ライフサイエンスコーパス: sulfate chain

1 that catalyzes the formation of the heparan sulfate chain.

2 eavy chains (HC1 and HC2) on its chondroitin sulfate chain.

3 itin in addition to low-sulfated chondroitin sulfate chains.

4 se activity related to elongation of heparan sulfate chains.

5 can present in other tissues without keratan sulfate chains.

6 n bearing chondroitin sulfate and/or heparan sulfate chains.

7 ble of carrying both heparan and chondroitin sulfate chains.

8 f the poorly sulfated domains in its heparin sulfate chains.

9 e the different populations of short heparan sulfate chains.

10 vitro, an activity that requires chondroitin sulfate chains.

11 an core protein after the removal of keratan sulfate chains.

12 in many non-corneal tissues without keratan sulfate chains.

13 MR106 cells was substituted with chondroitin sulfate chains.

14 o in the length and sulfation of its keratan sulfate chains.

15 substitution of these proteins with keratan sulfate chains.

16 can found to contain large, sulfated keratan sulfate chains.

17 to the initiation and termination of heparan sulfate chains.

18 ain and the extended conformation of heparan sulfate chains.

19 ane, where TG2 also colocalized with heparan sulfate chains.

20 nctional differences in the attached heparan sulfate chains.

21 ies on both its core protein and its heparan sulfate chains.

22 y influencing total sulfation of the heparan sulfate chains.

23 iable number of attachment sites for heparan sulfate chains.

24 odified with chondroitin sulfate and heparan sulfate chains.

25 chains (CS) and normal sulfation of heparan sulfate chains.

26 removal or reduction in the size of heparan sulfate chains.

27 is affected by 6-O-sulfation of the heparan sulfate chains.

28 d for the addition of sulfate to the heparin sulfate chains.

29 Th2 cells in the lung through their heparan sulfate chains.

30 glycosyltransferases that synthesize heparan sulfate chains.

31 has been attributed largely to their heparan sulfate chains.

32 o proteoglycans is mediated by their heparan sulfate chains.

33 due to structural differences of the heparan sulfate chains.

34 n one or more heparan sulfate or chondroitin sulfate chains.

35 uctures or after enzyme digestion of heparan sulfate chains, a distinct network with a diffuse electr

36 n of N-syndecan that was modified by heparan sulfate chain addition.

37 how the pattern of sulfation along a heparan sulfate chain affects its turnover, we examined heparan

38 ccharides alone or with a single chondroitin sulfate chain alone; however, there is severely impaired

39 glycan substituted with a single chondroitin sulfate chain and N-linked oligosaccharides and a core p

40 Binding involves the chondroitin sulfate chains and a specific site on the first immunogl

41 Because syndecan-1 has heparan sulfate chains and because exogenous heparan sulfate has

42 athepsin L is independent of its chondroitin sulfate chains and is effective at both pH 5.5 and 7.2.

43 genesis only requires the syndecan-1 heparan sulfate chains and not the intact ectodomain, suggesting

44 e known KSPG proteins, modified with keratan sulfate chains and sulfated on both N-acetylglucosamine

45 ecan-1 to uropods is mediated by its heparan sulfate chains and that targeting is regulated by cell s

46 ase involved in the synthesis of chondroitin sulfate chains and the receptor for PDGFbeta, a growth f

47 microg/ml), enzymatic removal of the heparan sulfate chains, and by chlorate inhibition of glypican s

48 LON-2/glypican protein, lacking its heparan sulfate chains, and secreted forms of LON-2/glypican are

49 re considerably smaller than the chondroitin sulfate chains, and the heparan sulfate disaccharide con

50 and intracellular trafficking of the heparan sulfate chains appeared normal, and the chains degraded

51 ng is dramatically enhanced when the heparan sulfate chains are enzymatically degraded or absent from

52 The dermatan sulfate chains are known to stimulate thrombin inhibitio

53 However, when all three heparan sulfate chains are present, significantly greater biolog

54 m chlorate, indicating that sulfated heparan sulfate chains are required for nuclear translocation.

55 These results suggest that soluble heparan sulfate chains, as products of the degradation of hepara

56 encode the copolymerase required for heparan sulfate chain assembly.

57 ith heparanase action by binding the heparan sulfate chain at a sequence next to the cleavage site or

58 CR4 is efficiently modified by a chondroitin sulfate chain at serine 18, but neither HIV-1 entry nor

59 ntaining the central domain have chondroitin sulfate chains attached to the protein core.

60 Silencing lymphatic heparan sulfate chain biosynthesis inhibited VEGF-C-mediated Erk

61 nvasion is dependent on the syndecan heparan sulfate chains, but a role for the syndecan-1 ectodomain

62 protein requires the presence of the heparan sulfate chains, but the interaction appears to be relati

63 d at the reducing termini of the chondroitin sulfate chains by digestion with chondroitin ABC lyase,

64 CD44 isoforms bearing heparin sulfate chains can bind to HGF/SF and facilitate its pre

65 regulation of expression of two key heparan sulfate chain-carrying core proteins, syndecan-1 and syn

66 h VI and to correlate activity with dermatan sulfate chain composition and structure.

67 Conversely, chondroitin/dermatan sulfate chain concentrations were increased by 60-70% in

68 Keratan sulfate chain concentrations were reduced by approximate

69 Intact keratan sulfate chains derived from bovine tracheal cartilage ha

70 The results show that heparan sulfate chains differ between various members of the pro

71 which remove 6-O sulfate groups from heparan sulfate chains, diminishes myeloma tumor growth in vivo.

72 arinase III, an enzyme that degrades heparan sulfate chains, dramatically inhibited the growth of pri

73 er investigated the role of EXTL2 in heparan sulfate chain elongation by gene silencing and overexpre

74 in more detail the role of EXTL2 in heparan sulfate chain elongation, we tested the ability of the o

75 rmore, our data suggest that the chondroitin sulfate chain engenders APP with novel biological functi

76 estrogen, both perlecan protein and heparan sulfate chain expression markedly increase.

77 ce, and a mutated syndecan-1 lacking heparan sulfate chains fails to concentrate within uropods.

78 The sulfation pattern of the heparan sulfate chains formed during biosynthesis in the Golgi c

79 Chondroitin and dermatan sulfate chains from arthritic cartilages were of essenti

80 owever, enzymatic removal of the chondroitin sulfate chains from biglycan proteoglycan does not induc

81 y purified activities from releasing heparan sulfate chains from core proteins and degrading them to

82 sulfate structure, we have analyzed heparan sulfate chains from the different surface proteoglycans

83 Instead, the heparan sulfate chains from the mutant were relatively resistant

84 The newly synthesized chondroitin sulfate chains had a similar composition to the endogeno

85 The heparan sulfate chains (HS) mediate stable high affinity binding

86 with the cell surface through their heparan sulfate chains (HS), but it is not known if they are oth

87 Interestingly, cargo bound to sSDC1 heparan sulfate chains (i.e. hepatocyte growth factor) was trans

88 modification of keratocan with long keratan sulfate chains in cornea, suggests that this molecule ma

89 ance between chondroitin sulfate and heparan sulfate chains in dictating ligand responses with implic

90 In conclusion, the lack of Sdc4 heparan sulfate chains in the kidneys of Sdc4-null mice abrogate

91 from mutant cells cleaved wild-type heparan sulfate chains in vitro.

92 lent cations in concert with the chondroitin sulfate chain influence the structure and stability of i

93 The negatively charged heparan sulfate chains interact with a multitude of different pr

94 The chondroitin sulfate chain interacted with all protein components and

95 ction or amount of syndecan-1 or its heparan sulfate chains is a valid therapeutic approach for this

96 d show that overall sulfation of the heparan sulfate chains is more important than sulfation at parti

97 (heparanase), an enzyme that cleaves heparan sulfate chains, is expressed at high levels in some pati

98 cell line had little or no effect on heparan sulfate chain length.

99 es elongation resulting in increased heparan sulfate chain length.

100 mechanism requiring sulfation of chondroitin sulfate chains linked to CD44.

101 lycopeptide containing two different heparan sulfate chains, namely the extracellular domain of synde

102 This labeled KSPG contained keratan sulfate chains of 4700 Da compared to 21,000 Da for bovi

103 nal antibody primarily targeting the heparin sulfate chains of GPC3 inhibited Wnt/beta-catenin signal

104 which preferentially recognized the heparan sulfate chains of GPC3, both the sulfated and nonsulfate

105 g modification of the proteins with dermatan sulfate chains of increased sulfation.

106 glycan form substituted with two chondroitin sulfate chains of molecular mass approximately 34 kDa (H

107 proteins actually interact with the heparan sulfate chains of one or more membrane or extracellular

108 nding, suggesting the involvement of heparan sulfate chains of proteoglycan in the interaction.

109 idase that specifically degrades the heparan sulfate chains of proteoglycan, a component of blood ves

110 Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has

111 paranase, an enzyme that cleaves the heparan sulfate chains of proteoglycans, is upregulated in a var

112 We discovered that the heparan sulfate chains of syndecan-1 captured VEGF and also atta

113 iated by the binding of gp120 to the heparan sulfate chains of syndecan.

114 aminoglycans (GAGs), such as the chondroitin sulfate chains of the proteoglycan versican, have been s

115 bronectin, which are ligands for the heparan sulfate chains of the proteoglycan.

116 r the cell surface CSF-1 and the chondroitin sulfate chain on secreted proteoglycan CSF-1 during rena

117 f viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans.

118 The heparan sulfate chains on growth plate perlecan were considerabl

119 The chondroitin sulfate chains on neurocan and phosphacan account for at

120 d bikunin covalently joined by a chondroitin sulfate chain originating at Ser-10 of bikunin.

121 uronic acid, keratan sulfate, or chondroitin sulfate chains over the concentration range studied.

122 ndicate that O-sulfate groups on the heparan sulfate chains play a critical role in heparin interacti

123 or the GDF-8 prodomain is likely the heparan sulfate chain present on perlecan domain V.

124 We have discovered that the heparan sulfate chains present on syndecan core proteins suppres

125 for this process by analyzing short heparan sulfate chains produced in vivo by Chinese hamster ovary

126 Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signaling, li

127 nonreducing termini of aggrecan chondroitin sulfate chains revealed important changes in chain termi

128 cetate increases the size of the chondroitin sulfate chain(s) attached to CD44 but not the proportion

129 Structural analysis of the heparan sulfate chains showed that 3-OST-1 generates sequences c

130 l brain endothelial cell HSPGs carry heparan sulfate chains similarly capable of forming a ternary co

131 Keratan sulfate chain size was reduced to 3-4 disaccharides; cha

132 Chondroitin/dermatan sulfate chain sizes were also decreased in all diseased

133 ity for endothelial-derived perlecan heparan sulfate chains than serglycin GAG chains.

134 In addition to its heparan sulfate chains, the core protein of syndecan-1 was also

135 ese findings assign new functions to heparan sulfate chains, thereby broadening our understanding of

136 The contribution of chondroitin sulfate chains to the binding of neurocan and phosphacan

137 V-1 entry depends on (1) presence of heparan sulfate chains to which virus can bind and (2) 3-O-sulfa

138 ; the presence of fully digested chondroitin sulfate chains was established.

139 ture, the amount of perlecan bearing heparan sulfate chains was unaffected by TGF-beta1 and decreased

140 The levels of perlecan bearing chondroitin sulfate chains were elevated with TGF-beta1 treatment an

141 ted syndecans having two, one, or no heparan sulfate chains were expressed in ARH-77 cells.

142 omponent of this network whereas its heparan sulfate chains were integrated into the collagen IV-cont

143 Alkaline borohydride-reduced keratan sulfate chains were isolated from human articular cartil

144 Short heparan sulfate chains were purified from CHO cells and labeled

145 -1080 cells was substituted with chondroitin sulfate chains, whereas about 50% of the biglycan expres

146 amily, are coupled to the N-terminal heparan sulfate chains, which augment high affinity binding and

147 glycan form substituted with two chondroitin sulfate chains with a median molecular mass approximatel

148 These proteins bear dermatan sulfate chains with increased sulfation compared with no

149 ans was examined by treating the [3H]heparan sulfate chains with nitrous acid or bacterial heparin ly

150 id bilayer, proteoglycan dimers, and heparan sulfate chains with realistic sequences.