ライフサイエンスコーパス: suicide gene

1 oma cells by virus-regulated expression of a suicide gene.

2 ed with mCherry, and the inducible Caspase-9 suicide gene.

3 0-fold, suggesting that it may be a superior suicide gene.

4 and a herpes simplex virus thymidine kinase suicide gene.

5 virus thymidine kinase or cytosine deaminase suicide genes.

6 several advantages over currently available suicide genes.

7 allow selection of transduced cells, whereas suicide genes allow selective deletion of administered T

8 the incorporation of an inducible caspase-9 suicide gene allowed efficient elimination of transgenic

9 Incorporation of suicide genes allows the selective destruction of allode

10 fy and to destroy tumor cells expressing the suicide gene alpha(1,3)Galactosyltransferase (alpha GT).

11 effectiveness of combination therapy using a suicide gene and cytokine genes for the treatment of met

12 term immune reconstitution did not carry the suicide gene and displayed high numbers of naive lymphoc

13 dies demonstrate the need for nonimmunogenic suicide genes and identify a strategy for detection of C

14 d herpes simplex virus thymidine kinase as a suicide gene, at different time points after sensitizati

15 ng GVHD reactions and the efficacy of HSV-tk suicide gene-based T-cell deletion.

16 ts thus show that locoregional delivery of a suicide gene by RCR vectors infused into the portal circ

17 ently deleted by using direct repeats, (iii) suicide genes can be functionally reconstituted during r

18 In addition, suicide genes can install a 'safety switch' on adoptivel

19 Therefore, (a) a lytic virus expressing a "suicide" gene can activate a prodrug; and (b) within rRp

20 rleukin 6 (IL-6) and the bacterial metabolic suicide gene cytosine deaminase (205-IL6-CD) become high

21 After confirmation of suicide gene cytotoxicity in vitro, multifocal hepatic t

22 rpes simplex virus-thymidine kinase (HSV-tk) suicide gene delivery and treatment with ganciclovir (GC

23 Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells

24 Finally, coexpressing a suicide gene enabled fast and efficient pharmacologic ab

25 ablated these cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kin

26 mbinant VSV (rVSV) that expressed the fusion suicide gene Escherichia coli cytosine deaminase (CD)/ur

27 ant-negative mutant rpoB gene is a potential suicide gene especially for the treatment of multidrug-r

28 ke vhs an interesting candidate for use as a suicide gene for HIV gene therapy.

29 We have created a highly compact marker/suicide gene for T cells combining target epitopes from

30 The genetic modification of T cells with a suicide gene grants a mechanism of control of adverse re

31 The introduction of an inducible suicide gene has been proposed as a strategy to exploit

32 ly modified donor T cells with an inducible "suicide" gene have the potential to improve the safety a

33 of either reporter red florescent protein or suicide genes [herpes simplex virus-thymidine kinase (TK

34 to oocytes in transgenic mice expressing the suicide gene, herpes simplex virus thymidine kinase (HSV

35 The SV40Tag sequence and a suicide gene, herpes simplex virus thymidine kinase (HSV

36 The suicide gene, herpes simplex virus thymidine kinase (tk)

37 l T cells expressing the inducible caspase 9 suicide gene (iC9-T cells).

38 o difficulties in the development of DT as a suicide gene in cancer gene therapy, because toxicity ap

39 nction suggested that vhs could be used as a suicide gene in certain gene therapy applications.

40 ne kinase (HSV1-tk) gene is widely used as a suicide gene in combination with ganciclovir (GCV) and a

41 1) thymidine kinase (TK) is widely used as a suicide gene in combination with ganciclovir.

42 hymidine kinase (HSV-tk) is widely used as a suicide gene in experimental gene therapy of cancer.

43 DeltaCD34-tk is an attractive candidate as a suicide gene in man because of the ensured expression of

44 rpes simplex virus-thymidine kinase (HSV-tk) suicide gene in mouse mammary adenocarcinoma (TSA) cells

45 we assessed the efficacy of the DeltaCD34-tk suicide gene in the absence of extended ex vivo manipula

46 the transduction and regulation of a double suicide gene in tumor cells and may provide a unique app

47 city can be accomplished by RIP coupled to a suicide gene in vivo, preventing hypoglycemic death.

48 We recently constructed a novel chimeric suicide gene in which the entire coding region of HSV th

49 ancer gene therapy by selectively expressing suicide genes in cancer cells and not normal cells.

50 ified MSCs to stably express a panel of four suicide genes including TK (TK007 and TK(SR39) mutants),

51 reacting T cells by T cell subset selection, suicide gene insertion or selective allodepletion, and t

52 Thus, Cas9-mediated suicide-gene insertion may be a viable genotype-specific

53 dly applicable to introducing therapeutic or suicide genes into patient-specific iPS cells for use in

54 l injections of a plasmid in which the HSVtk suicide gene is expressed from a melanocyte-specific pro

55 sgenic mice in which a thymidine kinase (TK) suicide gene is targeted to the T cell using a CD3 promo

56 th the herpes simplex virus thymidine kinase suicide gene linked to the IL-2 promoter were used as a

57 odel, we demonstrate that early-intervention suicide-gene-mediated senescent cell ablation improves p

58 The elimination of senescent cells by suicide gene-meditated ablation of p16(Ink4a)-expressing

59 We conclude that a suicide gene of pneumococcus is spxB, which induces an a

60 clusion, the insertion of the fusion CD/UPRT suicide gene potentiates the oncolytic efficiency of VSV

61 r stomatitis virus (VSV) able to produce the suicide gene product thymidine kinase (TK) or cytokine i

62 of the mutants make them good candidates for suicide-gene/protein-therapy applications.

63 rpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has resulted in enhanced antitumo

64 and herpes simplex virus-1 thymidine kinase suicide genes render malignant cells sensitive to specif

65 Replacement of the reporter gene with a suicide gene resulted in selective killing of SW480 cell

66 The use of any of these mutants as a suicide gene should provide a more effective and safer a

67 estes antigen NY-ESO-1, coexpressing the PET/suicide gene sr39TK.

68 e reconstitution associated with a different suicide gene strategy to abrogate graft-versus-host dise

69 The introduction of an inducible suicide gene such as the herpes simplex virus thymidine

70 of direct viral oncolysis to the HSV-tk/GCV suicide gene system resulted in a striking improvement i

71 A compact marker/suicide gene that utilizes established clinical-grade re

72 divided into four main areas: 1) transfer of suicide genes that convert inactive prodrugs into cytoto

73 cancer, one improvement would be to develop suicide genes that effectively kill both dividing and no

74 in which tumor cells are transfected with a 'suicide' gene that encodes a metabolic enzyme capable of

75 Prior transduction of T lymphocytes with the suicide gene, the viral thymidine kinase (TK), permits s

76 tween the oncolytic adenovirus and/or double-suicide gene therapies and radiation therapy.

77 ductase enzyme (NTR) has been widely used in suicide gene therapy (GDEPT and ADEPT) applications as a

78 They are self-immolative prodrugs for suicide gene therapy activation by the enzyme carboxypep

79 Cancer suicide gene therapy affords the prospect of using the m

80 , this cytokine approach was combined with a suicide gene therapy and subcutaneous B16 melanomas were

81 sent the findings on improved techniques for suicide gene therapy and various oncolytic viral therapi

82 In an effort to optimize this suicide gene therapy approach, we have determined the th

83 x virus type 1 (HSV-1) thymidine kinase (TK) suicide gene therapy as a potential antitumor treatment.

84 this attribute could be exploited in cancer suicide gene therapy by using a lentiviral (LV) vector e

85 ication-competent adenovirus-mediated double-suicide gene therapy can be combined safely with convent

86 hypothesis that the effectiveness of HSV-TK suicide gene therapy can be enhanced by coexpression of

87 deficiencies, chronic granulomatous disease, suicide gene therapy for graft-versus-host disease, vira

88 d HVP22 to enhance Etk/ganciclovir (Etk/GCV) suicide gene therapy for neuroblastomas by GCV cytotoxic

89 Clinical experience with suicide gene therapy for prostate cancer using first-gen

90 utic potential of BVP22 and HVP22 in Etk/GCV suicide gene therapy in this tumor system is not due to

91 Suicide gene therapy is one approach being evaluated for

92 emonstrate that CID-regulated, caspase-based suicide gene therapy is safe and can inhibit the growth

93 One example of suicide gene therapy is the bacterial nitroreductase (NT

94 Suicide gene therapy may contribute to the treatment of

95 Adenovirus-mediated suicide gene therapy may hold promise in the treatment o

96 Suicide gene therapy of cancer is a method whereby cance

97 e cell-based, non-viral or viral vectors for suicide gene therapy of cancer make more informed decisi

98 B1954) have been used for stem cell mediated suicide gene therapy of cancer.

99 ible to utilize such nucleoside analogues in suicide gene therapy or protein therapy applications tha

100 or obstacle to the successful application of suicide gene therapy strategies that rely on in situ tra

101 in combination with the pro-drug CB1954 in a suicide gene therapy strategy.

102 We have designed a targeted systemic suicide gene therapy that combines the advantages of tum

103 evaluated the safety and efficacy of a novel suicide gene therapy that could potentially spare normal

104 fferences have been exploited in a potential suicide gene therapy treatment for solid tumors.

105 Suicide gene therapy using the cytosine deaminase (CD) g

106 with established liver metastases show that suicide gene therapy using TK- vaccinia virus as a vecto

107 Suicide gene therapy using vv with the CD/5-FC system le

108 Thus, telomerase-specific suicide gene therapy vectors expressing bacterial nitror

109 In a mouse xenograft model of lung cancer, suicide gene therapy with LV-ARE-TK/GCV was effective co

110 Suicide gene therapy with the herpes simplex virus thymi

111 udied antiglioma gene therapy strategies are suicide gene therapy, genetic immunotherapy and oncolyti

112 est the potential therapeutic efficacy of DT suicide gene therapy, we first developed a DT-resistant

113 Using HSVtk suicide gene therapy, we showed that macrophages can dis

114 d molecular imaging agents targeting HSV1-tk suicide gene therapy.

115 nic alternative modality for prostate cancer suicide gene therapy.

116 ndidate for anti-microbial drug development, suicide-gene therapy, and cell-specific mRNA labeling te

117 Insulinoma-specific cytotoxicity using the suicide gene thymidine kinase (tk) was studied both in v

118 T cells expressing the HSV thymidine kinase suicide gene (TK+ cells).

119 approach likely requires the inclusion of a suicide gene to deal with the potential development of T

120 neered human CAF cell line with an inducible suicide gene to enable selective in vivo elimination of

121 bination of tumor killing by activation of a suicide gene to release tumor antigens and in situ HSP70

122 h donor T cells expressed a thymidine kinase suicide gene, to test whether separation of GVL and graf

123 . injection of plasmids encoding hsp70 and a suicide gene transcriptionally targeted to melanocytes g

124 st disease include CD4 lymphocyte infusions, suicide gene-transfected cells, and the use of cloned T

125 aft-versus-host disease may be controlled by suicide gene transfection of the donor lymphocytes.

126 r data suggest that the HSV-tk/GCV metabolic suicide gene transfer system could serve as an adjuvant

127 In situ killing of tumor cells using suicide gene transfer to generate death by a non-apoptot

128 Here we have developed an in vivo HSP-suicide gene tumor vaccine by generating a recombinant r

129 road relevance to the use of the in vivo HSP/suicide gene tumor vaccine in therapy for human solid tu

130 ful for positive T-cell selection and (2) a "suicide" gene useful for elimination of transfected T ce

131 erpes simplex virus-thymidine kinase (HSVtk) suicide gene, using a murine fibrosarcoma model, in the

132 pes simplex virus thymidine kinase (HSV-TK) "suicide gene," we demonstrate Smad4-responsive regulatio