ライフサイエンスコーパス: sugar nucleotide

1 ior to transfer to CMP to form the activated sugar nucleotide.

2 ucosamine (UDP-GlcNAc), forming a 3-hexulose sugar nucleotide.

3 phosphoribose diphosphate rather than from a sugar nucleotide.

4 studied several model systems based on amino-sugar nucleotides.

5 d the practical synthesis of a unique set of sugar nucleotides.

6 their corresponding uridine diphosphate(UDP)-sugar nucleotides.

7 ensively for the chemoenzymatic synthesis of sugar nucleotides.

8 ]lipid IV(A) in the presence of any of these sugar nucleotides.

9 of it is synthesized from readily available sugar nucleotides.

10 up by cancer cells and then converted into a sugar nucleotide analog, GDP-5T-Fuc, that blocks FUT act

11 t the transcriptome level, genes involved in sugar nucleotide and pectin metabolism are altered in th

12 el or improved methods for regenerating ATP, sugar nucleotides and 3-phosphoadenosine-5'-phosphosulph

13 e steady state concentrations of the uridine sugar nucleotides and imply that galactose metabolism mo

14 thod for determination of cellular levels of sugar nucleotides and related nucleotides in cultured ce

15 erase catalysts for the synthesis of complex sugar nucleotides and the practical synthesis of a uniqu

16 ntral to energy transduction and amino acid, sugar, nucleotide and lipid biosyntheses can be reconsti

17 enzyme is highly specific for this acetamido sugar nucleotide, and the procedure had a detection limi

18 uded ADP-ribose, diadenosine polyphosphates, sugar nucleotides, and deoxynucleoside triphosphates.

19 leotides, dinucleoside 5',5'-polyphosphates, sugar nucleotides, and nucleolipids.

20 e analysis identified deficiencies in simple sugars, nucleotides, and lipids in the livers of MPSI mi

21 Sugar nucleotides are activated forms of sugars used by

22 Sugar nucleotides are fundamental donor molecules in enz

23 s suggest that despite their polarity, these sugar-nucleotides are taken up by HL-60 cells.

24 relies on glycosyltransferases that use UDP-sugar nucleotides as donors.

25 sm, implicating this sequence as a potential sugar nucleotide binding motif.

26 he absence of involvement of this residue in sugar nucleotide binding.

27 missive mutants may be either in or near the sugar nucleotide-binding site.

28 of >700 genes, including enzymes involved in sugar-nucleotide biosynthesis, transporters, glycan exte

29 r via metabolic engineering of a promiscuous sugar nucleotide biosynthetic pathway.

30 the same time promoting the cleavage of the sugar nucleotide bond.

31 Separation of 9 sugar nucleotides (CMP-Neu5Ac, CMP-Neu5Gc, CMP-KDN, UDP-

32 hesis of uridine diphosphate (UDP)-GlcNAc, a sugar nucleotide critical to multiple glycosylation path

33 utative blueprint for base specificity among sugar nucleotide-dependent dehydrogenases and, in conjun

34 Other structurally related sugar nucleotides did not substitute.

35 It is not understood how OGT recognises its sugar nucleotide donor and performs O-GlcNAc transfer on

36 ptor and the carbohydrate moiety of either a sugar nucleotide donor or lipid-linked saccharide donor.

37 ytic activity due to a weak affinity for its sugar nucleotide donor, CMP-NeuAc, and that this catalyt

38 from which of the six core intermediates its sugar-nucleotide donor substrate stemmed.

39 en investigated through the use of the novel sugar-nucleotide donor substrate UMP-NeuAc.

40 The sugar nucleotide dTDP-L-rhamnose is critical for the bio

41 ll wall polysaccharides are synthesized from sugar-nucleotides, e.g. uridine 5'-diphosphoglucose (UDP

42 eta-N-acetylglucosamine (GlcNAc), is a donor sugar nucleotide for complex glycosylation in the secret

43 pyrophosphorylase that generates the reduced sugar nucleotide for the insertion of ribitol in a phosp

44 that platelets contain sufficient levels of sugar nucleotides for detection of glycosylation of exog

45 ynthesis of a range of natural and unnatural sugar nucleotides for in vitro glycosylation studies and

46 otides, it did not separate sufficiently the sugar nucleotides for quantification.

47 id method for efficiently removing salts and sugar nucleotides from cytosol (polyethylene glycol prec

48 ant glycosyltransferases and a corresponding sugar nucleotide functionalized by biotin.

49 The sugar nucleotide GDP-mannose is essential for Trypanosom

50 The structure of the formylated sugar nucleotide generated in vitro by ArnA was validate

51 By controlling the supply of sugar nucleotides in the lumen of the Golgi apparatus, t

52 lc), but the metabolic pathways that produce sugar-nucleotides in plants remain controversial.

53 erest concerns the enzymatic modification of sugar nucleotides, in relation to both secondary metabol

54 ) at comparable rates using a diverse set of sugar nucleotides, including GDP-mannose, ADP-mannose, U

55 rases coupled with effective regeneration of sugar nucleotides, including UDP-Gal, UDP-GalNAc, GDP-Fu

56 tylglucosamine from exogenously supplied UDP-sugar nucleotides into a high molecular mass (10(6) to 1

57 further demonstrate that only the formylated sugar nucleotide is converted in vitro to an undecapreny

58 or UDP-glucose mass and to test whether this sugar nucleotide is released as an extracellular signali

59 Analysis of sugar nucleotide levels in parasites with TbPMM or TbPAG

60 HPAEC method to determine the intracellular sugar nucleotide levels of cultured Spodoptera frugiperd

61 o enzymes that oxidize the C-4'' position of sugar nucleotides, like UDP-galactose epimerase, dTDP-gl

62 ethyl) iminosugars as glycosyl phosphate and sugar nucleotide mimics.

63 cular weight biochemicals, including lipids, sugars, nucleotides, organic acids, and amino acids, tha

64 It is proposed that ASQD arises from the sugar nucleotide pathway of sulfolipid biosynthesis by a

65 apparently not due to better binding of the sugar nucleotide precursors complexed to Mn ion because

66 Other structurally related sugar nucleotide precursors did not substitute in the el

67 In addition, we identified the sugar nucleotide precursors involved in Psl generation a

68 Only the authentic sugar nucleotide precursors, UDP-glucuronic acid (UDP-Gl

69 e similarity with a family of phospho-hexose sugar nucleotide pyrophosphorylases.

70 cose pyrophosphorylases, as well as of other sugar-nucleotide pyrophosphorylases, was used for compar

71 s, as well as throughout the super-family of sugar-nucleotide pyrophosphorylases.

72 owever, the molecular mechanisms involved in sugar nucleotide recognition and transfer to protein are

73 Unexpectedly, however, the sugar nucleotide selectivity of LpsB is greatly relaxed

74 P-GlcNAc to a novel, less negatively charged sugar nucleotide shown to be [alpha-(32)P]UDP-GlcNAc3N.

75 study confirms that oxidation occurs at the sugar nucleotide stage prior to glycosyltransfer, and su

76 sing a fluorescently labeled analogue of the sugar-nucleotide substrate, we demonstrate that E acts a

77 erase reactions in extracts with radioactive sugar nucleotide substrates and appropriate Skp1 glycofo

78 ient spectroscopy (WaterLOGSY) NMR for known sugar nucleotide substrates and selected phosphonate ana

79 O-antigen expression but, as their putative sugar nucleotide substrates are not currently available,

80 ten tolerate chemical modifications in their sugar nucleotide substrates, thus allowing the installat

81 ce of proteins were mainly involved in amino sugar, nucleotide sugar and fatty acid metabolism, one c

82 Nucleotide sugars, nucleotide sulfate, and ATP are substrates for t

83 e of a bifunctional plant enzyme involved in sugar nucleotide synthesis where a single polypeptide ex

84 ng of glycosyltransferases for combinatorial sugar nucleotide synthesis.

85 The conformational changes of the enzyme and sugar nucleotide that accompany metal binding may provid

86 amine for de novo synthesis of UDP-GlcNAc, a sugar-nucleotide that inhibits receptor endocytosis and

87 merase can change the required but expensive sugar nucleotide to a less expensive one.

88 glE) have recently been shown to modify this sugar nucleotide to form UDP-2-acetamido-4-amino-2,4,6-t

89 We demonstrate that H3 binds the sugar nucleotide UDP-glucose, as do glycosyltransferases

90 ination of the product to generate the novel sugar nucleotide UDP-l-Ara4N.

91 The sugar nucleotide UDP-N-acetylglucosamine (UDP-GlcNAc) is

92 '-amine of UDP-L-Ara4N, generating the novel sugar nucleotide, uridine 5'-diphospho-beta-(4-deoxy-4-f

93 Both sugar nucleotides were synthesized at nearly the same ra

94 producible separation of all nucleotides and sugar nucleotides with high sensitivity and reproducibil