ライフサイエンスコーパス: subunit composition

1 iation, post-translational modification, and subunit composition.

2 pse model to precisely control the GABA(A)-R subunit composition.

3 cellular factors, and not changes in channel subunit composition.

4 glycine receptors (GlyRs) depend upon their subunit composition.

5 y in NMDAR signaling created by diversity in subunit composition.

6 ation of distinct Kv channels based on their subunit composition.

7 tested whether Neto2 modulation varies with subunit composition.

8 ignaling and shows remarkable selectivity of subunit composition.

9 PSD, and they show how this alters receptor subunit composition.

10 c role for Mecp2 in the development of NMDAR subunit composition.

11 show that each complex has a conserved five-subunit composition.

12 NaC channels are characterized by a trimeric subunit composition.

13 ults in a decrease in the NR2A/NR2B ratio of subunit composition.

14 ions or N-methyl-d-aspartate (NMDA) receptor subunit composition.

15 ct the aforementioned difference in receptor subunit composition.

16 asticity determined by NMDA receptor, NR2A/B subunit composition.

17 find that these TARPs specify AMPA receptor subunit composition.

18 iates with a Set1-like HMT complex of unique subunit composition.

19 onotropic glutamate receptors via changes in subunit composition.

20 roperties that are strongly dependent on the subunit composition.

21 flect developmental changes in NMDA receptor subunit composition.

22 iated with changes in synaptic AMPA receptor subunit composition.

23 s for nicotinic drugs, we investigated their subunit composition.

24 on is mediated by changes in NMDAR and AMPAR subunit composition.

25 ulation of the size of GLUR fields and their subunit composition.

26 d to schizophrenia, regulates synaptic NMDAR subunit composition.

27 tein class, and are flexible with respect to subunit composition.

28 , suggesting a modification of NMDA receptor subunit composition.

29 d be formed by cell type- or tissue-specific subunit composition.

30 AR number or function, including a switch in subunit composition.

31 is not known what controls their number and subunit composition.

32 ely resulting from changes in GABAA receptor subunit composition.

33 eceptor ion channels are determined by their subunit composition.

34 monstrating its reliance on GABA(A) receptor subunit composition.

35 ate-gated ion channel receptors with defined subunit composition.

36 el distribution by NRA-2 is dependent on the subunit composition.

37 mediated current, loss of Neto1 alters NMDAR subunit composition.

38 dependent activation of AMPARs with distinct subunit composition.

39 ssion and their functionality depends on the subunit composition.

40 nAChR desensitization depends on subunit composition.

41 ning ion series to peaks and deciphering the subunit compositions.

42 may contain AMPA receptors (-Rs) with unique subunit compositions.

43 ticogeniculate synapses have distinct AMPA-R subunit compositions.

44 into nicotinic receptor pentamers of various subunit compositions.

45 d to simplify data analysis and decipher the subunit compositions.

46 DHA on BK channels with different auxiliary subunit compositions.

47 hat hECN GABAARs have an alpha2/3beta3gamma2 subunit composition - a composition that also predominat

48 y-induced synaptic scaling by regulating the subunit composition, abundance, and trafficking of GluA2

49 he functional study of NMDARs with different subunit composition after activation by glycine/D-serine

50 llosteric, ligand-gated ion channel with the subunit composition alpha2betagammadelta.

51 h form three plasma oligomers with different subunit compositions (alpha7beta1, alpha7beta0, and alph

52 ays, sodium pumping structures, cofactor and subunit composition, among others.

53 mutations correlated with alterations in ETC subunit composition and activity in primary glioma-initi

54 produce purified hemichannels of controlled subunit composition and apply it to the generation of he

55 ely related to eukaryotic RNAPII in terms of subunit composition and architecture, promoter elements

56 or the expression of receptors of predefined subunit composition and arrangement as tools for the dev

57 ptic AMPA receptors (AMPARs) depend on their subunit composition and association with transmembrane A

58 Subunit composition and binding of allosteric modulators

59 The subunit composition and Ca(2+) permeability of AMPA rece

60 that underlies transient alterations in the subunit composition and calcium permeability of synaptic

61 60b levels, a concomitant switch in BAF/Brg1 subunit composition and delayed myogenesis.

62 ed a decrease in relative synaptic NR2B/NR2A subunit composition and did not exhibit LTP.

63 zation to morphine altered hippocampal NMDAR subunit composition and enhanced the SK2 channel-mediate

64 in gamma-aminobutyric acid receptor (GABAAR) subunit composition and function, playing a crucial role

65 ticity occur via modulation of nAChR channel subunit composition and functional clustering.

66 in vivo as multiple subtypes that differ in subunit composition and functional properties.

67 to the eukaryotic V-ATPase but has a simpler subunit composition and functions in vivo to synthesize

68 GABAergic synapses, the relationship between subunit composition and IPSC decay is less clear.

69 shapes N-methyl-D-aspartate receptor (NMDAR) subunit composition and kinetics at excitatory synapses

70 s or remain highly localized, depending upon subunit composition and ligand.

71 lexes from detergent micelles, which reveals subunit composition and lipid binding.

72 et genes, resulting in altered NMDA receptor subunit composition and other molecular adaptations.

73 properties and function are regulated by its subunit composition and phosphorylation.

74 mplex, an important step is to elucidate its subunit composition and posttranslational modifications.

75 Determination of the subunit composition and previous mutational analysis all

76 a developmental shift in glutamate receptor subunit composition and regulation of glutamatergic syna

77 on in large amount, followed by deduction of subunit composition and stoichiometry and determination

78 We determined the exact subunit composition and stoichiometry for the intact cor

79 The subunit composition and stoichiometry of these membrane

80 oncatenated tetrameric channels with defined subunit composition and stoichiometry.

81 The subunit composition and subcellular distribution of AMPA

82 Here we report an analysis of the subunit composition and substrate specificity of the NSL

83 We investigated subunit composition and subunit-specific interactions in

84 tion of synaptic AMPARs by controlling their subunit composition and susceptibility to LTD.

85 PICK1 loss of function alters the subunit composition and the abundance of GluA2-containin

86 ium permeability depends critically on their subunit composition and the identity of associated auxil

87 heir properties are determined both by their subunit composition and their association with auxiliary

88 Receptor properties depend on NR2 subunit composition and variable splicing of NR1.

89 DPA antagonism was independent of NMDAR subunit composition and was similar at extrasynaptic and

90 tiation to inhibition, depending on receptor subunit composition and zinc concentration, with the alp

91 y, consist of several subtypes with distinct subunit compositions and functional properties.

92 channels also form, but their physiological subunit compositions and functions are largely unknown.

93 In addition, the subunit compositions and stoichiometries of the remainin

94 ctional alpha6beta2beta3* AChRs with defined subunit compositions and subunit orders.

95 , negative regulators, NF-kappaB binding and subunit composition, and MAPKs; conversely, IL-13(-/-) m

96 ype studied, their respective GABAA receptor subunit compositions, and critically, on the ambient GAB

97 Furthermore, subunit composition appears to specify interactions betw

98 NMDA/AMPAreceptor ratio and theAMPAreceptor subunit composition are altered in experimental parkinso

99 dual neurons, kainate receptors of different subunit compositions are targeted to various locations w

100 e results point to NMDA receptors of unusual subunit composition as a potential therapeutic target fo

101 e-gated Ca(2+) channel function or different subunit composition as possible mechanisms underlying th

102 Purified mutant complexes have the same subunit composition as that of the wild-type complex, bu

103 tion of Ca(2+) channel function or different subunit composition as the underlying mechanism.

104 of gamma-secretase complexes, based on their subunit composition, as a valid strategy.

105 ian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, bu

106 ic transmission and changes in AMPA receptor subunit composition at 72 h postsurgery.

107 t the acute activity-dependent switch in NR2 subunit composition at developing hippocampal synapses r

108 ecrease the NR2A/NR2B ratio of NMDA receptor subunit composition at glutamatergic synapses, a rejuven

109 In contrast, NMDARs subunit composition at mPP-DG synapses is not altered an

110 findings suggest that AIDA-1 regulates NMDAR subunit composition at synapses by facilitating transpor

111 ity of the coagonist not only with the GluN2 subunit composition at synaptic NMDARs but also with ast

112 GluN2 subunit composition at the synaptic site critically dete

113 evelopment and is associated with changes in subunit composition, but the mature channel composition

114 nAChRs expressed in the VTA exhibit diverse subunit compositions, but the functional and pharmacolog

115 In addition, we show that NMDAR subunit composition can be reverted back to the juvenile

116 implications, because a switch in the nAChR subunit composition can bring about a corresponding swit

117 implications, because a switch in the nAChR subunit composition can bring about a corresponding swit

118 that both the number of receptors and their subunit compositions can be altered.

119 Together our data suggest that multiple KCNQ subunit compositions can mediate the ImAHP, and that the

120 During development, the synaptic NMDARs subunit composition changes, switching from predominance

121 and altered postsynaptic glutamate receptor subunit composition, coinciding with a reduction in syna

122 sential for cell survival and has a distinct subunit composition compared to the eukaryal counterpart

123 Diversity in nAChR subunit composition complicates the development of selec

124 NMDAR subunit composition defines their biophysical properties

125 Thus, the subunit composition-dependent stimulation by DHA demonst

126 The subunit composition determines AMPA receptor (AMPA-R) fu

127 The subunit composition determines channel conductance prope

128 The specific subunit composition determines critical properties of a

129 Thus, because subunit composition dictates key channel properties, suc

130 cessed generating various forms differing in subunit composition due to the presence or absence of N-

131 change from a GluN2B- to a GluN2A-dominated subunit composition during postnatal development.

132 rs (NMDARs) with mature forms that differ in subunit composition, electrophysiological properties and

133 identify a category of tetramers that have a subunit composition equivalent to an octameric building

134 The determination of subunit composition for all three C. elegans body wall m

135 r results underscore the importance of NMDAR subunit composition for memory destabilization and sugge

136 ptic GluN2B responses, effecting a switch in subunit composition from GluN2B to GluN2A, a process nor

137 uired for viability and differs in structure/subunit composition from its eukaryal counterpart, it is

138 ynaptic N-Methyl-D-aspartate (NMDA) receptor subunit composition from predominantly GluN2B to GluN2A,

139 Dopamine depletion alters the subunit composition further, rendering Kir2 channels in

140 To date, AMPAR subunit composition has been quantitatively evaluated on

141 ate derivative dependent pathways, ribosomal subunit composition, hormone signaling, wound response,

142 KA2/GluR6 heteromers are the most prevalent subunit composition in brain.

143 a crucial unanswered question is the role of subunit composition in observed NMDAR mechanosensitivity

144 olecular methods to alter glutamate receptor subunit composition in olfactory bulb granule cells, the

145 gression may be mediated by changes in NMDAR subunit composition in the PFC, and point to a critical

146 tical events in determining changes in AMPAR subunit composition in the response to ischaemia.

147 in experience-dependent regulation of NMDAR subunit composition in vivo.

148 ltaTCRs also differ in their invariant chain subunit composition, in that alphabetaTCRs contain CD3ga

149 +) block was suggested to reflect an unusual subunit composition including the NR2C and NR3A subunits

150 rkedly enhance our ability to understand how subunit composition influences receptor function, as wel

151 iocatalytic properties, suggesting that beta subunit composition is a factor in archaeal proteasome f

152 Receptor subunit composition is believed to play a major role in

153 Their subunit composition is developmentally regulated.

154 the function of these subunits and receptor subunit composition is essential for understanding the p

155 of the S. pombe SAGA complex showed that its subunit composition is identical to that of Saccharomyce

156 In yeast, COX subunit composition is regulated by COX5a and COX5b gene

157 We show that this specialized subunit composition is required for ES cell maintenance

158 Distinct Mediator subunit composition is thought to contribute to gene reg

159 elopmental stage-specific regulation of PRC2 subunit composition leads to a switch from canonical sil

160 Pentamers with distinct subunit compositions localize differentially at synaptic

161 As TRP channels with specific subunit compositions may have different functional prope

162 NMDA responses depends strongly on receptor subunit composition: NR1/2A and NR1/2B receptors are mor

163 e prevalent in developing seeds likely has a subunit composition of 4alpha4beta(1), is most active at

164 e that ubiquitylation can directly alter the subunit composition of a core component of the transcrip

165 The subunit composition of alpha-amino-3-hydroxyl-5-methyl-4

166 trafficking events seem to be driven by the subunit composition of AMPA receptor tetramers.

167 The number and subunit composition of AMPARs at synapses determines the

168 nge in the synaptic current, by changing the subunit composition of AMPARs at the parallel fibre-to-c

169 ary visual cortex (area V1), the density and subunit composition of AMPARs differ among cortical laye

170 provides a functional quantification of the subunit composition of AMPARs in the CNS and suggests no

171 Subsequent analysis revealed that a subunit composition of AMPK (alpha2beta2gamma1) is prefe

172 Heart failure induced a shift in the subunit composition of ASICs within muscle afferents, wh

173 esis; however, the mechanisms regulating the subunit composition of BAF/Brg1 complexes, in particular

174 tiple subtypes of IP3R are co-expressed, the subunit composition of channels cannot be specifically d

175 most nothing is known about the structure or subunit composition of channels formed by TRPM1 or any o

176 The subunit composition of ECF transporters is similar to th

177 s, thus making it difficult to establish the subunit composition of functional receptors.

178 The subunit composition of GABA(A) receptors influences thei

179 To establish how the subunit composition of GABAARs influences their ability

180 ignificant brain-regional alterations in the subunit composition of glutamate ionotropic receptors.

181 However, the minimal subunit composition of gustatory receptors required for

182 Thus, how the subunit composition of heterotetrameric IP3R channels co

183 a membrane and simultaneously determines the subunit composition of hundreds of individual protein co

184 ative kinesin-1 and cytoplasmic dynein motor subunit composition of individual, endogenous amyloid pr

185 method has mainly been used to determine the subunit composition of ion channels and receptors at the

186 ry could be attributed to differences in the subunit composition of Kir2 channels.

187 re liquid chromatography, while the size and subunit composition of larger PAs were characterized usi

188 tracellular transport and steady-state motor subunit composition of mammalian prion protein (PrP(C))

189 ) and other techniques, we have compared the subunit composition of Mediator in three different struc

190 ested that H2Bub1 could either influence the subunit composition of methyltransferase complexes or di

191 advanced proteomic methods can determine the subunit composition of multi-protein complexes.

192 The subunit composition of N-methyl D-aspartate receptors (N

193 of nAChR density (Bmax ) and changes in the subunit composition of nAChRs.

194 roteomics approach, we show that a switch in subunit composition of neural, ATP-dependent SWI/SNF-lik

195 The subunit composition of neuronal TRPC channels remains un

196 Furthermore, the p38 kinase MAPK directs the subunit composition of NF-kappaB following UVB irradiati

197 Whether the subunit composition of NMDA receptors (NMDARs) controls

198 Subunit composition of NMDA receptors (NMDARs) determine

199 tral nervous system, there is a shift in the subunit composition of NMDA receptors (NMDARs) resulting

200 parallel with a developmental switch in the subunit composition of NMDA receptors from NR2B to NR2A.

201 However, since the putative subunit composition of NMDA receptors on oligodendrocyte

202 regulated by synapse-specific changes in the subunit composition of NMDA-type glutamate receptors (NM

203 the length of targeting presequences and the subunit composition of organellar processing peptidases

204 hat GluR1-S845 phosphorylation can alter the subunit composition of perisynaptic AMPARs by providing

205 Thus, CRL4(Cdt2) also regulates the subunit composition of Pol delta during the cell cycle.

206 The number and subunit composition of postsynaptic AMPA receptors (AMPA

207 Changes in the subunit composition of postsynaptic AMPA-type glutamate

208 osomal assembly step to regulate the variant subunit composition of potassium channels.

209 nd a single-molecule method to determine the subunit composition of proteins in the plasma membrane o

210 hroughout the insect nervous system, but the subunit composition of RDL-containing in native receptor

211 The subunit composition of recombinant GABA(A) receptors (GA

212 The subunit composition of SAGA was the same in each tissue;

213 The content and globulin subunit composition of soybean proteins are known to aff

214 We identified differences in the subunit composition of subcomplexes of ovine complex I a

215 s, selective trafficking mechanisms regulate subunit composition of surface hERG channels.

216 tic plasticity manifested as a switch in the subunit composition of synaptic AMPA receptors (AMPARs)

217 can induce a lasting change in the number or subunit composition of synaptic AMPA receptors (AMPARs).

218 The subunit composition of synaptic AMPA receptors can under

219 The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regul

220 The subunit composition of synaptic and extrasynaptic NMDA r

221 The precise subunit composition of synaptic ionotropic receptors in

222 The subunit composition of synaptic NMDA receptors (NMDAR),

223 Furthermore, we analyze the subunit composition of synaptic NMDA receptors in CA1 py

224 In addition, the subunit composition of synaptic NMDARs changes in chroni

225 ding on the pattern of NMDAR activation, the subunit composition of synaptic NMDARs is under extremel

226 Here we explore the subunit composition of synaptic NMDARs on hippocampal in

227 These data suggest that MPAE alters the subunit composition of synaptic NMDARs, leading to impai

228 ed to different GluN1/GluN2A to GluN1/GluN2B subunit composition of synaptic NMDARs.

229 This difference in subunit composition of the alphabeta- and gammadeltaTCRs

230 t is required for (a) maintaining the proper subunit composition of the complex and (b) cell cycle pr

231 Switching this selective subunit composition of the complex in rod photoreceptors

232 The subunit composition of the enzyme appears to vary with c

233 acts in opposition to Pum in regulating the subunit composition of the glutamate receptor.

234 ibodies failed to conclusively determine the subunit composition of the glutamate receptors on DB1 bi

235 The subunit composition of the holo-SWI/SNF and BAF57-deplet

236 uch regulation is typically dependent on the subunit composition of the ionotropic receptor or channe

237 hycocyanin (APC) in the antenna complex, the subunit composition of the phycobiliproteins, and the te

238 of synaptic transmission and a change in the subunit composition of the postsynaptic glutamate recept

239 The subunit composition of the purified receptor was determi

240 t of synapses is proposed to depend upon the subunit composition of the receptor.

241 To elucidate the subunit composition of the receptors we tested its pharm

242 The subunit composition of the residual alpha6-containing GA

243 Recent reports suggest that subunit composition of the retinal CNG channel influence

244 gest that individual spines can regulate the subunit composition of their NMDA-Rs and the effective f

245 The subunit composition of these bridges was unknown, althou

246 In hippocampal pyramidal neurons, the subunit composition of these extrasynaptic receptors may

247 physiological importance, the structure and subunit composition of thylakoid FtsH complexes remain u

248 These findings support the notion that the subunit composition of VTA GIRK channels is a critical d

249 e in excellent agreement and reveal that the subunit composition of yeast V(1)-ATPase is A(3)B(3)DE(3

250 t any instant, there is heterogeneity in the subunit compositions of PSII complexes within the cell.

251 The subunit compositions of the gamma-aminobutyric acid- and

252 e partially attributed to differences in the subunit compositions of their nuclear pore complexes.

253 In this study, we report that the subunit compositions of these complexes in striatum unde

254 To examine the effects of subunit composition on GABAR function in situ, we took a

255 f the absence of methods for assessing motor subunit composition on individual vesicular cargos.

256 hus, circuit-based therapies targeting NMDAR subunit composition on PV cells may provide novel treatm

257 their subcellular location rather than their subunit composition or mobility.

258 on of AMPA receptors without modifying their subunit composition or single-channel conductance.

259 s not associated with changes in the levels, subunit composition, or gross subcellular distribution o

260 c alterations in GABA(A) receptor (GABA(A)R) subunit composition over the ovarian cycle correlated wi

261 nsgenic mice to investigate the link between subunit composition, phosphorylation, and dopamine recep

262 Based on their subunit compositions, Pols IV and V clearly evolved as s

263 Because NMDA receptor subunit composition profoundly affects synaptic plastici

264 h a change in glutamate and glycine receptor subunit composition quantified via mRNA levels.

265 oRNAs primarily regulate Drosophila receptor subunit composition rather than overall receptor abundan

266 Emerging evidence suggests that the core subunit composition regulates distinct biological proces

267 lex in vitro and have identified the minimum subunit composition required for histone H3K4 methylatio

268 h levels of pS6 and demonstrate altered GluR subunit composition, resembling those of normal immature

269 ux through AMPARs triggers a switch in AMPAR subunit composition, resulting in loss of Ca(2+) permeab

270 cified by, for example, receptor location or subunit composition seem to govern glutamate-induced exc

271 The AMPA-type glutamate receptor (AMPAR) subunit composition shapes synaptic transmission and var

272 te this, both the terminal and the extension subunit compositions show little changes, while the mean

273 Despite that both terminal and extension subunit compositions show very small changes, mean degre

274 ture of PSI(PsaJF) and a monomeric PSI, with subunit composition similar to the viral PSI, providing

275 IC50 values varied with stereochemistry and subunit composition, suggesting that it may be possible

276 d TvoK, is of an apparent molecular mass and subunit composition that is consistent with the hetero-o

277 We also detected a shift in NMDAR subunit composition that, in contrast to the cell-wide s

278 dendritic GABAA receptors comprise distinct subunit compositions that are regulated differentially b

279 els located on spines depends on the channel subunit composition, the activity of kinases and phospha

280 Aside from the subunit composition, the N-terminal modification and pho

281 Depending on their subunit composition, these receptors exhibit distinct ph

282 meostatic plasticity regulate synaptic AMPAR subunit composition to increase the contribution of Ca(2

283 Instead, PICK1 permits changes in AMPAR subunit composition to occur in conjunction with synapti

284 mber of GABAA receptors (GABARs) of the same subunit composition to preexisting synapses.

285 tisubunit complex has a similar but distinct subunit composition to that of the Drosophila ADA2A-cont

286 Xenopus laevis optic nerve regeneration, NF subunit composition undergoes progressive changes that c

287 is heavily dependent upon the GABAA receptor subunit composition underpinning tonic inhibition, and o

288 NMDA receptor subunit composition varies throughout the brain, providi

289 The subunit composition was determined by luminescence reson

290 purified from primary keratinocytes, and its subunit composition was determined by mass spectrometry.

291 Subunit composition was unchanged.

292 Selectivity for PAs by subunit composition was variable between treatments, but

293 why different results for hippocampal AMPAR subunit composition were obtained using co-immunoprecipi

294 (PRC1) multi-protein complexes with diverse subunit composition whose functions are incompletely und

295 ecular framework for the regulation of NMDAR subunit composition with implications for synaptic plast

296 ematopoietic gamma-secretase has an atypical subunit composition with significantly altered subunit s

297 We observed a one-to-one similarity in subunit composition with their mammalian counterparts, w

298 tic contact formation is determined by their subunit composition, with the N-terminal ECDs of each of

299 alignment of synaptic AMPA and NMDA receptor subunit composition within specific subtypes of interneu

300 n complexes display remarkable plasticity in subunit composition, yet how a new subunit assembled int