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1 e extracellular ligand binding domain of the subunit.
2 GluA2 and GluA3 subunits, but not the GluA1 subunit.
3 s as well as their binding sites on the Swr1 subunit.
4 terminal proteolytic cleavage of the alpha1C subunit.
5 takes when applied through the integrin beta-subunit.
6 llular C-terminal domain of the GluN2B NMDAR subunit.
7 Astrin-SKAP complex, including a novel MYCBP subunit.
8 rcles the C-terminal segment of the IR alpha-subunit.
9 located on the surface of the 60S ribosomal subunit.
10 lele and in vip6, a mutant for another Paf1c subunit.
11 Glu76, which form hydrogen bonds between two subunits.
12 mplex biological systems comprising multiple subunits.
13 ee disulfide cross-links between the monomer subunits.
14 cts that consist of multiple cyclotryptamine subunits.
15 cooperative effects and the number of mutant subunits.
16 xes that contain no other detectable protein subunits.
17 ator that contains four different modules of subunits.
18 st Uganda and in 24 of 26 Kenya geopolitical subunits.
19 loosely but irreversibly assembled monomeric subunits.
20 for engineering AMPAR gating using auxiliary subunits.
21 ating an asymmetric configuration of the two subunits.
22 with it the IL-2 beta and gamma receptor (R) subunits.
23 ry (CHO) cells expressing the mouse or human subunits.
24 subunit with auxiliary alpha2delta and beta subunits.
25 scaffold, and the regulatory BECN1 and ATG14 subunits.
26 s composed of the SDH3, SDH4, SDH6, and SDH7 subunits.
27 r membrane complex is composed of 11 protein subunits.
28 ow the incorporation of even larger aromatic subunits.
29 in CaV2 or CaV3 voltage-gated Ca(2+) channel subunits.
30 at mGlu heterodimers composed of mGlu2 and 4 subunits.
31 rming alpha subunits (BKalpha) and auxiliary subunits.
32 A second lobe contains the ORC2/3 subunits.
33 heteromeric receptor composed only of alpha subunits.
34 n receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pub
35 k1 substrate is myosin phosphatase targeting subunit 1 (MYPT1), and we show that MYPT1 localization t
36 components, including the splicing factor 3b subunit 1 (SF3B1), are associated with hallmark cancer p
39 ly, we identified chaperonin containing TCP1 subunit 6A (CCT6A) as an inhibitor and direct binding pr
41 l-surface levels of GABAAR alpha2 and gamma1 subunits, along with increased alpha2beta1gamma1 GABAAR
42 e phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial
43 the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedly identifi
45 inic receptors comprised of alpha4 and beta2 subunits (alpha4beta2-nAChR) enhanced the firing of neur
46 resides in the mRNA entry channel of the 40S subunit and contacts mRNA via conserved residues whose f
47 th distinct surfaces of the larger catalytic subunit and influence the enzymatic properties of the DN
50 h non-mutated fluorescently labeled Galphai1 subunits and alpha2A-adrenergic receptor, GABAB, or dopa
51 antibodies for gliadins, gamma-gliadins, LMW subunits and antigenic epitopes to gain a better underst
52 nversely, the 100S ribosomes dissociate into subunits and are presumably recycled for new rounds of t
53 with altered gene expression of K(+)-channel subunits and ion channel modulators, relevant in human A
54 l p190B paralog, associates with all 13 eIF3 subunits and several other translational preinitiation f
55 elomerase holoenzyme and RPA complexes share subunits and that RPA subunits have distinct functions i
56 rocesses that encompass (a) synthesis of the subunits and their correct assembly and expression at th
57 fine direct structural roles for yeast CAF-1 subunits and uncover a previously unknown critical funct
58 e direct interaction between the yeast CAF-1 subunits, and mapped the CAF-1 domains responsible for H
60 st, however, about how individual structural subunits are assembled into a functional holoenzyme.
63 e pentamer, three anaesthetic-sensitive rho1 subunits are needed to impart full efficacy to the parti
64 holine receptors comprising alpha4 and beta2 subunits are the most abundant class of nicotinic acetyl
65 l further details about interactions between subunits as well as their binding sites on the Swr1 subu
67 ranslational cleavage of the CaValpha2delta1 subunit at the predicted membrane interface and further
68 ining mixtures of ATPase active and inactive subunits at defined positions in the hexameric ring.
70 investigated the possible involvement of the subunit b and the OSCP in the PTP by generating clonal c
71 , immunofluorescence and neural tracing with subunit B of cholera toxin (CTB), we analysed the periph
72 P1-DeltaOSCP, lacking the membrane domain of subunit b or the OSCP, respectively, in which the corres
73 y we show that a SWI/SNF chromatin remodeler subunit, BAF60, represses seedling growth by modulating
74 poorly understood how the non-catalytic ISWI subunits BAZ1A and BAZ1B might contact chromatin to dire
75 DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromodom
76 ome, with the splitting of the ribosome into subunits being somewhat dispensable, or whether their ma
78 2 alpha subunit enhanced the Nef.AP-2 sigma2 subunit BiFC signal and vice versa, suggesting that the
82 Ube3c dissociated rapidly (unlike other 26S subunits), but the inhibitor ubiquitin aldehyde slowed t
83 KB-catalyzed autophosphorylation on multiple subunits, but how this regulates CPC interactions with o
86 to regulate the balance between IL-12/IL-23 subunits causing a cytokine milieu rich in IL-23 to favo
87 cribe a unique role for the orphan catalytic subunit CcoN4 in colony biofilm development and respirat
89 ross patient samples and correlated with BCR subunit CD79B expression, but was inversely correlated w
90 pair 1Dx5 + 1Dy10 was recognized as superior subunit combination in wheat and contained an extra repe
91 Centromeres nucleate kinetochores, multi-subunit complexes that capture spindle microtubules to p
93 s, whereas the mitochondrial ATP synthase F0 subunit component is a vasoactive peptide on its release
94 wall of the tunnel between RNAP and the 30S subunit, consistent with its role in directing mRNAs ont
95 ian prototoxin, lynx1, and alpha3- and beta4-subunit-containing human nicotinic acetylcholine recepto
96 dings, indicates that heteromeric alpha/beta subunit-containing receptors underlie both synaptic and
100 ding yeast Saccharomyces cerevisiae, the ten-subunit Dam1/DASH complex bridges the interaction betwee
104 most T cells, TCRs are composed of alphabeta subunits displaying immunoglobulin-like variable domains
110 xin reductase, alkyl hydroperoxide reductase subunit F (AhpF), catalyzes the rapid reduction of the r
111 en almost impossible to identify independent subunits, flexible regions, or hinges simply by visual i
112 lymerase III transcription initiation factor subunit for further analysis, based on the predicted eff
113 the loss of the Ca(2+) channel alpha2delta-1 subunit function increases the susceptibility for develo
115 (TRPC1) proteins requires G protein alpha q subunit (Galphaq)/phospholipase C (PLC)beta1/protein kin
120 otentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-f
121 upplied a catalytic arginine to the opposing subunit, greatly accelerating the rate of GTP hydrolysis
123 study of pregnant BALB/c mice immunized with subunit H1N1 influenza vaccine, we demonstrate the advan
124 e necessity of six similar but non-identical subunits has been a mystery since its initial discovery.
125 nd RPA complexes share subunits and that RPA subunits have distinct functions in different heterotrim
127 reversible, swivel-like motions of the small subunit head domain within the elongation factor G (GDP)
128 t, since genetic ablation of the HIR complex subunit Hir1 decreases sensitivity to morphogenetic stim
129 insight into the structural dynamics of each subunit in a polymerization-competent antithrombin dimer
131 n of alpha2delta-1, the dominant alpha2delta subunit in pancreatic islets, results in glucose intoler
133 crystallographic study of a single human CCT subunit in the context of a hexadecameric complex can be
134 the localisation of the B domain of the Psf1 subunit in the free GINS complex, which was not visible
136 und that AHAs overexpressed the NMDAR GluN2D subunit in the prefrontal cortex (PFC) as compared to AN
137 expression of the mutant GlyR alpha1(Q177K) subunit in vivo was not sufficient to compensate for a d
138 ompelling interaction between STAT5A and PDC subunits in adipocytes under physiological conditions.
139 of pore-forming BKalpha and auxiliary beta1 subunits in arterial smooth muscle cells (myocytes).
143 s revealed higher amounts of alpha4 or beta2 subunits in the LS or HS nAChR populations, respectively
144 ncrease in expression of beta- and gammaENaC subunits in the SON and the translocation of alphaENaC i
147 Here the authors show that the IL-12p35 subunit induces regulatory B cells and can be used thera
148 The C-terminal domain of the human Ino80 subunit (Ino80CTD) binds cooperatively to DNA and dimeri
152 s proton binding by marked reorganization of subunit interface, altering the packing of beta-sheets t
154 Escherichia coli RNA polymerase (RNAP) beta subunit is a part of RNA binding domain in transcription
155 n which the catalytic ADP-ribosyltransferase subunit is activated when exposed to the reducing enviro
158 not contain homologs of bacterial RNAP alpha subunits, it contains, in addition to the beta and beta'
160 n of the voltage-dependent potassium channel subunit Kv1.1 substantially contributes to both the exci
162 t a pair of two-pore potassium channel (K2P) subunits, largely dispensable early in life, are necessa
163 equencing the D1 and D2 domains of the large subunit (LSU) nuclear ribosomal RNA (nrRNA) gene and by
164 rts are under way to improve the efficacy of subunit malaria vaccines through assessments of new adju
166 Real-time PCR measurements of SK channel subunits mRNA in supraoptic nucleus punches revealed a d
167 rmacological targeting of the oncogenic MUC1 subunit MUC1-C is sufficient to suppress PD-L1 expressio
168 consistent with YbAnbu forming defined 12-14 subunit multimers that differ in shape from both HslV an
169 We describe an extracellular GlyR alpha1 subunit mutation (Q177K) in a novel mouse startle diseas
172 c translocation intermediates of FGF2 with a subunit number in the range of 8-12 FGF2 molecules.
173 ox protein FBXW7 is the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-sup
175 cell surface and consists of CsgA, the major subunit of curli, and a membrane-associated nucleator pr
177 w that ATM is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is ch
178 ited via Doa4 binding to Vps20, which is the subunit of ESCRT-III that initiates assembly of the comp
180 ustekinumab, an antibody that binds the p40 subunit of interleukin-23 and interleukin-12 and thereby
181 m uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a critical role
182 r transcription factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member
183 s in PIK3CA, the gene encoding the p110alpha subunit of phosphatidylinositol 3-kinase (PI3Kalpha), ar
185 ell population, RNF2, the dominant catalytic subunit of PRC1, activates transcription of Sall4, which
186 n and substrate specificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dictated by P
189 Although the TATA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitr
190 aperones Skp and SurA, and BamA, the central subunit of the BAM complex, on the folding kinetics of a
191 ystem, and the identification of SPOP, a key subunit of the CUL3 ubiquitin E3 ligase complex, as a SE
192 s of action including inhibition of the QcrB subunit of the cytochrome bc1 complex, disruption of cel
194 tion of HAP4, the transcriptional activation subunit of the Hap2/3/4/5p complex, required for growth
196 pacity to form a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, IKKgamma (or
197 noclonal antibody directed against the alpha subunit of the interleukin-5 receptor that significantly
199 Brahma-related gene 1 (Brg1), a catalytic subunit of the mammalian SWI/SNF chromatin-remodeling en
204 exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOX
207 I(+) ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex.
208 re we reveal that BRG1, the essential ATPase subunit of the SWI/SNF chromatin-remodelling complex, is
209 rn when compared with mutations in the Trrap subunit of the TIP60 complex, both in the cell line pane
210 Tim17 is an essential, membrane-embedded subunit of the translocase; however, its function is onl
212 not located at the binding site on the Sra1 subunit of the WRC previously identified by mutagenesis
213 r are restricted to targeting one membranous subunit of V-ATPase or have poorly understood mechanisms
214 ble participation in the PTP; thus, the only subunits of ATP synthase that could participate in pore
215 eddylation targets are the cullins, scaffold subunits of E3 ubiquitin ligases, where neddylation as w
217 he KCTD proteins 8, 12, and 16 are auxiliary subunits of GABAB receptors that differentially regulate
220 e proteins (Neto) 1 and Neto2, the auxiliary subunits of kainate receptor (KARs), are phosphorylated
221 use genetic approach to disable nonredundant subunits of mTORC1, mTORC2, or both, we showed that mice
223 1 and the levels of catalytic and regulatory subunits of PKA were increased by glucocorticoids in wil
224 The EF1a interaction with small and large subunits of ribosomes did not appear to change due to H2
225 and genetic results, and the fact that other subunits of the AMPA receptor have already been associat
226 We identified a new set of genes encoding subunits of the BAF chromatin remodeling complex that ex
227 ly characterized SR-like proteins, including subunits of the mRNA 3'-processing factor CFIm, CFIm68 a
229 activity and role of the different catalytic subunits of the proteasome in different plant species.
230 ligomers, and most oligomers contained 10-12 subunits of the three dominant conformation classes.
232 oncovalently associates with the small alpha subunit on the intermembrane space side of the inner mem
233 d the role of beta and alpha2delta auxiliary subunits on Cav1 alpha1 function in TH2 lymphocytes and
234 bited decreased abilities to bind the PP2A-C subunit or activate PP2A and failed to reverse the tumor
235 he recognition of peptidyl-tRNA in the small subunit P site during EF-G-catalyzed translocation.
241 Protein-protein interactions (PPIs) of these subunits play pivotal roles in assembling the functional
242 In bacteria, the kdp operon encodes a four-subunit potassium pump that maintains intracellular home
243 a-isoform of protein phosphatase 1 catalytic subunit (PP1alpha) and eIF2alpha to assemble a phosphata
244 onsisting of protein phosphatase-1 catalytic subunit (PP1c) and MP target subunit-1 (MYPT1) as an eNO
245 furnish the cis- and trans-fused azadecalin subunits present in Aspidosperma and Kopsia alkaloids, r
246 anscription, the TBP-associated factor (TAF) subunits recognize downstream promoter elements, act as
249 interdependent assembly factors with pre-60S subunits, resulting in turnover of early preribosomes, b
250 N-terminally and C-terminally truncated Swr1 subunits reveal further details about interactions betwe
251 between AMPA receptors and auxiliary (TARP) subunits, revealing essential roles for the receptor tra
252 osis disrupt the binding between the protein subunit reverse transcriptase of the telomerase and its
254 n, we report the error rates of three single-subunit RNAPs measured from the catalytic efficiencies o
255 d, we have simulated hundreds of spontaneous subunit rotation events ( approximately 8 degrees ) usin
257 for ATP synthesis, and cannot convert gamma-subunit rotation into the conformational changes implici
259 ae pilus island 1 pili are composed of three subunits, RrgA, RrgB, and RrgC, and are assembled by thr
260 the E-loop and arginine R210 on the adjacent subunit's backbone alpha-helix form salt bridges in hexa
262 rylates beta1-Ser108 on the regulatory beta1-subunit, sensitizing AMPK to allosteric drugs, and activ
263 depends on interactions with both ribosomal subunits, some portion of 30S and 50S assembly must occu
264 and the correspondingly 10-fold higher CT B subunit-specific serum IgG response in IgA(-/-) mice aft
265 that are functionally recruited by auxiliary subunits, stargazin and cornichon 3, are located not onl
269 , small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previo
270 acy may also be the result of an age-related subunit switch from high affinity beta2-containing nAChR
272 protein into a large membrane-anchored beta subunit that noncovalently associates with the small alp
273 romoted via direct interactions between UvrD subunits that affect the rotational conformational state
274 that physostigmine interacts with regions of subunits that contribute to the ACh binding site, wherea
275 oid subnuclei suggests their clustering into subunits that exhibit unique functional organization.
277 in the N-terminal domain of CaV1 LTCC alpha1 subunits that is not conserved in CaV2 or CaV3 voltage-g
278 g proline residue resulting in 40S ribosomal subunits that were blocked from polysome formation.
279 inding to Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal degradation of
281 slocation in which ATP binding allows a Vps4 subunit to join the growing end of the helix and engage
282 ARs, but the contribution of these auxiliary subunits to AMPAR-mediated signaling in the spinal cord
283 of the complex, allowing five of the six VAT subunits to constrict into a tight helix that grips an
284 esolution electron microscopy can define the subunit topology and copper binding of a manganese oxidi
285 ansport, on the other hand, is global: actin subunits typically diffuse across the entire lamellipodi
288 ination with adjuvants as well as adjuvanted subunit vaccines were successful in the induction of NAb
289 RNA enters the P site of the small ribosomal subunit via reversible, swivel-like motions of the small
290 C3-C1 consists of the lipid kinase catalytic subunit VPS34, the VPS15 scaffold, and the regulatory BE
293 f G protein complexes carrying mutant Gbeta1 subunits were further analyzed by their ability to coupl
294 pecifically, electron-rich and electron-poor subunits were introduced in the conjugated backbone to m
296 We specifically focused on the GluN2B NMDAR subunit, which is highly expressed in the hippocampus an
297 by the cooperative aggregation of molecular subunits, which endows these SPs with extraordinary prop
298 increased NMDA currents enriched in the NR2B subunit with a concomitant upregulation of NMDA-only, si
299 propose that NDK5 dimer is an RS structural subunit with an additional mechanism that uses cross-tal
300 2.1 channels comprise a pore-forming alpha1A subunit with auxiliary alpha2delta and beta subunits.
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