ライフサイエンスコーパス: subtle

1 se retinal changes of early stages are often subtle.

2 mine the RR that allows earlier detection of subtle Abeta changes using (18)F-florbetaben PET.

3 Brain magnetic resonance imaging showed subtle abnormalities, including corpus callosum hypoplas

4 Furthermore, the subtle activation of striatonigral neurons sustained the

5 Our work points to the subtle adsorption-kinetics relationship in the OER and h

6 the sensitivity of our pipeline by detecting subtle alterations in normal cells when subjected to sma

7 We found that these subtle alterations in the timing of action potential fir

8 These results indicate subtle alterations in the underlying retinal circuitry t

9 ants with the heterozygote genotype also had subtle alterations in their sleep profile.

10 p-region is altered, but also when seemingly subtle alterations to the flanking residues are introduc

11 eta) peptide is thought to contribute to the subtle amnesic changes in Alzheimer's disease (AD) by ca

12 g because the symptoms of ovarian cancer are subtle and become apparent only during advanced stages o

13 ctive (CO2 x warming) treatment effects were subtle and contingent on water stress, phenology, and sp

14 striatum is the ability to characterize the subtle and early functional consequences of the CAG expa

15 mental signatures of Weyl-fermions are often subtle and indirect, in particular if they coexist with

16 that are simply competitive antagonists are subtle and intriguing.

17 longer follow-up period is needed to assess subtle and late adverse effects beyond 10 y.

18 nzyme is a carefully designed protein with a subtle and rigid secondary structure that enables the bi

19 presentations and disease progression can be subtle, and treatment strategies must be tailored.

20 -shifts with the effective SOC, depending on subtle aspects of molecular composition and structure.

21 Subtle aspects of their preparation can shift their limi

22 A subtle balance between competing interactions in iron-ba

23 A subtle balance between the internal cell polarization, C

24 ecular components is typically governed by a subtle balance of weak intermolecular forces that makes

25 Here we discover that I/R induces subtle BBB leakage within 30-60 min, likely independent

26 ations could be predicted through the use of subtle behavioral signatures that emerge in large-scale,

27 increase in size to 100 000s of individuals, subtle biases may influence conclusions.

28 The subtle bidirectional t-SNARE conformational switch was m

29 ver, molecular markers have failed to reveal subtle biogeographical trends in Espeletia diversificati

30 romatography-mass spectrometry for revealing subtle biogeographical trends in Espeletia diversificati

31 pability of optical chromatography to detect subtle biological differences in a rapid and sensitive m

32 We demonstrate that the subtle bonding differences among trivalent lanthanides c

33 Here, evidence of subtle brain changes in mTBI as revealed by these techni

34 y escapes proteasomal surveillance and shows subtle but clear changes in tertiary conformation.

35 ta suggest that cell based assays can reveal subtle but clinically relevant differences in IIRMIs fol

36 is issue is of interest for all fields where subtle but complex perceptual differences identify items

37 However, the produced data contain subtle but complex types of errors, biases and uncertain

38 This is the first report of a gene causing subtle but consistent variation in tooth shape resemblin

39 nts for epitope recognition, which include a subtle but critical element that is likely the basis for

40 a mutation analysis of human cancer revealed subtle but impactful copy number gains in E2F1 and E2F3

41 s in Parkinson's disease is known to cause a subtle but important adverse impact on behaviour, with i

42 etection approach is valuable for uncovering subtle but important differences in signaling, drug inse

43 ifferentiated from the rest of the corpus by subtle but important stylistic features.

44 e of catecholamine toxicity that may produce subtle but long-lasting myocardial alterations.

45 This manifests itself as subtle but pervasive high-order epistasis.

46 in modulation of dozens of OSN subtypes in a subtle but reproducible, specific and time-dependent man

47 tures and dynamical simulations demonstrates subtle but significant differences in the electrostatic

48 Application of MORPHE revealed subtle but significant differences in the stability of h

49 he bone marrow cells of Dnmt3a+/- mice had a subtle but statistically significant DNA hypomethylation

50 ed that each mutation of a gene could have a subtle but unique effect on protein function or network

51 many lncRNAs, Flicr's molecular effects are subtle, but by curtailing Treg activity, Flicr markedly

52 ctrochemical CO stripping/FTIR data revealed subtle, but important, differences in the formation and

53 The signal of negative selection is very subtle, but is detectable in several cancer types and in

54 ve targeting of genes by p63 correlates with subtle, but measurable transcriptional differences in mo

55 These subtle cardiogenic body movements have been measured wit

56 protection in vivo can be achieved by a very subtle change in the number of LHCIIs switched to the qu

57 g in the [2Fe-2S] cluster, indicating that a subtle change of protein structure may switch mitoNEET a

58 IR spectra via thin-film optics, to identify subtle changes (band shifts, deviation from linear appro

59 f small brain volumes, to identify early and subtle changes in brain vascular function in midlife dep

60 the essential cytoskeletal protein MreB for subtle changes in cell shape, cumulatively spanning appr

61 Premorbid personality may reflect subtle changes in cerebral function, may combine with sy

62 l epithelial populations was associated with subtle changes in chromosome content, which altered the

63 The results show that subtle changes in conformational dynamics can have a dra

64 ytic activity are diverse and often based on subtle changes in conformational dynamics.

65 S and YbaT in Cu tolerance, and suggest that subtle changes in core metabolic pathways may contribute

66 gene copy number imbalances, suggesting that subtle changes in gene expression impact the robustness

67 These subtle changes in ligand structure coupled with the cons

68 dynamic conformational equilibrium and that subtle changes in ligand structures can shift this equil

69 Results show that subtle changes in mass balance impart major changes in t

70 at (11)C-PBR28 should be able to detect more subtle changes in microglial activation in preclinical m

71 Therefore, subtle changes in mitochondrial energy production will p

72 l pilot) and revealed profound influences of subtle changes in mt DNA background variation on obesity

73 e heightened vulnerability of liver cells to subtle changes in nononcogenic RTK levels, allowing them

74 We here present a method to detect subtle changes in nuclear morphometrics at single-cell r

75 This heterozygous phenotype illustrates that subtle changes in receptor tyrosine kinase signalling ca

76 d volumetric uptake values are influenced by subtle changes in structure and chemistry.

77 Even mutations that cause subtle changes in the activity these channels are suffic

78 ectrometry measurements, we demonstrate that subtle changes in the chemical structure of a transient

79 in diverse organisms has revealed that more subtle changes in the intracellular redox state can act

80 These findings indicate that subtle changes in the relative strength of E/I of MSNs c

81 l closures during channel openings represent subtle changes in the structure of CFTR that are regulat

82 component analysis was used to identify the subtle changes in the ToF-SIMS spectra indicative of the

83 vestigate the covering nanomaterial based on subtle changes in the transmission of the nanomaterial w

84 ctional modification of membrane proteins by subtle changes in their bilayer environment.

85 y is proving to be valuable for the study of subtle changes in tumor-associated immune cells.

86 Neutron-scattering curves showed only subtle changes in wall structure, including a slight inc

87 s, offering a simple way to assess the often subtle changes to glycan profiles accompanying different

88 Seemingly subtle changes to groups, such as the loss of one indivi

89 Subtle changes to NP properties upon addition to environ

90 However, we detect a subtle charge density wave-like Fermi surface instabilit

91 gut epithelium are therefore equipped with a subtle chemosensory system that communicates the sensory

92 appeared to have amplified an existing, but subtle climatic signal that was previously absorbed by n

93 bioinformatically predicted, suggesting more subtle co-evolution of Cas13a enzymes.

94 of movement poverty and slowness, tremor and subtle cognitive deficits.

95 le breeds whose diversity has been shaped by subtle combinations of human and natural selection.

96 amic modelling demonstrates how the observed subtle compositional changes that result in fluidization

97 prosthenops australis NTD structures reveals subtle conformational alterations that lead to differenc

98 s through capsid pores are associated with a subtle conformational change.

99 complex defines the 5'-3' directionality and subtle conformational changes that clench the ssDNA with

100 r, the explanatory power of entrainment, and subtle connections with social cognition.

101 iewed here, each of which seems to have only subtle consequences for nerve-evoked excitatory postsyna

102 nges associated with signal transduction are subtle, constraining models of activation and system coo

103 s, and impaired systolic strain indicating a subtle contractile dysfunction.

104 ign was initially unsuccessful, and revealed subtle contributions to stability as designs became incr

105 transmission electron microscopy demonstrate subtle control of the supported metal structures from ap

106 Detection of subtle cues indicating sickness and avoidance of sick co

107 g techniques does not allow the detection of subtle CVD in midlife depression.

108 at congenital valve defects may arise due to subtle defects in this mechanotransduction pathway.

109 diologists learn to save lives by discerning subtle details of images that escape the notice of untra

110 The assay allows investigation of subtle details such as the effect of flanking sequences

111 alleles encoding catalytic mutants manifest subtle developmental abnormalities when subjected to tem

112 sical instrument, challenged them to monitor subtle deviations between predicted and actual auditory

113 nhanced fluctuations enable the recording of subtle deviations from a harmonic potential to accuratel

114 s variation in behavior is attributed to the subtle difference in ligand rotational freedom between t

115 se results demonstrate that in an nAChR, the subtle difference in structure between S-mTFD-MPPB and R

116 radient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenoty

117 ns to the metal-ligand bonding, in which the subtle differences between the transuranium actinide ion

118 ous analyses of tyrannosaurids, but produces subtle differences extending beyond the placement of Lim

119 ubstituent on the reactivity of allenes, the subtle differences in allene structures are manifested i

120 l resolution at nanoscale and sensitivity to subtle differences in chemistry and atomic structure, pr

121 Our observations show that the memory of subtle differences in earlier deformation paths must be

122 Experimental measures of the subtle differences in energetics and relative stabilitie

123 However, we observed subtle differences in genomic islands and prophages betw

124 We have found subtle differences in K segments led to changes in amino

125 le-size-dependent reactivity because of very subtle differences in local chemical bonding.

126 ation of juvenile eels varies in response to subtle differences in magnetic field intensity and incli

127 ifferent biological outputs, suggesting that subtle differences in MAPK signaling confer nonequivalen

128 y than existing approaches in distinguishing subtle differences in reproducibility and depicting inte

129 c data, executable network models can reveal subtle differences in signaling that help explain differ

130 antification of neutrophil rolling to detect subtle differences in speed distribution.

131 However, it is unknown whether or how subtle differences in spike timing drive differences in

132 tator cavity in the two co-crystals revealed subtle differences in steric interactions that account f

133 a deoxygenated dataset and distinguishes the subtle differences in texture alteration inside the oxyg

134 and reveal the sensitivity of the system to subtle differences in the binding of gaseous ligands.

135 We find that the subtle differences in the chemical structure of the two

136 correctly rank DNA force fields and resolve subtle differences in the conformational ensembles of nu

137 However, at high amplitudes, subtle differences in the form of fluctuations dramatica

138 However, subtle differences in the SID spectra of the activated c

139 ars, they have difficulty making full use of subtle differences in the sounds reaching the two ears [

140 ic aromatic hydrocarbons, and steroids, with subtle differences in the structure of subcomponents res

141 These proteins exhibit subtle differences in their GTP-binding, GDP/GTP-exchang

142 Our results demonstrate how subtle differences in words are gradually accumulated an

143 aprevir, danoprevir and vaniprevir, had only subtle differences relative to GT-1 despite orders of ma

144 lap between both differentiation methods but subtle differences which potentially give rise to their

145 relate to differences in modes of action or subtle differences within the same substrate specificity

146 Despite the subtle differences, the synII strain shows highly consis

147 Interestingly, our studies detected some subtle differential trends between the WT and Grp78(+/-)

148 will be needed to reliably discern the most subtle diffusion abnormalities, especially at high spati

149 ear of life, children make sophisticated and subtle distinctions among a wide range of positive emoti

150 ied different structural classes, related by subtle domain movements, which reveal conformationally d

151 d how disease-causing mutations deregulate a subtle dynamic conformational equilibrium involving the

152 vicinity of the active site, thereby masking subtle dynamic features that might be uniquely associate

153 lidity, we have applied this approach to the subtle dynamic regulation mechanism observed for Neisser

154 e epidemics and acutely ill individuals, the subtle dynamical influence of chronic shedding relative

155 omalies, feeding difficulties, deafness, and subtle dysmorphic facial features.

156 In contrast, DDC had a more subtle effect on AKT-NRAS(G12V) tumors and primarily enh

157 frequent ABCA4 variant c.5461-10T-->C has a subtle effect on splicing based on prediction programs.

158 However, loci with subtle effects are presumably more frequently involved i

159 structures of such proteins identified many subtle effects in length distribution of individual moti

160 o obtain sufficient statistics to reveal the subtle effects of changes in the membrane environment on

161 Our trial was not powered to detect subtle effects of hotspot-targeted interventions nor des

162 of local, intracellular concentrations, the subtle effects of SF1 phosphorylation on its association

163 ave been difficult to analyze because of the subtle effects of their natural variation.

164 orders, but it is not yet known whether more subtle effects on neurodevelopment may exist as well.

165 Typically, motor affordances only produce subtle effects on response time or on motor activity ind

166 g when studying other risk factors with more subtle effects.

167 h the Eu(III) and Nd(III) complexes revealed subtle electronic differences between the complexes of A

168 ore broadly, our work supports the idea that subtle enhancements of endogenous genome instability can

169 can be highly specific, even with respect to subtle environmental differences, but that this imprint

170 indings exemplify how negative selection and subtle enzyme changes can lead to major evolutionary shi

171 omponents could therefore dominate over more subtle expression traits inherent to cancer cells.

172 many individuals exhibit cerebellar ataxia, subtle facial dysmorphism, strabismus, and vesicoureteri

173 cipate in complex formation, suggesting that subtle factors differentiate each interaction type.

174 In 4 of 5 patients, subtle fascicular nerve lesions were detected in clinica

175 he spine, in whom plain radiographs revealed subtle findings and aided in making diagnoses.

176 utionary acquisition, possibly allowing more subtle fine-tuning of the maturation process.

177 their morphological variations which are too subtle for human eyes to detect.

178 suggests that Reln mutations may cause more subtle forms of human brain malformation than classic li

179 Not only can these favor new and subtle forms of matter, such as magnetism or superconduc

180 y was established by introducing some of the subtle Foxp3 mutations into the mouse germline by CRISPR

181 owed by spontaneous adherence; 3 eyes showed subtle graft folds with scar tissue anteriorly; in 2 eye

182 Subtle group differences were detected on two cognitive

183 These mutants display only subtle growth phenotypes despite the strong accumulation

184 absent in FG+/phenotype-negative relatives; subtle HCM developed in 11% during 6 years of follow-up.

185 cellular analyses can be used to rationalize subtle heterogeneities in ion abundance in MS images, no

186 le maintaining low-contrast detectability of subtle hypoattenuating focal liver lesions.

187 olution, and observer-based detectability of subtle hypoattenuating liver lesions and to estimate the

188 tures reveal that the S531L mutation imparts subtle if any structural or functional impact on RNAP in

189 these manipulations, however, produced only subtle impacts on maternal care, suggesting that this di

190 all showed inconclusive features on MRI, but subtle important radiographic findings led to a specific

191 Chiral inversions are subtle in that they do not change side-chain size, flexi

192 pically visible abnormalities (no matter how subtle) in order to accurately assess the grade of dyspl

193 lation of viral RNA levels by PGC1alpha is a subtle increase in cytoplasmic HBcAg/p21 polypeptide tra

194 This leads to a subtle increase in the effective volume fraction of this

195 ient to sleep-loss effects than those with a subtle increase.

196 e., apolipoprotein B100 only) exhibited only subtle increases in endoplasmic reticulum stress, sugges

197 ective of pH, and DeltaBbpacC conidia showed subtle increases in UV susceptibility.

198 e demonstrated genetically that in the liver subtle increases in wild-type Met RTK levels are suffici

199 of the alkanes is proposed and relies on the subtle influence of the achiral aryl imine substituent o

200 (LDR) differ for each electrode type due to subtle influences in how the detectable signal varies in

201 Anti-predator signals contain subtle information that is critical for avoiding predati

202 This subtle inhibitory control of plateau potential depends o

203 An ongoing challenge is to understand how subtle interactions between catalyst and substrate influ

204 Subtle interindividual genetic variation as well as vira

205 ion, PCR, and deep sequencing reveals that a subtle interplay between backbone flexibility, steric fa

206 These results highlight the subtle interplay between receptor binding sites in IgE-F

207 We show that the subtle interplay between these three factors is responsi

208 nce on their DNA template is determined by a subtle interplay of DNA mechanics and electrostatics, th

209 of competing quantum effects that allows the subtle interplay of water's quantum effects and their ma

210 However, the subtle interrelation of these phases remains poorly unde

211 ging was generally normal, but in 6 subjects subtle irregularities at the inner segment ellipsoid ban

212 These subtle issues become particularly apparent when estimati

213 lononane), taking into account the effect of subtle ligand flexibility on the electronic structure.

214 ying complex panicle traits, and demonstrate subtle links between panicle size and yield performance.

215 haperone cycle and its chaperone activity by subtle local perturbations at SBD allosteric 'hotspots'.

216 suggest that all living cells show fast and subtle mass fluctuations throughout the cell cycle.

217 inoline ligand underscores the importance of subtle matching between ligands and the directing groups

218 The results help understand how the subtle mechanism of molecular stripping actually occurs.

219 ty control methods, have been used to detect subtle metabolic differences in tissue that could aid in

220 GPD2 overexpression lines showed only subtle metabolic phenotypes and no significant alteratio

221 ae inflorescence complexity is determined by subtle modifications of transcriptional programs during

222 ments, we developed small molecules allowing subtle modulation of GSK-3beta activity.

223 ocessing, presents the capacity to highlight subtle molecular alterations associated with malignancy

224 ked phylogenetically and antigenically, even subtle molecular changes can impart critical shifts in m

225 pes of breast tumors can be classified using subtle morphological differences of microenvironmental m

226 We identified several subtle mutations in M that were less potent at suppressi

227 udy identifies a cellular mechanism by which subtle myelin abnormalities cause low-grade neuroinflamm

228 Overall, this study suggests that subtle natural variations in the HA RBS between subtypes

229 a threshold that is low enough for observing subtle near-surface changes such as water content variat

230 less commonly available details that enable subtle nuances of treatment to be studied.

231 We found only subtle objective cognitive impairment in alumni athletes

232 eficits associated with neurotoxicity can be subtle or disabling and frequently include disturbances

233 morphous gyroid character, demonstrating the subtle order achieved by evolutionary optimization and t

234 ith neural tube defects and autism, but more subtle outcomes such as cognition have not been studied.

235 ded the most stringent published cut-off for subtle parkinsonism of three definitions examined (p=0.0

236 fords limited resolving power for discerning subtle pathological changes associated with early diseas

237 o detect them are limited and insensitive to subtle pathological changes.

238 w that deletion of NDCBE in mice caused only subtle perturbations of Na(+) homeostasis and provide ev

239 nsitive, accurate, simple and able to report subtle perturbations of various pathways of energy metab

240 bled detection of new interactions involving subtle phenotypes.

241 ged muscle metabolism, to potentially unmask subtle phenotypes.

242 ugh deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three cl

243 f potential biases in the data and elucidate subtle phylogeographic patterns.

244 entially self-sorted nanostructures based on subtle pKa differences, whereas HCl addition leads to a

245 entropy-based measures, driven in part by a subtle positive correlation between the transcriptome an

246 ed on electroencephalogram (EEG) to evaluate subtle post-concussive alterations.

247 D data, limiting its potential to detect the subtle progression of COPD as well as varying subtypes.

248 hus offers a powerful approach for measuring subtle protein conformational changes in solution.

249 which is especially important to search for subtle PTMs in proteins.

250 of optimal cLogD values and the discovery of subtle PXR SAR that was not lipophilicity dependent.

251 Nevertheless, due to subtle, quantitative differences between the biochemical

252 The subtle quantum correlations in a Bose gas approaching th

253 Familiarity with subtle radiographic findings of these conditions may lea

254 sed that RNA-TVcurve can efficiently capture subtle relationships among RNAs for mutation detection a

255 e large combinatorial space involved and the subtle relationships of distant residues to catalytic fu

256 es can result from the cumulative effects of subtle residue substitutions.

257 aks are often not suitable for examining its subtle responses to altered DNA without strand breaks, s

258 In particular, SOC plays a subtle role in creating the electronic ground state but

259 Thus calcium chelating salts may play a more subtle role in modulating hydration during manufacture o

260 a close consideration of the many varied and subtle roles that water plays in living cells-a consider

261 l (M12L18) prisms by taking advantage of the subtle selectivities imposed by the different anilines a

262 Subtle sequence variation in the modular synthetic ligan

263 optimization, we demonstrate how to exploit subtle shape changes to infer cell wall material propert

264 of volume and cortical thickness, while more subtle shape measures may provide more sensitive and spe

265 d experimental insights rationalize how even subtle shifts in the availability of ribosomes, such as

266 The subtle size dependence is shown to be related to the key

267 rstood and modeled before analyzing the very subtle spectral variations related to the bone tissue va

268 breaking into language, infants must discern subtle statistical differences about people and voices i

269 s a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introdu

270 s with internal alkynes possessing only very subtle steric differences between two aliphatic substitu

271 are sensitive measures of the molecular and subtle structural changes following mTBI.

272 e two distinct HS-LS phases is the result of subtle structural changes in the alkyl chains and produc

273 affect the underlying topology, but induces subtle structural changes, such as ligand rotation, and

274 ore structures confirmed the degree to which subtle structural differences could be determined using

275 bility of their CAPTR product ions, even for subtle structural differences that are not apparent from

276 egions are not truly bulk-like, due to their subtle structural differences with the bulk.

277 istinct for isomeric carbohydrates with even subtle structural differences.

278 ar coordination complexes can be affected by subtle structural factors, which can be controlled easil

279 A subtle structural feature of the hERG selectivity filter

280 this is a rare event that can be overcome by subtle structural modifications of an AMP.

281 This points to an unusual and subtle structural organization effect of the anion recep

282 , macroscopic symmetry breaking is driven by subtle sub-wavelength variations in the pore geometry.

283 mprove health and which elicits a relatively subtle suite of changes from complex molecular profiles.

284 gh risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ).

285 anced accuracy makes it possible to identify subtle synthetic growth defects.

286 ontribute to multistep switching may be more subtle than previously anticipated.

287 rchers to uncover, in a reproducible manner, subtle time-dependent behavioral phenotypes that will al

288 in canonical or modified forms, making them subtle to detect and analyze.

289 nd used 3D surface morphometrics to quantify subtle variation between individuals.

290 ass difference of 20.5 mDa, arising from the subtle variation in nuclear binding energy between the t

291 es of these reactions is challenging because subtle variations in ligand structure can cause notable

292 membrane-binding proteins might distinguish subtle variations in lipid membrane composition and/or s

293 generate potential for the emergence of more subtle variations in phenotype that may be adaptively si

294 he LSPR measurement response is sensitive to subtle variations in the bilayer-substrate separation di

295 ead to a better general understanding of the subtle variations in the reaction mechanisms for C-H fun

296 However, subtle variations of this cluster, putative ancillary as

297 p 2, Novoalign) provide similar results with subtle variations.

298 ife depressed patients, suggesting early and subtle vascular impairments in this population at risk f

299 ourier-based methods, which alter or destroy subtle waveform features.

300 rder can affect socio-emotional cognition in subtle ways, an impairment not restricted to auditory in