ライフサイエンスコーパス: succinate dehydrogenase

1 ane-bound proteins (NADH dehydrogenase I and succinate dehydrogenase).

2 alpha-ketoglutarate dehydrogenase (KGDH) and succinate dehydrogenase.

3 ndrial proteins such as lipoate synthase and succinate dehydrogenase.

4 emical staining for cytochrome c oxidase and succinate dehydrogenase.

5 n, affects respiratory electron flow through succinate dehydrogenase.

6 eing a consequence of the effects of 3NPA on succinate dehydrogenase.

7 ctase-phospholipid vesicles replenished with succinate dehydrogenase.

8 ropionic acid (3-NP), a suicide inhibitor of succinate dehydrogenase.

9 reconstitutive activity of the mitochondrial succinate dehydrogenase.

10 ronments are not affected by the presence of succinate dehydrogenase.

11 es in the iron-sulfur enzymes, aconitase and succinate dehydrogenase.

12 dehydrogenase I, NADH dehydrogenase II, and succinate dehydrogenase.

13 analysis, pyruvate dehydrogenase complex and succinate dehydrogenase.

14 ropionate, a known irreversible inhibitor of succinate dehydrogenase.

15 h1, a subunit of the heterotetrameric enzyme succinate dehydrogenase.

16 y sensitive to the irreversible inhibitor of succinate dehydrogenase 3-nitropropionic acid (3-NP).

17 2 mV) increases slightly when complexed with succinate dehydrogenase (34 mV).

18 er normoxic conditions through regulation of succinate dehydrogenase A (SDHA) and fumarate hydratase

19 ome c oxidase subunits 1 and 2) and nuclear (succinate dehydrogenase A) DNA-encoded respiratory chain

20 The enzyme activity of succinate dehydrogenase, a control for mGPD, was normal

21 transcription of genes encoding subunits of succinate dehydrogenase, a Fe-requiring enzyme.

22 ining proteins are down-regulated, including succinate dehydrogenase, aconitase, cytochromes, and bio

23 Time-resolved kinetic measurements of succinate dehydrogenase activation by succinate furtherm

24 analyses of the catalysis and inhibition of succinate dehydrogenase activities in samples with both

25 to have reduced mitochondrial aconitase and succinate dehydrogenase activities.

26 f reactive oxygen species (ROS); 2) decrease succinate dehydrogenase activity (complex II of the elec

27 oxidase activity (COX-), hyperreactivity for succinate dehydrogenase activity (SDH++; also known as r

28 e in capillary density and a 23% increase in succinate dehydrogenase activity after 3 months of condi

29 ex II's electron transport function from its succinate dehydrogenase activity also suggested a mechan

30 The mutant strain also lacked succinate dehydrogenase activity and did not grow with a

31 y 4HNE is shown to involve the disruption of succinate dehydrogenase activity and subsequent activati

32 py, and function by cytochrome c oxidase and succinate dehydrogenase activity assays.

33 ere was, however, a significant reduction in succinate dehydrogenase activity associated with OAT act

34 :cat(+) strain exhibited wild-type levels of succinate dehydrogenase activity both in vivo and in vit

35 This indicates that succinate dehydrogenase activity had been blocked by the

36 Succinate dehydrogenase activity in islet mitochondrial

37 Peak VO2 was strongly related to integrated succinate dehydrogenase activity in patients (r = 0.896,

38 respiratory complex protein expression, and succinate dehydrogenase activity in skeletal muscles.

39 arate was provided to alleviate the need for succinate dehydrogenase activity in the tricarboxylic ac

40 A::cat(+) strain was completely deficient in succinate dehydrogenase activity in vitro and was unable

41 Moreover, in vitro succinate dehydrogenase activity observed in wild-type m

42 Lower mu(a) and lower succinate dehydrogenase activity of the fatty liver sugg

43 To assess mitochondrial integrity, succinate dehydrogenase activity was measured in transdu

44 Whole muscle succinate dehydrogenase activity was reduced by 12 +/- 0

45 sectional area was smaller, and single-fiber succinate dehydrogenase activity, a mitochondrial oxidat

46 rmogenesis, indicated by increases in muscle succinate dehydrogenase activity, SLN expression, mitoch

47 29SVEMS mice have a significant reduction of succinate dehydrogenase activity, succinate oxygen consu

48 r wild type grown under conditions requiring succinate dehydrogenase activity, suggesting that the su

49 and a reduction of cytochrome c oxidase and succinate dehydrogenase activity, when compared with non

50 that adaphostin had no effect on pyruvate or succinate dehydrogenase activity.

51 n approximate 50% decrease in complex II and succinate dehydrogenase activity.

52 espiratory complex II without fully blocking succinate dehydrogenase activity.

53 fibers, smaller fast twitch fibers and lower succinate dehydrogenase activity.

54 containing 5 coimmunoprecipitating proteins (succinate dehydrogenase, adenine nucleotide translocator

55 l cytochemistry for cytochrome c oxidase and succinate dehydrogenase allowed the detection of cytochr

56 onsumption of soy was associated with higher succinate dehydrogenase alpha levels and lower levels of

57 Expression of the TCA cycle protein succinate dehydrogenase alpha was decreased in animals t

58 presence of oxidized cytochrome c, purified succinate dehydrogenase also catalyzed oxidation of succ

59 The homologous enzyme succinate dehydrogenase also plays a prominent role in c

60 ition of the tricarboxylic acid cycle enzyme succinate dehydrogenase, also known as complex II of the

61 Malonic acid methyl ester, an inhibitor of succinate dehydrogenase, also specifically increased glu

62 and for the function, but not stability, of succinate dehydrogenase, an important component of the e

63 into a reconstitutively active, two-subunit succinate dehydrogenase and a two-subunit membrane ancho

64 further confirmed by observing decreases in succinate dehydrogenase and aconitase activities, whose

65 Strains with isc lesions had reduced succinate dehydrogenase and aconitase activities.

66 hern Sweden, with associated deficiencies of succinate dehydrogenase and aconitase in skeletal muscle

67 ted with a myopathy resulting from deficient succinate dehydrogenase and aconitase.

68 hondrial (mt) DNA and polypeptide abundance, succinate dehydrogenase and cytochrome oxidase histochem

69 s that TRX may deactivate both mitochondrial succinate dehydrogenase and fumarase and activate the cy

70 ccinyl-CoA ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and dimini

71 h shuts down the Krebs cycle by inactivating succinate dehydrogenase and fumarase.

72 which can accumulate to millimolar levels in succinate dehydrogenase and fumarate hydratase-mutant tu

73 rity to genes coding for the FeS subunits of succinate dehydrogenase and fumarate reductase, were del

74 ty of two mitochondrial iron-sulfur enzymes, succinate dehydrogenase and mitochondrial aconitase, as

75 Complex II of mitochondria contains succinate dehydrogenase and subunits to link this enzyme

76 Isolated succinate dehydrogenase and the SdhC-SdhD fraction alone

77 arkers of mitochondria (citrate synthase and succinate dehydrogenase) and glucose uptake capacity (GL

78 mRNAs for sodB (superoxide dismutase), sdh (succinate dehydrogenase), and a gene encoding a bacterio

79 sdh3 and sdh4 (encoding subunits 3 and 4 of succinate dehydrogenase), and we also show that these ge

80 d the activities of NADH dehydrogenase (ND), succinate dehydrogenase, and cytochrome c oxidase (COX)

81 ey electron transfer proteins (flavoprotein, succinate dehydrogenase, and cytochrome c) and the synth

82 ities of Fe-S proteins, including aconitase, succinate dehydrogenase, and MiaB.

83 y succinate in the presence of mitochondrial succinate dehydrogenase, and the rate of cytochrome b556

84 es of mitochondrial Fe-S enzymes (aconitase, succinate dehydrogenase, and ubiquinol-cytochrome c oxid

85 lly encoding alpha-ketoglutarate, malate, or succinate dehydrogenases are identifiable.

86 mRNA levels for the sdhCDAB operon, encoding succinate dehydrogenase, as well as five other genes pre

87 and determines total protein content, and a succinate dehydrogenase assay that uses dichloroindophen

88 and the respiratory chain Complex II subunit succinate dehydrogenase B (SDHB) in mitochondria of tumo

89 th von Hippel Lindau syndrome (VHL; n = 19), succinate dehydrogenase B-D mutation (n = 21), neurofibr

90 -mediated tumorigenesis in patients carrying succinate dehydrogenase-B mutations.

91 electron transport chain Complex II subunit succinate dehydrogenase-B, maintaining cellular respirat

92 y iron-sulfur enzymes, such as aconitase and succinate dehydrogenase, but also alters the regulation

93 ogenase, fumarase, malate dehydrogenase, and succinate dehydrogenase, but not KDH, are present, raisi

94 lie proximal to the divergently transcribed succinate dehydrogenase C gene, but Sdhc expression was

95 ductive pathway in the opposite direction of succinate dehydrogenase, can replace it during infection

96 fumarate reductase (Cj0408 to Cj0410) and a succinate dehydrogenase (Cj0437 to Cj0439).

97 onic acid (3-NP) and malonate, inhibitors of succinate dehydrogenase, compared with control cell line

98 The succinate dehydrogenase complex (complex II) is a highly

99 ffect patients with genetic mutations of the succinate dehydrogenase complex (SDHx).

100 2.4%; P < .001), COX4 (26.6%; P < .001), and succinate dehydrogenase complex subunit A (65.8%; P = .0

101 ein levels (P = 0.0006 and P = 0.005) of the succinate dehydrogenase complex subunit A and subunit B

102 SDHD encodes subunit D of the succinate dehydrogenase complex, an integral membrane pr

103 t results in the localization of sympathetic succinate dehydrogenase complex, subunit B, mutation-rel

104 ve metabolism in mice with disruption of the succinate dehydrogenase complex, subunit C gene (Sdhc).

105 most commonly a mutation of a subunit of the succinate dehydrogenase complex.

106 Activities of succinate dehydrogenase (complex II) (+44%) and malate d

107 three sites, NADH dehydrogenase (complex I), succinate dehydrogenase (complex II), and cytochrome c o

108 n enzymes NADH-dehydrogenase (complex I) and succinate dehydrogenase (complex II), inactivation of th

109 ted with decreased activity of mitochondrial succinate dehydrogenase (complex II).

110 l0823 open reading frames encode subunits of succinate dehydrogenase complexes that are active in the

111 Succinate dehydrogenase deficiency is a rare leukoenceph

112 s, the differential diagnosis should include succinate dehydrogenase deficiency, in particular if MRS

113 Nineteen individuals with succinate dehydrogenase deficiency-related leukoencephal

114 Succinate dehydrogenase-deficient leukoencephalopathy is

115 rial marker enzymes cytochrome C oxidase and succinate dehydrogenase, demonstrate abnormal accumulati

116 the largest subcomplex (IIa) represents the succinate dehydrogenase domain composed of SDH1 and SDH2

117 umulated succinate is rapidly re-oxidized by succinate dehydrogenase, driving extensive ROS generatio

118 conserved throughout the fumarate reductase/succinate dehydrogenase family of enzymes.

119 e identified one of the Complex II subunits, succinate dehydrogenase flavoprotein (SdhA) subunit, as

120 fumarase (fum-1), glyoxylate shunt (gei-7), succinate dehydrogenase flavoprotein (sdha-2), or solubl

121 d in metabolism (ATP synthase alpha-subunit, succinate dehydrogenase flavoprotein [SDH Fp] subunit, a

122 opionic acid, an irreversible inactivator of succinate dehydrogenase, forms a covalent adduct with th

123 Germline variants in succinate dehydrogenase genes (SDHx) co-occurring with P

124 e patient series that germline variations in succinate dehydrogenase genes (SDHx) occur in 8% (49/608

125 of the virulence-associated Rv0249c-Rv0247c succinate dehydrogenase genes demonstrated that CRP dire

126 ion in paragangliomas harboring mutations in succinate dehydrogenase genes.

127 Succinate dehydrogenase has a major effect on the PQ red

128 . jejuni and that the protein annotated as a succinate dehydrogenase has been misannotated.

129 tochondrial genes for fumarate hydratase and succinate dehydrogenase have been linked to uterine leio

130 Abundance of the 17-kd subunit of complex I, succinate dehydrogenase histochemical activity, and cris

131 ETS-abnormal, cytochrome c oxidase-negative/succinate dehydrogenase-hyperreactive (COX-/SDH++) fiber

132 These data indicate that Frd is the only succinate dehydrogenase in C. jejuni and that the protei

133 ty possibly resulting from inhibition of the succinate dehydrogenase in heart mitochondria, contribut

134 nfection by running in the same direction as succinate dehydrogenase in order to run a full TCA cycle

135 PQI toxicity in isolated liver mitochondria (succinate dehydrogenase inactivation, SDH) from these ra

136 ction and the most significant member of the succinate dehydrogenase inhibitor group of fungicides.

137 Kinetic results indicated that succinate dehydrogenase is activated by both ATP (K(1/2)

138 ly that flavinylation of the Sdh1 subunit of succinate dehydrogenase is dependent on a set of two spa

139 esults demonstrate that in vitro activity of succinate dehydrogenase is modulated by the protonmotive

140 The iron-sulfur subunit of succinate dehydrogenase is one of the four subunits of c

141 complete tricarboxylic acid (TCA) cycle and succinate dehydrogenase is small under heterotrophic con

142 These results suggest that reduced FAD of succinate dehydrogenase is the electron donor for oxygen

143 The results indicate that succinate dehydrogenase is the main respiratory electron

144 ivity of Fe-S-containing enzymes (aconitase, succinate dehydrogenase) is decreased, whereas the activ

145 It was previously shown that mutations in succinate dehydrogenase lead to the inactivation PHDs un

146 Succinate dehydrogenase mRNA abundance was greater in ce

147 reductase of Wolinella succinogenes and the succinate dehydrogenase of Bacillus subtilis.

148 NA encoding the iron protein (Ip) subunit of succinate dehydrogenase of yeast is its rate of turnover

149 ty between FsrA and the leader region of the succinate dehydrogenase operon is consistent with an RNA

150 cle mutants (sdh2Delta or fum1Delta) lacking succinate dehydrogenase or fumarase activities.

151 eductase activity increases as the amount of succinate dehydrogenase or the SdhC-SdhD fraction added

152 hD fraction is mixed with varying amounts of succinate dehydrogenase or vice versa succinate-ubiquino

153 succinate-ubiquinone reductase) and E. coli succinate dehydrogenase or vice versa.

154 ontrast, similar cation depletion stimulates succinate dehydrogenase (or glutamate dehydrogenase) in

155 gh potential 3Fe-4S cluster, situated in the succinate dehydrogenase part of the enzyme, and the low

156 teins, YgfY (a DUF339 protein, renamed SdhE; succinate dehydrogenase protein E) and YgfX (a DUF1434 p

157 dehydrogenase activity, suggesting that the succinate dehydrogenase reaction consumes energy.

158 value of 3.37, obtained by assuming 1 mol of succinate dehydrogenase reacts with 1 mol of SdhC and Sd

159 ation by the Fdh-N formate dehydrogenase and succinate dehydrogenase respectively.

160 han unimodal distribution of sizes and lower succinate dehydrogenase (SDH) activities for neurons of

161 d origin of each peak were assessed by using succinate dehydrogenase (SDH) activity as the IM marker

162 and analysis of biochemical traits including succinate dehydrogenase (SDH) activity, ATP content and

163 ubling time, and cell survival and growth by succinate dehydrogenase (SDH) activity.

164 sed mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitoch

165 Succinate dehydrogenase (SDH) and fumarate hydratase (FH

166 rs was supplied by the recent discovery that succinate dehydrogenase (SDH) and fumarate hydratase (FH

167 5 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of bo

168 Knowledge about succinate dehydrogenase (SDH) deficiency and mutations i

169 mocytomas and paragangliomas associated with succinate dehydrogenase (SDH) deficiency are characteriz

170 analyzed for cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) enzyme activities.

171 tion of myosin heavy chain (MHC) IIB and low succinate dehydrogenase (SDH) expressing myofibers, with

172 Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemistry was perform

173 ional role for stretch-induced inhibition of succinate dehydrogenase (SDH) in mediating normoxic HIF1

174 ng mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it

175 The role of mitochondrial succinate dehydrogenase (SDH) in salicylic acid (SA) sig

176 The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor suppressor.

177 Mitochondrial complex II or succinate dehydrogenase (SDH) is at the crossroads of ox

178 The enzymatic function of succinate dehydrogenase (SDH) is dependent on covalent a

179 Succinate dehydrogenase (SDH) is inhibited by mitoK(ATP)

180 ndrial alteration and by marked increases in succinate dehydrogenase (SDH) levels and activity.

181 rticularly high in tumors with an underlying succinate dehydrogenase (SDH) mutation.

182 /paragangliomas (PHEOs/PGLs) associated with succinate dehydrogenase (SDH) mutations.

183 Succinate dehydrogenase (SDH) requires a covalent additi

184 activity with cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) staining, retinal layer th

185 LACC1 constitutively associates with succinate dehydrogenase (SDH) subunit A, and amplifies p

186 imutation of additional genes, including the succinate dehydrogenase (SDH) subunit A, B, C, and D gen

187 ed by immunohistochemical analysis (IHC) for succinate dehydrogenase (SDH) subunit B, sequencing of S

188 Mutations in genes coding for succinate dehydrogenase (SDH) subunits are believed to c

189 anglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leadi

190 actor-1 (HIF-1), but mutations in Complex II-succinate dehydrogenase (SDH), a tumor suppressor, stabi

191 Succinate dehydrogenase (SDH), also known as complex II,

192 nts demonstrated that they were defective in succinate dehydrogenase (Sdh), an enzyme of the tricarbo

193 at alpha-ketoglutarate dehydrogenase (KGDH), succinate dehydrogenase (SDH), and aconitase were suscep

194 rs: mutated isocitrate dehydrogenases (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (F

195 ic acid (TCA) cycle, including aconitase and succinate dehydrogenase (SDH), are major targets of FsrA

196 have been identified in the metabolic genes succinate dehydrogenase (SDH), fumarate hydratase (FH) a

197 bstrate methylmalonyl-CoA and which inhibits succinate dehydrogenase (SDH), produced dose-related cel

198 rt that suppression requires inactivation of succinate dehydrogenase (SDH), which greatly reduces the

199 Although there was no difference in percent succinate dehydrogenase (SDH)-positive (type I) and SDH-

200 rs, type-I NAD(P)H dehydrogenase (NDH-1) and succinate dehydrogenase (SDH).

201 Germline mutations in three of the succinate dehydrogenase (SDH, mitochondrial complex II)

202 sophila mutant with a defect in subunit b of succinate dehydrogenase (SDH; mitochondrial complex II).

203 Mutations in mitochondrial complex II (succinate dehydrogenase; SDH) genes predispose to paraga

204 coding subunit B of the mitochondrial enzyme succinate dehydrogenase (SDHB) predispose to malignant p

205 s cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour

206 Succinate dehydrogenase (sdhCDAB) gene expression in Esc

207 d by mutations in genes encoding subunits of succinate dehydrogenase (SDHx) complex.

208 The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the mitochon

209 ady-state levels of the catalytic complex II succinate dehydrogenase subunit A alongside hyperpigment

210 Mutations of succinate dehydrogenase subunit B (SDHB) play a crucial

211 Analysis of the proteins in TCA cycle showed succinate dehydrogenase subunit B (SDHB) was nearly depl

212 and aggressiveness in certain patients with succinate dehydrogenase subunit B(SDHB) mutations sugges

213 ransport chain with a down-regulation of the succinate dehydrogenase subunit B, leading to deregulati

214 sidues lie at the protein-lipid interface of succinate dehydrogenase subunit B.

215 r-suppressor gene and germline variations in succinate dehydrogenase subunit D gene (SDHD-G12S, SDHD-

216 tations in SDHD, a mitochondrial complex II (succinate dehydrogenase) subunit gene at chromosome band

217 VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a develo

218 Germline mutations in succinate dehydrogenase subunits SDHB-D cause pheochromo

219 tural and catalytic properties of beef heart succinate dehydrogenase (succinate-ubiquinone oxidoreduc

220 acid (3-NP), is an irreversible inhibitor of succinate dehydrogenase that induces apoptosis in vitro

221 nitropropionic acid (3-NP) are inhibitors of succinate dehydrogenase that produce energy depletion an

222 itution is obtained when the weight ratio of succinate dehydrogenase to the SdhC-SdhD fraction reache

223 -nitropropionic acid (3-NP), an inhibitor of succinate dehydrogenase, to produce neurodegeneration.

224 twitch markers [myosin heavy chain 7 (MyH7), succinate dehydrogenase, troponin I 1, troponin C1, trop

225 ding the VHL, MET, FLCN, fumarate hydratase, succinate dehydrogenase, TSC1, TSC2, and TFE3 genes, hav

226 = 1), SDHB (n = 2), and SDHD (n = 4) (SDH is succinate dehydrogenase); von Hippel-Lindau (VHL; n = 2)

227 The electron donation capacity of succinate dehydrogenase was found to be an order of magn

228 Regulation of succinate dehydrogenase was investigated using tightly c

229 When succinate dehydrogenase was reconstituted with the bc1 p

230 r), malate dehydrogenase was unaffected, and succinate dehydrogenase was stimulated by Zn(2+).

231 The sdhCDAB operon, encoding succinate dehydrogenase, was cloned from the soybean sym

232 e-S cluster-containing enzymes aconitase and succinate dehydrogenase were dramatically reduced.

233 ndrial Fe-S enzymes, including aconitase and succinate dehydrogenase, were not affected.

234 -CoA to succinate, and a DeltasdhCDA mutant (succinate dehydrogenase), which blocks the conversion of

235 ccinate accumulation arises from reversal of succinate dehydrogenase, which in turn is driven by fuma

236 In contrast, succinate dehydrogenase, with high potential clusters, g