ライフサイエンスコーパス: sulfone

1 addition to tosylacetylene (ethynyl p-tolyl sulfone).

2 n sulfoxide, terbufos sulfone and disulfoton sulfone).

3 via isomerization to an electrophilic vinyl sulfone.

4 e location of the olefin with respect to the sulfone.

5 bsequent S-oxidation gives the corresponding sulfone.

6 tion process of a N-Boc-protected piperidine sulfone.

7 eferentially to the anti-N-benzylpyrrolidine sulfone.

8 t one-pot synthesis of alpha-alkyl-beta-keto sulfones.

9 -substituted internal alkynes from propargyl sulfones.

10 d with periodate to give their corresponding sulfones.

11 y of two new reaction modes of epoxides with sulfones.

12 yl-alpha-amino acids to 1-(N-acylamino)alkyl sulfones.

13 es access to various alpha-substituted vinyl sulfones.

14 nd enals for the synthesis of functionalized sulfones.

15 properties never observed for the respective sulfones.

16 f thioether substituents into sulfoxides and sulfones.

17 ule, cysteine protease inhibitors, the vinyl sulfones.

18 thiazole-5-carboxylates, -phosphonates, and -sulfones.

19 were mono- and dioxidized to sulfoxides and sulfones.

20 lfones and their ensuing reaction with allyl sulfones.

21 cetylenes, and easy access to arylacetylenic sulfones.

22 is crucial to the rate for the bispropargyl sulfones.

23 by ring expansion to generate novel bicyclic sulfones.

24 zation of bispropargyl substrates other than sulfones.

25 electivity, proving superior to phenyl vinyl sulfone 1 and with clear advantages over bis-sulfone 2.

26 Sulfone 10b had salmeterol-like potency and selectivity

27 Julia coupling of this compound with sulfone 15 produced the 19-norvitamin D analogue 4, poss

28 y with regard to hERG activity, led to alkyl sulfone 16.

29 Stereodiad sulfones 18a and 18b are key intermediates for polyketid

30 es revealed that the solid-state reaction of sulfone 2 occurs with a loss of long-range order despite

31 sulfone 1 and with clear advantages over bis-sulfone 2.

32 hyde (1) and ethyl 1-phenyl-1H-tetrazol-5-yl sulfone (2), considered a paradigmatic example of the re

33 d-generation synthetic routes to enantiopure sulfone 21 and aldehyde 24 are described.

34 pling with the anion of the phenylthiazoline sulfone 25.

35 Heteroaryl vinyl sulfone 3 presented excellent output in terms of reactiv

36 The easily available vinyl sulfone 3 showed great potential for new applications in

37 Oxidation of 30 to sulfone 31 and phosphonate hydrolysis completed the synt

38 ion from the acylsilane 3 and the acetylenic sulfone 4 to form the chiral epoxide 5.

39 o-Phe-Leu-Leu-4-aminomethyl-Phe-methyl vinyl sulfone (4a, LU-102), and a fluorescent activity-based p

40 ki olefination-reduction process between the sulfone 55 and the aldehyde 54.

41 The unusual trimethylated oxanorbornane sulfone 55 was successfully synthesized from the known e

42 ega)-heptaprenol, 4] using the nerol-derived sulfone 8 as the key intermediate.

43 Sulfone 8 is prepared by the literature route and is con

44 tion of this novel series delivered thiazole sulfone 93, which was able to disrupt the GK-GKRP intera

45 On the other hand, diallyl sulfone, a known metabolite of diallyl monosulfide, alky

46 enolates with beta,beta-difluorovinyl phenyl sulfone, a new (1'-fluoro)vinyl cation equivalent, and a

47 A vinyl sulfone acceptor olefin was developed, which allowed for

48 nt evidence that rigosertib, a styryl-benzyl sulfone, acts as a RAS-mimetic and interacts with the RB

49 which allowed for the efficient synthesis of sulfone adducts that could be used as branch points for

50 oxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted int

51 n of 2-hydroxybenzaldehydes and 2-bromoallyl sulfones afforded 2H- and 4H-chromenol derivatives endow

52 moothly with a number of different beta-keto sulfones, affording the adducts as single diastereomers.

53 The use of 1-(tert-butyl)tetrazolyl sulfone affords the construction of the Z-trisubstituted

54 The intermediate sulfone alcohol 11 used as the key reagent for introduct

55 ylation with an iodomethylphenyl sulfide and sulfone-aldehyde coupling/reductive desulfurization sequ

56 Key controlling aspects in the sulfone alkylation/oxidative desulfurization to join the

57 Thus, styryl sulfones alone, or in combination with chemotherapeutic

58 alpha-Sulfone-alpha-piperidine and alpha-tetrahydropyranyl hyd

59 f the sulfonamide) led to the discovery that sulfones also serve as useful directing groups for asymm

60 he selectivity of unsymmetrical bispropargyl sulfones, amines, methanes, and sulfides.

61 revealed moderate levels of activity for the sulfone analogue of hydrocodone.

62 c acid PDE4 inhibitors led to this series of sulfone analogues.

63 as-phase ion/molecule reaction of protonated sulfone analytes with trimethyl borate (TMB) that yields

64 c, intramolecular Michael addition of a keto sulfone and a tandem 1,3-sulfonyl shift/Mannich cyclizat

65 ion products (disulfoton sulfoxide, terbufos sulfone and disulfoton sulfone).

66 a chemical modification to the corresponding sulfone and ether derivatives.

67 n' aroma, while dimethyl sulfoxide, dimethyl sulfone and ethyl methyl sulfone were responsible for 's

68 h involves methylation of a pro-A ring vinyl sulfone and in situ traping of the allyl sulfonyl anion

69 Here, we demonstrate that sulindac, sulindac sulfone and indomethacin activate the NF-kappaB pathway

70 y optimization by incorporation of P1' alkyl sulfone and P2 methyl groups provided a macrocycle with

71 their reactions with beta-substituted vinyl sulfones and alpha,beta-unsaturated esters.

72 In summary, sulfones and aromatic carboxylic acids can be differenti

73 ctive compounds, such as keto-esters or keto-sulfones and cyclic or acyclic diketones, afforded more

74 otherwise difficult to obtain alkyl alkynyl sulfones and cyclic vinyl sulfones via 1,2-rearrangement

75 ization in two systems, namely bis-propargyl sulfones and ethers.

76 nes, hypervalent alkynyliodoniums, acetylene sulfones and in situ oxidized terminal acetylenes are th

77 the reaction between unsubstituted alkyl PT sulfones and linear aliphatic aldehydes.

78 Julia-Kocienski olefination with tetrazolyl sulfones and subsequent macrolactonization.

79 e desired monoarylated alpha-branched benzyl sulfones and sulfonamides were obtained in good yields,

80 um catalyzed Negishi-type alpha-arylation of sulfones and sulfonamides with a broad range of aryl bro

81 into sulfinate intermediates, and onwards to sulfones and sulfonamides, has been realized.

82 ed electrophiles then allows conversion into sulfones and sulfonamides, respectively, in a one-pot, t

83 ate intermediates leads to the corresponding sulfones and sulfonamides, two pharmacophores routinely

84 e overoxidation of the product sulfoxides to sulfones and the hydrolysis of epoxides to diols.

85 hotogeneration of aryl radicals from arylazo sulfones and their ensuing reaction with allyl sulfones.

86 Ozonolysis of these vinyl sulfones and vinyl phosphonates furnish complementary se

87 nion recognition units containing sulfoxide, sulfone, and sulfoximine groups at C4 unveils an enhance

88 subsequently converted to gamma-azido vinyl sulfones, and azide-alkyne click chemistry enabled the s

89 including cinnamates, crotonates, coumarins, sulfones, and chalcones were successfully functionalized

90 Esters, sulfones, and ketones were C-aminoimidoylated and C-thio

91 ons include carboxamides, amines, dithianes, sulfones, and sulfoxides, as well as some ketones, beta-

92 other oxygen-containing species, carbazoles, sulfones, and thiophenes from small crude oil samples (

93 ent couplings were accomplished by aldol and sulfone anion methodologies.

94 inal fragment coupling of the anomeric EFGHI-sulfone anion to the ABCD-aldehyde completed the converg

95 observed that fexinidazole and fexinidazole sulfone are more effective than benznidazole and nifurti

96 ds, leading to the identification of an aryl sulfone as a replacement for the 3-cyano pyridyl group.

97 es l-methionine sulfoximine and l-methionine sulfone as substrates, with Km(app) values of 1.3 +/- 0.

98 activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that t

99 ion of dicarbonyl compounds with alpha-amido sulfones as acyl imine precursors is described.

100 portant proteases and the potential of vinyl sulfones as antiparasitic drugs.

101 Herein, we describe a new class of aryl sulfones as disruptors of the GK-GKRP complex, where the

102 first examples of the use of sulfonamides or sulfones as effective directing groups in metal-catalyze

103 Sulindac sulfone at 600 mumol/L inhibited 14-3-3epsilon protein e

104 basis of the decreased cytotoxicity of vinyl sulfone-based inhibitors to HeLa cells as compared with

105 for the development of aryl vinyl sulfonate/sulfone-based PTP probes to interrogate PTP activity in

106 ick chemistry enabled the synthesis of vinyl sulfone-based triazoles as potential nonpeptidic cystein

107 elopment of inhibitors with penems and penam sulfones being amongst the most potent and broad spectru

108 Y-32 was more susceptible to inactivation by sulfone beta-lactamase inhibitors (i.e., sulbactam and t

109 d through a dual approach: 1) using CF2 as a sulfone bio-isostere to exploit the unique properties of

110 ent upon the nature of heteroatom (O or S in sulfone) bridging the propargyl arms.

111 s a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl r

112 mination has been studied for sulfoxides and sulfones, but this represents the first study of interna

113 lpyrrolidine (PhPyr) and phenyl trans-styryl sulfone by visible-light-absorbing colloidal CdS quantum

114 3 mins without formation of the highly toxic sulfone by-product.

115 ntitatively oxidized to either sulfoxides or sulfones by treatment with dilute hydrogen peroxide or m

116 n layer anchored on a microporous poly(ether sulfone) by surface grafting.

117 e mono-, di-, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalk

118 The most active dibenzo[b,d]thiophene sulfone co-polymer has a UV photocatalytic activity that

119 The dibenzo[b,d]thiophene sulfone co-polymer has an apparent quantum yield of 2.3

120 Arylazo sulfones, colored thermally stable derivatives of aryl d

121 e log scale, compared with the single styryl sulfone compound.

122 of the MCL lines upon treatment with styryl sulfone compounds in combination with other currently us

123 r Bay 11-7082 and structurally related vinyl sulfone compounds selectively inhibit NLRP3 inflammasome

124 Methionine sulfone containing peptides CLs J (11) and K (12) may be

125 An iron-catalyzed synthesis of sulfur- and sulfone-containing heterocycles is reported.

126 these molecules afforded many potent biaryl sulfone-containing Nampt inhibitors which also exhibited

127 A series of vinyl sulfone-containing peptidomimetics were rationally desig

128 on relevant macrophage cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was

129 Four sulfone-containing SMAs termed 11a, 11e, 11i and 12b wer

130 he higher and more prolonged exposure of the sulfone derivative.

131 s and LC50s for fipronil and its sulfide and sulfone derivatives were determined for 14 macroinverteb

132 A pair of easily accessible vinyl sulfones derived from styrene epoxide and monotosylated

133 to both the organomagnesium nucleophile and sulfone electrophile.

134 noate-enoate, ynoate-enenitrile, and alkynyl sulfone-enenitrile substrates.

135 o-4-iodopyridines to acetylenes activated by sulfone, ester, or ketone groups, followed by intramolec

136 he cGMP phosphodiesterase inhibitor sulindac sulfone (exisulind, aptosyn, hereafter called exisulind)

137 aldehyde aminooxylation, followed by a vinyl sulfone forming Horner-Wadsworth-Emmons olefination.

138 zed one-step synthesis of (hetero)aryl alkyl sulfones from (hetero)arylboronic acids, potassium metab

139 a one-pot sequence for the synthesis of aryl sulfones from simple starting materials.

140 2 fluorotelomer mercaptoalkylamido sulfonate sulfone (FTSAS-SO2), 6:2 fluorotelomerthiohydroxyl ammon

141 ication of drug metabolites that contain the sulfone functional group.

142 iral activity, although the incorporation of sulfone functionality resulted in a decrease in potency.

143 2-Bromoallyl sulfones functioned as synthetic equivalents of allenyl

144 otected 1,3-benzothiazol-2-yl (BT) propargyl sulfones gave corresponding BT fluoropropargyl sulfones,

145 Steric bulk around the azido and vinyl sulfone groups plays a significant role in deciding the

146 hain thioether linkages in these polymers to sulfone groups resulted in disruption of the alpha-helic

147 col for the synthesis of gamma-hydroxy vinyl sulfones has been developed using a proline-based aldehy

148 aturated glycosyl and alpha-D-mannopyranosyl sulfones has been developed via ruthenium-promoted direc

149 ion of silyl ketene acetals with N-Boc-amino sulfones has been developed.

150 A new series of 6 dimeric trioxane sulfones has been prepared from the natural trioxane art

151 obenzaldehydes and beta-substituted vinyl PT-sulfones has been realized for the synthesis of 3,4-unsu

152 rier reaction between nitroalkenes and vinyl sulfones has been successfully carried out for the first

153 onjugate additions to alpha,beta-unsaturated sulfones have been investigated, which provided the key

154 bsequent ring contraction, the corresponding sulfone in 83% yield.

155 , with O being trapped in a form of dimethyl sulfone in the electrolyte.

156 -mediated condensations of 1-fluoropropyl PT-sulfone in the presence of MgBr(2) x OEt(2) were Z-selec

157 rect access to gamma-keto- and gamma-hydroxy sulfones in a simple and reliable way through a sulfa-Mi

158 litates the preparation of a wide variety of sulfones in a straightforward fashion, including six- th

159 o acceptors to access alpha-D-mannopyranosyl sulfones in good yields with high regioselectivity.

160 mild conditions to give 1-(N-acylamino)alkyl sulfones in good yields.

161 eospecific formation of tertiary homoallylic sulfones in high yield.

162 entally for potassium- and lithium-metalated sulfones, in THF and toluene, respectively.

163 ctions with potassium- and lithium-metalated sulfones, in THF and toluene, respectively.

164 f DOX plus styryl sulfone or VCR plus styryl sulfone increased cytotoxicity by one log scale, compare

165 yme in complex with a covalently bound vinyl sulfone inhibitor (K777).

166 , the reaction between a 6-alkylidiene penam sulfone inhibitor, SA-1-204, in single crystals of OXA-2

167 A specific vinyl sulfone inhibitor, WRR605, synthesized based on the subs

168 55, a 6-alkylidene-2'-substituted penicillin sulfone inhibitor.

169 ion emerges despite that the penem and penam sulfone inhibitors form different types of intermediates

170 ve been investigated, which provided the key sulfone intermediate in just six steps from commercially

171 tes and alpha,beta-unsaturated ketones/vinyl sulfone is shown.

172 When an allenic sulfone is treated under palladium catalysis in the pres

173 When an allenic sulfone is treated with a phosphine nucleophile and a pr

174 neration of enantioenriched sulfonamides and sulfones is an important objective for fields such as or

175 roalkylation of isocyanides with fluorinated sulfones is enabled by visible-light photoredox catalysi

176 lfones gave corresponding BT fluoropropargyl sulfones, Julia-Kocienski reagents for the synthesis of

177 urated electrophilic functions such as vinyl-sulfones, -ketones, -esters, and -nitriles.

178 The 2'-substituted penicillin sulfone, LN-1-255, is proving to be an important lead co

179 s in the order ethyl acetate << methyl ethyl sulfone < acetonitrile < N,N-dimethylacetamide approxima

180 for the synthesis of alpha-substituted vinyl sulfones makes use of a combination of a triazole gold c

181 polar organics (o-DGT) without a poly(ether sulfone) membrane was developed, calibrated, and field-e

182 fluoromethylsulfonly)imide in the poly(ether sulfone) membrane with average pore size of approximatel

183 tic HLB disk covered by a 0.2 mum poly(ether sulfone) membrane, for monitoring polar organic micropol

184 0, PNU-101603, and PNU-101244 (sulfoxide and sulfone metabolites) at 1000 mg were 839, 3558, and 54 n

185 bases, either K2 CO3 or DBU, and subsequent sulfone-metal exchange and alkylation rapidly assembles

186 The 2-pyridylsulfone is critical for the sulfone-metal exchange because chelation anchors the org

187 The first general sulfone-metal exchange is described.

188 ionality were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage

189 lly, replacement of the epoxyketone by vinyl sulfone moieties further improves the selectivity of bet

190 beta2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ri

191 Except for protonated sulfones, most of the protonated compounds react very sl

192 methionine sulfoximine (MSX) and methionine sulfone (MSO).

193 , although oxidation of the sulfoxide to the sulfone occurred once all the CEES had been oxidized.

194 sters and on the corresponding sulfoxide and sulfone of the tert-butyl ester.

195 The benzyl styryl sulfone, ON 01910.Na, is a novel anticancer agent that i

196 r fused 6,5-heterocyclic moieties and biaryl sulfone or sulfonamide motifs.

197 ound that the combination of DOX plus styryl sulfone or VCR plus styryl sulfone increased cytotoxicit

198 s that are different from those observed for sulfones or aromatic carboxylic acids.

199 By using alkynyl sulfones or sulfonates as substrates, the oxidative gold

200 s with m-CPBA to yield the corresponding bis-sulfones (or tetraoxides).

201 rotonated analytes with a carboxylic acid, a sulfone, or a sulfonamide functionality formed diagnosti

202 ery of irreversible inhibitors with p-fluoro-sulfone- or p-fluoro-nitro-substituted N-1 benzyl groups

203 ent polar functional groups--ester, epoxide, sulfone, oxazolidinone, carbamate, and sulfamate--are fo

204 Fipronil and fipronil sulfone (oxidation derivative) each accounted for about

205 HCV NS3 protease inhibitors having a cyclic sulfone P3-cap have been discovered.

206 asopharyngeal specimens through a poly(ether sulfone) paper matrix, H1N1-specific in situ isothermal

207 unctional groups (aldehyde, ketone, nitrile, sulfone, pentafluorosulfur, and N-aryltrifluoroacetamide

208 In this work, a highly permeable poly(ether sulfone) (PES) based hollow fiber membrane was developed

209 ol (HPG), and then grafting it on poly(ether sulfone) (PES) hollow fiber membrane supports.

210 near triatomic anion, SeCN(-), in poly(ether sulfone) (PES) membranes and room-temperature ionic liqu

211 surface of commercially available poly(ether sulfone) (PES) membranes using the polyelectrolyte multi

212 afted on the substrate surface of poly(ether sulfone) (PES) membranes via covalent bonding.

213 onic acid (AMPS) onto microporous poly(ether sulfone) (PES) substrates and successfully demonstrated

214 enyl)benzene monomers on top of a poly(ether sulfone) (PES) ultrafiltration membrane support.

215 Poly(ether sulfone) (PES)/polyvinylpyrrolidone (PVP) membranes are

216 The previously unexplored beta-chloro vinyl sulfone pharmacophore provided mechanistic insight that

217 rsible even though it incorporated the vinyl sulfone pharmacophore that is well documented to give ir

218 mpound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl (LHVS), which was previously shown to inh

219 orpholinurea-leucine-homophenylalanine-vinyl sulfone-phenyl (LHVS), an irreversible inhibitor of cath

220 These sulfones possess red-shifted absorption and emission spe

221 lfur dioxide from the respective 16-membered sulfone precursors.

222 Another set of exocyclic vinyl sulfones prepared from 3-O-methylated- and 3-O-benzylate

223 ropyl, 5-hexenyl, and (cyclopropyl)methyl PT-sulfones proceeded under homogeneous conditions, fluorin

224 nation reaction that releases a methyl vinyl sulfone product and the parent IPA/NO anion which subseq

225 CEESO) without formation of the highly toxic sulfone product.

226 fied in cells treated with the peptide vinyl sulfone proteasome inhibitor Z-L(3)VS.

227 enyl vinyl sulfonate (PVSN) and phenyl vinyl sulfone (PVS) as a new class of mechanism-based PTP prob

228 sulfinate salts yields the much more stable sulfone radicals, which smoothly add to double bonds.

229 This method highlights sulfone reactivity and provides an easy approach for the

230 hat the C2 hydroperoxide of dibenzothiophene sulfone reacts with flavin to form a flavin-N5-oxide.

231 the intramolecular Michael addition and the sulfone rearrangement.

232 ions, fluorination of 2-methyl-2-propenyl PT-sulfone required heterogeneous fluorination conditions.

233 or l-methionine sulfoximine and l-methionine sulfone, respectively.

234 rt the one-step synthesis of poly(aryl ether sulfone)s (PSUs) from the depolymerization of PCs and in

235 tures of SHV-1 bound with penem 1, and penam sulfones SA1-204 and SA3-53.

236 nd biological profile of a novel spirocyclic sulfone series of gamma-secretase inhibitors (GSIs) rela

237 ridone derivatives containing sulfoxides and sulfones showed cellular activity against M. tuberculosi

238 lfur from sulfide (S), to sulfoxide (SO), to sulfone (SO2).

239 idge from sulfide (S), to sulfoxide (SO), to sulfone (SO2).

240 henylsulfonyl)vinyl AA-esters undergo smooth sulfone-stannane interchange to stereoselectively give t

241 A series of phenyl sulfone substituted quinoxaline were prepared and the le

242 Sulfone-substituted gamma- and delta-lactams have been p

243 Vinylic, allylic and homoallylic sulfone substitutions were investigated, and high enanti

244 nism among different bispropargyl substrates-sulfone, sulfide, ether, amine, and methane-toward Garra

245 Being mono-aza analogues of sulfoxides and sulfones, sulfimides and sulfoximines, respectively, are

246 onyl-containing functional groups, including sulfones, sulfonyl chlorides, and sulfonamides.

247 Examination of conjugated ethylenic sulfones, sulfoxides, and esters in Michael-type additio

248 h as alpha,beta-unsaturated ketones, esters, sulfones, sulfoxides, and phosphonates to yield the corr

249 ta-carbon atom of the alpha,beta-unsaturated sulfone system.

250 tribenzoate, DCDPS = 4,4'-dicarboxydiphenyl sulfone, TCPP = tetrakis(4-carboxyphenyl)porphyrin).

251 urther elaborated to incorporate an appended sulfone that was reacted with a suitably protected gluta

252 ions of racemic alpha-bromosulfonamides and -sulfones that furnish the desired cross-coupling product

253 drive cysteine protease inhibition by vinyl sulfones, the binding specificity of these important pro

254 orates with a variety of substituted alkenyl sulfones through an alpha-aminomethyl radical addition-e

255 involving the conversion of dibenzothiophene sulfone to 2-(2-hydroxyphenyl)-benzenesulfinic acid, is

256 ctive pyrone Diels-Alder reaction of a vinyl sulfone to construct the cyclophane architecture of the

257 ective organocatalyzed cyclization of a keto sulfone to establish the key C7 and C8 stereocenters and

258 ximal to the electrophilic, tetrasubstituted sulfone to override complex-induced deprotonation.

259 nating reagent for the one-pot conversion of sulfones to alkenes by way of the Ramberg-Backlund rearr

260 riles, forming the corresponding cyclopropyl sulfones under mild conditions in high yields and high s

261 ides were also found to undergo oxidation to sulfones under similar reaction conditions.

262 nctioned as synthetic equivalents of allenyl sulfones under these conditions.

263 Our results suggest that the sulfones undergo a relatively fast isomerization followe

264 benzo[b,d]thiophene or dibenzo[b,d]thiophene sulfone units greatly enhances the H2 evolution rate.

265 othiadiazepine 2,2-dioxide, the formation of sulfone via o-quinodimethane is the preferred pathway fr

266 tain alkyl alkynyl sulfones and cyclic vinyl sulfones via 1,2-rearrangement or 1,5-CH insertion, resp

267 ides a new avenue for the synthesis of vinyl sulfones via a decarboxylative radical coupling strategy

268 or the construction of alpha-alkyl-beta-keto sulfones via C(sp(3))-H bond functionalization followed

269 dratase (DH) domains by means of a 3-alkynyl sulfone warhead.

270 tert-butoxycarbonyl)methylidenecephalosporin sulfone was examined kinetically, spectroscopically, and

271 ence of other functionalities in addition to sulfone was found not to influence the diagnostic reacti

272 The resulting sulfone was reacted with aldehydes to access beta-substi

273 Their oxidation to sulfones was also demonstrated to have no effect on thei

274 tion of terminal alkynes to branched allylic sulfones was developed.

275 ve Ir-catalyzed hydrogenation of unsaturated sulfones was developed.

276 lfinates for the synthesis of arylacetylenic sulfones was developed.

277 sulfoxide, dimethyl sulfone and ethyl methyl sulfone were responsible for 'sulfurous' aroma.

278 Functionalized cyclic vinyl sulfones were directly converted to the "polarity revers

279 as observed, while only small amounts of the sulfones were formed, if any.

280 In addition, alkyl phenyl sulfones were found to be effective electrophiles in the

281 oro-5-hexenyl 1-phenyl-1H-tetrazol-5-yl (PT) sulfones were prepared by metalation followed by electro

282 Chiral cyclic and acyclic sulfones were produced in excellent enantioselectivities

283 y photo-oxygenation products (sulfoxides and sulfones) were found.

284 replaced with oxygen, sulfur, sulfoxide, and sulfone, were prepared by a short sequence from the ethy

285 ompounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles compara

286 As sulfoximines are analogues of sulfones where one of the two S[double bond, length as m

287 d with acrylates, styrenes, and vinyl phenyl sulfones, whereas the saturated alkylation products were

288 ed to the discovery of a one-carbon tethered sulfone which gave rise to substantial improvements in b

289 cycles were converted into the corresponding sulfones which were used as precursors of novel benzo-2,

290 ammatory drugs sulindac sulfide and sulindac sulfone, which attenuate beta-catenin transcription acti

291 y drug sulindac and its metabolite, sulindac sulfone, which were readily distinguished.

292 d a novel class of kinase inhibitors, styryl sulfones, which differ from prior cell cycle inhibitors

293 onformity with a diradical mechamism for the sulfone, while for the ether, the anionic [4 + 2] appear

294 ic fragment ions of m/z 75, 105, and 123 for sulfones, while an additional methanol elimination was o

295 Condensation reactions of fluoro PT-sulfones with aldehydes resulted in fluoroalkylidenes in

296 volves a Michael-aldol reaction of beta-keto sulfones with enones followed by a subsequent condensati

297 fonyl hydrazides to produce branched allylic sulfones with good to excellent yields and selectivities

298 a variety of (enantiopure) trans-cyclopropyl sulfones with high diastereoselectivity.

299 een developed that allows the union of vinyl sulfones with photoredox-generated alpha-amino radicals

300 Suzuki-Miyaura coupling of borylated allylic sulfones with various electrophiles in both inter- and t