ライフサイエンスコーパス: substratum

1 that mediate contact with other cells or the substratum.

2 sin-inhibiting drugs or the stiffness of the substratum.

3 ers of their species as they grow over their substratum.

4 ns with type I collagen, the most common ECM substratum.

5 nted by coating recombinant Alix on the cell substratum.

6 litated rolling interactions on a P-selectin substratum.

7 even following prolonged detachment from the substratum.

8 f experiments with a fibrinogen-coated glass substratum.

9 dherent, elongated cells that can invade the substratum.

10 ardless of the concentration, without an ECM substratum.

11 integrin, and is in close apposition to the substratum.

12 g, followed by exfoliation of cells from the substratum.

13 ow beta angles between spindle pole axis and substratum.

14 scale MT disassembly or cell adhesion to the substratum.

15 nd was caused by increased ligand binding to substratum.

16 helial cell rounding and detachment from the substratum.

17 ce between the bacterial cells and the solid substratum.

18 lly important that integrins detach from the substratum.

19 ay be unaffected by neighboring cells on the substratum.

20 fined to the cell bottom in contact with the substratum.

21 required for alpha5beta1 detachment from the substratum.

22 ly detaching above a critical angle with the substratum.

23 l adhesion, causing cells to detach from the substratum.

24 in at attachment sites between cells and the substratum.

25 oviducts and the deposition of eggs onto the substratum.

26 matic change of adhesion structures with the substratum.

27 rdial midgut cells along a visceral mesoderm substratum.

28 ntegrin and Shc caused by cell attachment to substratum.

29 regions avoided the collapsin-Fc-containing substratum.

30 polymer molecule is tethered to an immobile substratum.

31 ty is essential for cell migration over this substratum.

32 dia at sites that remained stationary on the substratum.

33 ithout axons providing a continuous physical substratum.

34 ve detachment of cells from the cell culture substratum.

35 gene expression responses to a collagen gel substratum.

36 ble in a cell subpopulation near the biofilm substratum.

37 elatively short-lived and recently colonized substratum.

38 ormation of a rod-shaped species on a planar substratum.

39 ites, specifically at the adherence point to substratum.

40 ulate the angle that they feed relative to a substratum.

41 erous for the users, the environment and the substratum.

42 s and stimulates their motility on an ICAM-1 substratum.

43 tractive force or bond between bacterium and substratum.

44 tially reversed in cells maintained on TINag substratum.

45 ges and grooves of varying pitch at the cell substratum.

46 e effects were ameliorated in cells on TINag substratum.

47 The oldest granules were found in substratum 4k (10,900-10,100 cal B.P.).

48 onstrated m-calpain being complexed with the substratum-adherent membrane with this increasing in an

49 e membrane protrusions, indicating that cell-substratum adhesion concomitantly influences lamellipodi

50 to coordinately regulate cell-cell and cell-substratum adhesion during tumorigenesis.

51 cell cycle activities are dependent on cell-substratum adhesion in nontransformed cells, and the abi

52 peptides may be applicable in promoting cell-substratum adhesion or in the design of drugs targeted t

53 the growth cone, the actin cytoskeleton and substratum adhesion sites.

54 e are mildly affected, RhoA activation, cell-substratum adhesion, and cytoplasmic elasticity are grea

55 N-cadherin-mediated cell clustering and cell-substratum adhesion, and primary Hdh(Q111) striatal neur

56 DEB keratinocytes demonstrated enhanced cell-substratum adhesion, increased proliferative potential,

57 isplay disturbed actin organization and cell-substratum adhesion.

58 adhesions, sites of integrin-rich, membrane-substratum adhesion.

59 eptide secretion and lowers the rate of cell-substratum adhesion.

60 cell without the complicating factor of cell-substratum adhesion.

61 filopodial growth while presumably reducing substratum adhesion.

62 de that cellular relaxation and loss of cell-substratum adhesions in HTM and SC cells could result in

63 nases activating calpain to destabilize cell-substratum adhesions in response to EGF stimulation.

64 y novel regulators of integrin-mediated cell-substratum adhesions.

65 n or "tug-of-war" between cell-cell and cell-substratum adhesions.

66 reflection microscopy revealed sites of cell-substratum adhesions.

67 s, and the formation and disassembly of cell-substratum adhesions.

68 CK5 in membrane protrusions and nascent cell-substratum adhesions.

69 We demonstrate that either decreasing substratum adhesivity or increasing cell-cell cohesivene

70 ured by tissue surface tensiometry, and cell-substratum adhesivity was assessed by a distractive meth

71 Growth cone to substratum adhesivity was measured using a blasting assa

72 Cell-substratum adhesivity was varied through the poly(ethyle

73 were found to correlate with short term cell-substratum adhesivity, indicating that signaling via FAK

74 ic substrata having different levels of cell-substratum adhesivity.

75 by both substratum charge and growth cone-to-substratum adhesivity.

76 Oligomerization of substratum-adsorbed galectin-3, through N- and C-termina

77 hat the majority of cells detaching from the substratum after EGF (but not paclitaxel or 5FUdR) were

78 f the adhesive footprint that remains on the substratum after tube foot detachment.

79 ng cell layer that interacts with a collagen substratum, an intermediate cell layer, and an upper cel

80 y correlated with the characteristics of the substratum and acoustic complexity was positively correl

81 onditions are conducive for motility and the substratum and bacterial surface are similarly hydrophob

82 rfaces is believed to require both bacterial-substratum and bacterial-bacterial interactions, and typ

83 Nuclei translated toward the substratum and began flattening during the early stages

84 stress, heat shock, and detachment from the substratum and by a membrane-permeable cGMP analog, a kn

85 d HA and blocks spreading of the cells on HA substratum and CD44-mediated branching morphogenesis and

86 rol of contact guidance by a balance of cell-substratum and cell-cell interactions, modulated by cell

87 rays of actin which are perpendicular to the substratum and contain tubular invaginations of the plas

88 The adhesion to substratum and distribution of vinculin in focal contact

89 The cells exhibit poor adhesion to a substratum and do not form tight cell-cell agglomerates

90 NIH/3T3 fibroblasts deposit less Alix on the substratum and have defects in alpha5beta1-integrin func

91 (3-14%) were explained by changes in depth, substratum and oceanographic stability, whereas environm

92 platelets play a critical role in forming a substratum and pave the way for neutrophils to enter the

93 al substratum for adhesion, adhering to that substratum and possibly by activating Rac and Cdc42.

94 ), inhibited detachment of viable cells from substratum and reduced tumorigenicity.

95 approximately 50% of the cell lifts from the substratum and remains elevated for up to 1 min.

96 s ultimately causes cells to detach from the substratum and rupture.

97 polarity, fucoid algal zygotes adhere to the substratum and select a growth axis according to environ

98 ing both the delivery of coral larvae to the substratum and settlement.

99 are having H(2) delivered from the membrane substratum and solving directly for steady state using a

100 tablishment of a stable association with the substratum and swarming motility.

101 cells close to contact exert stresses on the substratum and that the stresses are those that would be

102 the distal tip of a filament adsorbed to the substratum and the filament was pulled taut.

103 he mechanical forces exerted by cells on the substratum and through the substratum to act on other ce

104 We demonstrate here that binding to the substratum and to host cells is partially mediated by in

105 ility of the cells to properly adhere to the substratum and to suppress lateral pseudopod extension.

106 a key locality to test the influence of both substratum and winemaking procedure on the (87)Sr/(86)Sr

107 metaphase cortex, spindle alignment with the substratum, and columnar organization.

108 lls must reorganize their connections to the substratum, and during locomotion they must break rear a

109 rounding of cell bodies, detachment from the substratum, and eventual neuronal death.

110 remained at fixed positions relative to the substratum as cells moved forward.

111 ters that remained fixed with respect to the substratum as cells moved forward.

112 at deposition of laminin 5 onto the collagen substratum, as in wound repair, enables human foreskin k

113 otein, but not plectin, colocalize along the substratum-attached surface.

114 rticipates in intercellular aggregation, but substratum attachment of Lsr2 mutants is unaffected, the

115 through three genetically programmed stages: substratum attachment, intercellular aggregation and arc

116 actin cytoskeleton together with changes in substratum attachment.

117 l contact inhibition or presented by denuded substratum, because it also occurred in subconfluent mon

118 Here we show that the concentration of substratum-bound ligand (laminin) post-translationally r

119 mouse retinal axons when presented either as substratum-bound proteins or as soluble proteins directl

120 Substratum-bound rLARFN5C had potent neurite-promoting e

121 tions inhibited neurite outgrowth induced by substratum-bound rLARFN5C, consistent with receptor-base

122 istinct from human PSC progenitors on either substratum but still meet standard in vitro criteria for

123 racts at a constant rate and is bound to the substratum by adhesive bridges that are modeled as elast

124 in a retraction of its cell body toward the substratum by coiling its stalk.

125 of special interest that the strains on the substratum can change in the time course of a few second

126 d division of epithelial cells on a confined substratum cause overcrowding that leads to their extrus

127 chment of normal epithelial cells from their substratum causes apoptosis, termed anoikis.

128 the 49-mer had no effect on cell adhesion to substratum, cell growth, formation of focal contacts, or

129 ectric field is therefore influenced by both substratum charge and growth cone-to-substratum adhesivi

130 In growth cone collapse, substratum choice and neurite outgrowth assays, Sema5A t

131 In substratum choice assays, retinal axons tended to avoid

132 Also, substratum coated with collagen I (which binds alpha1bet

133 Importantly, substratum coated with combinations of collagen I and vi

134 ate whether integrin-mediated anchorage to a substratum coated with the extracellular matrix protein

135 presence of retinoids and on the appropriate substratum (collagen gels).

136 The impact of substratum compliance and/or Lat-B treatment on cell att

137 Substratum compliance profoundly influenced HTM cell beh

138 The inclusion of substratum compliance that reflects healthy or glaucomat

139 Similar results were obtained on a synthetic substratum composed of laminin and inhibitory CSPG.

140 ast, RhoA activity increases with increasing substratum concentration.

141 rin and actin in areas of cell-cell and cell substratum contact and is expressed in neuronal processe

142 emotaxis is accompanied by loss of both cell-substratum contact and morphological polarity, but after

143 cell retracted at its posterior margin, cell-substratum contact area decreased more rapidly than forc

144 signaling pathway, as monitored in the cell-substratum contact area using total internal reflection

145 pread cells provoked a reduction in the cell-substratum contact area, clearly detectable by the biose

146 eased focal complex formation at the site of substratum contact, and enhanced macrophage adhesion, yi

147 After cell-cell or cell-substratum contact, cytosolic proteins are recruited to

148 t technique not involving cell-probe or cell-substratum contact.

149 hasis on the adhesive properties of the cell-substratum contact.

150 tum turn or stop after encountering the test substratum containing ephrin-Fc.

151 s, as well as decreased biomass (8-fold) and substratum coverage (19-fold) in continuous-flow cells w

152 Animal cells migrating over a substratum crawl in amoeboid fashion; how the force agai

153 in-based gliding motility to move across the substratum, cross biological barriers, and invade their

154 e and show that our model is able to produce substratum deformations and force patterns that are quan

155 In cyanobacterial Nostoc species, substratum-dependent gliding motility is confined to spe

156 ted NCC motility on laminin, indicating that substratum-dependent integrin recycling is essential for

157 SF recombinant protein exhibits a potent and substratum-dependent motogenic activity, with half-maxim

158 MDCK type I cells, GFP-CFTR localization was substratum-dependent.

159 ents that occur in murine keratinocytes upon substratum detachment utilizing both primary cells and e

160 stimuli, including growth factor withdrawal, substratum detachment, ionizing radiation, and treatment

161 a programmed cell death process triggered by substratum detachment, is a critical step in the metasta

162 apoptosis, characterized by cell shrinkage, substratum detachment, vacuolated cytoplasm, and DNA deg

163 and the adhesion of the leading edge to the substratum during cell migration were defective in the m

164 The mechanical forces exerted on the substratum during these contractions have recently been

165 quiescent state on a basement membrane-like substratum (EHS matrix) were nonproliferative.

166 During cell motion on a substratum, eukaryotic cells project sheetlike lamellipo

167 ructure is required to deliver larvae to the substratum even in conditions mimicking calm back-reef f

168 ert much smaller contractile stresses on the substratum, even though the M2 cells have similar levels

169 varied alpha(5)beta(1) expression level and substratum fibronectin density.

170 blast migration under eight conditions: four substratum fibronectin levels and presence versus absenc

171 f the cellular focal contacts from the glass substratum, followed by complete rounding of the cells a

172 n mediating migration by creating an optimal substratum for adhesion, adhering to that substratum and

173 e-resistant collagen constitutes a defective substratum for angiogenesis.

174 g has been hypothesized to act as a guidance substratum for developing callosal axons.

175 plicated in vascular development, provides a substratum for endothelial cell migration and is involve

176 ls and the underlying cells that provide the substratum for migration.

177 th surfaces, thereby providing an attachment substratum for more overtly pathogenic organisms such as

178 /ras is required within epidermal cells, the substratum for most outgrowing axon, for appropriate out

179 ndritic cell network similarly served as the substratum for movement of follicular B cells.

180 Coating recombinant Alix on the culture substratum for NIH/3T3 cells promotes alpha5beta1-integr

181 Plastic has emerged as an abundant, stable substratum for oceanic dispersal of organisms via raftin

182 ential among growing cells that provides the substratum for progressive development to a frankly neop

183 ays adhesive ligands on a mechanically ideal substratum for promoting neovessel development.

184 e due to the fact that collagen VI is a poor substratum for supporting eNCC migration and can even in

185 r tumors and serves not only as a supporting substratum for trafficking cells, but also as a structur

186 epithelial clusters temper anisotropic cell-substratum forces, resulting in substantially lower dire

187 When these cells were cultured as substratum-free pellets keratocyte markers AQP1, B3GNT7,

188 Land plants are anchored to their substratum from which essential inorganic nutrients are

189 t and spreading activity was observed on the substratum (glassy silica-titania), when the serum level

190 OS-1 cells, punctin is deposited in the cell substratum in a punctate fashion and is excluded from fo

191 to cell surfaces and also to the intervening substratum in a stacked-brick configuration.

192 dle poles with cortical cues parallel to the substratum in all cells.

193 of colonies capable of growing on a gelatin substratum in standard medium for human PSCs at low but

194 e findings introduce a novel dopaminoceptive substratum in the brain and a unique D5 receptor-specifi

195 As well as exerting forces on the substratum in the direction of the long axis of the cell

196 Keratocyte phenotype was induced by substratum-independent pellet culture in serum-free medi

197 tion on both fibronectin- and laminin-coated substratum, indicating that EWI2/PGRL directly regulates

198 Type I collagen substratum induces the association of alpha(3)beta(1) in

199 ereas plating of melanoblasts on an ephrin-B substratum induces the formation of microspikes filled w

200 nd Eph-Fc, when present homogeneously in the substratum, inhibit neurite outgrowth from olfactory epi

201 step of adhesion and maturation of bacteria-substratum interaction on hydrophilic surface includes a

202 ion, disruption of normal cell-cell and cell-substratum interaction, inactivation of signal transduct

203 , apoptosis, DNA repair, and cell-cell, cell-substratum interaction.

204 lylation and subsequently cell-cell and cell-substratum interaction.

205 ion pathways by lactogenic hormones and cell-substratum interactions activate transcription factors a

206 of F-actin polymerization in regulating cell-substratum interactions and stresses required for motili

207 s do not form properly, suggesting that cell-substratum interactions are required for epithelial orga

208 studied effects of (a) inactivating integrin-substratum interactions by using integrin-binding peptid

209 expression is induced in response to loss of substratum interactions in breast epithelial cells.

210 ch-stressed epithelial sheet and in the cell-substratum interactions that mediate cell migration duri

211 -ABL) expression modifies cell-cell and cell-substratum interactions.

212 rovided by the coating that blocks bacterium-substratum interactions.

213 -containing filopodia occur both at the cell-substratum interface and at cell-cell contacts, with the

214 eakly on the detachment kinetics of the cell-substratum interface, in agreement with experimental dat

215 y Mfp-2 interaction with Mfp-5 at the plaque-substratum interface.

216 dent on the initial FA locations on the cell-substratum interface.

217 distribution of integrin tension on the cell-substratum interface.

218 uPAR aggregate at cell-substratum interfaces and at leading edges of migrating

219 Typically, uPAR clusters at cell-substratum interfaces, at focal adhesions, and at the le

220 amoeboid fashion; how the force against the substratum is achieved remains uncertain.

221 Spindle orientation with respect to the substratum is established in metaphase coincident with m

222 Our results indicate that a solid substratum is not a prerequisite for these cells to prod

223 ured animal cap ectoderm attaches to a glass substratum, it can self-organize to form complex organs

224 es in the forces applied by the cells to the substratum lead to changes in birefringence, which can b

225 Cell-substratum links promote formation of mounds as opposed

226 mable intracellular, intercellular, and cell-substratum links.

227 mizing opportunities for detachment from the substratum made it possible to isolate and cultivate the

228 Cells grown on a TINag substratum maintained their normal epithelial phenotype

229 energy, charge, topography, and stiffness of substratum material on bacterial adhesion.

230 um, tension reduced to 0.02 mN/m, and at the substratum, membrane invaginated, creating transient vac

231 luding attachment of individual cells to the substratum, microcolony formation, and maturation into c

232 to a 150 mV/mm EF or to a series of parallel substratum nanogrooves (NGs) 130 nm deep.

233 exquisitely sensitive to differences in the substratum nanoscale features of the surrounding extrace

234 Moreover, in patterned substratum, neurites growing on the standard substratum

235 tion of galvanotropism was determined by the substratum; neurites grew toward the negative electrode

236 Contact guidance by substratum NGs required rho but not cdc42 or rac activit

237 Using these matrices as substratum, nulliparous matrix was found to promote duct

238 obic respiration occurs predominantly in the substratum of gonococcal biofilms and that expression of

239 x vivo maintenance of rHpScs consisting of a substratum of hyaluronans and Kubota's medium (KM), a se

240 ow that culture of MCF-7 cells on a cellular substratum of murine preadipocytes also enhanced the fun

241 al day 6 cerebellar granule cells grown on a substratum of NgCAM, the chick homologue of L1, was inhi

242 trate that secreted Alix is deposited on the substratum of non-immortalized WI38 fibroblasts.

243 mutant displayed elevated accumulation on a substratum of S. gordonii.

244 the EPS composition can vary based upon the substratum on which the bacterial biofilm forms.

245 have reduced contact with ligand-expressing substratum or cells, a condition that occurs during the

246 sma membrane damage induced by scraping from substratum or crushing with glass beads.

247 TP, neither WT nor NRKvector attached to the substratum or formed cell-cell attachments.

248 cells that become temporarily 'stuck' to the substratum or when subjected to mechanical stretching.

249 Porifera accounted for 94% of hard-substratum organisms and cnidarians (Pennatulacea) domin

250 re also significantly influenced by the bone substratum, periodontitis, and smoking habit.

251 s upon the growth of cells on a photoelastic substratum, polydimethylsiloxane coated with a near mono

252 TSP1 or the same peptide immobilized on the substratum promotes their proliferation.

253 cell migration, integrin attachments to the substratum provide the means to generate the traction an

254 ce of BMP4 and absence of FGF2 on a Matrigel substratum rapidly convert to an epithelium that is larg

255 the adsorption of serum biomolecules to the substratum, rather than by soluble factors present in th

256 In culture, CSPGs anchored onto the substratum reduced the adhesion of mouse and human OPCs

257 e of tissue spreading over a two-dimensional substratum reflects a competition or "tug-of-war" betwee

258 Therefore, MEKK1 regulates calpain-mediated substratum release of migrating fibroblasts.

259 idermis, which we propose contributes to the substratum required for migration of the neighboring ray

260 redistribute on interaction with a cellular substratum, resulting in a 100-fold greater CD2 density

261 y migratory cells to an ephrin-B-derivatized substratum results in cell rounding and disruption of th

262 strate the potential of FLTM in studying how substratum rigidity regulates cellular rheological prope

263 sensitivity of genome-wide transcription to substratum rigidity.

264 ve potencies of electrotaxis and guidance by substratum shape (contact guidance) have never been dete

265 Data were gathered on age, sex, bone substratum, smoking habit, history of periodontitis, and

266 gely dependent on coral reestablishment, and substratum stability is critical to the survival of cora

267 RT-PCR was used to determine the impact of substratum stiffness and/or Lat-B treatment on the expre

268 Substratum stiffness impacts HTM matrix gene and protein

269 Integrating the use of biologically relevant substratum stiffness in the conduction of in vitro exper

270 Here, we explore how substratum stiffness modulates the YAP/TAZ pathway and e

271 er specimens revealed an association between substratum stiffness, ILK, and CSC markers, insofar as I

272 tro, YAP and TAZ were inversely regulated by substratum stiffness.

273 talk between Cdc42 and Rac1 is required for substratum-stimulated protrusion, whereas RhoA activity

274 o-dimensional magnetic tensile cytometry and substratum stretching.

275 me active; thereafter they detached from the substratum, suggesting that beta1-DN was impairing adhes

276 The microenvironment provides a functional substratum supporting tumour growth.

277 When DMAE was coated on substratum surfaces, biofilm formation was inhibited for

278 nd Escherichia coli DH5alpha, onto two model substratum surfaces, i.e., clean glass and silanized gla

279 lium-derived factor, which accumulate in the substratum surrounding cells.

280 This is the direct substratum that pioneer axons follow as they grow.

281 ntilever resulting from BoNT-B action on its substratum, the synaptic protein synaptobrevin 2, attach

282 Cells adhere to the substratum through specialized structures that are linke

283 bl-dependent adhesion of ISNb axons to their substratum, thus releasing the axons to respond to attra

284 d by cells on the substratum and through the substratum to act on other cells is described.

285 ParA-ATP binds nucleoid DNA and uses it as a substratum to deliver ParB-attached cargo DNA, and ParB

286 AgNPs/GQD-SH was utilized as a substratum to load antibody for detection of hepatitis C

287 the beta(3) integrin subunit or changing the substratum to type I collagen, Y-27632 and RhoA-N19 fail

288 emonstrated that the provision of biomimetic substratum topographic cues inhibits the progression tow

289 us may also act as a direct mechanosensor of substratum topography.

290 substratum, neurites growing on the standard substratum turn or stop after encountering the test subs

291 suggests that binding of the molecule to the substratum turns it on, perhaps mimicking cargo activati

292 ckout (KO) platelet attachment to a collagen substratum was also faulty and associated with elevated

293 Monte Carlo simulations and assuming a rigid substratum, we find that the cell speed depends only wea

294 mate of the material properties of the solid substratum where the cells are growing on.

295 wise rotating flagella of cells stuck to the substratum, which drives fluid clockwise around isolated

296 subsequent detachment of the cells from the substratum, which eventually led to cell death.

297 involves slippage between adhesions and the substratum, which increases traction force production.

298 ated and nonactivated human neutrophils to a substratum, which is carried out in a custom-made microf

299 olated endoderm is incubated in Matrigel(TM) substratum with Fgf-loaded beads.

300 n, approximately 0.2 dyn, is imparted to the substratum within 15 micrometers of the leading edge.