ライフサイエンスコーパス: sulfa

1 BAEPs are recorded at 6 or 24 h post-sulfa.

2 (50 mg/kg) administered 30 or 120 min after sulfa (200 mg/kg) in 16 days old jjs.

3 Sulfadimethoxine (sulfa) administration to jjs, which displaces bilirubin

4 precatalysts, a number of efficient carba-, sulfa-, and phospha-Michael additions were achieved very

5 ssociated uveitis, with special attention to sulfa class antibiotics, historically have been used to

6 designer drug consisting of sulfapyridine, a sulfa-containing antibacterial agent, and 5-amino-salicy

7 f such mutations in the United States, where sulfa-drug prophylaxis is widespread, to that in China,

8 of patients had DHPS mutations; 38% received sulfa-drug prophylaxis.

9 f patients had DHPS mutations; none received sulfa-drug prophylaxis.

10 Sulfa drugs are widely used in the treatment and prophyl

11 s have identified mutations in the target of sulfa drugs that appear to represent emerging resistance

12 ynthase gene (dhps), the enzymatic target of sulfa drugs used for PcP prevention and treatment.

13 tibacterial substances, organoarsenicals and sulfa drugs, but these were soon outshone by a host of m

14 mycin, cetylpyridinium chloride, and several sulfa drugs.

15 lving under positive selective pressure from sulfa drugs.

16 Minocycline administered prior to sulfa in jjs protects against BAEP abnormalities.

17 The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated al

18 Stereoselective sulfa-Michael addition of appropriately protected thioca

19 The mechanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona

20 honidine or cinchona alkaloid-urea catalyzed sulfa-Michael addition reactions, also applies to the ca

21 The products of the organocatalytic sulfa-Michael addition to alpha,beta-unsaturated alpha-a

22 ough C(aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination

23 Sulfa-Michael additions to alpha,beta-unsaturated N-acyl

24 of the alpha,beta-unsaturated ester, affords sulfa-Michael adducts in excellent yields (up to >99%) a

25 fones in a simple and reliable way through a sulfa-Michael reaction that proceeds with high yield and

26 sequential domino reactions, namely a domino sulfa-Michael/aldol condensation of alpha,beta-unsaturat

27 e scope of the procedure, some NHC-catalyzed sulfa-Michael/aldol organocascades were also investigate

28 A highly enantioselective cascade sulfa-Michael/Julia-Kocienski olefination reaction betwe

29 The minocycline 120 min post-sulfa (sulfa/mino+120) group had a significantly decreased ampl

30 The minocycline 30 min post-sulfa (sulfa/mino+30) group was not significantly different fro

31 -2-yl)-1,3-thiazol-2-yl]amino}pyrimidin-2-yl)sulfa nyl]octanoic acid) with IC50 = 0.3 and 0.4 muM, re

32 pneumonia (PCP) are affected by duration of sulfa or sulfone prophylaxis and influence response to s

33 In multivariate analysis, sulfa or sulfone prophylaxis and study site were indepen

34 in 76% of isolates from patients exposed to sulfa or sulfone prophylaxis compared with 23% of isolat

35 Thus, an increased duration of sulfa or sulfone prophylaxis increases the chance of dev

36 jority of patients with mutations respond to sulfa or sulfone therapy.

37 ulfone prophylaxis and influence response to sulfa or sulfone therapy.

38 e treatment; mutations increased the risk of sulfa or sulfone treatment failure (RR, 2.1; P=0.01).

39 ht percent of patients with mutations failed sulfa or sulfone treatment; mutations increased the risk

40 ed with 4% (3/76) of patients not exposed to sulfa prophylaxis (P=.017).

41 sing frequency and have been linked to prior sulfa prophylaxis and possible emergence of sulfa resist

42 association between DHPS mutations and prior sulfa prophylaxis and shows that the prevalence of DHPS

43 bserved in 19% (6/31) of patients exposed to sulfa prophylaxis, compared with 4% (3/76) of patients n

44 regions and are similar to those that cause sulfa resistance in other organisms.

45 ne are likely involved in the development of sulfa resistance in P. carinii.

46 tent with positive directional selection for sulfa resistance mutations.

47 sulfa prophylaxis and possible emergence of sulfa resistance.

48 The sulfa/saline treated jjs exhibited a significantly incre

49 The minocycline 120 min post-sulfa (sulfa/mino+120) group had a significantly decreas

50 The minocycline 30 min post-sulfa (sulfa/mino+30) group was not significantly differ

51 ed mutations in 16 of the 37 isolates; prior sulfa/sulfone prophylaxis was associated with the presen

52 The nucleotide sequences of the sulfa target enzyme, dihydropteroate synthase (DHPS), di

53 We present herein several sulfa-Tn antigens incorporated in MUC1 sequences that po