ライフサイエンスコーパス: subvert

1 ion, or if the regulatory B-cell response is subverted.

2 oxically, SrfH was shown in another study to subvert a different host protein, IQGAP1, in a manner th

3 Thus, reduced BMPR2 can subvert a stress granule response, heighten GM-CSF mRNA

4 cell subsets and immunosuppressive cytokines subvert adaptive immune responses.

5 The mechanism by which B. melitensis subverts adaptive immunological memory is poorly underst

6 We review the strategies that EBV uses to subvert and evade host immunity and discuss the implicat

7 t examples of bacterial strategies to evade, subvert and in some cases even utilize these receptors.

8 ine seeking, and that its role is ultimately subverted and devolves instead to the aDLS only followin

9 ta suggest that CD4(+)CD25(+)FoxP3(+) T-Regs subvert antimycobacterial immunity in human TB.

10 that induce NKG2D ligands on myeloid cells, subverting antitumor immune responses.

11 epatocytes exacerbates Tfr cell responses to subvert antiviral immunity.

12 rial infection modulates miRNA expression to subvert any innate immune response.

13 sites with AP1 motifs, suggesting that BCL6 subverts AP1 activity.

14 e of the pathway, some pathogens are able to subvert autophagy for their benefit.

15 hagocytic destruction, some viruses can also subvert autophagy for their own benefit.

16 Many pathogens subvert autophagy to enhance their replication, but the

17 ral effects of the autophagy pathway, others subvert autophagy to facilitate replication.

18 myocilin through ER-associated degradation, subverting autophagy.

19 IAV therefore subverts autophagy by mimicking a host short linear prot

20 TNFalpha-mediated suppression of BMPR-II subverts BMP signalling, leading to BMP6-mediated PASMC

21 rate how the cellular death machinery can be subverted by an invasive pathogen to ensure bacterial co

22 ifferentiation and activation are frequently subverted by B cell lymphomas for their unlimited growth

23 icking mechanism of STING regulation that is subverted by bacterial pathogens and is deregulated in h

24 discuss the manner in which phagocytosis is subverted by certain pathogens and consider congenital d

25 reparative and homeostatic functions can be subverted by chronic insults, resulting in a causal asso

26 Peptide inhibition of F may be subverted by continued engagement of receptor by H, a fi

27 an important regulator of polarity, which is subverted by HCV in epithelial cells.

28 ing a variety of solid malignancies, but are subverted by immune evasion mechanisms active within the

29 Ps and identify an antiviral pathway that is subverted by JUNV.IMPORTANCE Arenaviruses are important

30 r distinct aggregation-prone proteins can be subverted by manipulating ER chaperones, leading to more

31 e inert structures and explains why G3BP1 is subverted by many viruses to promote a productive infect

32 The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the

33 tracellular organisms, and often found to be subverted by pathogens through use of host anti-apoptoti

34 r replace antibiotic treatments that are now subverted by resistance.

35 The process can also be subverted by tumor cells to invade other tissues and to

36 ruitment and activation of IRF-3 that can be subverted by viral proteins to evade innate immune respo

37 To identify the host factors subverted by viruses, high-throughput genomics and globa

38 mplicated in myriad human cancers and can be subverted by viruses.

39 1 and other primate immunodeficiency viruses subvert cell cycle regulatory mechanisms to achieve thes

40 idence that primate immunodeficiency viruses subvert cell cycle regulatory mechanisms to enhance repl

41 dria is a powerful strategy for pathogens to subvert cell physiology and establish infection.

42 coli, Salmonella, Yersinia, and Shigella, to subvert cell signaling and host responses.

43 s of the mechanisms by which C. gattii might subvert cell-mediated immunity, we found that C. gattii

44 rs into the cytosol of mammalian host cells, subverting cell signaling and facilitating the onset of

45 nderstanding how Pol III-dependent microRNAs subvert cellular and viral pathways will contribute to d

46 oligomers as secondary toxins to efficiently subvert cellular functions of actin while functioning at

47 uring infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to

48 Many viruses encode or subvert cellular microRNAs (miRNAs) to aid in their gene

49 lex interplay between viral determinants and subverted cellular membrane homeostasis in biogenesis an

50 r to the cytoplasm of infected cells thereby subverting cellular processes.

51 ined epigenetic programs through which KDM2B subverts cellular differentiation and drives the pathoge

52 genes, the least characterized of which, E5, subverts cellular proliferation and immune recognition p

53 in, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy tar

54 The tobacco industry's documented history of subverting control efforts required innovative approache

55 ed a remarkable array of tactics for rapidly subverting control over and dominating cellular regulato

56 MET regulation via the juxtamembrane domain subverts core MET receptor functions that regulate osteo

57 Adenovirus E4-ORF3 and E1B-55K converge in subverting critical overlapping cellular pathways to fac

58 HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-

59 gammaherpesvirus-specific tegument protein, subverts cytosolic DNA sensing by directly inhibiting cG

60 Thus, MV subverts DC-SIGN to control RLR activation and escape an

61 of host proteins, alter auxin signaling, and subvert defense signaling and immune responses.

62 To subvert defense, they may mimic host proteins at the seq

63 Ralpha-PLZF acts as a modifier oncogene that subverts differentiation in the granulocytic lineage by

64 enerated by pathogens, is both activated and subverted during human gammaherpesvirus infection in cul

65 This balance, however, is subverted during infection, injury or autoimmune respons

66 The osteogenic default pathway may be subverted during pathological conditions, leading to ske

67 with many physiologic processes that become subverted during tumorigenesis, the chaperoning activity

68 ndings support the conclusion that gammaHV68 subverts early NF-kappaB activation and cytokine product

69 d explores underappreciated factors that can subvert efforts to purposefully alter cytokine biodistri

70 We found that the cellular Rpn11 is subverted for tombusvirus replication and Rpn11 has a pr

71 ghly infectious bacterial pathogens avoid or subvert host autophagy mechanisms normally employed to m

72 tudies indicate that pathogenic bacteria can subvert host cell phosphoinositide (PI) metabolism by tr

73 These effectors subvert host cell signaling pathways to ensure bacterial

74 Phosphorylated effectors eventually subvert host cell signaling, aiding disease development.

75 ly co-opts autophagy-initiation complexes to subvert host clearance and promote infection.

76 manipulate host cell signaling pathways and subvert host defense mechanisms.

77 To subvert host defenses, some microbial pathogens produce

78 locate effector proteins into plant cells to subvert host defenses.

79 r proteins directly into eukaryotic cells to subvert host functions.

80 g HIV and hepatitis C virus, to overwhelm or subvert host immune responses contributes to a prolonged

81 Pathogens use numerous methods to subvert host immune responses, including the modulation

82 Understanding how viruses subvert host immunity and persist is essential for devel

83 human macrophages, thereby allowing M.tb to subvert host immunity and potentially increase its virul

84 ), we investigated whether these drugs might subvert host immunity by activating PAF-R.

85 Many plant pathogens subvert host immunity by injecting compositionally diver

86 oral bacterium Porphyromonas gingivalis, can subvert host immunity to remodel a normally symbiotic mi

87 To subvert host immunity, influenza A virus (IAV) induces e

88 iological processes or signaling pathways to subvert host immunity.

89 is associated with its ability to dampen or subvert host innate immune response.

90 ciated EV-D68, have developed a mechanism to subvert host innate immune responses by simultaneously t

91 d EV-D68, have developed novel mechanisms to subvert host innate immune responses by targeting key fa

92 h its hosts, PEDV has acquired mechanisms to subvert host innate immune responses for its survival ad

93 cular structures enable microbial enzymes to subvert host lipid signaling, suppress inflammation, and

94 Many intracellular pathogens subvert host membrane trafficking pathways to promote th

95 revealed an important bacterial strategy to subvert host responses in infected cells, demonstrating

96 cts virus escape from immune surveillance by subverting host cell intracellular signaling and membran

97 amily, are likely to play important roles in subverting host defenses, and constitute a valuable pool

98 e that supports intracellular replication by subverting host proteins that control biogenesis and fus

99 We show that the virus subverts host cell trafficking pathways to effect the re

100 Hepatitis C virus (HCV) subverts host cholesterol metabolism for key processes i

101 Staphylococcus aureus subverts host defences by producing a collection of viru

102 In this study we propose that PSTVd subverts host DNA ligase 1, converting it to an RNA liga

103 The human pathogen Shigella flexneri subverts host function and defenses by deploying a cohor

104 filarial nematode Acanthocheilonema viteae, subverts host immune responses towards anti-inflammatory

105 by 3C(pro) may be a mechanism by which EV68 subverts host innate immune responses.

106 viral gene transcription and replication but subverts host innate immunity, therefore identifying M2-

107 ar bacterial pathogen Legionella pneumophila subverts host membrane transport pathways to promote fus

108 release could be a KSHV-mediated strategy to subvert IL-1beta functions.

109 iological responses in host cells thought to subvert immune defenses.

110 ccessfully infect host cells, pathogens must subvert immune responses and avoid detection to prevent

111 al and non-professional phagocytic cells and subvert immune responses for chronic persistence in the

112 us (HBV) has been described as stealth virus subverting immune responses initially upon infection.

113 Cancers are able to grow by subverting immune suppressive pathways, to prevent the m

114 Because S. aureus biofilms are capable of subverting immune-mediated clearance, we examined whethe

115 N. meningitidis subverts immune responses by hijacking a host-immune reg

116 pothesize that this effect of FLT3-ITD might subvert immunosurveillance and promote leukemogenesis in

117 sponses to injury, a continuum that often is subverted in cancer.

118 a model in which Treg-cell stability can be subverted in certain inflammatory sites, but is maintain

119 various mechanisms and consider how they are subverted in disease.

120 beta-dependent program of gene expression is subverted in SCCs from various body sites, and there are

121 inant in the M1T1 GAS clone, allowing GAS to subvert innate immune functions that are critical in cle

122 It is well established that UPEC can subvert innate immune responses, but the role of UPEC in

123 eptococcus (GAS) has developed mechanisms to subvert innate immunity.

124 The extent to which this important pathogen subverts innate immune responses by directly targeting t

125 Therefore, Y. pseudotuberculosis subverts intestinal barrier function by altering the int

126 HIV and simian immunodeficiency virus (SIV) subvert intracellular membrane traffic as part of their

127 retain dependency on the target oncogene or subvert it through a parallel pathway.

128 cifically degrading Galpha(i2), Nef directly subverts leukocyte migration and homing.

129 Hepatitis C virus subverts liver-specific microRNA, miR-122, to upregulate

130 Mucosal vaccination subverted lung T cell priming by inducing matrix metallo

131 The molecular factors it utilizes to subvert macrophage antimicrobial defenses are largely un

132 e may select for pneumococci, which avoid or subvert macrophage NF-kappaB activation.

133 uggest that L. donovani may exploit SOCS for subverting macrophage apoptotic machinery toward establi

134 any intracellular pathogens cause disease by subverting macrophage innate immune defense mechanisms.

135 2'-O methylation of the 5' cap of viral RNA subverts mammalian antiviral responses by evading restri

136 These viruses subvert many aspects of the innate and adaptive immune r

137 The subverted membranes facilitate the assembly of viral rep

138 n response, bacteria have evolved systems to subvert metal sequestration and toxicity.

139 Adenoviruses (Ads) subvert MHC class I Ag presentation and impair host anti

140 ith considerable potential to preferentially subvert MHC class I-restricted T-cell responses after bo

141 s, suggesting that influenza virions form by subverting microvesicle production.

142 proteins in the miRNA biogenesis pathway to subvert miRNA-induced antiviral effects.

143 The findings in this study suggest that CVB subverts mitophagy machinery to support viral disseminat

144 two important viral pathogens that naturally subvert multiple death pathways via a single evolutionar

145 taching and effacing (A/E) lesions, but also subvert multiple host cell signalling pathways during in

146 onaute pathway may play a pathogenic role in subverting neuronal function in FXTAS.

147 cterial pathogens have evolved mechanisms to subvert NF-kappaB signaling.

148 re commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hem

149 In response to illness, animals subvert normal homeostasis and divert their energy utili

150 tnatal life, PAX3/FOXO1A and PAX7/FOXO1A may subvert normal PAX3 and PAX7 functions.

151 at dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the

152 Here we report that HPV type 8 (HPV8) E6 subverts NOTCH activation during keratinocyte differenti

153 ng enzyme functional diversity, that help to subvert obstacles presented by the human host, which per

154 However, some viruses can subvert or even enhance host autophagic machinery to inc

155 t become clinically manifest have managed to subvert or hide from immunosurveillance.

156 ted microbes to manipulate these pathways to subvert or inhibit plant defense.

157 HCMV) employs numerous strategies to combat, subvert, or co-opt host immunity.

158 y viruses, bacteria, and parasites to alter, subvert, or otherwise manipulate host DNA damage and rep

159 ectly infects subsets of monocytic cells and subverts overall immune responses.

160 uses an enzyme, GlpQ, to hydrolyze ChoP and subvert PAF function, suggesting that mimicry-driven imm

161 pects of this explanation have been recently subverted, particularly those related to how GTP-tubulin

162 In summary, various (+)RNA viruses might subvert PE to build membrane-bound VRCs for robust repli

163 he microtubule-associated protein MAP65-1 to subvert plant immunity.

164 presses NPR1-dependent SA signaling, thereby subverting plant innate immunity.

165 These findings reveal a natural means of subverting PRC1 activity, linking key epigenetic modulat

166 effect induced by some microbial products to subvert production of antigen-specific immune responses.

167 ectly with pathogen recognition receptors to subvert proinflammatory signaling via T regulatory cells

168 ons, many pathogens have evolved to avoid or subvert pyroptosis.

169 his study enhances our knowledge of proteins subverting Rab1 function at the Legionella-containing va

170 We found that the effector SifA subverted Rab9-dependent retrograde trafficking of MPRs,

171 Cancer is a disease of subverted regulatory pathways.

172 Unlike other effector proteins that subvert Rho GTPases to modulate uptake, CirA is the firs

173 A proviral role to subvert RNA silencing through binding of these host RNP

174 in (HlyA) insert into host-cell membranes to subvert signal transduction and induce apoptosis and cel

175 ems to deliver proteins into host cells that subvert signaling pathways controlling membrane transpor

176 In this review, we focus on effectors that subvert signaling pathways that impact on endosomal traf

177 novirus early region 4 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to pertur

178 Bacterial pathogens subvert signalling pathways to promote invasion and/or r

179 s focused on novel approaches that strive to subvert skin's excellent barrier function, and broaden t

180 e a dual role of sensing the environment and subverting specific host defense processes.

181 to microbes that have devised strategies to subvert Stat1-dependent responses.

182 ate cell surface VT1/VT2 binding uniform and subverted subsequent Gb(3)-dependent retrograde transpor

183 rms race, viruses have evolved strategies to subvert sumoylation.

184 levels through chaperone manipulation, thus subverting synaptic plasticity defects caused by tau's t

185 enhances virulence, suggesting that bacteria subvert syndecan-1 ectodomains released by shedding for

186 rogrammed death-1 (PD-1) ligand 1 (PD-L1) to subvert T-cell-mediated immunosurveillance.

187 Ablation of ITK subverts Th2 immunity, thereby potentiating Th1-based im

188 ally to the germ cells of transgenic mice to subvert the activity of endogenous receptors.

189 me pathogens, including several RNA viruses, subvert the autophagy pathway, or components of the path

190 th cellular factors to disrupt signaling and subvert the cell cycle.

191 ow a lentiviral accessory protein is able to subvert the cell's normal protein degradation pathway to

192 sm utilized by the Old World alphaviruses to subvert the cellular antiviral response.

193 Persistent virus is able to subvert the cellular interferon response, a powerful bra

194 rect afferents by deep brain stimulation may subvert the clinical efficacy of deep brain stimulation.

195 s against avirulent mutants that exploit and subvert the division of labor within these populations.

196 s identify a mechanism whereby the virus may subvert the early HIV-1-specific humoral immune response

197 mor response, immune regulatory pathways can subvert the effector phase and enable tumor escape.

198 nding can inform therapeutic strategies that subvert the evolution of drug resistance.

199 ment control protein (VCP), respectively, to subvert the host complement system.

200 rax, relies on multiple virulence factors to subvert the host immune defense.

201 encode chemokines and chemokine receptors to subvert the host immune response.

202 w that LANA blocks MHC-II gene expression to subvert the host immune system by disrupting the MHC-II

203 Cancers subvert the host immune system to facilitate disease pro

204 HIV-1 envelope protein (Env) has evolved to subvert the host immune system, hindering viral control

205 type II decoy receptors used by poxvirus to subvert the host innate immune response would be an attr

206 ucleoprotein and phosphorylation protein, to subvert the host innate immune system.

207 entirely due to their ADPR activities, which subvert the host response by targeting the antibacterial

208 ggest a novel mechanism that CVB3 employs to subvert the host signaling and facilitate consequent vir

209 evidence indicates that pathogenic bacteria subvert the host UPS to facilitate infection.

210 To subvert the host's immune response, Y. enterocolitica us

211 athogenic microbes often release toxins that subvert the host's immune responses to render the enviro

212 ccus aureus has very efficient strategies to subvert the human immune system.

213 n most common strategies that viruses use to subvert the IFN response with examples from publications

214 How they subvert the immune check-point function of the spleen to

215 at mediate the host-pathogen interaction and subvert the immune response are shut off at intermediate

216 s been hypothesized that sGP may potentially subvert the immune response or may contribute to pathoge

217 results show how pandemic influenza viruses subvert the immune response.

218 tly considered one of the pathogens that can subvert the immune system by limiting the activation of

219 e that tumor-derived oxysterols can serve to subvert the immune system by recruiting protumorigenic n

220 Bacteria subvert the immune system by suppressing antimicrobial r

221 athogens that utilize 2'-O-MTase activity to subvert the immune system.

222 rsistently replicating viruses outcompete or subvert the initial antiviral response, allowing the est

223 Mycobacterium tuberculosis (MTB) is able to subvert the innate immune response and survive inside ma

224 lved several ways to target IRF3 in order to subvert the innate immune response.

225 g RNA transcript employed by adenoviruses to subvert the innate immune system protein double-stranded

226 Bacterial pathogens often subvert the innate immune system to establish a successf

227 Like other viruses, VZV must subvert the intrinsic antiviral defenses of differentiat

228 ens have developed specialized strategies to subvert the mammalian immune response controlled by the

229 Cancer cells subvert the natural balance between cellular life and de

230 intact TIR domain was essential for TcpB to subvert the non-canonical inflammasome activation as a T

231 Influenza viruses subvert the transcriptional machinery of their hosts to

232 immunity and that a range of plant pathogens subvert the ubiquitin-proteasome system to enhance their

233 eed, the singular loss of B-cell MHC class I subverted the conversion to clinical diabetes in NOD mic

234 Furthermore, inactivation of the MSH pathway subverted the expression of whiB3 along with other pH-sp

235 Remarkably, C. muridarum infection subverted the immune suppressive role of CD4(+)CD25(+)Fo

236 enesis by affecting genomic stability and by subverting the cellular molecular signaling machinery an

237 in the pathogenesis of Bacillus anthracis by subverting the host defenses.

238 d for virulence of Francisella tularensis by subverting the host innate immune response.

239 An important player in subverting the host response to HCV infection is the vir

240 (G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GD

241 irst expressed, and its dominant function in subverting the nuclear program of the stem cell, leading

242 eptidase cleaves the SNARE complex proteins, subverting the synaptic exocytosis responsible for acety

243 Here, we have shown how HCV subverts the ability of NK cells to positively mediate c

244 e that activity-dependent Cl(-) accumulation subverts the actions of PV(+) interneurons to perpetuate

245 HCV subverts the antiviral actions of these miRNAs by dampen

246 enomic analyses to elucidate how P. syringae subverts the attack and defense responses of the cohabit

247 Vpr subverts the DDB1-cullin4-associated-factor 1 (DCAF1) ad

248 HCMV lytic infection subverts the host cell cycle machinery in multiple ways.

249 cific Us3 kinase as an mTORC1 activator that subverts the host cell energy-sensing program to support

250 trate a mechanism by which this binary toxin subverts the host immune response.

251 for the mechanisms by which PVM efficiently subverts the IFN response of the murine cell.

252 Understanding how S. aureus subverts the immune response is critical for the rescue

253 Understanding the mechanisms by which Tax subverts the immune system may lead to the development o

254 findings provide a miRNA-based strategy that subverts the immunosuppression of CTLs that is often obs

255 Here we demonstrate that GITR ligation subverts the induction of Foxp3(+) Tregs and directs the

256 establish that the HSV-1 Us3 protein kinase subverts the normal response to low-energy-induced stres

257 ytes to facilitate viral dissemination, HCMV subverts the short 48-h life span of monocytes by induci

258 The parasite subverts the structure of the host Golgi, resulting in i

259 Here, we show that CagA subverts the tumor suppressor function of apoptosis-stim

260 2, released by the host on pathogen contact, subverts the tyrosine signaling network of a number of b

261 e cytosol of intestinal epithelial cells and subvert their function.

262 ors are enzymes that modify host proteins to subvert their normal functions.

263 etastases, tumor cells send signals that can subvert their tissue microenvironment.

264 nstrate that Tregs can finely adapt, or even subvert, their classical inhibitory machinery in distinc

265 w of these processes, pathogen strategies to subvert them, and their crosstalk with various cell deat

266 ncode inhibitors of programmed cell death to subvert these host responses during infection, thereby f

267 specific mechanisms by which microorganisms subvert these host responses have been uncovered.

268 lved diverse anti-CRISPR (Acr) proteins that subvert these immune systems.

269 esponse, DENV has developed numerous ways to subvert these intracellular antiviral responses and dire

270 To subvert these pathways and suppress the antimicrobial re

271 volved multiple strategies to inhibit and/or subvert these pathways and to take advantage of their in

272 drate diets have been suggested to partially subvert these processes by increasing energy expenditure

273 t human pathogens have evolved mechanisms to subvert these responses.

274 the vertebrate host via the salivary glands; subverting these processes could be used to interrupt pa

275 etii infection and define a role for CvpA in subverting these transport mechanisms.

276 Here we attempt to subvert this block by expressing the licensing control f

277 onella enterica serovar Typhi, can partially subvert this critical innate immune recognition event.

278 he phagosome quickly (15-60 min) and thereby subvert this host defense, reaching the cytosol where th

279 ruses causing chronic infections are able to subvert this immune response and represent a human healt

280 mechanisms used by malignant brain tumors to subvert this innate type of immune surveillance remain u

281 However, sialic acid-expressing pathogens subvert this mechanism through molecular mimicry.

282 rly interruption of pathogen infection is to subvert this pathogenic trickery using exogenously intro

283 As such, viruses have evolved strategies to subvert this potent antiviral response.

284 t surprising that viruses have found ways to subvert this process.

285 owever, pathogens have evolved mechanisms to subvert this process.

286 have shown that 2 strains (J96 and 536) can subvert this role and reduce ureteric contractility.

287 in, providing an unparalleled opportunity to subvert this viral protein as a tumour-specific target.

288 vo, H. influenzae has evolved mechanisms for subverting this host defense, most of which have been sh

289 barriers to a colloidal phase transition are subverted through measured, periodic variation of drivin

290 By understanding how these 4 foci are subverted to cause disease, we aim to improve the identi

291 need to understand how single stem cells are subverted to cause tumors.

292 er, how the functional activity of PrP(C) is subverted to deliver neurotoxic signals remains uncertai

293 s from liver sinusoidal endothelial cells is subverted to promote fibrosis.

294 the bone marrow niche in which AML arises is subverted to support leukemic persistence at the expense

295 s in the context of chronic inflammation and subverted tolerogenesis.

296 regs are developmentally linked and GITR can subvert tolerogenic conditions to boost Th9 immunity.

297 ed it as being a dominant negative ligand to subvert TRAIL-mediated killing.

298 The oxidation instability of I is subverted via its incorporation into the coordinated str

299 as well as antiviral factors responsible for subverting viral infection.

300 ve, alternative preventive approach where we subvert virus-induced pneumococcal disease without inter