ライフサイエンスコーパス: succumb

1 with 7 x 10(5) TCID(50) of A/Vietnam/1203/04 succumbed.

2 tection; whereas 100% of the control animals succumbed.

3 HeV infection, and three of the four animals succumbed 8 days after exposure.

4 ion in the p110delta gene (p110delta(D910A)) succumbed acutely to nonlethal dose LPS challenge.

5 scence occurred within 4 to 9 days, and mice succumbed approximately 10 to 20 days after treatment te

6 mation of the lung, causing infected mice to succumb at 4 to 6 days postinfection.

7 reated cecal ligation and puncture mice that succumbed at 48 h.

8 no disease, whereas 20% of the PKR(-/-) mice succumbed at a dose of 10(8) PFU.

9 hy until both developed cancer to which they succumbed at the ages of 10 and 12 years, respectively.

10 Surprisingly, c-IAP2(H570A) mice succumbed because of T cell production of high levels of

11 (-/-) mice exhibited severe encephalitis and succumbed between 6 and 8 days postinfection.

12 h AGM and marmosets; animals of both species succumbed between days 9 and 11 postexposure.

13 osis, and systemic T helper type 2 immunity, succumbing by 11 weeks of age.

14 c(+) dendritic cells and LysM(+) macrophages succumbed completely to DENV infection, while mice defic

15 verely blocked in scat crisis mice, and ~94% succumb during the second crisis (~30 d of age) from cat

16 Many MTM patients succumb early in life, but some have a more favorable pr

17 wever, the diabetic D2KO/LIRKO group rapidly succumbed early compared with a relatively normal lifesp

18 a decline in non-SIV-specific Ab titers, and succumbed faster to intestinal bacterial infections.

19 ow that these Clec9a(Kras-G12D) mice rapidly succumb from disease and display massive accumulation of

20 e (Myocd) develop dilated cardiomyopathy and succumb from heart failure within a year.

21 vely well, whereas mice producing GM-CSF can succumb from left ventricular rupture, a complication mi

22 forms of early onset disease, and ultimately succumb from liver, heart or brain failure.

23 mice developed nonresolving inflammation and succumbed from disseminated BCG infection.

24 In contrast, those who succumbed have minimal influenza-specific immunity and l

25 As so many sepsis survivors succumb later to persistent, recurrent, nosocomial, and

26 infection and observed MIF-deficient mice to succumb more quickly with higher organism burden, increa

27 e suffer more severe damage in the colon and succumb more rapidly from acute radiotoxicity than the c

28 die mutant flies have shortened lifespan and succumb more rapidly than controls when infected with Si

29 omparable conditional deletion (IKKbeta cKO) succumb more rapidly to lethal Ft.

30 IL-36beta, but not IL-36alpha or IL-36gamma, succumbed more frequently to HSV-1 infection than wild t

31 ed with Stx1 before TNF-alpha administration succumbed more quickly than mice given Stx1 alone.

32 erable to WNV infection than wild-type mice, succumbing more quickly and with greater overall mortali

33 ecame severely ill, and three of the animals succumbed on days 12, 12, and 14, respectively.

34 sive endometrial adenocarcinoma, and instead succumbed prematurely to multi-organ failure.

35 ion, as mice lacking the type I IFN receptor succumb rapidly following infection and have high levels

36 ific, actin-bundling protein L-plastin (LPL) succumb rapidly to intratracheal pneumococcal infection.

37 In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.

38 veloped multiple symptoms typical of ACS and succumbed rapidly.

39 is express iNOS, and mice need iNOS to avoid succumbing rapidly to tuberculosis.

40 ose concentration by 40%, and the mosquitoes succumb sooner after exposure to desiccation or heat.

41 high levels of DO are maintained, all cells succumb, sterilizing the culture.

42 g fever bacterium Borrelia turicatae rapidly succumb to a brain hemorrhage if they are unable to clea

43 he majority of cystic fibrosis (CF) patients succumb to a chronic infection of the airway with Pseudo

44 D485N]) develop autoimmunity as they age and succumb to a disease resembling lupus nephritis in human

45 SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however,

46 enomegaly, anemia, and thrombocytopenia, and succumb to a rapidly progressing and fully penetrant neo

47 However, virtually all patients succumb to acquired EGFR tyrosine kinase inhibitor resis

48 ion of HDAC3 become severely hypothermic and succumb to acute cold exposure.

49 ted toxicity, causing all treated animals to succumb to acute pancreatitis and hyperglycemic coma.

50 ithelial ovarian cancer (EOC) patients often succumb to aggressive metastatic disease, yet little is

51 s of correct proximo-distal patterning, they succumb to apoptosis from embryonic day 9.75 onwards.

52 lity is that the affected motor neurons only succumb to apoptosis once they have exhausted functional

53 While NZW and BALB/c mice, which do not succumb to autoimmune disease, are not affected by ralte

54 hich can be isolated from blood products and succumb to cART once activated.

55 In contrast, they did not succumb to challenge via the corneal route even with hig

56 coccal polysaccharide-specific responses and succumb to challenge with live type 3 serotype pneumococ

57 ority of advanced-stage patients relapse and succumb to chemoresistant disease.

58 rotected and relatively abundant species may succumb to climate-induced stresses.

59 s lacking subdued gene activity more readily succumb to death caused by ingesting the pathogenic bact

60 With progressive disease, most patients succumb to death from respiratory or heart failure, or b

61 ely known that individual motor pools do not succumb to degeneration simultaneously.

62 -induced disease were already more likely to succumb to dementia with age.

63 Intravenously inoculated mice begin to succumb to dengue disease 72 h after infection, at which

64 tress, individuals either show resilience or succumb to despair.

65 and microbial stimuli, IKKbeta(EE)(IEC) mice succumb to destructive acute inflammation accompanied by

66 rter also survive in NWLE, but progressively succumb to differentiation.

67 myeloma (MM), nearly all patients ultimately succumb to disease relapse and progression despite new t

68 al responses to stimuli can affect how cells succumb to disease.

69 often develop drug resistance and eventually succumb to disease.

70 ouse adenovirus-1, naive mice lacking TRIM21 succumb to encephalomyelitis within 7 d.

71 ts and when challenged by certain stressors, succumb to enhanced tumour development and aneuploidy.

72 Astrocytes do not easily succumb to ER stress but rather activate an inflammatory

73 Women suffering from breast cancer often succumb to incurable recurrent disease resulting from th

74 expression in T cells (GR(lck-Cre)) rapidly succumb to infection despite displaying parasite burdens

75 impaired parasite control and caused mice to succumb to infection during late acute/early chronic sta

76 These mice succumb to infection more rapidly than WT mice or mice l

77 the hcl1 mutant took significantly longer to succumb to infection than mice infected with the wild-ty

78 Correspondingly, these flies quickly succumb to infection with normally nonpathogenic Escheri

79 ial to treat individuals who would otherwise succumb to infection with rabies virus.

80 n increases infectivity, but 30%-40% of mice succumb to infection without neutralization.

81 Although most mice did not succumb to infection, the detection of an immunoglobulin

82 t secondary sites colonized by T. gondii and succumb to infection.

83 igeminal ganglia in mice that may ultimately succumb to infection.

84 ox Consequently, Eros-deficient mice quickly succumb to infection.

85 Toll pathway mutant flies succumb to injected C. glabrata.

86 Males succumb to intestinal challenges to which females are re

87 xpressing breast carcinoma cells that do not succumb to lapatinib, this Her1/2 inhibitor disrupts the

88 onstrated that mice maintained on a VLP diet succumb to lethal challenge at greater rates than mice m

89 when only macrophages are initially present, succumb to lethal challenge with far fewer P. aeruginosa

90 We found that Muc2-deficient mice succumb to lethal disease from ETBF colonization in a B.

91 ns of genital herpes disease; and 4) did not succumb to lethal infection (p < 0.005) after intravagin

92 ent mice fail to control IAV replication and succumb to lethal respiratory infection.

93 aggerated inflammatory responses and rapidly succumb to lipopolysaccharide (LPS).

94 Some patients, however, present with and succumb to locally destructive disease.

95 Further, mice deficient in HO1 succumb to M. tuberculosis infection more readily than d

96 d neutrophils (polymorponuclear cells, PMNs) succumb to M. tuberculosis within 30 days, an extremely

97 n vivo tumorigenesis, Apc(min/+) mice, which succumb to massive intestinal polyposis, were bred to Ct

98 urvive into early adulthood, they eventually succumb to massive intracardiac thrombosis.

99 atic ductal adenocarcinoma (PDAC) invariably succumb to metastatic disease, but the underlying mechan

100 ndary malignant tumor in patients who do not succumb to metastatic melanoma within the first few post

101 Fbx4(+/-) and Fbx4(-/-) mice succumb to multiple tumor phenotypes, including lymphoma

102 mporal lobe (MTL) is the first brain area to succumb to neurofibrillary tau pathology in Alzheimer's

103 sea cucumber fisheries throughout the world succumb to overexploitation driven by rising demand, the

104 1 and demonstrated that Chil1-deficient mice succumb to P. aeruginosa infection more rapidly than the

105 ar cells accumulate ZGs, but the mice do not succumb to pancreatic damage or worse pancreatitis outco

106 not sustained, and most patients eventually succumb to progressive disease, indicating that antiangi

107 If untreated, patients succumb to recurrent infections.

108 radigm for antimicrobial action that may not succumb to resistance.

109 is high, and despite progress, most patients succumb to respiratory failure.

110 typically transient and patients frequently succumb to SCLC within a year following diagnosis.

111 imals homozygous for asparagine at codon 146 succumb to scrapie under natural conditions.IMPORTANCE I

112 However, these mutant mice succumb to severe diabetes and die at an early age.

113 Moreover, some individuals who do not succumb to severe malaria present long-term cognitive de

114 (Sf) mice, which are deficient in Tregs and succumb to severe multiorgan inflammation by 4 weeks of

115 (SIDS), insofar as seemingly normal infants succumb to SIDS when exposed to respiratory stressors (e

116 isingly, unlike p53 null mice, which rapidly succumb to spontaneous thymic lymphomas, early-onset tum

117 Why do some individuals succumb to stress and develop debilitating psychiatric d

118 However, mutant mice rapidly succumb to systemic infection with Salmonella Typhimuriu

119 Tp53-deficient (Tp53(-/-)) mice succumb to T lineage lymphomas lacking clonal translocat

120 Affected individuals usually succumb to the disease in adolescence.

121 ent of ATL and, unfortunately, most patients succumb to the disease within a few years.

122 Despite aggressive therapy, many patients succumb to the disease, and survivors experience severe

123 ic castration-resistant PC (CRPC) invariably succumb to the disease.

124 ill develop recurrent BC and will eventually succumb to the disease.

125 -resistant prostate cancer (CRPC) invariably succumb to the disease.

126 king and chemotherapy, 75% of patients later succumb to the disease.

127 all patients with advanced ccRCC eventually succumb to the disease.

128 ever, will eventually develop resistance and succumb to the disease.

129 , although virtually all patients eventually succumb to the disease.

130 as a complete responder eventually recur and succumb to the disease.

131 ients ultimately develop drug resistance and succumb to the disease.

132 Most patients will succumb to the emergence of chemoresistance or transform

133 ility of photoreceptors that otherwise could succumb to the high metabolic flux and photo-oxidative s

134 CB17 SCID mice infected with R. typhi(GFPuv) succumb to the infection with kinetics similar to those

135 Many insects, including Drosophila, succumb to the physiological effects of chilling at temp

136 In addition, CDR-deleted mice seemed to succumb to their disease faster than MDR-deleted mice.

137 , yet 40% to 50% of patients will eventually succumb to their disease, demonstrating a pressing need

138 tion chemotherapy, most patients relapse and succumb to their disease.

139 mor in children, where one-third of patients succumb to their disease.

140 nitive locoregional treatment and eventually succumb to their disease.

141 select individuals, the majority of patients succumb to their disease.

142 g-term side effects, and many patients still succumb to their disease.

143 erapy, the majority of the affected patients succumb to their disease.

144 with relapsed and refractory lymphoma often succumb to their disease.

145 cally clear FV3 infections, whereas tadpoles succumb to them.

146 r, the susceptibility of ago mutant cells to succumb to this apoptotic program appears to depend on l

147 thin a few weeks, whereas tadpoles typically succumb to this virus.

148 ymphocytopenia of A-T patients and routinely succumb to thymic lymphomas with t(12;14) translocation,

149 ir defective CD8 T-cell response, these mice succumb to Toxoplasma gondii infection more readily than

150 Most patients who die from cancer succumb to treatment-refractory advanced metastatic prog

151 isplay enhanced sensitivity to endotoxin and succumb to upregulated proinflammatory cytokine producti

152 but in the absence of CD4 T cell help, mice succumb to viral recrudescence and disease.

153 ntact adaptive immunity in the periphery but succumb to WNV infection caused by loss of virologic con

154 thrombin-activatable fibrinolysis inhibitor succumb to yersiniosis with a phenotype resembling fibri

155 Mice with low tissue factor activity succumb to yersiniosis with a phenotype similar to fibri

156 A ligase IV (Lig4), another key NHEJ factor, succumbed to aggressive lymphoma in the absence of tumor

157 Seven animals succumbed to AIDS.

158 row in the absence of wildtype support cells succumbed to bone marrow failure (median survival, 328 d

159 patient, who, despite aggressive management, succumbed to C gattii meningoencephalitis.

160 12D) activation and Pten homozygous deletion succumbed to cancer by 3 weeks of age.

161 Infected Cx3cr1-/- mice uniformly succumbed to Candida-induced renal failure, but exhibite

162 These mice had no evidence of progeria but succumbed to cardiomyopathy.

163 ence of parasites in the hearts of those who succumbed to Chagas disease.

164 Animals that succumbed to challenge harbored staphylococci in abscess

165 Ahr-deficient mice succumbed to Citrobacter rodentium infection, whereas ec

166 ently died as a result of lymphoma, but nine succumbed to complications associated with extensive pri

167 xia, Nrf2-deficient, but not wild-type mice, succumbed to death during recovery.

168 pressing hCD26/DPP4 viral receptor uniformly succumbed to death within 6 days, making it difficult to

169 ere protective, while all unvaccinated birds succumbed to death.

170 nfection, only 30% (3/10) of Tbx21(-/-) mice succumbed to disease during the cerebral phase of infect

171 ompromised mice bearing established lymphoma succumbed to disease significantly earlier than tumor be

172 MuLV-infected Mll-AF9 mice succumbed to disease significantly faster than controls

173 ll suffered severe neurological disease: 60% succumbed to disease, and the survivors experienced long

174 While all untreated animals succumbed to disease, NP siRNA-LNP treatment conferred 1

175 lood glucose levels, developed polyuria, and succumbed to disease.

176 e no clinical signs of infection and no mice succumbed to disease.

177 Most homozygous Hbb-b2(Plt12/Plt12) mice succumbed to early lethality associated with emphysema,

178 Although all untreated animals succumbed to EBOV infection, 33%-67% of the animals in e

179 axinine E (2) and taxabaccatin III (3), have succumbed to enantioselective total synthesis for the fi

180 Fish exposed to seawater succumbed to epitheliocystis from 21 days post hatching,

181 These mice rapidly succumbed to fatal bone marrow failure, demonstrating th

182 ing or lacking PD-1 signaling in CD8 T cells succumbed to fatal CD8 T cell-mediated immunopathology e

183 rious compositional elements in patients who succumbed to fatal intracoronary thrombosis.

184 While naive animals succumbed to GTOV infection, 88% of the Car(91)-exposed

185 r rodentium infection, while Nfkb2(-/-) mice succumbed to gut infections owing to stromal defects.

186 TERT-p mutations, except for the one SM that succumbed to hematogenous metastasis.

187 by cardiopulmonary failure and he ultimately succumbed to his infection.

188 Animals became viremic within 4 days and succumbed to infection between 8 and 9 days, and a petec

189 hours and then rapidly decreased as animals succumbed to infection between days 5 and 8 after exposu

190 devoid of T cells failed to control VACV and succumbed to infection despite a marked increase in NK c

191 ntaining Ifnar-deficient hematopoietic cells succumbed to infection early, whereas Ifnar-deficient mi

192 MyD88 KO mice succumbed to infection more rapidly than wild-type mice.

193 itions of lethal T. cruzi challenge, WT mice succumbed to infection whereas IFNAR(-/-) mice were ulti

194 protein of CDV vaccine strain Onderstepoort succumbed to infection with a more recent wild-type stra

195 mally (i.d.) or intranasally (i.n.) with LVS succumbed to infection with doses 2 log units less than

196 coincident with increased demyelination, and succumbed to infection within 3 weeks.

197 iking features were observed in animals that succumbed to infection, including high viral titers in a

198 t terminal stages of disease in animals that succumbed to infection, indicating substantial consumpti

199 ice developed pneumonia and splenomegaly and succumbed to infection, whereas wild-type mice cleared t

200 ith K3995 exhibited intestinal pathology and succumbed to infection, while none of those infected wit

201 Within 36 h, all infected mice succumbed to infection.

202 ed animals experienced rapid weight loss and succumbed to infection.

203 t, as neonatal animals lacking either factor succumbed to infection.

204 infected animals that received vehicle alone succumbed to infection.

205 increase in circulating monocytes, and they succumbed to infection.

206 ivity accelerated virus control, 50% of mice succumbed to infection.

207 ly lethal, only 50% of NiVM-infected animals succumbed to infection.

208 e, ILC-deficient Raggammac(-/-) mice rapidly succumbed to infection.

209 Accordingly, Toso(-/-) mice succumbed to infections of L. monocytogenes, whereas WT

210 (Ifit2(-/-)) suffered severe weight loss and succumbed to intranasal infection with SeV strain 52 at

211 highly reactive with cysteamine and rapidly succumbed to irreversible nucleophilic addition.

212 eutic efficacy was not durable and most mice succumbed to late relapse.

213 layed, a small number of suckling mice still succumbed to lethal intracerebral infection with the miR

214 icantly, however, mice lacking TNFR1 in MDCs succumbed to listeria infection, although they displayed

215 s required because most SCID mice eventually succumbed to local tumor recurrence even with combined c

216 Trif(-/-)Cardif(-/-) (MyTrCa(-/-)) mice that succumbed to low-dose i.v. VSV infection with similar ki

217 These mb1-cre:Tp53(flox/flox) mice succumbed to lymphoid tumors containing Ig gene rearrang

218 , these mice were remarkably tumor prone and succumbed to malignancies significantly faster than sing

219 Cdk2 wild-type or heterozygous mice succumbed to mammary tumors with mean latencies of 16 an

220 While TNF-deficient mice rapidly succumbed to mycobacterial infection, huTNF KI mice surv

221 Four out of 25 primary mice succumbed to myeloproliferative disorders, some of which

222 er, P. berghei ANKA-infected Card9(-/-) mice succumbed to neurological signs and presented with disru

223 ous for asparagine at codon 146 (NN animals) succumbed to oral challenge.

224 RB6-8C5 MAb-treated mice succumbed to oral infection with Toxoplasma gondii, simi

225 d females supplemented with 17beta-estradiol succumbed to P. aeruginosa challenge earlier than proges

226 in a paralytic killing assay, whereas worms succumbed to paralysis and death in its absence.

227 ease; these findings confirmed that the mice succumbed to prion disease.

228 All mice ultimately succumbed to progressive leukemia.

229 ing after herpes simplex virus infection and succumbed to rapid disease.

230 Six of 13 (46.2%) recipients succumbed to rejection-related complications.

231 allografts, nearly all TSP-1 null allografts succumbed to rejection.

232 stemic tissues to occur, and mice eventually succumbed to relapsing infection.

233 arial drugs developed so far have eventually succumbed to resistance.

234 With the exception of 1 patient who succumbed to respiratory complications of Pompe disease

235 her clinical signs were noted and no macaque succumbed to RVFV infection.

236 directly damaged by the initial insult, but succumbed to secondary degeneration, remain unclear.

237 ice were protected and B cell-deficient mice succumbed to secondary infection.

238 However, Lig4(-/-)p53(R172P) mice succumbed to severe diabetes.

239 Nevertheless, these mice ultimately succumbed to spontaneous bleeding events shortly after b

240 Just several weeks later, when it likely succumbed to starvation in a drought-stressed ecosystem,

241 y, WT mice cleared infection with Eap(+) but succumbed to sublethal infection with Eap- S. aureus.

242 iously infected with an H3N2 influenza virus succumbed to systemic disease and encephalitis after H5N

243 Sirpalpha(-)/(-) mice succumbed to systemic infection with attenuated Salmonel

244 H5N1 influenza virus, naive ferrets rapidly succumbed to systemic infection.

245 The data demonstrate that individuals who succumbed to the disease show stronger upregulation of i

246 auses smallpox, one-third of infected people succumbed to the disease.

247 covered, while the untreated control animals succumbed to the disease.

248 ains of animals that were treated, but still succumbed to the disease.

249 ative treatment was planned but both of them succumbed to the illness.

250 in response to S. typhimurium infection, and succumbed to the infection 2 days before control mice.

251 and T cells developed clinical symptoms and succumbed to the infection earlier than the wild-type gr

252 st, mice lacking the IFN-alpha/beta receptor succumbed to the infection, with VSV spreading throughou

253 J2.2 ineffectively cleared virus and rapidly succumbed to the infection.

254 viruses induced severe weight loss, and mice succumbed to the infection.

255 ved for approximately 2 weeks until the mice succumbed to the infection.

256 teria than the standard adult dose uniformly succumbed to the infection.

257 Although the transgenic birds succumbed to the initial experimental challenge, onward

258 ive immunity to T. gondii, as CCR7(-/-) mice succumbed to the parasite early in the acute phase of in

259 led to mount cross-reactive CD8+ T cells and succumbed to the second challenge with heterologous H3N2

260 ents who, in earlier generations, would have succumbed to their critical illness.

261 6% achieved a disease-free state, whereas 3% succumbed to their underlying disease.

262 Transgenic mice expressing 96GG deer PrP succumbed to this agent, but tg mice expressing 96SS dee

263 6 of 8 compound Ero1l and Ero1lb mutant mice succumbed to this level of beta adrenergic blockade (P <

264 Furthermore, Sirt2-/- mice succumbed to TNF induced Systemic Inflammatory Response

265 ve been known for nearly 4 decades, none has succumbed to total synthesis.

266 oxB; however, CGNs from STAT1 knock-out mice succumbed to ToxB-induced apoptosis as readily as wild-t

267 e resistance; however, these mice eventually succumbed to toxoplasmic encephalitis, despite the prese

268 ays of composting, only one in five hamsters succumbed to TSE disease, suggesting at least a 4.8 log1

269 All the animals rapidly succumbed to tuberculosis.

270 Furthermore, 80% of IRAK-4(-/-) mice succumbed to virulent M. tuberculosis within 100 d follo

271 spontaneous inflammation and VFHhip animals succumbed to wasting and death.

272 After surgery, recipient mice succumbed to widespread overt metastatic disease in lymp

273 ar1(-/-)) developed neurological disease and succumbed to ZIKV infection, whereas single Irf3(-/-), I

274 ce different outcomes, with some individuals succumbing to acute infection while others control the p

275 ruggle with a chemotherapeutic insult before succumbing to apoptosis is largely unknown.

276 hyperbilirubinemia, with 8-10% of hUGT1 mice succumbing to CNS damage, a phenotype that is presented

277 of three intracerebrally challenged animals succumbing to disease at 766 d and displaying all of the

278 mplex navigation and decision making without succumbing to distractions and unforeseen obstacles.

279 Those succumbing to early embryonic death had markedly deforme

280 ays 5 and 6, maintaining a high fever before succumbing to EVD between 6 and 8 days after challenge.

281 tance when investigating how organisms avoid succumbing to infection.

282 7 to 8 days after infection, when mice began succumbing to MAV-1 infection.

283 on in vivo and survive until late gestation, succumbing to multiple cardiac abnormalities.

284 e cytosol but also for preventing TRC35 from succumbing to RNF126-mediated ubiquitylation and degrada

285 at several time points prior to the animals succumbing to salmonellosis were like those seen with th

286 ME49 survived for at least 12 months without succumbing to the chronic infection.

287 largely unexplored despite asplenic patients succumbing to the infection in the first 24 h, suggestin

288 cies, with virtually all patients eventually succumbing to their disease.

289 increase the immunogenicity of cancer cells succumbing to treatment.

290 This estimation problem also succumbs to a penalized MM algorithm.

291 water intrusion support heterotrophy, which succumbs to autotrophy under groundwater discharge.

292 - and the parasitoid offspring it carries - succumbs to extrinsic mortality.

293 d minimize an ion's diffusive path before it succumbs to transmembrane electrochemical gradients.

294 e NKAP conditional knockout bone marrow also succumb with a similar time course.

295 Both wild-type and IRF-3(-/-) mice succumbed with equivalent frequencies to infection with

296 fected intranasally with pneumococci rapidly succumbed, with 80% mortality after 48 h, whereas the ma

297 is an incurable disease where most patients succumb within the first year of diagnosis.

298 nderwent cardiopulmonary resuscitation (CPR) succumbed within a median survival of 1 day (75% and 25%

299 w as 10 PFU of SFTSV, with animals generally succumbing within 5 to 6 days after subcutaneous challen

300 ce are highly susceptible to CVB3 infection, succumbing within a few days of challenge.