ライフサイエンスコーパス: subtly

1 fer when dietary composition is varied, even subtly.

2 ain and the catalytic core that only changes subtly.

3 from 2.66 A, but the Fe-P bonds only change subtly.

4 ds whose chemical behavior often differ only subtly.

5 uring the interpretation of 20 normal and 20 subtly abnormal mammograms.

6 mbrane changes indicate that the protein can subtly adapt to its environment without large structural

7 ion and by down-regulating motility, thereby subtly adjusting and maintaining energy usage and pmf.

8 -1D morphological transition was achieved by subtly adjusting the intermolecular forces.

9 able to tune tRNA suppression efficiency by subtly adjusting the tRNA sequence and inter-convert poo

10 In addition, NAC also subtly adjusts other cellular functions to keep pace wit

11 nds to LRP2 near the mutation cluster, might subtly affect development and could lead to autism-assoc

12 ermine whether polymorphisms exist that more subtly affect enzymes yet are augmentable in the same wa

13 se genes display defects in cell fusion that subtly affect mating efficiency.

14 s confirms that both N100Y and N100W mutants subtly affect the chemistry of the PLP.

15 Mutations in the CA-CTD domain of Gag which subtly affect the self-assembly of Gag abrogated RNA sel

16 ifferences observed between strains, but can subtly affect turns and certain beta-sheet components.

17 roanatomical structures may be profoundly or subtly affected by the interplay of genetic and environm

18 agar to folate in vegetative cells were only subtly affected in Arp2 phosphorylation mutants.

19 condensed mitotic chromosomes, its deletion subtly affected the nucleoplasmic distribution of the pr

20 t, mediolateral patterning is generally only subtly affected.

21 nalysis reveals that loss of an HMGN variant subtly affects expression of numerous genes in specific

22 enetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum ti

23 Abeta(1-38) isoform, indicating that NSAIDs subtly alter gamma-secretase activity without significan

24 neuropathy is caused by mutations that more subtly alter myelin structure and which probably disrupt

25 domain and that mutations at the P2 position subtly alter the conformation about this site.

26 ose that structural alterations in eIF2gamma subtly alter the conformation of Met-tRNA(i)(Met) on the

27 a mechanism of amino acid substitutions that subtly alter the conformation of NA in and around the ac

28 However, the removal of denaturant does subtly alter the distribution of backbone dihedral phi,p

29 do not affect the affinity of GR for DNA but subtly alter the electrophoretic mobility of the GR-DNA

30 ggests that, in some cases, the mutation may subtly alter the entire protein-RNA interface.

31 ) small overall changes in conformation that subtly alter the nucleotide triphosphate binding site su

32 pecies than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms.

33 ard point mutations at the same sites, these subtly altered amino acids preserve the wild-type voltag

34 onstruction of C. albicans strains that were subtly altered at the mating-type-like (MTL) locus, a cl

35 Telomere sequences are subtly altered in est2-LT strains, but similar changes i

36 nnels and voltage-gated calcium channels are subtly altered in genetic disorders and mutations in the

37 The binding of PTB is subtly altered in the presence of the central domain (p5

38 Although grossly normal, these mice have a subtly altered proliferative phenotype, with increased c

39 memory deficits, impaired fine motor skills, subtly altered social interactions, and decreased dendri

40 eliminated the nucleosome-free gap but only subtly altered the distribution of SAGA.

41 Using unnatural amino-acid mutagenesis, we subtly altered the properties of this Trp to reveal spec

42 nscriptional profile of these Treg cells was subtly altered, with an overrepresentation of IRF4-depen

43 ever, their size and protein composition are subtly altered.

44 e segrosome interactively with ParG, thereby subtly altering centromere conformation.

45 s the role played by CH...pi interactions in subtly altering conformational preferences of three-resi

46 stability by binding across CA molecules and subtly altering interhexamer interfaces remote to the li

47 ier observations that CQR can be overcome by subtly altering the CQ side-chain length.

48 Conversely, the sugar moiety subtly alters DNA interactions.

49 le, and chromatin organization in cells, and subtly alters its nuclear mobility.

50 We show that addition of HA subtly alters mechanical properties and structure of the

51 We predict that calcium subtly alters scruin conformation through its calmodulin

52 e show here that mutation of this Gln to His subtly alters the active site structure but preserves 30

53 g multiple low-energy conformations and only subtly alters the average conformation and orientation.

54 This neomorphic mutation subtly alters the DNA-binding preference of OCT2, leadin

55 anifest the symptoms of FXTAS, although more subtly and less often than their male counterparts.

56 ted with IF1, the equivalent site is changed subtly and the enzyme is incapable of binding thiophosph

57 endings varied both between strains of mice (subtly) and between species (more dramatically).

58 ism neither shifted their gaze away nor more subtly averted their gaze to peripheral locations.

59 n of production of short transcripts differs subtly between basal and enhanced transcription, indicat

60 The pathogenicity island, which varies only subtly between strains, is approximately 150 kilobases i

61 istical topography, specific energetic terms subtly bias the representative structures giving rise to

62 ily genes; and Dkk4 transgenic mice showed a subtly but appreciably modified claw phenotype.

63 Unexpectedly, this early response was subtly but significantly different in people older than

64 dings indicate that the Ser-700 polymorphism subtly but significantly sensitizes the calcium-binding

65 ay produce "silent" programming defects that subtly, but irrevocably, jeopardize life-long well-being

66 ial community composition and structure were subtly, but significantly, altered by fertilization, wit

67 e, irradiation time, and photon flux), IRMPD subtly, but significantly, outperforms resonant-excitati

68 ficity for the two enzymes can be controlled subtly by manipulation of the privileged quinolone core

69 phenotypic differentiation was defined more subtly by nonrandom transcriptional network organization

70 emoval of extracellular Ca(2+), was enhanced subtly by raising extracellular [Ca(2+)] from 2 mm to 10

71 es, the inhibition modulated neuronal output subtly, by elevating spike threshold or altering firing

72 These replacements subtly changed the chemistry of two amino acids, but the

73 ches, usually altered IH more distinctly and subtly changed the kinetics.

74 reduces free IAA content in roots, but only subtly changes free IAA content in tomato hypocotyls.

75 em can substantially alter these motions, by subtly changing mechanical properties such as body or le

76 ions in the mitochondrial proteome gained by subtly changing steady-state protein assembly, stability

77 92% (S)-2) using the same chiral catalyst by subtly changing the structure of the achiral boronic aci

78 cating advanced multifunctional materials by subtly combining contrasting multi-components.

79 e tendon, we fabricated a novel composite by subtly combining two contrasting components: NiTi shape-

80 gnetoencephalography studies, or may be more subtly composed of differentiated activity of individual

81 method to locate and align only those, often subtly, conserved patterns essential to the family as a

82 erous cis-acting sites, which therefore very subtly contribute to the regulation of the "switch".

83 ed that the C20orf54 rs13042395 genotype was subtly decrease the risk of ESCC (T vs. C: OR = 0.95; 95

84 morphism was significantly associated with a subtly decreased cancer risk in under-weight group and n

85 show that yeast nucleosomes are likely to be subtly destabilized as compared with nucleosomes from hi

86 be applicable to any mixture of complex and subtly different analytes for which nucleic acid-based r

87 ll agonists where binding modes will be only subtly different and confined to only one binding site.

88 Baseline synaptic responses in CA1 were only subtly different between the two MA groups, but long-ter

89 e first study which attempts to quantify the subtly different binding specificities of a transcriptio

90 eural Networks (ANNs), are able to recognize subtly different biological entities.

91 iable C-terminal peptide residues and elicit subtly different CLR conformations.

92 ovative therapies that take advantage of the subtly different collagens that exist within the skin.

93 r proteins interact with the same domain but subtly different contact points of P450MT2.

94 ntrol presentation of sugar functionality in subtly different contexts.

95 Moreover, we find that subtly different environmental conditions can lead to dr

96 ergoing a slow conformational exchange among subtly different environments.

97 tion in developing control over enactment of subtly different facial expressions and therefore skills

98 the nucleobase with the active site are only subtly different for G versus oxoG, hOGG1 fails to catal

99 gy of polyps from SMAD4 mutation carriers is subtly different from other JPS polyps, notably includin

100 at these analogues may have a mode of action subtly different from that of the parent drug artemisini

101 ears to have an overall conformation that is subtly different from that of the wild-type enzyme.

102 shared by all CD4 TCRs, and that it is only subtly different from the common orientation proposed fo

103 One of these morphologies was subtly different from the previously published 27-A-reso

104 signal sequence variations may correspond to subtly different functional properties.

105 tion' - genes encoding similar proteins with subtly different functions, such as olfactory receptors.

106 complexes in vivo, suggesting that they have subtly different functions.

107 Many glycoproteins contain populations of subtly different glycoforms; therefore, with stricter or

108 The left and right eyes receive subtly different images from a visual scene.

109 stablishing a clear role for ARBs, have been subtly different in distinct patient populations.

110 hat each snoRNA forms two different snoRNPs, subtly different in how the proteins are bound to the C/

111 -type enzyme, and the crystal structures are subtly different in the active sites of the D256E and wi

112 Muller cells are subtly different in the GFAP(-/-)vim(-/-) mouse retina b

113 dominantly off-pathway oligomers, albeit via subtly different mechanisms.

114 s while HBV and CCMV capsids fit similar but subtly different models of nucleation-limited assembly t

115 whose nonequivalent packing is reflected in subtly different morphologies of the two protomers.

116 have started to illuminate the multiple and subtly different pathways that animal viruses use to ent

117 led to generation of several substrains with subtly different phenotypes.

118 ge of systems with an ability to distinguish subtly different processes.

119 Chromatin immunoprecipitation revealed subtly different promoter targeting between the differen

120 pplications but is made challenging by their subtly different properties.

121 Both methods give comparable although subtly different results.

122 from mating naturally by their responses to subtly different sex pheromone isomers, (E)-12- and (Z)-

123 e the P-box region in discrimination between subtly different small molecules.

124 cid catabolic pathways studied to date use a subtly different spectrum of decarboxylases from the fiv

125 light direction and body orientation evolved subtly different strategies and performed less robustly.

126 vely, which have the same stoichiometry, but subtly different structures.

127 issae to distinguish between surfaces having subtly different textures and shapes.

128 ), homosexual men tend to be infected with a subtly different variant of HIV-1 than intravenous drug

129 eadily interchanged or "shuffled" to produce subtly different variants with distinct molecular shapes

130 , PIPK1gamma and layilin in similar although subtly different ways.

131 A series of subtly different, designed substrate analogues based on

132 However, their stratification patterns are subtly different, with M4 dendrites positioned just dist

133 biochemical properties of these enzymes are subtly different.

134 ir underlying protofilament hierarchy may be subtly different.

135 e neural code for letter strings may also be subtly different.

136 the structures of Yb2CdSb2 and Ca2CdSb2 are subtly different: Ca2CdSb2 has a layered structure built

137 the chemical bonding in the two compounds is subtly different; in the (Eu(1-x)Ca(x))(2)Ge(2)Pb struct

138 ng site for E2F transcription factors and is subtly distinct from a canonical p53-transactivating ele

139 Cell-based assays revealed subtly distinct intracellular sites of NS1 localization

140 mixing approach opens the door to a range of subtly distinct materials for chemical and biological ap

141 Even subtly distinct structural isomers evoked posterior resp

142 no acids, peptides, and nucleotides yielding subtly distinct taste qualities.

143 that the precise alignment of substrates is subtly distorted.

144 However, it represents an example of either subtly divergent or powerfully convergent evolution, bec

145 ated with previous learning can be delivered subtly during SWS to selectively enhance memory consolid

146 ce charge, were found to both decisively and subtly effect therapeutic efficacy.

147 Although single HSP90 mutants showed subtly elevated levels of lesions, double mutant analysi

148 not show abnormal pathology, but do display subtly elevated levels of the highly amyloidogenic 42- o

149 ce for independence comes from the fact that subtly elevating Mad2(MDF-2) levels bypasses the require

150 sitions the peptide main chain and generates subtly enhanced interactions between the analogue peptid

151 Canoe loss subtly enhances AJ planar polarity and dramatically incr

152 states, but the average conformation differs subtly, especially at the G34-I35 linkage and V27 side c

153 proliferation in vitro but in vivo may more subtly exploit the proliferative pathways provided by ly

154 mines cardiac repolarization, and HERG-G628S subtly facilitates the genesis and propagation of premat

155 rs recognized by PvdS orthologues may differ subtly from species to species.

156 This pattern differs subtly from that described previously in rats.

157 This behaviour differs subtly from that of seeds overwintered in the soil seed

158 ootprint of MAb E33 on the E protein differs subtly from that of the well-characterized DIII-LR MAb E

159 tationary gating kinetics that differed only subtly from that produced by agonist binding.

160 nvolved in the binding to MHC class I differ subtly from those involved in binding to class II protei

161 The two species differ subtly in phenotype and cannot be differentiated by mito

162 tion from pre-SMA to STN when choices differ subtly in reward values, allowing more time to choose th

163 oragog and intestinal epithelia but differed subtly in the kidneylike nephridial tubules; neither Zn

164 f T cells by MHC-peptide ligands that differ subtly in their structure have largely been based on eit

165 evels of histone H3 K18 and K27 acetylation, subtly increased H3 K27me3 and unaltered overall levels

166 engineered dopaminergic PC12 cell lines with subtly increased levels of MAO-B mimicking those observe

167 We report an intervention that subtly increases the observability of public goods contr

168 many new questions, the answers to which may subtly influence our approach to the treatment of reject

169 udy provides evidence that maternal PCOS may subtly influence the neurodevelopment of the offspring,

170 fruit-flies suggest that very many genes can subtly influence the trait.

171 at WM performance in healthy subjects may be subtly influenced by functional differences in CRHR1 and

172 First, it subtly influences centriole length by counteracting the

173 imary role at only a handful of origins, but subtly influences initiation timing globally.

174 This approach, which subtly integrates coverage information into the procedur

175 Protein homeostasis is subtly maintained on the mitochondrial inner membrane an

176 The cycle time of the distractor actions was subtly manipulated across trials, and the cycle time of

177 Subtly manipulating the relative timing of Kenyon cell s

178 r work emphasizes that spatial structure can subtly mediate intraspecific competition and the effects

179 Our data showing that A(1)AR activation subtly mediates a proarrhythmic Ca(2+) entry through TRP

180 nal in translation in vivo but is presumably subtly misfolded.

181 to characterize how immune responses may be subtly modified by tissue context.

182 These subtly modified electrical properties may result in atyp

183 Most strains possess factors that subtly modulate the host environment, increasing the ris

184 thought to either strongly "drive", or more subtly "modulate" activity patterns respectively.

185 This mimicry can be subtly modulated by different social contexts.

186 , whose catalytic function in translation is subtly modulated by posttranscriptional modifications.

187 s, possibly due to higher N demand, AM fungi subtly modulated NO3- leaching, decreasing losses by 54%

188 The D130I mutation subtly modulates the helical structure.

189 rotein synthesis and may affect longevity by subtly modulating this pathway.

190 replicates to higher titers in vivo, and is subtly more virulent, than the parental virus.

191 ponses are lost in a mouse line expressing a subtly mutated alpha2AAR, D79N alpha2AAR, created by two

192 ement proceeds with high selectivity between subtly nonequivalent acetal oxygen atoms.

193 line silicate frameworks are shown to depend subtly on the architectures of the organic species, whic

194 tend to change shape in a way that converges subtly on the flightless form.

195 mobility of DNA knots depends crucially and subtly on the physical properties of the gel and, in par

196 satisfied then the eventual outcome depends subtly on the strength of local superiority of one speci

197 of-function effects are dependent, sometimes subtly, on the nature and apparently the extracellular,

198 ination, they can also alter gene expression subtly or powerfully.

199 ight result in neighboring molecules packing subtly out of register, leading to premature crystal gro

200 Non-fluorescent alpha1(V) THP subtly perturbed amide NMR chemical shifts of MMP-12 not

201 To examine this link directly, we subtly perturbed electron transport chain function in th

202 overall expression of the Treg signature was subtly perturbed in T1D, but not T2D, patients.

203 The low-dimensional representation is subtly perturbed in the solvated phase relative to the i

204 the thermal stability of DJ-1 in solution by subtly perturbing the structure of DJ-1 without causing

205 More subtly, phylodynamic models indicate that widespread cro

206 embryos lacking B4galt1, NOTCH signaling is subtly reduced during somitogenesis.

207 ers has been restricted to recent reports of subtly reduced fluid-fluid transition temperatures.

208 eutrophil accumulation was unchanged or only subtly reduced relative to wild-type control mice.

209 wo similar genomes on a similar phenotype is subtly reflected in their genotypes: only 30 genes are d

210 The shape of the Sun subtly reflects its rotation and internal flows.

211 constitutes one of the most spectacular yet subtly regulated phenomena in cell biology.

212 th the apposition of active-site domains and subtly repositions zinc-binding residues.

213 lu activity have played an important role in subtly reshaping the structure of primate genomes.

214 The precise magnitude of the bend is subtly sequence dependent (consistent with a curved gene

215 y onset diabetes of youth in whites presents subtly similar to type 2 diabetes in adults.

216 substantially different from T(EM) but only subtly so from T(N).

217 lity that excess adiposity may paradoxically subtly suppress hypothalamic-pituitary-gonadal function

218 receptors may influence spatial memory more subtly than previously thought.

219 More subtly, these early AD-linked calcium alterations also r

220 and alkynyl ligand electronics combine more subtly to drive the magnetism of the new complexes repor

221 in a heterogeneous TS ensemble that responds subtly to mutation or changes in the solvent conditions.

222 our studies, we show that race biases can be subtly transmitted via televised nonverbal behavior.

223 tiphase transport, in a highly selective and subtly triggered fashion and without clogging, has inspi

224 expression in response to synaptic input to subtly tune their firing properties.

225 equilibrating alkyl-palladium complexes were subtly tuned to form either a primary or trisubstituted

226 ich allows it to access and persist within a subtly unique niche of the memory compartment characteri

227 tion profile of the gamma HC subunit changed subtly upon Ca(2+) addition, suggesting that the entire

228 Saccharides are complex, subtly variable, and camouflaged by hydroxyl groups that

229 also suggests that other factors contribute subtly when the structure of the substrate is altered.

230 alters protein stability and misfolding only subtly, whilst changing Ser to Asn at codon 169 causes i

231 was revealed for producing errors that were subtly wrong.

232 duced by the TLR7 receptor agonist imiquimod subtly yet reproducibly decreases time to skin graft rej