ライフサイエンスコーパス: sulfated

1 nd 12 metabolites (methylated, glucuronided, sulfated).

2 S was significantly increased and abnormally sulfated.

3 primary CD4(+) T cells is inherently highly sulfated.

4 nd this glycosaminoglycan was 2,6-O- and 3-O-sulfated.

5 e remaining 23, 21 were tested, and all were sulfated.

6 The highly sulfated (1-->3)-alpha-l-fucan from S. cichorioides was

7 Sulfated 2-acrylamido-2-methyl-1-propanesulfonic acid (A

8 A highly sulfated 3-linked beta-arabinan (Ab1) with arabinose in

9 in the fibromodulin N-terminal domain are O-sulfated, a posttranslational modification often involve

10 f trisulfated glucosamine [N-, 3-O-, and 6-O-sulfated] (A*) is bifurcated, owing to the presence of A

11 rbed on Bronsted acidic sulfated ZrO2 (ZrS), sulfated Al2O3 (AlS), and ZrO2-WO3 (ZrW).

12 To discover promising sulfated allosteric modulators (SAMs) of glycosaminoglyc

13 Carrageenans are sulfated alpha-1,3-beta-1,4-galactans found in the cell

14 r(CH(3))(3) adsorbed on Bronsted superacidic sulfated alumina (AlS).

15 CR5 mutants severely damaged in the tyrosine-sulfated amino terminus or extracellular loop 2.

16 ] with aqueous sulfuric acid to generate its sulfated analogue, MOF-808-2.5SO4 [Zr6O5(OH)3(BTC)2(SO4)

17 To limit intestinal absorption, C7-sulfated analogues designed to avoid active and passive

18 We discover 20 sulfated and 4 acetylated N-glycans on IgGs.

19 This library covers 4-O-sulfated and 6-O-sulfated oligosaccharides ranging from

20 lso identified an HPLC peak corresponding to sulfated and glucuronidated estradiol in serum from wild

21 both sources, including structures carrying sulfated and methylated variants of the histo-blood grou

22 n TPST and peptides around tyrosines of both sulfated and non-sulfated proteins to differentiate them

23 the heparan sulfate chains of GPC3, both the sulfated and nonsulfated portions.

24 Based on the controlled production of both sulfated and nonsulfated variants in plants, we could un

25 ular assemblies containing various original, sulfated, and carboxylated polysaccharides.

26 ormones and processes it to a unique, triple-sulfated, and N-terminally truncated product distinct fr

27 These results show that this novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity

28 Less sulfated arabinans obtained from the same seaweed have l

29 up to dodecasaccharide, as well as a highly sulfated Arixtra-like heptamer.

30 ed library led to the identification of 6, a sulfated aromatic mimetic of heparin.

31 one composed of 3-alpha-Glc1 units partially sulfated at 2- and 4-positions and branches of Pyr(4,6)a

32 of which two are sulfated at C-3 and one is sulfated at C-2.

33 dihydroxypent-4-enoic acid, of which two are sulfated at C-3 and one is sulfated at C-2.

34 of repetitive disaccharide units that can be sulfated at specific positions by heparan sulfate O-sulf

35 Our work presents the sulfated benzofuran scaffold as a promising framework to

36 gnition between the two structurally related sulfated benzofurans.

37 because of the unique positioning of the 3-O-sulfated beta-galactose headgroup.

38 method is illustrated by the synthesis of a sulfated beta-mannuronic acid disaccharide.

39 Loading also increased with content of sulfated BP in microspheres.

40 Sulfated BP-PLGA microspheres were capable of loading LY

41 The peak at m/z 433 is also sulfated, but it contains an additional oxygen, as confi

42 eas the major bile salts in adult liver were sulfated C27 bile alcohols.

43 ited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a beta-galact

44 of Siglec-8 toward different sialylated and sulfated carbohydrate ligands and determined the structu

45 structures, langerin has the ability to bind sulfated carbohydrate ligands as 6-sulfated galactosides

46 HIV-1 entry by adding or removing a tyrosine-sulfated CCR5 peptide from the culture medium.

47 fluenza virus particles using novel magnetic sulfated cellulose particles is presented and compared t

48 rifugation method, use of the novel magnetic sulfated cellulose particles reduced the influenza A vir

49 ) B cells release ACh after stimulation with sulfated cholecystokinin but not norepinephrine.

50 ions and increased concentrations of the non-sulfated chondroitin disaccharide D0a0 and the disacchar

51 This nematode produces large amounts of non-sulfated chondroitin in addition to low-sulfated chondro

52 method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans usi

53 non-sulfated chondroitin in addition to low-sulfated chondroitin sulfate chains.

54 for these complexes; indeed, for the highly sulfated chondroitin sulfate motifs, CS-E and CS-D, ther

55 parated mixtures, with a particular focus on sulfated compounds.

56 were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic ac

57 We have examined the effect of increased sulfated content of galactosylceramides (sulfatides) on

58 2 as the site of binding for the most potent sulfated coumarin.

59 Overall, sulfated coumarins represent first-in-class, sub-maximal

60 thrombin was impaired in the presence of the sulfated coumarins suggesting that allosteric partial in

61 We synthesized a focused library of some 36 sulfated coumarins to discover two agents that display s

62 eport demonstrates the use of differentially sulfated CS chains for neuronal navigation.

63 M NaCl) were found to predominantly contain sulfated CS disaccharides, including disulfated disaccha

64 (0.1-0.5 M NaCl) contained unsulfated and 4-sulfated CS disaccharides.

65 M NaCl and found to contain unsulfated and 4-sulfated CS disaccharides.

66 We could indeed detect sulfated CS in both wild type and mutant nematodes.

67 ere analyzed for their reactivity with the 4-sulfated CS linkage region antibody (2B6).

68 also describe the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing either a 6-O-sul

69 Here, we identified a sulfated derivative of the Escherichia coli polysacchari

70 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both

71 iched in galactosylceramide (GalCer) and its sulfated derivative sulfatide.

72 group of LC-PCBs and their hydroxylated and sulfated derivatives by selective displacement of the fl

73 rmore, analysis of a minilibrary of variably sulfated derivatives of Escherichia coli K5 polysacchari

74 ccharide to be converted into 12 differently sulfated derivatives.

75 -sulfotransferases-1 (3-OST1) to provide 3-O-sulfated derivatives.

76 companied by a decrease in iduronic acid 2-O-sulfated disaccharide structures.

77 ts displayed a relative increase in mono-6-O-sulfated disaccharides accompanied by a decrease in idur

78 parallel increase in iduronic acid mono-2-O-sulfated disaccharides.

79 The tyrosine-sulfated domain and the leucine-rich repeat domain both

80 gth fibromodulin and its N-terminal tyrosine-sulfated domain purified from tissue, as well as recombi

81 pro-pathogenic activity is dependent on 2-O-sulfated domains in HS, indicating that the effects of s

82 These results demonstrate that 2-O-sulfated domains in syndecan-1 HS halt disease progressi

83 VEGFA and proteoglycan co-receptors require sulfated domains in the HS chains.

84 d length are used as chemical analogs of the sulfated domains of heparan sulfate and examined for the

85 Altering specific 3-O-sulfated epitopes provides a mechanism to rapidly respon

86 effects of different PGs and their assorted sulfated epitopes.

87 s for urinary estrus signals, as well as for sulfated estrogen (SE) compounds.

88 Thus we have shown that excess overly sulfated extracellular HS binds, and sequesters CXCL12,

89 posed mechanisms of sulfatase catalysis is a sulfated FGly intermediate.

90 Interestingly, sulfated fibulin 2 significantly reduced the rate of cel

91 gene, dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S), and characteristics of attention

92 CFH binds more strongly to heparin (a highly sulfated form of HS) than CCP19-20, and that their sulfa

93 portantly, the peptide is only active in the sulfated form, further confirming the importance of the

94 aran sulfate occurring in N-acetylated and N-sulfated forms, and as the unmodified amine.

95 te OH stretches, as a means to differentiate sulfated from phosphorylated peptides within the framewo

96 es, including the characterization of labile sulfated functional groups.

97 Surprisingly, even sulfated fungal Myc-LCOs and Sinorhizobium meliloti Nod-

98 y controlling Wnt3a availability through its sulfated GAG chains.

99 emely mild matrix for the analysis of highly sulfated GAG disaccharides by infrared matrix-assisted l

100 several micrograms), particularly for highly sulfated GAG ions.

101 The sulfated GAG oligosaccharides derived from cartilage pos

102 This research establishes that chicken sulfated GAG polysaccharides can enhance iron uptake by

103 Both the cartilage and skin sulfated GAG polysaccharides showed greater ferritin for

104 Heparin, the most highly sulfated GAG, binds sCT in the pH interval 3-7.

105 nt positive charge, and its interaction with sulfated GAG-polymers were quantitatively investigated u

106 Enzymatic digestion of sulfated GAGs canceled their effects on trigeminal neuro

107 While no sulfated GAGs have been found in marine sponges, chondro

108 ate highly informative EDD spectra of highly sulfated GAGs on the liquid chromatography (LC) timescal

109 HSV-1 recognized all sulfated GAGs, but not the nonsulfated hyaluronan, indic

110 several classes of GAGs; however, the highly sulfated GAGs, such as heparins, have remained a relativ

111 n inexpensive, colorimetric urinary assay of sulfated GAGs.

112 ghput, de novo structural analyses of highly sulfated GAGs.

113 tain polyanionic, low-methylated pectins and sulfated galactans, a feature shared with the cell walls

114 alactosamine dominated, we also detected 6-O-sulfated galactosamine residues.

115 rmed by unique loop regions, recognizing 6-O-sulfated galactose dictates tight specificity distinct f

116 group antigens, and glycans with terminal 6-sulfated galactose.

117 y to bind sulfated carbohydrate ligands as 6-sulfated galactosides in the Ca(2+)-dependent binding si

118 Sulfated galactosylceramides (sulfatides) are glycosphin

119 o receive the N-acetyl and sulfate groups of sulfated GalNAc residues of glycosaminoglycans such as c

120 tion and possible developmental roles of 2-O-sulfated GlcA (GlcA2S).

121 epolymerized for compositional analysis, 3-O-sulfated glucosamine at the reducing ends appears to be

122 hat specifically degrades HS chains with 3-O-sulfated glucosamine at the reducing-end.

123 critically depend on the distribution of 6-O-sulfated glucosamine residues, which is generated by glu

124 in the peptide backbone and acid sensitive O-sulfated glycan chains.

125 ycopeptide containing aspartic acid and an O-sulfated glycan was synthesized.

126 ed Bacteroides species, to metabolize highly sulfated glycans (i.e. mucins and glycosaminoglycans (GA

127 Human naive and memory B-cells express sulfated glycans as high affinity CD22 ligands, which ar

128 similar applications based on permethylated sulfated glycans have not been fully investigated.

129 Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the ident

130 based nanoLC-MS/MS analysis of permethylated sulfated glycans in negative ion mode and demonstrate th

131 ) are a class of heterogeneous, often highly sulfated glycans that form linear chains consisting of u

132 Sulfated glycans were selectively recovered from the aqu

133 ed mucin preparations carried sialylated and sulfated glycans, bound to eosinophils and induced their

134 an easy way to separate and hence enrich the sulfated glycans.

135 exchange cartridges facilitated detection of sulfated glycans.

136 pathways and action mechanisms via distinct sulfated glycoconjugate-mediated processes.

137 ted to suggest that the shifting between the sulfated glycoconjugates as distinct targets of CTX A2,

138 ins as well as enhanced expression of MECA79 sulfated glycoepitope at the luminal aspect of HEVs, thu

139 ugh interactions with adhesion receptors and sulfated glycolipids (Figure 1, bottom).

140 We report here on supramolecular sulfated glycopeptide nanostructures, which display a tr

141 ursor to produce a variety of differentially sulfated glycopolymers.

142 oprotective factor prosaposin (also known as sulfated glycoprotein-1), we purified full-length prosap

143 Food grade sulfated glycosaminoglycan (GAG) polysaccharides were su

144 osition of AF-specific extracellular matrix (sulfated glycosaminoglycan and collagen type I), indicat

145 result from differences in intracellular HA, sulfated glycosaminoglycan concentration, apoptosis, or

146 ed by 36 and 30%, respectively, and SDC4 and sulfated glycosaminoglycan in the culture medium were in

147 Heparin is a highly sulfated glycosaminoglycan that shares a common biosynth

148 K is promoted by chondroitin sulfate (CS), a sulfated glycosaminoglycan.

149 that specifically degrade heparan sulfate, a sulfated glycosaminoglycan.

150 riments (BIAcore) determined that DMAV binds sulfated glycosaminoglycans (e.g. heparin, KD ~100 nmol/

151 Degraded fragments of sulfated glycosaminoglycans (GAGs) are key reporters for

152 Structural characterization of highly sulfated glycosaminoglycans (GAGs) by collisionally acti

153 y langerin was demonstrated to interact with sulfated glycosaminoglycans (GAGs), in a Ca(2+)-independ

154 importance of tissue-specifically expressed, sulfated glycosaminoglycans (GAGs), like HS, in determin

155 ients that are achieved by interactions with sulfated glycosaminoglycans (GAGs).

156 Proteoglycans are proteins that carry sulfated glycosaminoglycans (GAGs).

157 ned by our demonstrated N6L interaction with sulfated glycosaminoglycans and consequently the control

158 IMP-3 K26A/K45A retained higher affinity for sulfated glycosaminoglycans than K42A/K110A and exhibite

159 Highly sulfated glycosaminoglycans within the cartilage matrix

160 g of CpClec-Fc was specifically inhibited by sulfated glycosaminoglycans, particularly heparin and he

161 osomal sulfatases involved in degradation of sulfated glycosaminoglycans.

162 e and sialyl-globotetraosylceramide, and the sulfated glycosphingolipids sulfatide, sulf-lactosylcera

163 ochemistry, and electron microscopy, whereas sulfated glycosphingolipids were only found in intracell

164 fication of various fucosylated, sialylated, sulfated glycotopes and definitive determination of the

165 ct patients revealed that circulating highly sulfated heparan fragments persisted for greater than 3

166 lines of evidence suggested the role of 3-O-sulfated heparan sulfate (3-OS HS) during HCMV-mediated

167 lope glycoprotein D (gD) to the receptor 3-O-sulfated heparan sulfate (3-OS HS) mediates viral entry.

168 of cells in sodium chlorate, indicating that sulfated heparan sulfate chains are required for nuclear

169 both NDST1 and NDST2, expressing a very low sulfated heparan sulfate, can take the initial step towa

170 decreased glomerular expression of a highly sulfated HS domain, and albuminuria.

171 ografts we found increased expression of 6-O-sulfated HS domains in tubular epithelial cells during c

172 e cleaves at the non-reducing side of highly sulfated HS domains, exposing cryptic growth factor bind

173 To examine the role of 6-O-sulfated HS in the development of fibrosis, we generated

174 GAGs from Idua(-/-) BM and specifically 2-O-sulfated HS, elevated in Idua(-/-) BM, both inhibited CX

175 thelial cells and that these effects require sulfated HS.

176 Enzymes generating a specific type of 3-O-sulfated-HS (3-O-HS) are enriched, and fibroblast growth

177 ed binding region to chondroitin sulfate and sulfated hyaluronan but not to the non-sulfated hyaluron

178 e and sulfated hyaluronan but not to the non-sulfated hyaluronan, confirming binding specificity.

179 fate) and compared our results to chemically sulfated hyaluronan.

180 ot require compounds such as hydrocarbons or sulfated hydrocarbons, however, it cannot be explained o

181 Four new metabolites of PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and glucuronidated

182 rides, suggesting that the disaccharide; 2-O-sulfated iduronic acid linked to 6-O-sulfated N-glucosam

183 Both antibodies were efficiently sulfated in planta on coexpression of an engineered huma

184 ally modified by tyrosine sulfation, and the sulfated isoform is present outside the cell, whereas th

185 the HS structure revealed that the highly O-sulfated K5 polysaccharides inhibited HMPV infection, id

186 Heparan sulfate, a sulfated linear polysaccharide modified in a complex var

187 s to HA, suggesting that the CS containing 4-sulfated linkage region structures and disulfated disacc

188 face via interactions with surface-localized sulfated lipid and protein receptors.

189 Thus, other, as-yet unidentified sulfated macromolecules must contribute to infection.

190 e mass measurement confirmed m/z 417 to be a sulfated metabolite of glyceollins.

191 Interactions of these sulfated metabolites of LC-PCBs with HSA, however, have

192 Several acetylated, hydroxylated, and/or sulfated metabolites were identified, some of which were

193 etabolites, together with glucuronidated and sulfated metabolites, were detected.

194 Here, we report superacidity in a sulfated metal-organic framework (MOF) obtained by treat

195 ed by tremendous structural heterogeneity of sulfated modifications.

196 We conclude that interaction with the sulfated N terminus of CCR2 destabilizes the dimerizatio

197 de; 2-O-sulfated iduronic acid linked to 6-O-sulfated N-glucosamine, which contains a free amine at p

198 sferase-1 (GlcNAc6ST-1) failed to synthesize sulfated N-glycans and exhibited abnormal myelination an

199 Here, we report that sulfated N-glycans are involved in peripheral nervous sy

200 Major sulfated N-glycans were identified in both porcine and m

201 ie-Tooth neuropathy, has abundant GlcNAc-6-O-sulfated N-glycans.

202 myelin glycoproteins contain highly abundant sulfated N-glycans.

203 to be responsible for the degradation of 3-O-sulfated N-sulfoglucosamine residues of heparan sulfate

204 se residues as well as from an authentic 3-O-sulfated N-sulfoglucosamine standard.

205 ping using the MCP-1 mutants showed that the sulfated N-terminal region of CCR2 binds to the same reg

206 of human-, swine-, and avian-origin viruses; sulfated Neu5Acalpha2-3 substructures were associated wi

207 Because sulfated neurosteroids also modulate NMDARs, here we exa

208 ilar to cationic channel blockers but unlike sulfated neurosteroids, DPA antagonism was voltage depen

209 n-6) polyunsaturated fatty acids (PUFAs), 2) sulfated neurosteroids, which play a role in brain devel

210 re essential for growth and development; low sulfated neurosteroids, which play a role in brain devel

211 y a mechanism indistinguishable from that of sulfated neurosteroids.

212 d both undersulfated (NA) domains and highly sulfated (NS) domains as well as very well defined non-r

213 Also, nearly 100% of the sulfated O-linked glycans were recovered in the aqueous

214 ed to carry high densities of sialylated and sulfated O-linked glycans.

215 try (MALDI MS), for quantitative analysis of sulfated oligosaccharides in biological samples.

216 Three sulfated oligosaccharides of natural origin were chosen

217 This library covers 4-O-sulfated and 6-O-sulfated oligosaccharides ranging from trisaccharides to

218 First, sulfated oligosaccharides such as chondroitin-4-sulfate

219 tures of oligo-porphyrans, a class of highly sulfated oligosaccharides.

220 method for detection and characterization of sulfated oligosaccharides.

221 It comprised major amounts of units sulfated on C-2 and C-4 and constitutes the first polysa

222 receptors are commonly post-translationally sulfated on tyrosine residues in their N-terminal region

223 s expand the "cationic" metal center-anionic sulfated oxide surface distances, and this separation/we

224 f PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and glucuronidated PCMC) were identified

225 But only one metabolite, sulfated PCMC, was confirmed in wastewater and in urine.

226 We recently introduced sulfated pentagalloylglucopyranoside (SPGG) as an allost

227 We present the discovery of sulfated pentagalloylglucoside (6) as a highly selective

228 e-sulfated region) when the soluble tyrosine-sulfated peptide is present, we show that HIV-1JRCSF wit

229 nthomonas oryzae pv. oryzae (Xoo) produces a sulfated peptide named RaxX, which shares similarity to

230 In two-dimensional NMR experiments, sulfated peptides derived from the N-terminal region of

231 at variations in sequences and structures of sulfated peptides.

232 measurements of self-binding forces of this sulfated polysaccharide and their chemically desulfated

233 Heparin is a linear, highly sulfated polysaccharide consisting of alternating glucos

234 and of purified calcium spirulan (Ca-SP), a sulfated polysaccharide contained therein.

235 Fucoidan, a sulfated polysaccharide from Fucus vesiculosus, decrease

236 rotein 2 significantly more than the natural sulfated polysaccharide heparin, and promoted regenerati

237 Heparan sulfate (HS) is a sulfated polysaccharide that decorates cell surface and

238 Heparan sulfate (HS) is a linear sulfated polysaccharide that is a component of the cell

239 Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiologic

240 Its sulfated polysaccharide units, which were characterized

241 ferent from those found previously for other sulfated polysaccharides and glycosaminoglycans.

242 with binding domains for the highly diverse sulfated polysaccharides are important growth factors in

243 m-dependent multivalent self-interactions of sulfated polysaccharides components of extracellular mem

244 The sulfated polysaccharides from brown algae - the fucoidan

245 The highly sulfated polysaccharides heparin and heparan sulfate (HS

246 Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of p

247 glycosaminoglycans (GAGs), a class of linear sulfated polysaccharides which are present on most anima

248 in infection in relevant models, we utilized sulfated polysaccharides, heparan sulfate mimetics, and

249 ysaccharides alginates and fucose-containing sulfated polysaccharides.

250 n between ICP-associated levels of the 3beta-sulfated progesterone metabolite epiallopregnanolone sul

251 Here we report that the 3beta-sulfated progesterone metabolite epiallopregnanolone sul

252 Our discovery that sulfated progesterone metabolites are a prognostic indic

253 t cause cholestasis are not known but 3alpha-sulfated progesterone metabolites have been shown to be

254 ed in ICP, leading us to study the impact of sulfated progesterone metabolites on farnesoid X recepto

255 dynamics simulation of model tripeptides and sulfated protein complexes, potentials of mean force for

256 is essentially unknown how the formation of sulfated protein-binding domains in HS can be regulated

257 only a small fraction of the total predicted sulfated proteins has been identified to date.

258 imilar procedures can be applied to identify sulfated proteins in yeast and human proteome microarray

259 es around tyrosines of both sulfated and non-sulfated proteins to differentiate them.

260 Among the 4256 E. coli K12 proteins, 875 sulfated proteins were identified using antisulfotyrosin

261 curring amyloid deposits are associated with sulfated proteoglycans and other factors.

262 Heparan and chondroitin/dermatan sulfated proteoglycans have a wide range of roles in cel

263 potential for interactions with membranes or sulfated proteoglycans is lacking and it is possible tha

264 nd infection via Ca(2+)-dependent binding to sulfated proteoglycans on intestinal epithelial cells.

265 re was significantly less total collagen and sulfated proteoglycans present in the type VI collagen-d

266 rter that promotes a ventral accumulation of sulfated proteoglycans, which is required for ventral PM

267 XIa), we screened a library of 26 synthetic, sulfated quinazolin-4(3H)-ones (QAOs) resulting in the i

268 Here we found that a synthetic sulfated RaxX derivative comprising 13 residues (RaxX13-

269 terminal amino acids, including the tyrosine-sulfated region) when the soluble tyrosine-sulfated pept

270 -O sulphate group from glucosamine in highly sulfated regions of HS chains.

271 remove 6-O-sulfate groups within the highly sulfated regions on HS.

272 S from NMuMG cells contained frequent highly sulfated regions, whereas the non-bound material demonst

273 as the non-bound material demonstrated fewer sulfated regions.

274 tic cleavage of the glycoside bond between 3-sulfated rhamnose and uronic acid according to a beta-el

275 of disaccharide building blocks comprising 3-sulfated rhamnose linked to d-glucuronic acid (GlcUA), l

276 s that preferentially bind anionic residues (sulfated rhamnose, glucuronic/iduronic acid).

277 tween amino acids of viral glycoproteins and sulfated saccharides on the GAG chain.

278 HS is composed of sulfated saccharides that are biosynthesized through a c

279 We used an mAb and/or a multimeric synthetic sulfated sialoglycan ligand recognizing Siglec-8 in comb

280 s positively charged molecules on the highly sulfated side chains of aggrecan.

281 Third, the sulfated SK (sSK) and sSK-related peptides were more pot

282 designed a group of novel exosite-2-directed sulfated, small, allosteric inhibitors of thrombin.

283 arin showed marginal competition with highly sulfated SPGG variants but robust competition with less

284 Maps to a panel of sulfated steroid odorants identified tightly juxtaposed

285 based PXR antagonists inspired by the marine sulfated steroids solomonsterol A and B as natural leads

286 ich range from small, volatile molecules and sulfated steroids to large families of proteins.

287 Using mixtures of sulfated steroids, key constituents of urine, we found t

288 rder of hydrophilicity, with the more highly sulfated structures eluting first.

289 in two serotypes suggesting a propensity for sulfated-sugar binding.

290 sponses as intact heparin, (ii) that a fully sulfated tetrasaccharide isolated from bacterial heparin

291 f the Delta-2S-iduronate to expose the fully sulfated trisaccharide (GlcNS(6S)-IdoUA(2S)-GlcNS(6S)) d

292 l efficacy of PG9 and RSH is the presence of sulfated tyrosine residues in their antigen-binding regi

293 eptides in the PSY (plant peptide containing sulfated tyrosine) family.

294 sess this, we synthesized SbO4L based on the sulfated tyrosine-containing sequence of GPIbalpha.

295 second variable loop (V2) of gp120 contains sulfated tyrosines (Tys173 and Tys177) that in the CD4-u

296 rm, further confirming the importance of the sulfated tyrosines for function.

297 d variable loop (V3), functionally mimicking sulfated tyrosines in CCR5 and anti-coreceptor-binding-s

298 GG variants but robust competition with less sulfated variants.

299 t Cp*ZrBz2 /ZrS (Cp*=Me5 C5 , Bz=benzyl, ZrS=sulfated zirconia) catalyzes the single-face/all-cis hyd

300 complexes are chemisorbed on Bronsted acidic sulfated ZrO2 (ZrS), sulfated Al2O3 (AlS), and ZrO2-WO3