ライフサイエンスコーパス: sulfo group

1 ne unit carrying either a 3-O-sulfo or a 6-O-sulfo group.

2 accharide sequence containing a critical 3-O-sulfo group.

3 ride composition and content and position of sulfo groups.

4 onic acid linked to glucosamine carrying 6-O-sulfo groups.

5 oligosaccharides with precisely located 6-O-sulfo groups.

6 acid) linked to glucosamine carrying various sulfo groups.

7 g oligosaccharides with different numbers of sulfo groups.

8 on laser irradiation, reflecting lability of sulfo groups.

9 ated, in part, with the solvolytic loss of N-sulfo groups.

10 kinetic studies showed that loss of the 3-O-sulfo group affected both the ability of the pentasaccha

11 Alexa Fluor 350, a coumarin tag containing a sulfo group, along with guanidation of epsilon-amino gro

12 ified heparins showed that the presence of N-sulfo groups and either 2- or 6-O sulfo groups were requ

13 ght or more saccharide residues with seven O-sulfo groups and four N-sulfo groups exhibited potent in

14 osamine residue of heparan sulfate can carry sulfo groups at the 2-N, 3-O, and 6-O positions, leading

15 strength and pH showed that loss of the 3-O-sulfo group caused a massive approximately 60% loss in b

16 esults in up-regulation of 2-O-, 6-O-, and N-sulfo group-containing disaccharides, further emphasizin

17 ides and resistant tetrasaccharides with 3-O-sulfo group-containing glucosamine residues at their red

18 The content of 3-O-sulfo group-containing tetrasaccharides in a heparin cor

19 block copolymers containing S-domains (high sulfo group content) placed adjacent to N-domains (low s

20 p content) placed adjacent to N-domains (low sulfo group content) were chemoenzymatically synthesized

21 esidues with seven O-sulfo groups and four N-sulfo groups exhibited potent inhibition.

22 2-O-sulfotransferase (HS-2OST) transfers the sulfo group from 3'-phosphoadenosine 5'-phosphosulfate (

23 These findings demonstrate that the 3-O-sulfo group functions as a key determinant of heparin pe

24 luor 350, a coumarin derivative containing a sulfo group (i.e., bearing strong negative charge), show

25 To elucidate the role of the 3-O-sulfo group in the activation mechanism, we compared the

26 that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin

27 ethod for controlling the positioning of 6-O-sulfo groups in oligosaccharides.

28 determination of chain length and number of sulfo groups in the intact GAGs.

29 This sulfo group interacts with the guanidinium group of Arg1

30 350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with

31 The location of the sulfo group of S-pyr is postulated to mimic the phosphon

32 to proceed through hydride transfer and the sulfo group of the oxidized and reduced molybdenum cente

33 ronic acid monosaccharides or the N- and 6-O-sulfo groups of the glucosamine sulfate monosaccharides.

34 ys-146, and Arg-147 from apoE and N- and 6-O-sulfo groups of the glucosamine units from the heparin f

35 dues make direct contact with either the 2-O-sulfo groups of the iduronic acid monosaccharides or the

36 drogen bonding distances to the carboxyl and sulfo groups of the uronic acid unit.

37 (o) The enhancement of enzyme affinity by a sulfo group on C-6 of Gal was demonstrated by an increas

38 In contrast, 6-O-sulfo groups on HS are likely excluded by steric and ele

39 This requirement for the N-acetyl or N-sulfo groups on the glucosamine substrate can be explain

40 we compared the effects of deleting the 3-O-sulfo group or mutating the Lys(114) binding partner of

41 the detection and localization of the lost N-sulfo groups, potentially providing valuable insights in

42 ementary to heparan sulfate rich in N- and O-sulfo groups such as that found in the liver and the bra

43 O-sulfotransferase (2OST) that transfers the sulfo group to the 2-OH position of iduronic acid (IdoA)

44 HS 2-O-sulfotransferase (2OST) transfers the sulfo group to the 2-OH-position of glucuronic or iduron

45 ferase (3-OST) is an enzyme that transfers a sulfo group to the 3-OH position of a glucosamine unit.

46 2-O-sulfotransferase (CS-2OST) transfers the sulfo group to the hexauronic acid that is adjacent to N

47 The product ions resulting from the sulfo-group transfers were characterized by MS(3) experi

48 sence of N-sulfo groups and either 2- or 6-O sulfo groups were required for inhibition of toxicity.

49 Sulfo groups were transferred from adenosine 3'-phosphat