ライフサイエンスコーパス: sulfonamide

1 tional mechanism of the ion transport by bis(sulfonamides).

2 cropollutants (i.e., diclofenac and targeted sulfonamides).

3 ch we refer to as SPLAMs (splicing inhibitor sulfonamides).

4 peting reduction of the azide substrate to a sulfonamide.

5 ty over hNaV1.5 comparable to the heteroaryl sulfonamide.

6 idation of the ynamine intermediate with the sulfonamide.

7 reducing polar surface area and capping the sulfonamide.

8 B yielded an additional oxidized adduct, the sulfonamide.

9 g better yields than more encumbered N-alkyl sulfonamides.

10 ible with our reaction conditions as well as sulfonamides.

11 an efficient and direct route to a range of sulfonamides.

12 applied to rapidly generate the derived acyl sulfonamides.

13 s generally associated with the synthesis of sulfonamides.

14 he synthesis of sulfonyl azides from primary sulfonamides.

15 rotelomer carboxylates and n:2-fluorotelomer sulfonamides.

16 ly enhance the metabolic stability of isatin sulfonamides.

17 rearrangement involving aryl and heteroaryl sulfonamides.

18 including sulfones, sulfonyl chlorides, and sulfonamides.

19 nation was observed for carboxylic acids and sulfonamides.

20 f only two described natural product primary sulfonamides.

21 Using the previously reported tertiary sulfonamide 1 as a starting point, we engineered structu

22 The sulfonamides 1-21 inhibited all the isoforms, with Ki va

23 -1H-carbazol-4a-yl)ethyl]-4-ch lorobenzene-1-sulfonamide (1, Of1), from bioinspired synthesis of a hi

24 optimization of the 6-(indol-2-yl)pyridine-3-sulfonamide 2 to improve DMPK and safety properties.

25 a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacteri

26 alysis has led to the development of various sulfonamide/2-aminoDMAPs as bifunctional acid/base organ

27 n-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide (25) was identified as the lead compound in

28 Vinyl amide 2 and vinyl sulfonamide 4 potently inhibit TTR dissociation and amyl

29 ,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4MP-TQS), together with all other possible

30 fication of a novel bis-pyridinyl piperazine sulfonamide (51) that was a potent disruptor of the gluc

31 Isoindoline-5-sulfonamide (6f, PF-06471553) selectively inhibits MGAT3

32 f two largely employed antibiotics families: sulfonamides (9 SDs) and fluoroquinolones (6 FQs).

33 eviously described the synthetic naphthalene sulfonamide ABA agonist pyrabactin, which activates seed

34 termediates, including methylperfluorobutane sulfonamide acetic acid and the n:2 and n:3 fluorotelome

35 Aryl sulfonamides add to benzyne upon fluoride activation, an

36 Sulfenamide, sulfinamide, and sulfonamide adduct formation occurred at Cys(34) (Aalpha

37 timicrobial activity of phenyl-thiazolylurea-sulfonamides against Staphylococcus aureus PheRS are dep

38 g esters, aryl halides, aryl boronic esters, sulfonamides, alkyl tosylates, and alkyl bromides.

39 nium sulfoxide (FTSHA-SO), 6:2 fluorotelomer sulfonamide alkylamine (FTAA) and C3 to C6 perfluoroalka

40 The sulfonamide alkylation partner appears to be only limite

41 rotelomer sulfonamide (FTSAm), fluorotelomer sulfonamide alkylbetaines (FTABs), fluorotelomer betaine

42 ic acids, phenols, thiophenol, and secondary sulfonamide also provide the desired products of esters,

43 ation strategy that primarily focused on the sulfonamide and benzamide appendages of the scaffold.

44 Sulfonamide and chloramphenicol ARG levels were largely

45 onds in conjunction with vicinal addition of sulfonamide and nitrile groups across an alkene.

46 ioselective alkene difunctionalizations with sulfonamide and nitrile groups.

47 SPdCEs) for the multiplexed determination of sulfonamide and tetracycline antibiotics residues in mil

48 A large number of aromatic/heterocyclic sulfonamides and 5-mercapto-1,3,4-thiadiazoles were inve

49 differentiated from each other and also from sulfonamides and aliphatic carboxylic acids based on rea

50 Sulfonamides and coumarins incorporating arylsulfonylure

51 ith dihydropteroate synthase (DHPS), such as sulfonamides and p-aminosalicylic acid (PAS), we hypothe

52 ethods for the generation of enantioenriched sulfonamides and sulfones is an important objective for

53 sulfonyl fluorides can be converted to aryl sulfonamides and sulfonic esters using Cs2CO3 under mild

54 action (qPCR), and antimicrobials, including sulfonamides and tetracyclines, were measured using liqu

55 To monitor the levels of sulfonamides and their metabolites in farms in Lebanon,

56 , 167, 170, 195, and 209 and perfluorooctane sulfonamide) and paternal (PCBs 172 and 195) serum conce

57 tane sulfonamidoacetic acid, perfluorooctane sulfonamide, and PFOS.

58 gh-risk" drugs such as antiepileptic agents, sulfonamides, and antiretroviral drugs accounted for the

59 composting process, including tetracyclines, sulfonamides, and fluoroquinolones.

60 zed reactions of alkanes with simple amides, sulfonamides, and imides (i.e., benzamides, tosylamides,

61 to the functionalization of primary amides, sulfonamides, and other N-functional groups that typical

62 ct classes of arenes, conjugated pi-systems, sulfonamides, and silyl enol ethers.

63 boxylic acids (FTCA/FTUCAs), perfluoroalkane sulfonamides, and sulfonamidethanols (FOSA/FOSEs), and o

64 acids (e.g., carboxylic acid based polymers, sulfonamides, anionic polysaccharides, and anionic polyp

65 Aryl sulfonamide antagonists bind to CCR4 at an intracellular

66 y developed for the broad recognition of the sulfonamide antibiotic family, a graphite composite elec

67 Sulfapyridine (SPy) is a sulfonamide antibiotic largely employed as veterinary dr

68 al immunosensor has been developed to detect sulfonamide antibiotic residues in food samples.

69 sotalol (a beta-blocker) and sulfadiazine (a sulfonamide antibiotic) exhibited a marked photosensitiz

70 ted approach for the facile integration of a sulfonamide antibiotic-sensing layer with SAW technology

71 this population were to penicillins (12.8%), sulfonamide antibiotics (7.4%), opiates (6.8%), and nons

72 sitized transformation rate constants of two sulfonamide antibiotics (sulfamethoxazole and sulfadiazi

73 rformed with this matrix have indicated that sulfonamide antibiotics are conjugated to sugars rapidly

74 ed honey samples revealed that nine relevant sulfonamide antibiotics can be detected with limit of de

75 Sulfonamide antibiotics form stable covalent bonds with

76 for a human blood factor in the activity of sulfonamide antibiotics.

77 lux pump and mediate bacterial resistance to sulfonamide antimetabolite drugs.

78 tion of such a molecule - an AminoPYrimidine-Sulfonamide (APYS1) that has potent, bactericidal activi

79 Sulfonamides are antimicrobial agents widely employed in

80 Primary sulfonamides are broad specificity inhibitors of CA enzy

81 to the N-O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described.

82 ty inhibitors of CA enzymes, while secondary sulfonamides are generally poor CA inhibitors.

83 Sulfonamides are known not only to be antimicrobial drug

84 rt the discovery and optimization of triaryl sulfonamides as a novel series possessing significant CB

85 d optimization of a novel class of tricyclic sulfonamides as allosteric GlyR potentiators.

86 imines to afford the corresponding secondary sulfonamides as single diastereomers.

87 Here we show bis(sulfonamides) as efficient receptors for selective Cl(-)

88 s, such as indoles, pyrazole, and carbazole, sulfonamides, as well as electron-deficient aromatic and

89 nto sodium sulfonates, sulfonate esters, and sulfonamides, as well as styrenes by Julia-type olefinat

90 designed and synthesized a total of 32 beta-sulfonamide Asp analogues and characterized their pharma

91 n small structural differences in these beta-sulfonamide Asp analogues provide analogues with diverse

92 enzyme overexpressed in hypoxic tumors, with sulfonamide-based imaging agents.

93 Fluorotelomer- and perfluoroalkyl sulfonamide-based polyfluorinated compounds were transfo

94 luorinated diastereo- and enantiopure isatin sulfonamide-based potent and selective caspase-3 and -7

95 ity of high-molecular-weight perfluorooctane sulfonamide-based substances such as the EtFOSE-based ph

96 namide headgroup have emerged, with the acyl sulfonamide bestowing levels of selectivity over hNaV1.5

97 Notably, fluorotelomer sulfonamide betaines (8:2-FTAB and 10:2-FTAB), fluorotel

98 of the structures revealed that the mode of sulfonamide binding correlates well with their inhibitor

99 aries bearing combinations of modifications (sulfonamide, biotin, mannose) against matched targets (c

100 X-ray crystal structures of two new sulfonamides bound to the physiologically dominant CA II

101 Once assembled, the synthesis of a sulfonamide by reacting 4-chlorobenzenesulfonyl chloride

102 identified a nanomolar potent PEGylated bis-sulfonamide CA inhibitor (25) able to significantly redu

103 both normoxic and hypoxic conditions, unlike sulfonamide CA inhibitors that show such effects only in

104 t CAs is unprecedented for classical primary sulfonamide CA inhibitors.

105 and metastases, considering the fact that a sulfonamide CA IX inhibitor (SLC-0111) is presently in p

106 the desymmetrized product using the complete sulfonamide catalyst I.

107 In particular, the C6' sulfonamides catalyzed the reaction with the alpha,beta-

108 ng and an unprecedented bis(trifluoromethane)sulfonamide-catalyzed tert-butylation renders the synthe

109 g reductive elimination from a Pd(IV) fluoro sulfonamide complex.

110 uinolinone sulfonamide inhibitors [ Bicyclic sulfonamide compounds as sodium channel inhibitors and t

111 we have demonstrated for several 2-thiophene-sulfonamide compounds.

112 2674 mug/g of sludge wet weight (ww), while sulfonamide concentrations were lower than 6.3 mug/g of

113 A novel sulfonamide-conjugated benzo-[2,1-b:3,4-b']bithiophene s

114 Unsymmetrical bis-propargyl ethers and sulfonamides containing various combinations of aryl/het

115 Analogues of the sulfonamide-containing COX-2 inhibitor Celecoxib were pr

116 seawater, where according to the literature sulfonamides content is minimum compared with other envi

117 The crystalline sulfonamides could be further elaborated by alkylation a

118 Aliphatic carboxylic acids and sulfonamides could not be differentiated from each other

119 The sulfonamides could withstand conditions that functionali

120 rom previous studies, we identified pyrazole sulfonamide, DDD85646 (1), a potent inhibitor of TbNMT.

121 In this study, we synthesized four (18)F sulfonamide derivatives and evaluated their potential fo

122 alkaloids includes known C6' (thio)urea and sulfonamide derivatives and several novel species with a

123 n and reductive elimination with a series of sulfonamide derivatives are in good agreement with exper

124 In particular, sulfonamide derivatives of cinchona alkaloids are highly

125 Some new sulfonamide derivatives were synthesized in aqueous solu

126 h arylsulfinic acids to yield the respective sulfonamide derivatives.

127 te nanoparticles for specific and label-free sulfonamide detection is reported.

128 itro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt) in the BLA (0, 0.3, or 1.0 mu

129 Indisulam is an aryl sulfonamide drug with selective anticancer activity.

130 g of a terminal alkyne, secondary amine, and sulfonamide enables efficient synthesis of amidines.

131 , the PFOS-precursor N-ethyl perfluorooctane sulfonamide (EtFOSA) is used in Sulfluramid, a pesticide

132 ahydropyridin-1-yl]ethyl}-3-methylb enzene-1-sulfonamide) exhibited a broad antipsychotic-, antidepre

133 dy, the PFAS alternative, perfluoro-1-butane-sulfonamide (FBSA), was identified for the first time in

134 of the post-2002 product was perfluorobutane sulfonamide (FBSA), which was coincident with the detect

135 studies of a previously disclosed nonacidic sulfonamide FFA4 agonist.

136 The PFASs detected included perfluorohexane sulfonamide (FHxSA), 6:2 fluorotelomer sulfonamide (FTSA

137 The ratio between perfluorooctane sulfonamide (FOSA) and its metabolite perfluorooctanesul

138 hile transformation products perfluorooctane sulfonamide (FOSA) and PFOS are sufficiently mobile to l

139 and three products including perfluorooctane sulfonamide (FOSA) for PFOSAmS through high-resolution m

140 uorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and C8-C14 perfluoroalkyl carboxylat

141 rom the pre-2002 product was perfluorooctane sulfonamide (FOSA), and coincident with the detection of

142 s for any substances, except perfluorooctane sulfonamide (FOSA).

143 tant intermediate precursor (perfluorooctane sulfonamide: FOSA), into a prevalent compound in most wi

144 uorotelomer alcohols (FTOHs), perfluorooctyl sulfonamides (FOSAs), and sulfonamidoethanols (FOSEs), w

145 fonamidoethanols (FOSEs), and perfluoroalkyl sulfonamides (FOSAs), were assessed in 61 residential in

146 X-ray diffraction studies on two indazole sulfonamide fragments suggested the presence of an impor

147 An approach to the synthesis of sulfonamides from sulfamoyl inner salts and organometall

148 ocol for the direct formation of substituted sulfonamides from sulfonyl azides and amines via nucleop

149 exane sulfonamide (FHxSA), 6:2 fluorotelomer sulfonamide (FTSAm), fluorotelomer sulfonamide alkylbeta

150 on of cyclic ketones bearing amide, urea, or sulfonamide functional groups.

151 ytes with a carboxylic acid, a sulfone, or a sulfonamide functionality formed diagnostic adducts that

152 improvement compared with the control ligand sulfonamide-GGGG.

153 ABPP revealed that the sulfonamide glycine inhibitors have at least three off-t

154 By eliminating the polar 3-sulfonamide group and grafting a heterocycle at the 4 po

155 e indole N-1, C-5, and C-6 positions and the sulfonamide group to limit the potential for in vivo oxi

156 ds via the protonation of oxygen atom of the sulfonamide group.

157 the electronic effects of ether, ester, and sulfonamide groups in the homoallylic position.

158 After introduction of bis(2-ethylhexyl) sulfonamide groups via a simple two-step synthesis, the

159 istant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific si

160 ng affinity resulting from modulation of the sulfonamide H-bond donor strength.

161 ctive aminolysis of aromatic trans-2,3-epoxy sulfonamides has been accomplished, which was efficientl

162 reaction of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides has been accomplished.

163 inones (including AZT), inosines, and cyclic sulfonamides has been examined.

164 the medicinal chemistry pedigree of primary sulfonamides has dominated for several decades.

165 However, saccharin, a cyclic secondary sulfonamide, has unusually good inhibition of CA IX (Ki

166 e intermediates, and onwards to sulfones and sulfonamides, has been realized.

167 phaCA with a family of acetazolamide-related sulfonamides have been determined.

168 that acyl group protected carbohydrate-based sulfonamides have potential as prodrugs for selectively

169 Glycine sulfonamides have recently been identified by a high thr

170 5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8- sulfonamide) have the combined properties of agonists an

171 acophoric features that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail gro

172 atic tail groups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfon

173 Potency optimization of the sulfonamide hit compounds was undertaken as informed by

174 A biaryl acyl sulfonamide hit from this library was elaborated, optimi

175 In contrast to conventional troublesome sulfonamide hydrolysis, a near-stoichiometric amount of

176 and structural biology for a novel series of sulfonamide hydroxamate LF inhibitor analogues specifica

177 ith the Cr catalyst prepared from the chiral sulfonamide identified via the toolbox approach.

178 inyl amide in 2 with the more reactive vinyl sulfonamide in 4 hastens the conjugation kinetics.

179 derived by lead optimization of the benzene-sulfonamide in silico hit compound 3.

180 g block in combination with an aromatic acyl sulfonamide in the P1P1' position.

181 The reactivity of sulfonamides in comparison to trifluoroacetamide is comp

182 ed by phototransformation experiments of the sulfonamides in DOM-containing solutions.

183 MS) was developed to measure trace levels of sulfonamides in fish tissue.

184 titative screening of 12 different regulated sulfonamides in honey.

185 d determination of the total content of some sulfonamides in milk using solid-phase extraction and a

186 routine screening method for quantitation of sulfonamides in milk.

187 (beta-lactams, tetracyclines, quinolones and sulfonamides) in milk within 20 min.

188 Several fluorescent sulfonamides incorporating either the fluorescein-thiour

189 is the first time a natural product primary sulfonamide inhibitor has been assessed for inhibition a

190 ding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3

191 ion of a series of atropisomeric quinolinone sulfonamide inhibitors [ Bicyclic sulfonamide compounds

192 cture-activity relationship study of glycine sulfonamide inhibitors and their brain membrane proteome

193 e cancer, obesity, epilepsy, glaucoma, etc., sulfonamide inhibitors as those reported here may be of

194 n HCAII that stabilizes the apolar moiety of sulfonamide inhibitors is replaced with a more open, hyd

195 Sulfonamide inhibitors of HpalphaCA possess anti-H. pylo

196 offer ADME advantages over known heteroaryl sulfonamide inhibitors.

197 s a variety of biaryl substituents, (ii) the sulfonamide is required for inducing a specific orientat

198 When the sulfonamide is unprotected, the characteristic ring-open

199 lity to discriminate among various different sulfonamides is demonstrated.

200 timicrobial activity of phenyl-thiazolylurea-sulfonamides is mediated by PheRS inhibition, validating

201 of a series of benzo-fused bi- and tricyclic sulfonamides is reported.

202 stasis by the transported Cl(-) ion, via bis(sulfonamide), is found to impose cell death.

203 ,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, is a strong positive allosteric modulator (

204 family of dibenzoxepane and dibenzosuberane sulfonamides, is a potent anti-inflammatory agent with s

205 hane (Crwn-THF), a P2'-methoxybenzene, and a sulfonamide isostere, is highly active against laborator

206 )-N, N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L).

207 was explored through preparation of a crude sulfonamide library and evaluation of the library in a B

208 nanticipated oxygen-nitrogen exchange of the sulfonamide ligand prior to an inner-sphere SN2-type red

209 nhydrase (HCA) and a series of benzothiazole sulfonamide ligands with different patterns of fluorinat

210 ))-N bond-forming reductive elimination from sulfonamide-ligated Pd(IV) complexes.

211 ate attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-

212 sulfonyl fluoride activation leading to the sulfonamide linkage to TTR.

213 The sulfonamide linker is critical to activity, substitution

214 (pyridin-3-ylamino)-5,8-dihydronaphthalene-1-sulfonamide (LY5), was confirmed to bind to STAT3 SH2 by

215 1) and K2P10.1 (TREK-2) activators-an N-aryl-sulfonamide, ML335, and a thiophene-carboxamide, ML402-d

216 Compounds incorporating 4, 8, 16, and 32 sulfonamide moieties were thus obtained, which showed an

217 ferroptosis inhibitors containing amide and sulfonamide moieties with improved stability, single dig

218 of these highly polar molecules that possess sulfonamide moieties.

219 f 0.48); however, the reparametrization of a sulfonamide moiety improved the agreement with experimen

220 Under the directing effect of the sulfonamide moiety the ring-opening reaction proceeded s

221 Therefore, sulfonamides must be first released before the analysis,

222 a logical correlation between the acidity of sulfonamide N-H proton and binding strength.

223 to the pyrimidine nitrogen and (2) from the sulfonamide N-H to the gatekeeper threonine.

224 in the transition state, especially when the sulfonamide NH is deprotonated, drastically raises the a

225 in the absence of a protecting group on the sulfonamide nitrogen.

226 d cyclization of propargylic carbonates with sulfonamide nucleophiles is critically dependent on the

227 This procedure is based on SPE of sulfonamides on hypercrosslinked polystyrene, elution wi

228 s) and two neutral precursors perfluoroalkyl sulfonamides (PFASAs), were identified and quantified.

229 , perfluorononanoate (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sulfonate (PFOS), a

230 At low extents of DOM preoxidation, the sulfonamide phototransformation rate constants remained

231 ation and enables facile deprotection of the sulfonamide products with thioglycolic acid.

232 only limited by sterics, with unsubstituted sulfonamides providing better yields than more encumbere

233 The biotransformation of perfluorooctane sulfonamide quaternary ammonium salt (PFOSAmS) was very

234 LME) and QuEChERS for the determination of 9 sulfonamides, regulated by the EU Council in milk sample

235 Some of the sulfonamides reported here showed significant intraocula

236 The biaryl acyl sulfonamides reported herein may also offer ADME advanta

237 Sulfonamide residues could be detected in forty-six samp

238 for the first time, for the determination of sulfonamides residues in milk using a highly polar sol-g

239 of Escherichia coli and its plasmid-encoded sulfonamide resistance gene sul1 in different water matr

240 cis, Bordetella pertussis, and B. anthracis (sulfonamide resistance gene, sul1), respectively.

241 les then allows conversion into sulfones and sulfonamides, respectively, in a one-pot, two-step proce

242 ing (HtiS) procedure for the analysis of the sulfonamide (SA)-sugar conjugated fraction of antibiotic

243 The residues of the four sulfonamides (SAs) were analyzed by extraction process a

244 S/MS for 40 target antibiotics (including 16 sulfonamides (SAs), 12 fluoroquinolones, 6 macrolides, 2

245 y high-throughput screening, we identified a sulfonamide scaffold that served as a pharmacophore to g

246 ructure-activity relationship of the benzene-sulfonamide scaffold that yielded a series of highly pot

247 ivity relationship (SAR) of the quinolinol-5-sulfonamide scaffold was explored through preparation of

248 nd MBX2546, with aminoalkyl phenol ether and sulfonamide scaffolds, respectively, that specifically i

249 ulfonamides, tasisulam and chloroquinoxaline sulfonamide, share the same mechanism of action as indis

250 Most of the prepared sulfonamides showed low inhibition against hCA I isoform

251 This novel indole sulfonamide shows in vitro activity comparable to known

252 Recently, we have shown that sulfonamide substituted 2-benzamidobenzoic acids, which

253 f the reaction is very broad with respect to sulfonamide substrate, but the position and electronic n

254 er, ketone, nitrile, ketal, trifluoromethyl, sulfonamide, sulfonate ester), both aryl and vinyl halid

255 nion-binding and transport activity of a bis(sulfonamide) system are far superior compared to those o

256 of novel gallium-radiolabeled small-molecule sulfonamides targeting CA IX.

257 Two other clinically tested sulfonamides, tasisulam and chloroquinoxaline sulfonamid

258 report here a novel series of benzimidazole sulfonamides that act as antagonists of the S1P1 recepto

259 A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.

260 -H bonds over reduction of the azides to the sulfonamides that is higher and with substrate scope tha

261 an additional, alternative binding site for sulfonamides that is not present in HCAII.

262 a-lactam drugs and the other containing both sulfonamides, three aminoglycosides, and tetracycline.

263 We describe a method for the synthesis of sulfonamides through the combination of an organometalli

264 highlights the potential of cyclic secondary sulfonamides to be exploited for the discovery of potent

265 )3] together with Tz(o) sulfonate esters and sulfonamides to facilitate the site-selective replacemen

266 The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a

267 d a double reduction of the resultant cyclic sulfonamide, to afford the cis-3a-aryloctahydroindole sk

268 N,N-Dibromo-p-toluene sulfonamide (TsNBr2) has been found to be an effective r

269 ates leads to the corresponding sulfones and sulfonamides, two pharmacophores routinely encountered i

270 Treatment with a novel sulfonamide-type gamma-secretase inhibitor (GSI) attenua

271 on of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.

272 Unsaturated N-sulfonamides undergo a Rh(III)-catalyzed allylic C(sp(3)

273 f more common electron-withdrawing amide and sulfonamide units.

274 yl azides and either 3- or 4-ethynyl benzene sulfonamide using Cu(I)-catalyzed azide alkyne cycloaddi

275 can be easily used both for quantitation of sulfonamides using spectrophotometry and for naked-eye s

276 r domain IV (VSD4), where their anionic aryl sulfonamide warhead engages the fourth arginine gating c

277 The benzoxazinone-3-sulfonamide was prepared by nitrosation of a beta-ketosu

278 et testing limit of 10 ng/g in honey for the sulfonamides was used based upon action limits set for o

279 These sulfonamides were also found effective upon oral adminis

280 e limits of quantification obtained for most sulfonamides were between 12.5 and 25 mug kg(-1), detect

281 beta-lactams, tetracyclines, quinolones and sulfonamides were determined to be 8 ng/mL, 2 ng/mL, 4 n

282 The sulfonamides were especially suited as bifunctional orga

283 The synthesized primary and secondary sulfonamides were investigated as inhibitors of six phys

284 (18)F-labeled sulfonamides were obtained in 16.3%-36.8% non-decay-corr

285 oarylated alpha-branched benzyl sulfones and sulfonamides were obtained in good yields, and overaryla

286 A series of aromatic/heterocyclic bis-sulfonamides were synthesized from three established ami

287 alkylamine, piperazine, piperidine, but not sulfonamide) were well tolerated in vitro, and the hydro

288 aper describes modifications to the pyrazole sulfonamides which markedly improved blood-brain barrier

289 This screen found that sulfonamides, which inhibit folate biosynthesis in plant

290 edict relative reaction rates with different sulfonamides, which is successful only after considering

291 s of esters, ethers, thioether, and tertiary sulfonamide with 43-93% yields.

292 Negishi-type alpha-arylation of sulfones and sulfonamides with a broad range of aryl bromides has bee

293 X-ray crystallography of adducts of several sulfonamides with CA II, the effective inhibitory proper

294 ing the utility of the method for delivering sulfonamides with drug-like properties.

295 ligomeric or polymeric diamines to yield bis-sulfonamides with short or long (polymeric) linkers.

296 An intermolecular alkylation of sulfonamides with trichloroacetimidates is reported.

297 Chemoselective acidic hydrolysis of sulfonamides with trifluoromethanesulfonic acid has been

298 ng/mL for quinolones, and 0.1-3.98 ng/mL for sulfonamides, with linear correlation coefficients highe

299 carbonic anhydrase yielded a potent ligand, sulfonamide-WIVP, with Kd = 6.7 +/- 2.1 nM, a 20-fold im

300 Both aliphatic carboxylic acids and sulfonamides yield several fragment ions in these MS(4)