substrain shows high immobility/despair-like behavior in

115 icroevolution within a clonal population and substrain shuffling in recurrent infections.

116 ndom fashion, a process that we refer to as "substrain shuffling".

117 reation of 2 new mutually exclusive congenic substrains (Sisa1a and Sisa1b) and interrogation of cand

118 Only 1 of the substrains (Sisa1a) continued to demonstrate a BP differ

119 Of eight substrains studied for EAE and 13 for EAO, BALB/cJ mice

120 Mice of 10 C3H substrains (subcolonies) were immunized with cartilage p

121 plasticity was identical in the 6JOla and 6J substrains, suggesting that adult plasticity occurs by a

122 C3H/HeJBir is a mouse substrain that is highly susceptible to colitis.

123 C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in li

124 ility to L. major and even more so for those substrains that are relatively resistant to IFN-gamma me

125 ntially regulated expression between the two substrains that might be candidates in CP progression in

126 mammals and present a framework to use mouse substrains to identify previously unknown genes and alle

127 P lowering effect retained by the S.R(ET3x2) substrain together define the RNO3 BP QTL-containing reg

128 ce of the rd8 mutation in the C57BL/6N mouse substrain used widely to produce transgenic and knockout

129 This clearer understanding of 129 substrain variability allows consideration of its negati

130 A second iteration of congenic substrains was used to localize the QTL further to a 2.4

131 DNA segment found to be deleted from all BCG substrains, was conserved in all virulent laboratory and

132 gle region (RD1), which is absent in all BCG substrains, was deleted from virulent M. bovis and Mycob

133 oss of visual acuity between these two DBA/2 substrains, we also conclude that DBA/2NHsd mice are a s

134 t background, further iterations of congenic substrains were constructed and characterized to fine-ma

135 In the current work congenic substrains were constructed from the progenitor congenic

136 the congenic region of RNO3 and six congenic substrains were developed that carry shorter segments of

137 Seven 129 substrains were put through a battery of tasks to determ

138 hibitor swainsonine selected for a resistant substrain, whereas, in its absence, the susceptible subs

139 pr) and MRL/Mp-+/+ (MRL/+) mice are congenic substrains, which differ only by a single autosomal rece

140 This fragment was present in the DBA/2N substrain with Rmcf-mediated resistance but not in virus

141 read demand has led to generation of several substrains with subtly different phenotypes.

142 is demyelinating disease exists among BALB/c substrains, with BALB/cAnNCr mice being susceptible whil

143 s and reduced startle relative to the DBA/2J substrain without alterations in auditory sensitivity, a

144 he forced swim test (FST), while the control substrain, WKY Less Immobile (WLI), shows no depressive

145 l cytochrome c-551 from Pseudomonas stutzeri substrain ZoBell has been mutated to convert the invaria

146 e cluster nirFDLGH from Pseudomonas stutzeri substrain ZoBell on a high copy plasmid.

147 for cytochrome c-551 in Pseudomonas stutzeri substrain ZoBell, was engineered to mutate Met61, the si