ライフサイエンスコーパス: subtype

1 cesses (e.g. time-course dynamics or disease subtypes).

2 rs and is the most aggressive mammary cancer subtype.

3 by MAML3 and CSDE1, and a cortical admixture subtype.

4 psing MS more resilient than the progressive subtype.

5 lls and tissues but without regard to cancer subtype.

6 man parvalbumin-expressing inhibitory neuron subtype.

7 the detection of strabismus, overall and by subtype.

8 cient DLBCLs irrespective of their molecular subtype.

9 ecurrent tumors, regardless of breast cancer subtype.

10 oup of breast cancers of the basal molecular subtype.

11 ertion in the 260-loop compared to any other subtype.

12 at differentiate steatosis from NASH in each subtype.

13 i-EPX and anti-nuclear antibodies of the IgG subtype.

14 ormance differed as a function of depression subtype.

15 scaffolds have been selected to target CB2R subtypes.

16 atment success or failure in common lymphoma subtypes.

17 s to generate trimers that now span multiple subtypes.

18 development at early stages across different subtypes.

19 ween LTPA, BMI, and the risk of different HF subtypes.

20 rimination between influenza virus types and subtypes.

21 agonist with nanomolar affinity for all four subtypes.

22 ctal carcinoma in situ and all breast cancer subtypes.

23 th age at diagnosis, sex, and ductal and IBD subtypes.

24 f MRD assessment, cutoff levels, and disease subtypes.

25 tion programs between distinct breast cancer subtypes.

26 tial proteins that are mutated in various FA subtypes.

27 ime since vaccination across influenza types/subtypes.

28 nization allowed a finer discrimination into subtypes.

29 ctural and staining characteristics of druse subtypes.

30 y with regard to arrhythmia risk for certain subtypes.

31 g scales can be used to identify distinct AD subtypes.

32 CL from both germinal center (GC) and non-GC subtypes.

33 discovering trends within and between cancer subtypes.

34 combinations likely will be needed for most subtypes.

35 sing interneurons (CCK-INTs), a prominent CB subtype-1 receptor (CB1R) expressing neuronal population

36 sing transgenic mice, we found that dopamine subtype 2 (D2) receptor-expressing medium spiny neurons

37 in vivo evidence that somatostatin receptor subtype 2 (sst2) antagonists are better tools to target

38 ed the best overall characteristics for sstr subtype 2 targeting and was therefore selected for clini

39 H2), an antagonist with selectivity for sstr subtype 2, showed the best overall characteristics for s

40 ribe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2.

41 redominantly subtype A (43.02%), but 7 other subtypes (33.14%), 20 circulating recombinant forms (CRF

42 The env sequences were predominantly subtype A (43.02%), but 7 other subtypes (33.14%), 20 ci

43 hat the poorer viral replicative capacity of subtypes A and C may paradoxically contribute to their m

44 lecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype,

45 a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE

46 We constructed phylogenetic trees for 794 subtype A1 and 64 subtype B sequences and identified fac

47 Recently, the BoNT serotype A (BoNT/A) subtypes A1 and A2 were reported to possess similar pote

48 ecombinants of 2 or more subtypes, including subtypes A1, F, G, H, J, and K and unclassified fragment

49 Acting at a single metabotropic receptor subtype, ACh exerts two opposing actions in cortical pyr

50 derstanding how each of the many interneuron subtypes affects brain network activity is critical.

51 This voltage-gated sodium (Nav) channel subtype also plays an important role in mechanical pain

52 e distribution of strabismus, overall and by subtype, among children 7 years or younger.

53 tures identified a layer 6 excitatory neuron subtype and a unique human parvalbumin-expressing inhibi

54 sistently differentially methylated in every subtype and all implicated genes are localized to the ch

55 CSS and OS were associated with approximated subtype and chemotherapy response and were lowest in TNB

56 Heterogeneity was driven by neuropathologic subtype and DKI technique.

57 calation are affected differentially by ADHD subtype and gender.

58 y over a panel of receptors including 5-HT2B subtype and hERG channel, which suggests no major cardia

59 pose To investigate the performance of tumor subtype and various magnetic resonance (MR) imaging para

60 he expression levels of some markers for AML subtypes and c-MYC regulated genes were considered poten

61 cancer cell lines and tumors into the common subtypes and correlated with the basal classification.

62 f developing neurons to dissect/identify NPC subtypes and critical developmental stages of alternativ

63 to the diversity of breast cancer molecular subtypes and explain much of the differences compared wi

64 tients with HER2-positive or triple-negative subtypes and extracranial metastases.

65 We perform survival analysis of several TCGA subtypes and find that GRAPE pathway scores perform well

66 iomyoma subtypes emphasize the importance of subtypes and genotypes in designing nonsurgical therapeu

67 rtcomings such as ill-defined parameters for subtypes and grading criteria prone to arbitrary judgmen

68 aries across avian and human influenza virus subtypes and is also evolvable.

69 (ii) cultures exhibit heterogeneous neuronal subtypes and maturation stages.

70 ards the expression of different behavioural subtypes and neurobiological substrates.

71 d p105 signaling in defining DLBCL molecular subtypes and posit MYD88/p100 signaling as a regulator f

72 the proposed approaches can be used to learn subtypes and the molecular networks that define them.

73 rkers for the classification of histological subtypes and the prediction of clinical outcomes.

74 y facilitate better population-level disease subtyping and characterization, as well as individual-le

75 bjectives included determination of delirium subtype, and effect of delirium on duration of mechanica

76 The atypical MDD subtype, and only this subtype, was prospectively associ

77 regard to age at diagnosis, sex, histologic subtype, and other tumors presented by these patients.

78 bindin are molecular markers for interneuron subtypes, and are co-expressed with aromatase in human t

79 To report the incidence, prevalent subtypes, and clinical characteristics of pediatric nyst

80 comprises a heterogeneous group of clinical subtypes, and further refinement is needed to improve tr

81 33 nM, selectivity versus other P2Y receptor subtypes, and is thought to act as an allosteric antagon

82 for D4, relative to other dopamine receptor subtypes, and that this activity might underlie the uniq

83 ers for differentiating ccRCC from other RCC subtypes are aorta-based corrected AV and aorta-based co

84 The intrinsic subtypes are associated with measures of clinical aggres

85 These molecular subtypes are found in 582 Asian, but less so in 265 Cauc

86 d knockin mouse lines in which endogenous H1 subtypes are tagged.

87 unity against a wide divergence of influenza subtypes as compared to traditional vaccines.

88 upregulation of hippocampal alpha4betagamma2 subtypes, as well as increased cell-surface levels of GA

89 Subtype associations for several immune-related markers-

90 ofiles that suggest different roles for each subtype at the start and end of tethered-walking turns.

91 ution cryo-electron microscopy structures of subtype B B41 SOSIP Env trimers in complex with CD4 and

92 phylogenetic trees for 794 subtype A1 and 64 subtype B sequences and identified factors associated wi

93 In part B, subtype B-infected subjects received 40 mg or 80 mg GSK3

94 poxvirus (ALVAC) and recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vacc

95 genotypes, the heritability of breast cancer subtypes (basal vs nonbasal) was estimated to be 0.436 (

96 n be subdivided into four neurophysiological subtypes ('biotypes') defined by distinct patterns of dy

97 nt for FIVPle transmission for the two major subtypes, but the relative contribution of each factor w

98 e numbers of specific cortical output neuron subtypes by controlling the genes that are required to p

99 o the MHC-B downregulation function in HIV-1 subtype C and show that carriage of Nef variants with en

100 A subtype C isolate was similar, while a simian immunodefi

101 type/phenotype analyses in a cohort of HIV-1 subtype C-infected patients (n = 168), together with sit

102 tudies showed that the NA proteins of the N9 subtype can bind sialic acid via a separate binding site

103 lymphoblastic leukemia (ALL) is a high-risk subtype characterized by genomic alterations that activa

104 tive breast cancer (TNBC) is a breast cancer subtype characterized by marked differences between Whit

105 roblem is the discovery of molecular disease subtypes characterized by relevant clinical differences,

106 In rodents, subtype classification has associated subtypes to functi

107 investigate the robustness of these proposed subtype classifications, we evaluated 12 public datasets

108 tial networks, coupled with consideration of subtype co-infection, was likely to be important for FIV

109 c NK potential on the basis of KIR3DL1/HLA-B subtype combinations in vitro and evaluated their impact

110 ering analysis was applied to derive disease subtypes comprising subgraphs of highly connected comorb

111 nd persistent bacterial vaginosis (BV); this subtype could be predicted with high specificity and sen

112 Thus, through distinct receptor subtypes coupled with different K(+) channels, astrocyte

113 K and unclassified fragments, including one subtype CRF25 isolate, which branched basal to all CRF25

114 dels representative of the diverse human STS subtypes critical.

115 genetic tools, we characterize a 5-HT neuron subtype defined by expression of Tachykinin1 and Pet1 (T

116 Analysis of EHV-1-reactive IgG subtypes demonstrated that vaccination with the VC2-EHV-

117 During fetal development, several cIN subtypes derive from the medial ganglionic eminence (MGE

118 atric symptoms, and the accuracy of dementia subtype diagnosis.

119 ntify Gag-protease as a major determinant of subtype differences in disease progression among HIV-1 s

120 first evidence that neutrophils can undergo subtype differentiation in vitro in response to bacteria

121 ta+ counterparts, all patients with MCI SNAP subtypes displayed better preservation of temporoparieta

122 Residual B cell subtype distribution was disrupted in the spleen, but ad

123 nosis and stratification of distinct disease subtypes down to the cellular level.

124 type, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admix

125 ALVAC) and recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine effica

126 and progesterone on these uterine leiomyoma subtypes emphasize the importance of subtypes and genoty

127 Each subtype ensemble is also tuned for rotation.

128 though common events were shared among three subtypes, ER+ HER2-, ER- HER2-, and HER2+, many events o

129 ceptors and identification of the primary GC subtypes, even beneath nerve fibers.

130 functionally distinct endothelial cell (EC) subtypes from cardiogenic versus hemogenic mesoderm with

131 rentiation of cardiomyocytes and endothelial subtypes from hPSCs.

132 fferences in disease progression among HIV-1 subtypes; furthermore, we propose that the poorer viral

133 different novel, zoonotic influenza A virus subtype groups in 29 countries, Taiwan, and Hong Kong ha

134 Notably, all recombinant subtype H fragments branched basal to the H clade.

135 including the hemagglutinins of influenza A subtypes H1N1 and H3N2 and B lineages Yamagata and Victo

136 (polyPLA), to identify antigenic variants of subtype H3N2 swine IAVs.

137 pathogenic avian influenza (LPAI) viruses of subtypes H5 and H7 into poultry from wild birds have the

138 Importantly, tumors with a luminal molecular subtype have a significantly higher rate of Her2 alterat

139 ith the triple-negative breast cancer (TNBC) subtype have the worst prog-nosis.

140 g evidence suggests impulse control disorder subtypes have dissociable correlates, which indicate tha

141 in kidney transplantation outcomes across GN subtypes have rarely been studied.

142 To examine subtype heterogeneity across known breast cancer risk fa

143 Subtype heterogeneity for breast cancer risk factors has

144 lerated progression compared to non-CRF01_AE subtypes (HR = 3.14, 95%CI: 1.39-7.08, P = 0.006).

145 Items scored positive in the CFI-S and subtypes identified by SASS in different individuals pro

146 Medulloblastoma subtypes identified through integrative clustering have

147 e determination of the histomorphologic pRCC subtype in combination with the MYC immunohistochemical

148 ral instability and gait difficulty motor PD subtype in linear regression analysis, but staging of al

149 ckness and BPnd for either dopamine receptor subtype in the control group.

150 servation surgery in different breast cancer subtypes in a large, randomized clinical trial with long

151 terologous primary isolates of various HIV-1 subtypes in a standardized in vitro neutralization assay

152 Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS.

153 citability, but the roles of the various Nav subtypes in specific neuronal functions such as synaptic

154 Results NHL subtypes included mantle cell lymphoma (MCL; n = 28), fo

155 eritability of MR exists across different MR subtypes including nonprimary MR.

156 nomes were complex recombinants of 2 or more subtypes, including subtypes A1, F, G, H, J, and K and u

157 nce by age differed for different strabismus subtypes, indicating differences in age at onset and the

158 biological functions to specific FZD and Wnt subtype interactions.

159 on between NAFLD and CCA, stratifying by its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA

160 tatory neurotransmission is mediated by AMPA-subtype ionotropic glutamate receptors (AMPARs).

161 but the molecular comparison within exosome subtypes is largely unknown.

162 igate the relative risk of HF overall and by subtype (ischemic and nonischemic HF) in patients with R

163 dentification of several intrinsic molecular subtypes: luminal A, luminal B, human epidermal growth f

164 ine availability and the large number of STS subtypes, making development of STS cell lines and anima

165 One subtype maximizes its output when the mouse advances, ot

166 propose that women with this BVAB1-dominated subtype may have chronic genital inflammation due to per

167 Little is known about which lesion subtypes may serve as CRC precursors in young adults.

168 and CXCR4 pathways in a murine model of SHH-subtype medulloblastoma exerts potent antitumor effects.

169 Overall, we identify NAc neuronal-subtype molecular control of dendritic morphology and re

170 e likelihood of relapse including histologic subtype, MYC rearrangement, protein expression, and extr

171 Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute and inflam

172 ated expression of the three major brain Nav subtypes (Nav 1.1, Nav 1.2, Nav 1.6) in area CA1 and den

173 e (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma.

174 de classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event

175 At least 2 HMPV subtypes occurred each season.

176 astatic CRC and define a clinically distinct subtype of CRC with an excellent prognosis.

177 ortality after developing dementia or the AD subtype of dementia, separately, using adjusted Cox prop

178 Randomization was stratified according to subtype of FLT3 mutation: point mutation in the tyrosine

179 y determined the full genome of both a novel subtype of HCV genotype 6, and a co-infecting human pegi

180 Spastic paraplegia type 5 (SPG5) is a rare subtype of hereditary spastic paraplegia, a highly heter

181 Intranuclear rod myopathy is a subtype of NM in which rod-like bodies are seen in the n

182 e B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma.

183 ascular network of pilomyxoid astrocytoma, a subtype of optic glioma with abundant myxoid matrix, is

184 inal stromal tumor (GIST) is the most common subtype of sarcoma.

185 een mutated genes and pathways, and stage or subtype of T-ALL.

186 ent reflects what we have learned about this subtype of the disease.

187 Given its selective action on the omega1 subtype of the gamma-aminobutyric acid A receptor, zolpi

188 Overall, 17 of 20 BrM retained the PAM50 subtype of the primary BrCa.

189 model of the luminal androgen receptor (LAR) subtype of TNBC.

190 In summary, our data indicate a new subtype of Treg cells in cGN.

191 therapies inhibited tumor growth only in the subtype of tumor where the therapy was designed to be ac

192 iagnosis and suggested management of various subtypes of angioedema.

193 enge in bridging the gap between identifying subtypes of asthma to understand causal mechanisms and t

194 of these cells may help delineate different subtypes of asthma.

195 However, a specific description of subtypes of atopic dermatitis depending on the timing of

196 es to OFF-selective T5 cells and to all four subtypes of both cell classes.

197 When molecular subtypes of breast cancer were considered, GRPR was over

198 of cancer patients with different molecular subtypes of breast cancer.

199 n predicting several known histopathological subtypes of breast cancer.

200 There are believed to be multiple subtypes of CD, which contributes to its observed clinic

201 sive, just as the association with molecular subtypes of CRC.

202 l disorders, impairments are observed across subtypes of decisional impulsivity, possibly reflecting

203 examined the associations between total fat, subtypes of dietary fat, and food sources rich in satura

204 ll-like and germinal center (GC) B cell-like subtypes of diffuse large B cell lymphoma (DLBCL).

205 s) and double-expressor lymphomas (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associ

206 To characterize the subtypes of dorsal horn neurons engaged by dopamine sign

207 tions between risk factors and the molecular subtypes of EAC.

208 ncreasing effects, respectively, in clinical subtypes of frontotemporal dementia against neurological

209 While molecular subtypes of glioblastoma (GBM) are defined using gene ex

210 Molecular subtypes of HCAs associated with different patients' ris

211 Furthermore, subtypes of HIV-associated vasculopathy may manifest as

212 m for high-efficiency generation of distinct subtypes of human neurons.

213 Distinct subtypes of inhibitory interneuron are known to shape di

214 TMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological

215 The items were clustered around the anatomic subtypes of IOI: idiopathic dacryoadenitis and idiopathi

216 es that included data on multiple histologic subtypes of lymphoma or non-MALT lymphomas (988 patients

217 However, in many subtypes of lymphoma, the application of MRD assessment

218 functions seem to be associated to different subtypes of melanopsin cells.

219 These functions are served by distinct subtypes of mesodiencephalic dopamine neurons located in

220 with steatohepatitis, we identified 2 major subtypes of NAFLD and markers that differentiate steatos

221 We found that although subtypes of optic gliomas are indistinguishable on imagi

222 ies of these processes define three distinct subtypes of PDAC, which demonstrate differences in survi

223 hese dimensions, we identified five distinct subtypes of perinatal depression: severe anxious depress

224 We defined two major genomic subtypes of primary stage Ta tumors.

225 a novel paradigm optimized to dissociate the subtypes of reward-prediction errors that function as th

226 ith alopecia areata and further refine which subtypes of the disease these methods are best indicated

227 ed that varied strengths of inhibition among subtypes of the ubiquitous KIR3DL1 and its cognate ligan

228 framework to develop strategies for specific subtypes of this disease using current therapeutics and

229 Anatomic subtypes of uveitis included anterior, posterior, and pa

230 ations with cardiometabolic risk factors and subtypes of vascular disease, thereby suggesting differi

231 estigated the impact of age and BC molecular subtype on overall survival after RT using a meta-analys

232 rRNA gene sequences revealed three clusters (subtypes), one of which was strongly associated with gen

233 g revealed three distinct vaginal microbiome subtypes, one of which was characterized by extreme geni

234 associated with increased risk of basal-like subtype [OR 4.17; 95% confidence interval (CI) 1.89-9.21

235 BC-infected individuals using a large, multi-subtype panel of 30 tier 2-3 Env-pseudotyped viruses.

236 assed certain hemorrhagic cases in other HCA subtypes, particularly IHCA.

237 the specific involvement of each of the PDE4 subtypes (PDE4A, 4B and 4C) in different categories of b

238 ed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs betwee

239 Sst interneuron subtypes, residing in different cortical layers and inne

240 ignaling in GCB-DLBCL lines, reflecting this subtype's exclusive use of tonic BCR signaling.

241 ron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR c

242 ensing domains provides an avenue to develop subtype selective tools.

243 Using novel mGlu receptor subtype-selective allosteric modulators along with knock

244 V channels but cannot account for its unique subtype selectivity.

245 piriform cortex (APC) can be divided into 2 subtypes: semilunar (SL) and superficial pyramidal (SP)

246 e findings demonstrate that HIV type but not subtype significantly affects viral mutation frequencies

247 ls diverse carcinogenic processes across its subtypes, some unrelated to sun exposure, and extends po

248 nd HER2+, many events on the exon level were subtype specific.

249 lks discuss novel developmental and neuronal subtype-specific contributions to the excitatory/inhibit

250 ed mutagenesis, revealed Nef position 9 as a subtype-specific determinant of differential HLA-A versu

251 Integration of genetic subtype-specific MRD values allowed more refined risk gr

252 rgeted therapies that are being evaluated in subtype-specific or biomarker-driven clinical trials.

253 lding blocks optimized for interactions with subtype-specific residues in the PPARdelta ligand-bindin

254 odular synergism between miRNAs and neuronal subtype-specific transcription factors can drive lineage

255 ive contribution of each factor was strongly subtype-specific.

256 Subtype specification is controlled by a stochastic deci

257 ion consists of two morphologically distinct subtypes, spindle-shaped and round-shaped cells (SS-hAFS

258 g that Her2 activity is also associated with subtype status.

259 y interchangeable and that multiple receptor subtypes subserving inhibition may offer diverse mechani

260 of Her2 alterations than those of the basal subtype, suggesting that Her2 activity is also associate

261 but also between different pol III promoter subtypes, suggesting that the +1 nucleosome may be invol

262 This intermediate filament subtype switching induced dysregulation of the actin cyt

263 e on omalizumab use in the following 9 CIndU subtypes: symptomatic dermographism, cold urticaria, del

264 of myotome subdivisions or the specific RAR subtype that is required for somite patterning.

265 antibody alone, represent a more aggressive subtype that warrants closer clinical follow-up.

266 umors within the "proneural" and "classical" subtypes that are addicted to aberrant signaling from in

267 These findings support the presence of ARDS subtypes that may require different treatment approaches

268 three intrinsic parameters that vary by cell subtype - the slow afterhyperpolarization, the sag, and

269 espiratory disease of dogs caused by two CIV subtypes, the H3N8 and H3N2 viruses, of equine and avian

270 Among the different existing receptor subtypes, the homomeric alpha7 nAChR has attracted consi

271 e sequencing the test allows the major prion subtypes to be differentiated in vivo.

272 dents, subtype classification has associated subtypes to function.

273 Comparing specific BRAF subtypes to the wild type, BRAF V600E was associated wit

274 ccurs predominantly in poor prognosis serous subtype tumours, and this genetic deletion is associated

275 Overall, the CRF01_AE subtype was correlated with a significant risk of accele

276 pha ribosome-associated messenger RNA in MSN subtypes was assessed after repeated cocaine using D1-Cr

277 f an overall difference in RT effect between subtypes was weak ( P = .21).

278 Additionally, fimH subtyping was evaluated on a phylogenetic network of 122

279 The atypical MDD subtype, and only this subtype, was prospectively associated with a higher inci

280 rmine activity of novel compounds in these 2 subtypes, we conducted an unbiased pharmacologic in vitr

281 ally study the expression and function of H1 subtypes, we generated knockin mouse lines in which endo

282 Diagnoses of MDD and subtypes were based on DSM-IV symptoms.

283 undred and one IBS patients covering all IBS subtypes were recruited, and 39 non-IBS subjects were in

284 e tool to investigate gastric adenocarcinoma subtypes where RAS/MAPK pathway activation and E-cadheri

285 ntial evolutionary pressures acting on virus subtypes, which can manifest into landscape-level effect

286 ing the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic response.

287 s on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples

288 For patients with the epithelial subtype who underwent trimodality therapy, median surviv

289 nts with histologically confirmed MZL of all subtypes who received >/=1 prior therapy with an anti-CD

290 e predicted by mRNA data (n = 1960) for most subtypes with 95-100% accuracy.

291 cancer types into morphological types and 35 subtypes with 99% and 76% accuracy, respectively.

292 idity patterns captured most of the major PH subtypes with known pathological basis defined by the Wo

293 OCA encompasses a range of subtypes with overlapping, often hypomorphic phenotypes.

294 principle experiment, treatment of these two subtypes with targeted therapies inhibited tumor growth

295 A methylation microarray data to infer tumor subtypes with the consideration of tumor purity.

296 One predominately AD subtype (with a large proportion of SQCC) shared molecul

297 each class of shifting neurons exists in two subtypes, with spatiotemporal activity profiles that sug

298 ting evidence points to specialized neuronal subtypes within the serotonergic neuronal system, borne

299 old) toward MC4R over MC3R and MC5R receptor subtypes without compromising agonist potency.

300 rences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progress