ライフサイエンスコーパス: substrate

1 f about 0.03%, for a deep UV-LED grown on Si substrate.

2 tion of conserved disulfide bonds within the substrate.

3 eK3 and NleB2 were not active against either substrate.

4 ter treated, varies markedly with the carbon substrate.

5 xchange field (MEF) from a ferromagnetic EuS substrate.

6 bserved with either glass or stainless steel substrate.

7 , which transformed the protein into an FtsH substrate.

8 -crystalline LiFe5 O8 thin film on polyimide substrate.

9 abstraction plus H2 generation from a model substrate.

10 ted-state iridium photocatalyst and an amine substrate.

11 and high-quality polymer films on an aqueous substrate.

12 usceptibility because aztreonam is not an L1 substrate.

13 the photoexcited photoredox catalyst and the substrate.

14 lycolysis was sufficient to supply requisite substrate.

15 g isolated starch and cooked potato tuber as substrates.

16 s are successfully realized on common fabric substrates.

17 free hydroxyl groups, pyranose, and furanose substrates.

18 1-dependent priming and self-priming of Plk1 substrates.

19 vity enabling use of electronically unbiased substrates.

20 f new modes of reactivity of polyunsaturated substrates.

21 ome of which are common for the two types of substrates.

22 variants with a slowed reaction rate toward substrates.

23 -GlcNAc sugar moiety to thousands of protein substrates.

24 ity toward hydroxyproline-containing peptide substrates.

25 ally use free polyunsaturated fatty acids as substrates.

26 ecific brain regions from mice and humans as substrates.

27 ng inhibitors and incubations with exogenous substrates.

28 B showed low catalytic efficiencies for both substrates.

29 sylation and the consequences of this PTM on substrates.

30 l, Msh2 promotes the rejection of mismatched substrates.

31 l reagent, mainly for reducing carbonyl-type substrates.

32 surface microfluidic mixing devices on open substrates.

33 sources fabricated on short-carrier-lifetime substrates.

34 ent behavioural subtypes and neurobiological substrates.

35 o O-O cleavage or reactivity toward external substrates.

36 he key downstream messenger insulin receptor substrate-1 phosphorylated at serine residue 312 in neur

37 ibly dead general base mutant by a synthetic substrate, 3beta-hydroperoxycholestane (3HPC) in which t

38 terconversion of the corresponding triketide substrates (3R,4E)-3-hydroxy-4-hexenoyl-FosACP2 (18) and

39 A novel peptide substrate (A G G P L G P P G P G G) was developed for qu

40 nhibitory regions, CBD and LAVP, which block substrate access to the substrate-binding groove.

41 on, but little is known about the structural substrates accounting for these common neurological defi

42 P production, Ca(2+) uptake and release, and substrate accumulation depend on the proton electrochemi

43 A catalytically relevant catalyst-substrate adduct has been observed, and its constitution

44 ental correlates of parameters in the model: substrate adhesion strength, actin polymerization rate,

45 endent quantitative decreases in TJ and cell-substrate adhesions.

46 yases and DMSP demethylases (DmdAs) have low substrate affinities, but AcuIs have very high substrate

47 bstrate affinities, but AcuIs have very high substrate affinities, suggesting that an effective detox

48 rdiffusion of Y from the YIG and Gd from the substrate, an addition magnetic layer is formed at the i

49 grown in the presence of the non-cyclizable substrate analog 2',3'-dideoxyguanosine-5'-triphosphate,

50 or its ubiquitin ligase activity towards the substrate and also the self-ubiquitylation.

51 fied numerous factors that modify the atrial substrate and increase AF susceptibility.

52 RT N and C termini contribute to transporter substrate and inhibitor affinities.

53 most effective minimal combination of carbon substrate and inoculum to drive pH neutralization and el

54 ifference between SacII digestion of both MB substrate and maintenance methylated MB corresponds to d

55 physical arrangement of the polymers in the substrate and refer to the directed movements as polymer

56 r even atomically thin graphene, between the substrate and the brittle thin film.

57 Diverse online transformations, in which the substrate and/or product of the reaction is an acyl chai

58 matin- and DNA-modifying enzymes make use of substrates and cofactors that are intermediates of metab

59 uitin chains are removed only from committed substrates and fast enough to prevent their co-degradati

60 ligation ("sortagging") of LPXTG-containing substrates and Gly-terminated nucleophiles occurs in vit

61 y interplay between the prochlorosin peptide substrates and the lanthionine synthetase suggests that

62 e intrinsic preference of AID for structured substrates and uncover the importance of G4 recognition

63 cognize and reglucosylate its many different substrates and/or enable reglucosylation of N-linked gly

64 residues that interact with the polyanionic substrate, and confirmed the functional relevance of the

65 ber A (RhoA), a KCTD13/CUL3 ubiquitin ligase substrate, and is reversed by RhoA inhibition, suggestin

66 ted to be the turnover-limiting step for one substrate, and this is facilitated by solvent 2,2,2-trif

67 nsferases was highly specific for stilbenoid substrates, and we confirmed their subcellular location

68 Most substrates are first covalently modified by ubiquitin, w

69 eoselective olefin metathesis where Z-alkene substrates are required.

70 However, Mps1's error correction-relevant substrates are unknown.

71 MARCKS (myristoylated alanine-rich C kinase substrate) as a potential target molecule for kidney can

72 for beta-lactam mimicry of the peptidoglycan substrates, as foundational to the mechanistic understan

73 Loss of RNF146 stabilized its substrate AXIN1, leading to impairment of WNT3a-induced

74 s allow proteasomes to remove ubiquitin from substrates before they are translocated into the core pa

75 is composed of a GSH binding "G site" and a substrate binding "H site".

76 ts into a general principle that confers the substrate binding adaptability and specificity to OGA in

77 , and Arg(245) to interrogate their roles in substrate binding and catalytic activity.

78 The putative substrate binding and processing site is located on the

79 induced allosteric regulation of polypeptide substrate binding and release.

80 uggesting that these residues participate in substrate binding and/or catalysis.

81 Substrate binding breaks the six-fold symmetry of the co

82 rpheein model of enzyme hysteresis, in which substrate binding induces conformational changes that pr

83 This effect could be explained by productive substrate binding that protects LPMOs from oxidative sel

84 in the 2nd SIA-binding site, indicating that substrate binding via this site enhances NA catalytic ac

85 The substrate binding yields characteristic Cotton effects t

86 y affect residue 132, which helps coordinate substrate binding.

87 e site and provides additional restraints on substrate binding.

88 ons in the heme-binding (R374W and R448C) or substrate-binding (W116C) site of 11beta-hydroxylase, or

89 g of its nucleotide-binding domain (NBD) and substrate-binding domain (SBD).

90 as Esp1) contains four domains (I-IV), and a substrate-binding domain immediately precedes the cataly

91 nd LAVP, which block substrate access to the substrate-binding groove.

92 nd whose activity is repressed by a flanking substrate-binding leucine-rich repeat (LRR) domain when

93 We present an atomic model of a substrate-bound inner mitochondrial membrane AAA+ qualit

94 of substituted sodium phenolates to form the substrate-bound O(MeAN)-RPhO(-) species that leads to or

95 selectins facilitates adhesion to a distinct substrate-bound protein with different kinetic propertie

96 Without a ground state substrate-bound structure for the prototypical nonadiaba

97 No other sugars were used as substrate by this enzyme.

98 (MeAN) and perform the oxidation of external substrates by two complementary strategies: (i) coordina

99 The racemic allylic alcohol substrates can be converted to the enantioenriched keton

100 eflectivity difference between two different substrates can be tracked and controlled.

101 Interestingly, dialkynyl substrates can undergo tandem benzannulations to give su

102 Using a model substrate (casein), we report cryo-electron microscopy s

103 ations made within the predicted transporter substrate channel differentially altered the potency for

104 udying how metabolic enzymes communicate via substrate channeling.

105 ble gaps, to semi-metallic, depending on the substrate, chemical functionalization and strain.

106 high quality epitaxial growth, which limits substrate choice and thus possible photonic applications

107 strate drives a gradual reduction in droplet-substrate contact.

108 retch of the membrane and deflection of cell-substrate contacts points, respectively.

109 e nickel-catalyzed arylative cyclizations of substrates containing a Z-allylic phosphate tethered to

110 ular [2+2+n] (n = 1 or 2) cycloaddition with substrates containing three diyne units.

111 t that the phosphorylation of many different substrates contributes to cAMP-dependent regulation of t

112 p70s, its activity relies on nucleotide- and substrate-controllable docking and undocking of its nucl

113 ex is a competent intermediate that promotes substrate coordination via proton-coupled ligand exchang

114 OS and deposited on Ag substrate, or another substrate covered with Ag, by drop casting.

115 determination of onset potentials, while the substrate current, which is recorded in parallel, is due

116 This coupling between deubiquitination and substrate degradation is ensured by the Ins-1 loop of Rp

117 in ligase assembly, function, and ultimately substrate degradation.

118 n cultures, but remains poorly understood in substrate-dependent cells.

119 (462)LAVP(465), which competitively inhibits substrate dephosphorylation.

120 olomic profiling to examine the time-varying substrate depletion from a mixture of 19 amino acids and

121 or kinase specificity (MAKS) to identify the substrates directly and to map the phosphorylation site(

122 stinct confined environments, reminiscent of substrate discrimination at the buried metal centers of

123 inward motion of the phase boundary near the substrate drives a gradual reduction in droplet-substrat

124 aneous delamination of nanosheets from their substrate due to delithiation-induced mismatch.

125 l and citral occurs by co-oxidation with the substrate, due to very fast self-termination and cross-t

126 nclude that additional contacts with protein substrates enhance catalytic efficiency.

127 A substrate envelope-guided design strategy is reported fo

128 in the ATP-induced opening of Hsp70 to allow substrate exchange.

129 cognizing both the enzyme factor IXa and the substrate factor X.

130 eristic of a "feedback-amplified domineering substrate" (FADS).

131 ynthesis of these complex molecules requires substrate flux from the isoprenoid pathway, enzymes invo

132 nucleoprotein particles (RNPs) that form the substrate for axonal translation.

133 important role in the health of an infant as substrate for beneficial gut bacteria.

134 xidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidat

135 lglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antenn

136 tennary glycan, generated by GnT-V, is not a substrate for FUT8.

137 DP-4-N3-GlcNAc served as a chain termination substrate for hyaluronan or heparosan synthases; the res

138 disorders and constitutes a neuroanatomical substrate for investigating the underlying molecular mec

139 M. lysodeikticus is a typical enzymatic substrate for lysozyme.

140 at the cerebellum input stage, providing the substrate for phase-dependent binding of mossy fiber spi

141 generates the requisite 3' single-strand DNA substrate for RecA-mediated strand invasion.

142 s of which form the direct, pathophysiologic substrate for SCD.

143 niquely differentiated picture of the neural substrate for the first 500 ms of word recognition.

144 raction assays identified FDH as a potential substrate for the RING-type ubiquitin ligase Keep on Goi

145 orescence (REF) that uses custom fluorogenic substrates for bacterial enzymes allows rapid and specif

146 ed a biochemical toolbox that includes lipid substrates for enzymatic assays, potent inhibitors, and

147 icient information to select candidate paper substrates for fluorophore-labeled assays.

148 pment to screen Rab proteins predicted to be substrates for ICMT (ste14 in flies).

149 N(tz)AD(+) and N(tz)ADH serve as substrates for NADase, which selectively cleaves the nic

150 of using antibodies as bivalent biomolecular substrates for the templated assembly of a functional RN

151 The substrates for these reactions are generated in 1-3 step

152 properties of ZnO QDs and is applied towards substrate-free Schottky photodetector applications.

153 nzyme independently follows its own specific substrate gradient, which in turn is produced by the pre

154 in that they lack an electrostatic loop for substrate guidance and have an unusual open-access coppe

155 een the functional groups and C-H bonds of a substrate has been exploited to achieve meta-selective C

156 nt for a wide range of organic and inorganic substrates has been investigated.

157 Specifically, SrTiO3 (001) substrates have been annealed to achieve alternating che

158 branch of the kinome, with and without known substrates, highlighting the applicability of the method

159 lent, but coordination of an enantioenriched substrate immediately gives rise to intense Cotton effec

160 not the catalytic base that deprotonates the substrate in ChOx.

161 e to the Me-Cbl cofactor with respect to the substrate in the enzyme active site.

162 rs that transport amphipathic or hydrophobic substrates in a detergent-free native or artificial memb

163 natural UDP-sugar donors were then tested as substrates in glycosaminoglycan synthesis catalyzed by v

164 indings demonstrate that the levels of ESX-1 substrates in M. marinum are fine-tuned by negative feed

165 s binding is required for processing protein substrates in nucleoprotein complexes, and that Lon may

166 tein complex that can degrade or process RNA substrates in the 3'-to-5' direction.

167 ttached to other Ub molecules and to protein substrates in various forms, imposes a major challenge f

168 lin switch regions are particularly good AID substrates in vitro.

169 very high level of selectivity towards small substrates including the natural indole-3-acetic acid, a

170 insertion of a range of unsaturated organic substrates, including azides, isocyantes, and nitriles,

171 f promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carb

172 ular explanation for the previously baffling substrate-inhibition behavior of the enzyme.

173 d role of the eukaryote-specific cofactor in substrate interaction.

174 ut and efficient strategy to identify the E3-substrate interaction.

175 ed the conformational dynamics of the kinase-substrate interface.

176 bly, and actin retrograde flow at the T-cell-substrate interface.

177 inding leucine-rich repeat (LRR) domain when substrate is absent.

178 taxial Fe3 O4 thin film on a Nb-doped SrTiO3 substrate is investigated.

179 One Cyclin A/Cdk1 substrate is myosin phosphatase targeting subunit 1 (MYP

180 The high preference for the (S)-substrate is of synthetic value.

181 Hence, an anatomic substrate is present, which may enhance the occurrence o

182 Thus, substrate is released prior to ATP hydrolysis.

183 r in a checkerboard nanostructure on plastic substrates is presented for digital detection.

184 xy-the growth of a crystalline material on a substrate-is crucial for the semiconductor industry, but

185 thin film deposition onto an optical grating substrate, it is possible to increase the grating amplit

186 ur simulation results, because the different substrates lead to the formation of different ice polyty

187 rial oxidative phosphorylation, increases in substrate level generation of ATP and reducing equivalen

188 rk, we identified the major protein kinase C substrate MARCKS (myristoylated alanine-rich C kinase su

189 o defects generated in common dielectric and substrate materials.

190 dence that conformational restriction of the substrate may play a role in catalysis.

191 ted ischemic AMPK activation, alterations in substrate metabolism, and an increased sensitivity to is

192 G-quadruplex (G4)-containing substrates mimicking the mammalian immunoglobulin switch

193 7% (95% confidence interval, 46%-72%) in the Substrate-modification group (P=0.86).

194 ecurred in 28 PVI-only group patients and 24 Substrate-modification group patients, for 1-year freedo

195 owever, gecko adhesion is shown to depend on substrate modulus.

196 On soft substrates, most paxillin binds to endocytic factors and

197 Unfortunately, the landscape of human E3-substrate network has not been systematically uncovered.

198 Our results show that WASp is a novel substrate of ALK and has a critical role in regulating i

199 irst time, the integration on a single glass substrate of different thin film technologies in order t

200 hed intimal lesions tailored to resemble the substrate of human eroded plaques, acute flow perturbati

201 signaling in hippocampal neurons as a novel substrate of importance in the higher-order regulation o

202 lectrolyte bath, to provide information on a substrate of interest.

203 ermore, we showed that activation of IRF3, a substrate of TBK1, was independent of the TBD.

204 In this study, we report that PSY is a substrate of the Clp protease.

205 Identifying the substrates of an E3 holds the key to elucidate its role

206 ics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated

207 in situ, and the spatial distribution of the substrates of this machine before secretion.

208 enzyme that does not utilize carotenoids as substrate or perform double-bond cleavage.

209 calate between monolayer MoS2 and underlying substrates or in the interlayer space of thicker MoS2 by

210 sing antigens presented by either artificial substrates or live cells, we show that B cells primarily

211 solution of PVC and DOS and deposited on Ag substrate, or another substrate covered with Ag, by drop

212 ons, such as when there is a large excess of substrate over enzyme.

213 four-electron O2 reduction and two-electron substrate oxidation.

214 We show that accumulation of the autophagy substrate p62/SQSTM1 in stressed Kras(G12D) acinar cells

215 hieve band-like transport on a wide range of substrate platforms.

216 we observed a constrained, horseshoe-shaped substrate pocket, formed from an alpha-helix, a 310 heli

217 uirements for polyST autopolysialylation and substrate polysialylation overlap.

218 ied Ydr109c and FGGY proteins showed a clear substrate preference of both kinases for d-ribulose over

219 showed that recombinant BAR and PAT exhibit substrate preference toward phosphinothricin over the 20

220 ctivity, we analyzed Prp enzyme kinetics and substrate preference using a fluorogenic peptide cleavag

221 ister RNA requires proper orientation of the substrate prior to T1 closure such that the U5-A6 cleava

222 to jam the SecYEG channels with an arrested substrate protein to "freeze" them in their SecA-inserte

223 ctive electrochemical biosensors for robotic substrate quantification in 24-well microplates.

224 Substrate recognition and binding are critical for the r

225 we precisely mapped key residues involved in substrate recognition and catalysis by PI3Kalpha.

226 The structural basis for substrate recognition and translocation is unknown.

227 tained quality control factor that comprises substrate recognition and ubiquitin transfer activities

228 Here, we show that beta-TrCP, the substrate recognition component of an E3 ubiquitin ligas

229 The F-box protein FBXW7 is the substrate-recruiting subunit of an SCF ubiquitin ligase

230 s and release promotes helix disassembly and substrate release at the lagging end.

231 ic SHM-targeting rates of nucleotides across substrates representing maturation stages of human VRC-P

232 te (InsP6), acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralstonia solanacearum 1 (RRS1-R

233 ional studies of MalA' in complex with three substrates revealed that the enzyme represents a new cla

234 showed excellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation rea

235 A broad substrate scope is demonstrated for both quinazolinone a

236 to the sulfonamides that is higher and with substrate scope that is broader than those of enzymes co

237 tical role for polyST autopolysialylation in substrate selection and polySia chain elongation.

238 at some SNPs allosterically modulate PCSK9's substrate sequence specificity.

239 alue of the model, we extracted a variety of substrate sequence-derived features and compared the per

240 Substituting preferred cathepsin G substrate sequences into sunflower trypsin inhibitor-1 (

241 the substitution patterns, readily available substrates, short reaction time, transition metal-free,

242 eved in virtue of the Ag nanoseeds in the 3D substrate, showing a low overpotential ( approximately 0

243 With terpene-derived substrates, similar trends in reactivity toward tertiary

244 ped using the thrombin-specific, fluorogenic substrate SN-59 (100 muM).

245 An interesting substrate-solvent hydrogen-bonding interaction was obser

246 equiring mechanisms for tight repression and substrate-specific activation.

247 any breakthroughs, there are limitations to 'substrate-specific' stable isotope tracers, which limit

248 of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with artificial degradat

249 tive cytidine deaminases that exhibit unique substrate specificities and thermosensitivities.

250 tural evolution leading to improved or novel substrate specificities are not wholly defined.

251 rometry, allowing one to rapidly analyze the substrate specificities of chitosan hydrolases that can

252 Curiously, despite their mutually exclusive substrate specificities, PON1 and diisopropyl fluorophos

253 s the potential signature sequence for their substrate specificity and activity.

254 Characterizing the substrate specificity of protease enzymes is critical fo

255 Understanding the substrate specificity of these enzymes could create oppo

256 st method for measuring the average rate and substrate specificity of XNA polymerases in a standard q

257 65 A resolution, and we compare its in vitro substrate specificity with those of fungal Icp55 enzymes

258 substitutions in human RR additively affect substrate specificity.

259 y of the transporters accompanied changes in substrate specificity.

260 The substrate structure incorporates three key features: (a)

261 layer graphene (FLG) systems on a dielectric substrate such as SiO2, the addition of each extra layer

262 metal single crystals but also on other flat substrates such as highly ordered pyrolytic graphite.

263 and Eu vapor in ultrahigh vacuum to an inert substrate, such as graphene.

264 during strand displacement on a nontelomeric substrate, suggesting that WRN recruitment and cooperati

265 However, one-site linear DNA is a poor substrate, supporting a mechanism where CglI complexes m

266 ng its proteolysis of the endogenous protein substrate, synaptosomal-associated protein 25 (SNAP-25).

267 the Al surface is controlled by changing the substrate temperature during the deposition process to p

268 a range of putative para-hydroxybenzoic acid substrates tested.

269 ative framework to select a low-fluorescence substrate that minimizes both the overlap of paper and f

270 are deemed most relevant; and (2) the neural substrates that support such dynamic prioritization.

271 al way of removing blanket layers from their substrates, the new process reported here enables 3D con

272 Populations of cells are dispersed onto the substrate, their locations determined using optical micr

273 nanostructures on low-cost ink coated glass substrates through a facile and flexible single pulsed n

274 bonds over competing reduction of the azide substrate to a sulfonamide.

275 to produce a mimetic Kdo-lipid A domain AlmG substrate to that synthesized by V. cholerae.

276 le switch, which affects access of the NADPH substrate to the enzyme.

277 nversion of carbon-containing bioconvertible substrates to electricity with smaller space, less mediu

278 a B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover.

279 ation and strongly accelerated by mechanical substrate translocation into the AAA+ motor.

280 We also provide evidence that substrate-transport elicited endocytosis of other amino

281 ing-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a central pore.

282 Chaperones of the HSP100 family help with substrate unfolding, and additional accessory proteins a

283 (2+) and NAD(+) and the absence of exogenous substrates upon inner membrane pore formation by alameth

284 d around each virus particle captured on the substrate using a portable interface.

285 e only toxin that also cleaves non-canonical substrates VAMP4, VAMP5 and Ykt6.

286 dots fabricated on an indium tin oxide (ITO) substrate via a block copolymer template was developed f

287 ndium tin oxide/poly(ethylene terephthalate) substrate via a low temperature (</=100 degrees C) solut

288 k-SMase recognizes the choline moiety of its substrates via an NPP7-specific aromatic box composed of

289 ered that B1 and VRK2 target a common set of substrates vital to productive infection of this large c

290 d inductively coupled plasma etching, the Si substrate was prepared with very high pattern density an

291 probable candidate for the slowly exchanging substrate water in the S0 state.

292 rtual reaction extraction tool, 38 potential substrates were tested as prenyl acceptors in assays wit

293 Novel patterned collagen substrates were used to investigate alignment and migrat

294 orescence intensity compared to a bare glass substrate, which enabled us to image single fluorescent

295 utamate from vitamin B9 and other glutamated substrates, which activate mGluR I.

296 the growing end of the helix and engage the substrate, while hydrolysis and release promotes helix d

297 ional catalyst/reagent and can be applied to substrates with a wide range of substitution patterns.

298 Conforming materials to rigid substrates with Gaussian curvature-positive for spheres

299 semiconductor field-effect transistors on Si substrates with low leakage currents and high on/off rat

300 cancer biomarker, produce optically tunable substrates with two orders of magnitude fluorescence enh