ライフサイエンスコーパス: substrate-specific

1 Notably, AKT signaling in melanoma cells is substrate specific.

2 or one or more cdks, but none is known to be substrate specific.

3 to dsx shows that the requirement for Doa is substrate specific.

4 dc20 inhibition by the spindle checkpoint is substrate specific.

5 eins is ordered, occasionally redundant, and substrate-specific.

6 these effects were both enzyme-specific and substrate-specific.

7 amatic change upon PKA phosphorylation was a substrate-specific, 7-fold increase in both K(m) and k(c

8 different catalytic strategies to accomplish substrate-specific acetylation.

9 equiring mechanisms for tight repression and substrate-specific activation.

10 We show here that resveratrol is a substrate-specific activator of yeast Sir2 and human Sir

11 d Cdh1 proteins were identified as limiting, substrate-specific activators of APC-dependent proteolys

12 es toward a tyrosine-phosphorylated TCR zeta substrate (specific activity ranging from 0.23 to 40 pmo

13 lation turnover to generate clearly resolved substrate-specific activity thresholds, which in turn en

14 cells before gastrulation; and third, it has substrate-specific activity, cleaving Xnr1, Xnr2, Xnr3 a

15 ADAM10 complexes may allow cell type- and/or substrate-specific ADAM10 targeting.

16 stabilization of each loop conformation and substrate-specific adaptation of the active site.

17 odel of S2P substrate specificity in which a substrate-specific adapter protein tethers the S2P to it

18 lin 3a (CUL3a) in the cytoplasm, likely as a substrate-specific adapter protein.

19 x, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin li

20 ntains the stability of the Pcu1p-associated substrate-specific adaptor protein Pop1p.

21 es in which we propose that ETO1 serves as a substrate-specific adaptor protein.

22 of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3.

23 roteins, which modulate protein stability as substrate-specific adaptors for ubiquitination, have bee

24 F-box family of proteins, which function as substrate-specific adaptors of Cul1-based ubiquitin liga

25 However, the substrate-specific adaptors of this ligase remain unchar

26 e expression or the function of select F-box substrate-specific adaptors that results in neoplastic c

27 ltisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquity

28 ligases often use repeat domain proteins as substrate-specific adaptors.

29 ls5p-Als6p constructs, the regions mediating substrate-specific adherence were localized to the N-ter

30 e findings represent the integration of both substrate-specific and global regulatory systems, and ma

31 whereas the ADP-ribosylation by ExoS is poly-substrate-specific and includes Ras as an early target f

32 This reconstitution is substrate-specific and is reminiscent of the SC35-mediat

33 We find rates are substrate-specific and obey predictions of classical nuc

34 gates, indicating that SUMO deconjugation is substrate-specific and plays a critical role in determin

35 inct NXF variant proteins carry out separate substrate-specific and tissue-specific RNA regulation.

36 The requirement for this RS domain is substrate specific, and correlates with the strength of

37 The activity of each HalM enzyme is substrate-specific, and the assay products exhibit antim

38 ern blot analysis using a phosphorylated Akt substrate-specific antibody of Akt immunoprecipitated fr

39 KA upon exposure to EJ, as detected by a PKA substrate-specific antibody.

40 the Hsp90 molecular chaperone system to the substrate-specific arm of SCF ubiquitin ligase complexes

41 upon protein tyrosine phosphorylation and is substrate specific, as it is induced by vitronectin and

42 of a cargo to protect its adaptor is adaptor substrate-specific, as adaptors with artificial degradat

43 lant higher eukaryotes and inconsistent with substrate-specific base excision repair mechanisms found

44 wever, the action of Ras/NORE1A/beta-TrCP is substrate-specific because IkappaB, another substrate of

45 y state for both substrates while displaying substrate-specific behaviors.

46 ith the MAPK binding linear motif to achieve substrate specific binding, and it also enables co-recru

47 Together, these studies suggest that substrate-specific binding by sirtuin proteins involves

48 ted to play a particularly important role in substrate-specific binding by the sirtuin proteins.

49 nus) domain ubiquitin ligases occurs through substrate-specific binding domains.

50 nths prior to death, to evaluate region- and substrate-specific binding of the highly fluorescent PiB

51 witching may involve the removal of an early substrate-specific binding site as a mechanism to exclud

52 tural variability in regions associated with substrate-specific binding.

53 Although substrate-specific carbohydrate transporters and hydrola

54 y a tyrosine finger motif, thereby providing substrate-specific catalytic activity.

55 For example, the formation of substrate-specific cavities within bulk silica, while co

56 ced folate carrier (RFC1) resulted in marked substrate-specific changes in folate binding and the ind

57 eate across the outer membrane do so through substrate-specific channels proteins.

58 herefore, we hypothesize that, in analogy to substrate-specific channels that evolved to bind certain

59 These data provide further evidence for the substrate-specific chaperone function of FlgN and FliT a

60 The data suggest that FliS acts as a substrate-specific chaperone, preventing premature inter

61 les and identify one set of sodium-dependent substrate-specific chemical shifts.

62 robiome, and mechanisms of site-specific and substrate-specific citrullination.

63 elevated expression of F-box Skp2 protein, a substrate-specific component of SCF (Skp1-Cullin-F box p

64 port that these functions depend on SPOPL, a substrate-specific CUL3 adaptor.

65 hemical assays, pathogenic Lon proteins show substrate-specific defects in ATP-dependent proteolysis.

66 transport of at least two substrates showed substrate-specific defects in transport.

67 ible connection between MsRH2-1 function and substrate specific degradation via the ubiquitin pathway

68 Substrate-specific degradation is a key feature of the u

69 BAG6 and inhibiting its capacity to promote substrate-specific degradation.

70 er stability of the PP1-PPP1R15A complex nor substrate-specific dephosphorylation.

71 activation and therefore was probably due to substrate-specific differences in transporter/substrate

72 es, despite its sequence similarity to broad-substrate specific dioxygenases that do.

73 nzyme produced in Escherichia coli is highly substrate specific, displaying a strict requirement for

74 Substrate-specific DNA binding activity was detected in

75 pment of protein kinase inhibitors targeting substrate specific docking sites, rather than the highly

76 ound that the Hex3.Slx8 complex has a robust substrate-specific E3 ubiquitin ligase activity.

77 uitin-conjugating enzyme, and, frequently, a substrate-specific E3 ubiquitin-protein ligase.

78 with telomerase, rather than it being a DNA substrate-specific effect.

79 These results support the role for a substrate specific electrostatic interaction between the

80 ining hydroxylation, and identify additional substrate-specific elements that contribute to distinct

81 Mus81 is a highly conserved substrate specific endonuclease.

82 These experiments revealed a substrate-specific energetic barrier to cpTat-mediated t

83 nformational landscape of promiscuous versus substrate-specific enzymes.

84 These proteins exhibit a blend of substrate specific exo- and endonuclease activities and

85 s FlgN and FliT have been proposed to act as substrate-specific export chaperones, facilitating incor

86 n multiple SCF complexes involving different substrate-specific F-box proteins that are involved in d

87 oting complex (APC), in association with its substrate-specific factor Cdh1.

88 ptidase activity of individual subunits in a substrate-specific fashion.

89 We suggest that FlgN and FliT are substrate-specific flagellar chaperones that prevent oli

90 By tagging synaptic proteins with a peptide substrate specific for CaMKII and expressing them in cul

91 )-Ala(12)] angiotensin I is an ACE-resistant substrate specific for chymase.

92 inhibition of prenylation of Ki-Ras, HDJ2, a substrate specific for FPTase, and Rap1A, a substrate sp

93 substrate specific for FPTase, and Rap1A, a substrate specific for GGPTase-I.

94 7) (S)-BEL, a chiral enantiomer of suicidal substrate specific for iPLA2beta, could be effectively u

95 We also propose a new substrate specific for PR3.

96 Since pp120 is the first identified substrate specific for the insulin vis-a-vis the IGF-1 r

97 l)butyl]guanine ([(18)F]FHBG), a radioactive substrate specific for the sr39TK PET reporter protein.

98 rine protease activity against a fluorogenic substrate specific for TLSPs.

99 e activities in phosphorylating an exogenous substrate specific for ZAP-70 and Syk kinases.

100 protein system which allows for a variety of substrates (specific for MRI, florescence, or protein pu

101 Addition of excess unlabeled substrates specific for 10 distinct mammalian P-450 subf

102 e preparation was active against fluorogenic substrates specific for cathepsin D and E and inactive a

103 c for cathepsin D and E and inactive against substrates specific for cysteine cathepsins.

104 cence polarization assay against fluorogenic substrates specific for MMPs or TLSPs.

105 Transfected switch substrates specific for mu-->gamma3 and mu-->gamma1 are

106 Its effects on protein turnover are substrate-specific, for unknown reasons.

107 ur results reveal an unanticipated degree of substrate-specific functionality encoded in N-terminal s

108 romiscuous GSTA1-1 that is not observed with substrate-specific GSTA4-4.

109 The substrate-specific H-bonding interactions play a critica

110 Each H/ACA RNP contains a substrate-specific H/ACA RNA and four common proteins, t

111 Target substrate-specific hammerhead ribozyme cleaves the speci

112 efficient conversion of activated PP2A into substrate-specific holoenzymes, thus minimizing unregula

113 that most transport systems are exquisitely substrate specific, how are diverse protein sequences re

114 This effect of spermine was substrate specific; i.e. with casein as substrate, sperm

115 Remarkably, the substrate-specific increase in activity caused by T-loop

116 a result, these mutants not only regain the substrate-specific induction on catabolic arginine and h

117 herefore prove to be a valuable compound for substrate-specific inhibition of other RecQ family helic

118 Substrate-specific inhibition of the proteasome has been

119 s phosphorylation is inhibited by heparin, a substrate-specific inhibitor of CK2.

120 kely applicable for the development of other substrate-specific inhibitors as well.

121 n help in the discovery of ADAM isoform- and substrate-specific inhibitors.

122 the development of therapeutically valuable substrate-specific inhibitors.

123 ought about by the reversible interaction of substrate-specific inner-membrane proteins with an outer

124 dings fill an important gap in understanding substrate-specific inside-out signal transfer along clea

125 ods, the affinity method based on the enzyme-substrate specific interaction between amylase and glyco

126 e lifetime is achieved by the phosphorylated substrate-specific interaction with a bifunctional ligan

127 To find the structural elements that provide substrate-specific interactions and to allow identificat

128 bind ions, the modification of the QDs with substrate-specific ligands or receptor units, and the ch

129 rocytes secondary to an up-regulation of its substrate-specific light chain, xCT, and that this occur

130 hese data demonstrate that BB0646 is a broad substrate specific lipase that contributes to lipolytic

131 pH influenced CBL affinity isolation in a substrate-specific manner that paralleled pH effects on

132 translocon and demonstrate that it acts in a substrate-specific manner to facilitate the initiation o

133 n compartmentalization can be modulated in a substrate-specific manner to generate biologically signi

134 rs was found to vary as much as 60-fold in a substrate-specific manner, an unexpected finding for act

135 nverted repeats of salmonid transposons in a substrate-specific manner, and it mediates precise cut-a

136 te the anaphase-promoting complex (APC) in a substrate-specific manner, there is no evidence that the

137 he anaphase-promoting complex/cyclosome in a substrate-specific manner.

138 stabilizing SIRT1/peptide interactions in a substrate-specific manner.

139 f, can phosphorylate exogenous proteins in a substrate-specific manner.

140 tylation and internal modifications in a NAT substrate-specific manner.

141 slation during ER stress, inhibits RIDD in a substrate-specific manner.

142 ein-1/tolloid-like proteinase activity, in a substrate-specific manner.

143 proteins into the endoplasmic reticulum in a substrate-specific manner.

144 hway involving multiple membrane-associated, substrate-specific mannosyltransferases (ManTs) responsi

145 ent targets only partially overlap, implying substrate-specific mechanisms of HuC-mediated splicing r

146 cleavage of EGF ligands can involve the same substrate-specific metalloprotease but does require diff

147 We propose that Rrp47p functions as a substrate-specific nuclear cofactor for exosome activity

148 ealkylation activities, including regio- and substrate-specific O-demethylation and O,O-demethylenati

149 olvement of this protein in the catalysis of substrates specific of the anaerobe cytoplasm of DvH.

150 in angiosperms and gymnosperms, mediated by substrate-specific OMTs, represents one of the fundament

151 Substrate-specific outer membrane channels of gram-negat

152 active molecules at electrodes modified with substrate-specific oxidative enzymes.

153 into the active pocket of CYP9Q1, a broadly substrate-specific P450 with high quercetin-metabolizing

154 to additional ERAD substrates to interrogate substrate-specific pathways.

155 r dialysis with 5 microM MLCK(11-19)amide, a substrate-specific peptide inhibitor of MLCK, markedly r

156 The unique ability to interchange substrate-specific peptides into the linear self-assembl

157 nzyme for mannitol biosynthesis, is a highly substrate-specific phosphatase and, accordingly, represe

158 onist dose-dependent cAMP/PKA activities for substrate-specific phosphorylation dictated by dual regu

159 Such substrate-specific properties of signals were evolutiona

160 ions that are critical for the catalytic and substrate-specific properties of the IMP-1 enzyme.

161 We predict that substrate-specific protease-accessibility-regulation con

162 ns, we briefly exposed inside-out patches to substrate-specific proteases.

163 establish a versatile platform for analyzing substrate-specific proteasome function and indicate that

164 In P. aeruginosa, the largest family of substrate-specific proteins is the OccD (previously repo

165 s, the ubiquitin-proteasome system regulates substrate-specific proteolysis during the cell cycle, ap

166 not calpain 2, in mouse hearts demonstrated substrate-specific proteolytic activity under basal cond

167 strated that polyarginine potently inhibited substrate-specific proteolytic cleavage by furin.

168 altered mitochondrial function, and ordered, substrate-specific proteolytic events.

169 egradation of oxalic acid is catalyzed, in a substrate-specific reaction, by oxalate decarboxylase (O

170 2 (S phase kinase-associated protein 2), the substrate-specific receptor of the ubiquitin ligase resp

171 olecular mechanisms of how E3 ligases confer substrate-specific recognition, and their role in substr

172 Cyp4f14-null mice exhibited substrate-specific reductions in liver microsomal vitami

173 Cdc20 and Cdh1/Hct1, have been identified as substrate-specific regulators for APC-dependent proteoly

174 f parallel experimentation to develop novel, substrate specific results.

175 ines a recognition motif for the assembly of substrate-specific RING/cullin 3/BTB ubiquitin ligase co

176 other gram-positive bacteria have a similar substrate-specific role.

177 dly reduced (by 30%); these results indicate substrate-specific roles for His(91) and Phe(84).

178 no reaction is operationally simple, robust, substrate specific, selective and high yielding.

179 reover, inhibition of TGase-modified htt was substrate-specific since overall TGase activity in the s

180 implications for the rational design of new substrate-specific SIRT1 modulators.

181 gest that cleavage results from binding at a substrate-specific site.

182 cs and deduce that this behavior arises from substrate-specific stabilization of a conformational cha

183 The application of substrate-specific stable isotope tracers has permitted

184 any breakthroughs, there are limitations to 'substrate-specific' stable isotope tracers, which limit

185 As C-1 Sec7 was much less substrate-specific than cytohesin-1, it appears that str

186 nto the role of stable isotope tracers, from substrate-specific to novel D2 O approaches, in facilita

187 Ketoconazole (KET) and quinidine (QIN), substrates specific to cyt P450 3A enzymes, were used to

188 of fecal contamination, were detected using substrates specific to enzymes produced by each species.

189 structure is not what one would expect of a substrate-specific transmembrane channel, leading us to

190 of two ATP-binding cassette-type ATPases, a substrate-specific transmembrane protein (S component) a

191 tems use related outer membrane proteins for substrate-specific transport across the outer membrane.

192 Numerous studies have sought to characterize substrate-specific transport by NSTs; however, the avail

193 dL, which may provide an explanation for the substrate-specific transport of TodX and TbuX observed w

194 single metal ion is mediated by two or more substrate-specific transport systems.

195 -associated degradation due to their role in substrate-specific ubiquitination, which is required for

196 Activation is substrate specific, with a smaller effect noted for reti