ライフサイエンスコーパス: substructure

1 ) in an ANCOVA with an adjustment for hidden substructures).

2 ransfer hydrogenation catalysts with Cp*IrCl substructure.

3 itochondrial sequences indicate an east-west substructure.

4 role of "functional aggregation" in nuclear substructure.

5 are both colocalized in the same chloroplast substructure.

6 logistic regression adjusting for population substructure.

7 to admixed populations and populations with substructure.

8 ustness under the presence of the population substructure.

9 tness property in the presence of population substructure.

10 presence of an otherwise reactive norbornene substructure.

11 trogen to give new products with a thioamide substructure.

12 xins with a novel carboxy-indolocarbazole TD substructure.

13 ting for age, sex, education, and population substructure.

14 s, and with stringent handling of population substructure.

15 f ~8 nm and an underlying highly crystalline substructure.

16 ) , gender, alcoholic drinks, and population substructure.

17 MPIs with a triazole-substituted hydroxamate substructure.

18 corners, yielding an unprecedented silicate substructure.

19 tinal and choroidal vasculature networks and substructure.

20 eleton featuring a 3-azabicyclo[3.1.0]hexane substructure.

21 o confounding due to population admixture or substructure.

22 n used in bioinformatics to infer population substructure.

23 e genetically too different, e.g. population substructure.

24 12) contains a rare 1,2-3,4-bis-epoxydecalin substructure.

25 by combining DOXO with appropriate H2S donor substructures.

26 that alter proper functionality of valvular substructures.

27 o obtain structurally similar structures and substructures.

28 or taxa to visualize and discover community substructures.

29 rgent means of assembling Type II polyketide substructures.

30 vendors, specific physical properties or any substructures.

31 ria and red algae, composed of rods and core substructures.

32 ilding subunits for the needle and inner rod substructures.

33 chments in intact metabolites and individual substructures.

34 to integration with complex microfabricated substructures.

35 es not necessarily imply the absence of such substructures.

36 te/polymer crystals do not have nanoparticle substructures.

37 nted assembly, and that exhibit nanoparticle substructures.

38 ole, azetidine, tetrahydropyran, and oxetane substructures.

39 luoromethyl groups into a variety of organic substructures.

40 iscrete complex distinct from other axonemal substructures.

41 fs with biochemically or chemically relevant substructures.

42 EPL1 assembles into irregular meshwork-like substructures.

43 easure the cooperativity of a protein or its substructures.

44 ally occurring mono-, di-, and trisaccharide substructures.

45 mall subsets now linked through their common substructures.

46 onvergent construction of type II polyketide substructures.

47 to the lipid A and core oligosaccharide (OS) substructures.

48 of trypanosome nucleoporins to discrete NPC substructures.

49 This compound consists of a chromophore substructure 1,7-diazaheptamethin.

50 ontacts are formed between a specific set of substructures, after which folding proceeds downhill in

51 A substructure analysis of the cocrystallized PDE ligands

52 lem of adequately controlling for population substructure and admixture in RV association studies and

53 fficult to adequately control for population substructure and admixture, and spurious associations ca

54 um test (TDT), which is robust to population substructure and admixture.

55 equately control for population admixture or substructure and analyze pedigrees with missing genotype

56 staining, while the FS method often revealed substructure and cellular staining specificity.

57 ollisionless CDM predict halos with abundant substructure and central densities that are too high to

58 rsification of a single natural product-like substructure and enables production of a highly diverse

59 ounding of genetic effects due to population substructure and heterogeneity due to different patterns

60 Tumor substructure and its effect on disease progression and r

61 oid natural products share a 7-membered-ring substructure and may potentially arise from a common bio

62 cles are visualized with respect to cellular substructures and are found to accumulate in the perinuc

63 ragmentation is complex, and identifying the substructures and chemical formulas for these fragment i

64 is insufficient for detecting the population substructures and correcting population stratifications

65 uctural diversity guided by incorporation of substructures and functional groups known to diminish li

66 ocalization of chemical reactions to network substructures and the identification of critical sites w

67 ties for analyzing RNA structures, including substructuring and search tools.

68 (Phi(M) > 1) in the rate-determining loop 1 substructure, and conclusively identify mutations and po

69 xes--one axis is defined through a benzamide substructure, and the other axis is associated with diff

70 the testing of multiple markers, population substructure, and ultimately a requirement for replicati

71 these lesions cosegregate within the clonal substructure, and we have demonstrated that hyperdiploid

72 The substructure annotations and rankings provided detailed

73 accuracy of linking neutral loss analysis to substructure annotations using 19 329 accurate mass tand

74 molecules, and strategies for accessing this substructure are important for developing therapeutic ca

75 ariance to assess whether xenobiotic-derived substructures are among the most-variant Mass2Motifs.

76 These substructures are assembled from chromophore-bearing phy

77 atrophy of specific retinal layers and brain substructures are associated over time, in order to furt

78 ch the fingers/palm/connection, thumb and RH substructures are connected by flexible (disordered) lin

79 Discrete substructures are likely to be important to RNA-protein

80 tical coherence tomography-reflective drusen substructures are optical coherence tomography-based bio

81 Our findings show how and when spine substructures are remodeled during LTP and explain why s

82 Organic micropollutants containing aniline substructures are susceptible to different light-induced

83 truncation mutants uncovers the role of this substructure as a hydrophobic membrane anchor.

84 n microscopy, explicitly visualizing nuclear substructures at several tens of nanometer resolution, a

85 rences in cell wall material and chromoplast substructure between matrices influenced carotenoid rele

86 We validate the differential prevalence of substructures between two distinct samples groups and ap

87 We observed genetic substructuring between Ecuador and West Africa and betwe

88 e logarithmic slope of the mass function for substructure beyond the local Universe to be 1.1(+0.6)(-

89 a consequence of the complexity of cellular substructures, but also plays an important functional ro

90 haracterization of these dynamic proteolipid substructures by high-resolution experimental techniques

91 These substructures, called nanoclusters, were proposed to be

92 tly similar structures, suggesting that such substructures can be used as fragments in glycan modelin

93 Substructures can help make highly diverse sequence data

94 Thus, mini-protein substructures can only rarely be derived from natural te

95 the interaction mode of the aryloxymethylene substructure cannot be assimilated to that of benzodioxa

96 the natural structural barriers (chromoplast substructure/cell wall) and of the phases (soluble/insol

97 o new methods, one based on binding-specific substructure comparison (TM-SITE) and another on sequenc

98 s the alpha-allyl-alpha,alpha-difluoroketone substructure, complementary palladium-catalyzed decarbox

99 the overall secondary structure into smaller substructures composed of a single base-pair stack, whic

100 ntary examples of non-canonical nucleic acid substructure conformations.

101 barley samples was potentially an effect of substructures consisting of longer repetitive cellotrios

102 Cell walls and chromoplast substructures constitute natural structural barriers gov

103 Ultimately, such substructuring could be useful for RNA 3D structure pred

104 e identified compounds as a starting point a substructure directed search against CHEMBL Database rev

105 (-)-Englerin A features high substructure dissimilarity to known ligands for voltage-

106 In this material, the guest substructure does not exhibit three-dimensional ordering

107 e-domain interactions globally such that all substructure-domain contributions to drug-target interac

108 GIFT was then implemented to predict substructure-domain interactions based on drug repositio

109 ons, or GIFT, is proposed herein to evaluate substructure-domain interactions globally such that all

110 Eighteen of the top 100 predicted combined substructure-domain interactions had corresponding drug-

111 patiotemporal reorganization of postsynaptic substructures during long-term potentiation (LTP) at ind

112 of the mouse vomeronasal organ, an olfactory substructure essential for social recognition.

113 e used for PCA and adjustment for population substructure, estimating homozygosity rates in individua

114 Te2, with interlocked rigid and weakly bound substructures, exhibits lattice thermal conductivity as

115 sh intricate projections across different CX substructures, exist in four isomorphic groups that resp

116 lpiperazine moiety is considered a necessary substructure for high histamine H4 receptor (H4R) affini

117 proteins FliM and FliN, whereas an analogous substructure for the closely related non-flagellar (NF)

118 t noncovalent protein complexes into smaller substructures for quaternary structure analysis.

119 lass of materials with quasi-one-dimensional substructures for various applications.

120 s been applied to the synthesis of important substructures found in natural products and biologically

121 m the entries with the glycan sequence whose substructure (fragment) or entire sequence is matched to

122 among distal residues, dissecting individual substructures from the context of folded proteins result

123 estimation to better decompose mixture model substructure; fuzzy clustering to better identify substr

124 2-8Neu5Ac and Neu5Gcalpha2-6Galbeta1-4GlcNAc substructures; Galbeta and GlcNAcbeta terminal substruct

125 hybridization approach using two privileged substructures gave instant access to a new series of tan

126 oducing enhancements to automate learning of substructured genomic mixtures, with specific emphasis o

127 An (E)-iminium vinylogous substructure has been shown as the common cation scaffol

128 owever, access to more highly functionalized substructures has been limited because of the harsh reac

129 ction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for

130 These substructures have low-molecular weight and serve as a p

131 on into both intact metabolites and specific substructures have slowed extension of these techniques

132 For both the lipid A and core OS substructures, HCD and UVPD produced highly informative

133 ing biclusters which are the most meaningful substructures hidden in gene expression data remains a h

134 ottleneck (small ROHs) and recent population substructuring (highly homozygous individuals).

135 is modulated by ECD binding to peptidoglycan substructures, however, the molecular mechanisms underpi

136 These substructures, identified in a 10 mus all-atom trajector

137 aneous and mediated by four specific protein substructures; (ii) the ability of PITPalpha to initiate

138 These substructures impede productive folding and can serve as

139 mary cilia are ubiquitous mammalian cellular substructures implicated in an ever-increasing number of

140 re, providing further support for population substructure in Asia [8] and suggesting that this persis

141 This is an uncommon substructure in drugs that gives reactivity concerns.

142 An alkyne substructure in each candidate small molecule enables af

143 ll type deconvolution by taking advantage of substructure in genomic mixtures via a strategy called s

144 pproach for the identification of population substructure in high-density genotyping data/next genera

145 slands sampled here indicate little regional substructure in MC1R.

146 ructure; fuzzy clustering to better identify substructure in sparse, noisy data; and automated model

147 ying driver mutations and delineating clonal substructure in three different human tumor data sets.

148 e their effectiveness in identifying mixture substructure in true breast cancer CNV data from the Can

149 support for a complex role of the inner rod substructure in type III secretion.

150 abled their application as stains of vesicle substructures in confocal fluorescence microscopy imagin

151 n and spraying, in terms of the sharpness of substructures in the images demonstrated by imaging at s

152 ions of the four images provide evidence for substructures in the lensing galaxy.

153 ation about the relative positioning of RRE2 substructures in three dimensions.

154 Although population substructuring in P falciparum has resulted in clonal ou

155 These substructures, in turn, support putative de novo structu

156 st-variant Mass2Motifs to xenobiotic-derived substructures including paracetamol/acetaminophen mercap

157 that label small subsets of neurons in brain substructures, including known and novel cell types.

158 s via external interactions with neighboring substructures, indicating that subdomain interactions ca

159 resentations may reveal underlying community substructures invisible in 2D representations.

160 The alpha-carboxy-tropone substructure is ideal for this purpose as the proton can

161 subjects are related and whether population substructure is present.

162 Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry

163 (i.e., local unfolding of previously folded substructures is required when moving from the unfolded

164 For a given region, substructure, layer or even cell type, variability in ne

165 We found that chimpanzee population substructure makes genetic information a good predictor

166 ch extracts biochemically relevant molecular substructures ("Mass2Motifs") from a collection of fragm

167 ch extracts biochemically relevant molecular substructures ("Mass2Motifs") from spectra as sets of co

168 pectrum, characteristic fragment, and common substructure matches.

169 developed characteristic fragment and common substructure matches.

170 tical coherence tomography-reflective drusen substructures may be a clinical entity helpful in monito

171 nce with the principle that ventral striatum substructures may cooperate to guide motivated behaviors

172 d fingerprint and graph-based maximum common substructure (MCS) methods.

173 rch in the Cambridge Structural Database for substructures Me-C horizontal lineC-Ph, Me-C-C-Ph, and M

174 of embedded CF3 substituents within organic substructures necessitates the development of diverse me

175 ves, covering elemental composition, typical substructures, neutral losses, and adducts, InterpretMSS

176 tical coherence tomography-reflective drusen substructures (ODS) and examine their associations with

177 acteristic ortho heterodisubstituted phenoxy substructure of 1, the S enantiomer of the dihydrobenzof

178 likelihood-based method for determining the substructure of anomalously scattering atoms in macromol

179 re this behavioural symptom by examining the substructure of apathy in ALS and to determine the relia

180 e hierarchical and laminated, similar to the substructure of bone, superior crack resistance can be r

181 ty relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439, we com

182 To quantify the substructure of FAs, we developed a clustering method ba

183 ted detachment of chromatin from the nuclear substructure of freshly isolated, unfixed cells, followe

184 th the templates D-glucuronic acid (GlcA), a substructure of hyaluronan, and N-acetylneuraminic acid

185 ameter and sensing of dynamic changes in the substructure of myelin at nanoscale.

186 of the stereochemical structure of the core substructure of the citrinadins.

187 In Salmonella, the rod substructure of the flagellum is a periplasmic driveshaf

188 heckpoint proteins are integrated within the substructure of the kinetochore and will aid in understa

189 vided important insight into the origins and substructure of these commonly used laboratory strains.

190 ne to generate the rather uncommon 1,4-diene substructure of these compounds.

191 and differentiation, and explain the clonal substructure of tumors.

192 cture-function analysis and requirement of a substructure of U6atac 3' stem-loop in U12-dependent in

193 linical trajectories, and pathophysiological substructures of ASD.

194 In the substructures of both the central complex and basal gang

195 th hierarchical trees of in silico generated substructures of candidate molecules to explain the obse

196 ones that strictly respect the known spatial substructures of IT ("face patches") did not improve pre

197 t identifies high scoring fragments that are substructures of known inhibitors.

198 Our analysis predicted 15 compounds and 24 substructures of potential oncometabolites that could re

199 Spatial visualization of proteins in substructures of rat brain, and in human ovarian cancero

200 ral trees or by de novo identification using substructures of similar trees.

201 et interactions, such as those involving the substructures of synthetic drugs and protein domains, is

202 This pivotal cascade sequence generates substructures of the actinophyllic acid core that are no

203 eal both the morphological and compositional substructures of the cell walls.

204 a slight redistribution of water through the substructures of the cells, as a function of the length

205 e outer layer (subcuticle) to surround inner substructures of the copepod nervous systems, and electr

206 rocess, the chaperone HJURP protects various substructures of the dimer, serving both as a folding an

207 xpresses a repertoire of enzymes that target substructures of the glycosaminoglycans with variable su

208 ts for transition-state structure within all substructures of the WW domain fold (hydrophobic core, l

209 Nonetheless, the internal substructures of these N-glycans, particularly, the subs

210 The half bridge is a SPB substructure on the nuclear envelope (NE), playing a key

211 proteins assemble into transient, nano-sized substructures on the plasma membrane.

212 structural barriers (cell walls, chromoplast substructures) on carotenoid bioaccessibility, was devel

213 ven when there are high levels of population substructure or admixture.

214 gnoring the competitive effects of different substructures or domains, but this could lead to high fa

215 ed multi-molecular structures, such as viral substructures or intact viruses.

216 excellent marker to follow changes in clonal substructure over time.

217 dataset of RNA tertiary (3D) structures and substructures plus a web-based search tool-designed to e

218 versatile synthetic intermediates as well as substructures present in many bioactive natural products

219 t HS causes deconstruction of all centrosome substructures primarily through degradation by centrosom

220 d data set of 153 drug pairs, we showed that substructure profiles are useful in predicting synergy.

221 present a computational framework that uses substructure profiles derived from the molecular structu

222 approach are the extensive design and use of substructure queries to compile a set of commercially av

223 g procedure combining ligand-based (frequent substructure ranking) and structure-based (Snooker) tool

224 Super-resolution microscopy reveals stable substructures, referred to as cores, within stress granu

225 lows molecules to be grouped based on shared substructures regardless of classical spectral similarit

226 eral physicochemical compound properties and substructures related to OATP1B1/1B3 inhibition or inact

227 th brain substructure volumes, all OCT-brain substructure relationships were adjusted for intracrania

228 sibility while, in tomatoes, the chromoplast substructure represented the most important barrier gove

229 However, issues such as delamination and substructure resistance are generated by the intrinsic l

230 rray screening employing PS-I repeating unit substructures revealed the disaccharide Rha-(1-->3)-Glc

231 t-based search on rich metadata and chemical substructure search allow precise identification of desi

232 t is, a lectin-glycoprotein interaction, via substructure search and the knowledge of site-specific g

233 harmacophore search followed by docking, and substructure search resulted in five additional ligands.

234 It is tightly bound to the latter via a substructure search tool that maps each ligand to full s

235 ucture-based virtual screening and hit-based substructure search were utilized to identify small mole

236 bitor of tankyrases through a combination of substructure searching of the Amgen compound collection

237 tudies, the chloro-gem-dimethyl-anthracenone substructure seen in the fasamycins is predicted to repr

238 strates for chemoenzymatic synthesis through substructure similarity and virtual chemical transformat

239 for rapidly identifying whole organ and some substructure staining, while the FS method often reveale

240 ware packages are widely used in analysis of substructure: Structure and Eigenstrat.

241 biomolecules containing a push-pull nitrogen substructure, such as bioamines, amino acids, and peptid

242 ion relationship between amygdala anatomical substructures, supporting the use of network analysis te

243 much higher resolution picture of population substructure than it can be obtained with existing metho

244 e Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ri

245 vents in the local field potential exhibited substructure that mapped onto the maze topology.

246 producing a unique inorganic-organic hybrid substructure that reinforced the multilayered architectu

247 ctures of these N-glycans, particularly, the substructures that are closer to the protein, show signi

248 a system lacking cell walls and chromoplast substructures that could hamper carotenoid release.

249 However, more detailed and refined substructures that determine host tropisms are still not

250 currence in the gut have indicated community substructures that may reflect functional and metabolic

251 In one substructure, the fan-shaped body, automated analysis re

252 vironments annotated with the small molecule substructures they bind.

253 ws the texture of large samples with complex substructures to be scanned and opens up the conceptual

254 formation across diverse ligands with shared substructures to generate predictions.

255 This substructure, together with the pterin-binding pocket, e

256 The smaller C-terminal domain, a substructure unique to LpxK, helps bind the nucleotide s

257 (iv) interpretation of possible fragment ion substructure using an internal database, (v) annotation

258 rovided an accurate prediction of population substructure using variants with a minor allele frequenc

259 n can drive the formation of dynamic droplet substructures (vacuoles) with tunable lifetimes.

260 mplex scenarios of demography and population substructure, various models for selection and dominance

261 is already known to be associated with brain substructure volumes, all OCT-brain substructure relatio

262 etinal nerve fiber layer thickness and brain substructure volumes.

263 sonance imaging brain scans (including brain-substructure volumetrics) were performed annually.

264 Strong population substructure was found for B. heracleifolia (FST=0.364,

265 The same PAINS substructure was often found in consistently inactive an

266 Despite overall lack of population substructure, we identified 114 highly divergent SNPs as

267 For carrots, cell walls and chromoplast substructure were important barriers for carotenoid bioa

268 vian-origin viruses; sulfated Neu5Acalpha2-3 substructures were associated with the binding of human-

269 dose-distribution parameters of the cardiac substructures were collected from three-dimensional comp

270 orted neutral losses and their corresponding substructures were collected.

271 Retinal layers and neuronal substructures were delineated on foveal sections of fixe

272 xtensively tested compounds containing PAINS substructures were detected, and their hit rates were de

273 CBMs) that preferentially bind to cellulosic substructures were fluorescently labeled.

274 motility due to mutation of various axonemal substructures were greatly enhanced compared with wild t

275 Combinations of different chemical substructures were included since they may function as o

276 e Loop 4 of DBL2betaPF11_0521, although both substructures were previously implicated in binding ICAM

277 n their ability to generate distinct TD core substructures were recovered from eDNA libraries.

278 ino ozonides with cycloalkyl and heterocycle substructures were superior to their acyclic counterpart

279 ith internal thieno[3,2-b;4,5-b']dithiophene substructures were synthesized.

280 e repeating unit of PS-I and oligosaccharide substructures were utilized to produce large quantities

281 MT; adjustments for sex, age, and population substructure where applicable; minor allele frequency 0.

282 P complexes are heavily tethered to cellular substructures, whereas PKA-RI-AKAP complexes have remain

283 ty of crystals contain quasi-one-dimensional substructures, which yield distinctive electronic, spint

284 an effectively dissociate the complexes into substructures while preserving the native topological in

285 ations are correct annotating the associated substructures, while the absence of mass spectra feature

286 The analysis allows us to isolate molecular substructures, whose presence allows molecules to be gro

287 ze and understand conformation properties of substructures widely used in medicinal chemistry.

288 reby reconciling haplotype-phased chromosome substructure with sequence.

289 tes to give medicinally relevant fluorinated substructures with complete regiocontrol.

290 luorescence microscopy, cross confirming the substructures with immunostaining.

291 been shifting their attention towards these substructures with the help of fluorescence techniques.

292 Recent Hi-C mapping has unveiled substructure within chromatin compartments called topolo

293 At a finer geographic scale, the genetic substructure within the Central sorghum population is as

294 myloid load, in addition to the detection of substructures within single amyloid plaques correlating

295 y and high resolution, the identification of substructures within single amyloid plaques, and the qua

296 y interference and could excellently resolve substructures within the brain.

297 Molecular dynamics simulations reveal substructures within the liquid-ordered phase of lipid b

298 with each enzyme displaying specificity for substructures within these glycosaminoglycans that displ

299 bstructures; Galbeta and GlcNAcbeta terminal substructures, without sialic acid branches, were associ

300 ggests that it has more than one cooperative substructure yielding two separate unfolding transitions