ライフサイエンスコーパス: suis

1 nt (38.8% for M. haemofelis and 31.1% for M. suis).

2 ecies and subsequently serotyped as Brucella suis.

3 Streptococcus pyogenes, S. agalactiae and S. suis.

4 a species: B. abortus, B. melitensis, and B. suis.

5 ide polymorphisms with B. melitensis than B. suis.

6 hare a common ancestor that diverged from B. suis.

7 y with cell morphology and attenuation of B. suis.

8 s of Brucella abortus, B. melitensis, and B. suis.

9 cessary for the intracellular survival of B. suis.

10 lla abortus, B. melitensis, B. canis, and B. suis.

11 Bordetella bronchiseptica, and Streptococcus suis.

12 ch correlated well with host clearance of S. suis.

13 ZYH33 of the zoonotic pathogen Streptococcus suis.

14 cy, focussing on suilysin from Streptococcus suis.

15 is (6 persons), C. felis (6 persons), and C. suis (1 person) infection.

16 p died within 1 week after challenge with S. suis (10 of 11 in each of two trials).

17 co-regulated genes, we searched the Brucella suis 1330 and B. abortus 2308 genomes for genes with an

18 te 9-941 and compare it to those of Brucella suis 1330 and Brucella melitensis 16 M.

19 Only B. suis 1330 appears to have an intact beta-ketoadipate pat

20 mpleted Brucella melitensis 16M and Brucella suis 1330 genomes have facilitated the investigation of

21 minal processing protease (CtpA) of Brucella suis 1330 is a member of a novel family of endoproteases

22 pon which the published sequence of Brucella suis 1330 is based and describe the differences between

23 ld isolates compared to the newly revised B. suis 1330 reference genome identified on average 13, 15,

24 sic infectious Brucella reference strain, B. suis 1330, was also used.

25 n and liver, but were less efficient than B. suis 1330.

26 Here, we found that S. suis 2 can escape phagocytic clearance by adenosine synt

27 cate that Ssads play an important role in S. suis 2 escaping human innate immunity in the context of

28 ant roles in developing therapies against S. suis 2 infection.

29 he most common clinical manifestations of S. suis 2 infection.

30 However, the mechanisms of S. suis 2 surviving in human blood remains unclear, so to i

31 Ssads could impair PMN's defense against S. suis 2 with decreasing of oxidative activity and degranu

32 Streptococcus suis serotype 2 (S. suis 2) is a highly invasive pathogen in pigs and humans

33 nated as Ssads (the adenosine synthase of S. suis 2).

34 fection with the nematode parasite Trichuris suis alters systemic cytokine levels, cellular cytokine

35 elA and RelQ are identified in Streptococcus suis, an important emerging zoonotic Gram-positive bacte

36 40-fold coverage of adult male and female T. suis and approximately 80-Mb draft assemblies.

37 Only B. suis and B. canis isolates clustered together and could

38 We have investigated how B. suis and B. melitensis enter human monocytes and in whic

39 Genome sequencing of B. suis and B. melitensis revealed that both are complete d

40 In contrast to B. suis and B. melitensis, it was found that B. neotomae is

41 While occasional detection of C. suis and C. muridarum in poultry is reported here for th

42 Trichuris suis and Oesophagostomum dentatum larvae were similarly

43 two closely related species, Actinobacillus suis and Pasteurella multocida.

44 ctiae, S. equi, S. mutans, S. pneumoniae, S. suis and S. uberis, as well as representative enterococc

45 mologues in Helicobacter pylori and Brucella suis and the archaeal type II secretion ATPase GspE, a u

46 distinct from "H. heilmannii" type 1 and "H. suis" and clustered with "H. heilmannii" types 2 and 4.

47 eria meningitidis, Haemophilus influenzae, S suis) and O tsutsugamushi, Rickettsia typhi/Rickettsia s

48 B. abortus, B. melitensis, B. suis, and B. canis produced identical PCR interspace pro

49 cella melitensis, Brucella abortus, Brucella suis, and Brucella canis were extracted and distributed

50 cella melitensis, Brucella abortus, Brucella suis, and Brucella canis) is problematic for many clinic

51 In Streptococcus mutans, Streptococcus suis, and species of the bovis, salivarius and pyogenic

52 regulatory cytokine IL-10 in response to T. suis antigens.

53 Brucella abortus, B. melitensis, and B. suis are pathogenic to humans, whereas B. ovis and B. ne

54 sent, to our knowledge, the first case of S. suis arthroplasty infection and streptococcal toxic shoc

55 tients infected with B. abortus and Brucella suis as well as rabbit antisera prepared against killed

56 a that are distinct from type 1 and from "H. suis." As "H. heilmannii" type 1 predominates in people,

57 of Wb and S708 phages that are lytic for B. suis, B. abortus and B. neotomae.

58 s were shared between only B. abortus and B. suis, B. abortus shared more fragments and had fewer nuc

59 species-Brucella abortus, B. melitensis, B. suis, B. canis, and B. ovis-using whole-genome compariso

60 and unlike B. abortus, B. melitensis, and B. suis, B. neotomae has not been observed to infect humans

61 nella strains was 84 to 92%, with that of E. suis being most similar to that of the H. felis strain f

62 une electron microscopy demonstrated that S. suis BgaC is an atypical surface-anchored protein in tha

63 Therefore we concluded that S. suis BgaC is an atypical surface-exposed protein without

64 Bioinformatics analyses revealed that S. suis BgaC shared the conserved active sites (W240, W243

65 ucella abortus-Brucella melitensis, Brucella suis-Brucella canis, Brucella ovis, and Brucella ceti.

66 Besides Gln, H. suis can also convert glutathione (GSH) to glutamate, an

67 hat administration of the nematode Trichuris suis can be beneficial in treating various immune disord

68 fection with highly pathogenic Streptococcus suis can cause septic shock, which is characterized by h

69 oteins in data banks, such as Tritrichomonas suis, Candida albicans, and Saccharomyces cerevisiae pro

70 Streptococcus suis causes disease in pigs worldwide and is increasingl

71 Helicobacter (H.) suis causes gastric pathologies in both pigs and humans.

72 killed S. suis vaccine (group 6) prior to S. suis challenge or a single 2-ml intramuscular dose of an

73 sows were randomly assigned to Streptococcus suis challenge or control subgroups.

74 tion for three consecutive days following S. suis challenge was the most effective regimen for minimi

75 ion-only group and 5 of 23 piglets in the S. suis-challenge-only group (1 of 12 in trial 1 and 4 of 1

76 Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont M

77 role in the activation of neutrophils and S. suis clearance, which further reduced severe inflammatio

78 We identified a zoonotic S. suis clone that diverged from a non-zoonotic clone by me

79 imizing disease associated with PRRSV and S. suis coinfection.

80 duced mortality associated with PRRSV and S. suis coinfection.

81 isolates (no species name), B. canis, and B. suis, confirmed that all but the latter two species coul

82 The B. suis CtpA protein shared up to 77% homology with CtpA pr

83 n of glutamine (Gln) in the medium during H. suis culture.

84 tilocus sequence typing (MLST) scheme for S. suis developed in order to begin to address these issues

85 94 S. suis isolates obtained from various S. suis diseases and from asymptomatic carriage representin

86 Most of the piglets in the PRRSV-S. suis dual-infection group developed suppurative meningit

87 verall, 20 out of 22 piglets in the PRRSV-S. suis dual-infection group died within 1 week after chall

88 ustness of the core metabolic pathways in S. suis during the infection process.

89 We report a fatal case of Brucella suis endocarditis initially misdiagnosed by automated id

90 tance at < or =11 mm, and for Actinobacillus suis, Erysipelothrix rhusiopathiae, and Streptococcus su

91 Application of this method to six Brucella suis field isolates compared to the newly revised B. sui

92 ll as by a marked host range (e.g., Brucella suis for swine, B. melitensis for sheep and goats, and B

93 e sequences, the Haemobartonella spp. and E. suis formed a distinct clade more closely related to Myc

94 The sequence of E. suis from a pig in Illinois was identical to that from a

95 from Agrobacterium tumefaciens and Brucella suis (G-) and to the transfer protein TcpC from Clostrid

96 , and both reactions are catalyzed by the H. suis gamma-glutamyltranspeptidase (GGT).

97 Analysis of the B. suis genome reveals transport and metabolic capabilities

98 B. abortus, Brucella melitensis and Brucella suis; Group III was composed of Wb and S708 phages that

99 Labeling experiments with S. suis grown ex vivo in blood or cerebrospinal fluid refle

100 g isotopologue patterns in amino acids of S. suis grown under in vitro and ex vivo conditions.

101 Streptococcus suis has emerged as an important cause of bacterial meni

102 rate that the released proteins of larval T. suis have significant immunomodulatory capacities and ef

103 from Agrobacterium tumefaciens and Brucella suis Here, we studied the structure and function of TraE

104 istence of B. abortus, B. melitensis, and B. suis in mice up to 4 weeks after infection, since deleti

105 etracycline has been described for Chlamydia suis in pigs.

106 l role of PEP carboxylation for growth of S. suis in the host was supported by experiments with a PEP

107 fficacy and safety of the helminth Trichuris suis in therapy of ulcerative colitis.

108 plementation with Gln was shown to temper H. suis induced gastritis and epithelial (hyper)proliferati

109 showed clinical symptoms compatible with S. suis infection 24-48 hours after ingestion of SS2.

110 a more severe proinflammatory response to S. suis infection and increased the mortality rate, while i

111 nse, and the outcome of highly pathogenic S. suis infection in a mouse model.

112 A 21-day T. suis infection in four pigs induced a significant change

113 s to examine its effect on the outcome of S. suis infection.

114 ated in swine spleen cells in response to S. suis infection.

115 food-borne transmission in Asia, zoonotic S. suis infections are mainly occupational hazards elsewher

116 S. suis interaction with human and pig IEC correlates with

117 ore, B. melitensis but not B. abortus nor B. suis interfered with the invasive capacity of EVT-like c

118 Brucella suis is a causative agent of porcine brucellosis.

119 We found that B. suis is a highly divergent clade with extensive intraspe

120 Streptococcus suis is a neglected zoonotic pathogen that has to adapt

121 Streptococcus suis is a zoonotic swine pathogen and a major public hea

122 Streptococcus suis is an emerging swine-associated zoonotic agent that

123 Streptococcus suis is an emerging zoonotic pathogen, and causes sepsis

124 Streptococcus suis is an important pathogen of pigs and occasionally c

125 assical growth experiments, we found that S. suis is auxotrophic for Arg, Gln/Glu, His, Leu, and Trp

126 Brucella suis is the causative agent of swine brucellosis and is

127 suis, is a cysteine protease distinct from previous char

128 The cleavage patterns of DNA from S. suis isolated from the sows matched the cleavage pattern

129 matched the cleavage patterns of DNA from S. suis isolated from their respective pigs.

130 otential, we compared whole genomes of 98 S. suis isolates from human patients and pigs with invasive

131 sekeeping gene fragments from each of 294 S. suis isolates obtained from various S. suis diseases and

132 indicator of genetic relatedness between S. suis isolates, these findings suggest that capsular gene

133 Both for H. pylori and H. suis, it has been hypothesized that the degradation of G

134 retory (E/S) products of first-stage (L1) T. suis larvae (Ts E/S) using LC-MS/MS analysis and examine

135 Of note, infection by T. suis led to a significant shift in the metabolic potenti

136 e starvation induced adaptive response in S. suis makes a great contribution to understanding better

137 suggest that the Haemobartonella spp. and E. suis may be reclassified in the same genus in the family

138 stribution of disease-causing isolates of S. suis, most isolates previously characterized as of high

139 amplified from purified DNA of Eperythrozoon suis, Mycoplasma genitalium, and Bartonella bacilliformi

140 annosyldiacylglycerol found in Streptococcus suis or alpha-mannosylceramide demonstrated markedly les

141 previously identified as unique to either B. suis or B. melitensis were present in the B. abortus gen

142 eceived three weekly doses of 2500 Trichuris suis ova (n = 45) or placebo (n = 44) over 6 months.

143 Trichuris suis ova (TSO) have been tested for therapeutic applicat

144 o assess the safety or efficacy of Trichuris suis ova in allergies, inflammatory bowel diseases, mult

145 ormation supports further investigation of T suis ova in patients with immune-mediated diseases, part

146 Patients received 2500 Trichuris suis ova or placebo orally at 2-week intervals for 12 we

147 suggests that cytokines induced by Trichuris suis ova treatment do not alter allergic reactivity to p

148 C cytokine responses were not affected by T. suis ova treatment.

149 Trichuris suis ova were obtained from the US Department of Agricul

150 Eggs of the pig whipworm (Trichuris suis ova) have been shown to be safe in multiple studies

151 oduction of T. suis-specific cytokines in T. suis ova-treated participants, allergen-specific cytokin

152 a sub-cohort of randomized participants (T. suis ova-treated, n = 12, Placebo-treated, n = 10).

153 However, little is known about the S. suis population structure, the clonal relationships betw

154 es may be moving horizontally through the S. suis population.

155 B. suis primarily infects pigs and is pathogenic to humans.

156 disease, exposure to the helminth Trichuris suis reduces disease activity.

157 llous trophoblasts (EVTs), B. abortus and B. suis replicated within single-membrane acidic lysosomal

158 4 bp and 742,431 bp for M. haemofelis and M. suis, respectively, are typical of mycoplasma species, h

159 s MIT 94-022 and MZ 640285, and Helicobacter suis, respectively.

160 sults indicate that zoonotic potential of S. suis results from gene loss, recombination and horizonta

161 . abortus, Brucella melitensis, and Brucella suis results in rough, attenuated mutants which fail to

162 supplementation, and analyzed for Chlamydia suis S-45 infectivity.

163 T. suis secretes extremely high amounts of PGE2 (45-90 ng/m

164 We conclude that T. suis secretes PGE2 to suppress proinflammatory responses

165 The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammat

166 nged intranasally with 2 ml of Streptococcus suis serotype 2 (10(8.30) CFU/2 ml).

167 Streptococcus suis serotype 2 (S. suis 2) is a highly invasive pathoge

168 dercooked pork is a risk factor for human S. suis serotype 2 (SS2) infection.

169 Streptococcus suis serotype 2 is an encapsulated bacterium and one of

170 ydrogenase (GDH) enzymes of 19 Streptococcus suis serotype 2 strains, consisting of 18 swine isolates

171 Isolates of Streptococcus suis serotype 5 collected from three sows and nine of th

172 on with human and pig IEC correlates with S. suis serotype and genotype, which can explain the zoonot

173 r americanus) or porcine whipworm (Trichuris suis) show that they are safe and may be effective thera

174 es, an active component was purified from T. suis soluble products (TsSPs) that suppress---- TNF and

175 Treatment with Trichuris suis soluble products during monocyte-to-macrophage diff

176 Despite increased production of T. suis-specific cytokines in T. suis ova-treated participa

177 Our studies showed that smooth virulent B. suis strain 1330 (S1330) prevented programmed cell death

178 e with virulent B. abortus strain 2308 or B. suis strain 1330 but no protection against B. melitensis

179 lasma haemofelis strain Ohio2 and Mycoplasma suis strain Illinois, which are the first available geno

180 infected macrophages and rough attenuated B. suis strain VTRS1 (a vaccine candidate) induced strong m

181 ttle geographical clustering of different S. suis subpopulations, and the bacterium undergoes high ra

182 ation of ova from the pig whipworm Trichuris suis (T. suis; TSO) has been proposed for the treatment

183 sipelothrix rhusiopathiae, and Streptococcus suis tested on enriched chocolate Mueller-Hinton agar, s

184 sent crystal structures of VirB8 of Brucella suis, the causative agent of brucellosis, and ComB10, a

185 p)ppGpp in glucose starvation response in S. suis, the growth curves and transcriptional profiles wer

186 ova from the pig whipworm Trichuris suis (T. suis; TSO) has been proposed for the treatment of allerg

187 soluble products derived from the Trichuris suis (TsSP) significantly affect the differentiation of

188 administered with emulsifying adjuvants, S. suis type 2 CPS is able to induce potent IgM and isotype

189 gate prototypes were prepared by coupling S. suis type 2 CPS to tetanus toxoid, and the immunological

190 S. suis type II was recovered from their brains and joints.

191 nged intranasally with strain MN 87555 of S. suis type II.

192 ection and disease following challenge by S. suis type II.

193 dissect the central metabolic activity of S. suis under different conditions of nutrient availability

194 tramuscular doses of an autogenous killed S. suis vaccine (group 6) prior to S. suis challenge or a s

195 ort the complete genome sequence of Brucella suis VBI22, which was isolated from raw milk from an inf

196 ing organisms: Brucella melitensis, Brucella suis, Vibrio cholera, Yersinia pestis, and Francisella t

197 The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylor

198 Furthermore, B. suis was determined to be paraphyletic in our analyses,

199 The recombinant BgaC protein of S. suis was purified to homogeneity.

200 n and potential bioterrorism agent, Brucella suis, was determined.

201 nderstand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed

202 f H. felis, and two strains of Eperythrozoon suis were sequenced and compared.

203 cine proximal colon in response to Trichuris suis (whipworm) infection using 16S rRNA gene-based and

204 Comparison of B. suis with Brucella melitensis has defined a finite set o

205 We compared in vitro interaction of S. suis with human and porcine intestinal epithelial cells

206 Culture of T. suis with several cyclooxygenase (COX) inhibitors that i

207 milarity of the 16S rRNA gene sequence of E. suis with those of three Haemobartonella strains was 84