ライフサイエンスコーパス: sulfonium

1 n through the formation of an unusual Fe(II) sulfonium.

2 Tris(trimethylsilyl)sulfonium 1 and methylbis(trimethylsilyl)sulfonium 2 ion

3 k(alpha)/k(normal)) 1.124 for dimethylphenyl sulfonium, 1.512 for dimethyl-1-naphthyl sulfonium, 1.83

4 nyl sulfonium, 1.512 for dimethyl-1-naphthyl sulfonium, 1.835 for dimethyl-9-anthracenyl sulfonium, a

5 lyl)sulfonium 1 and methylbis(trimethylsilyl)sulfonium 2 ions were prepared as long-lived species by

6 d to a methionine-deficient diet, choline or sulfonium analogs of betaine induced BHMT expression.

7 AdoMet facilitates reductive cleavage of the sulfonium and the generation of transient 5'-deoxyadenos

8 sulfonium, 1.835 for dimethyl-9-anthracenyl sulfonium, and 1.137 for S-methyldibenzylthiophenium.

9 m, proton removal at carbons adjacent to the sulfonium, and reductive cleavage to generate 5'-deoxyad

10 g the upper critical solution temperature of sulfonium- and ammonium-based polymer zwitterions in wat

11 The initially produced 1,3-betaine (o-sulfonium/aryl carbanion) undergoes intramolecular proto

12 plying selected ammonium-, phosphonium-, and sulfonium-based ionic liquids (IL) with bis(trifluoromet

13 re we have demonstrated that the presence of sulfonium-beta-sp(2) carbon and flexible, medium-sized s

14 We also determined the structures of one sulfonium bisphosphonate bound to farnesyl diphosphate s

15 results are of interest since they show that sulfonium bisphosphonates can have potent activity again

16 We investigated three series of sulfonium bisphosphonates for their activity in inhibiti

17 The third series consisted of 17 n-alkyl sulfonium bisphosphonates, the most active species havin

18 The first series consisted of 6 cyclic sulfonium bisphosphonates, the most active species havin

19 onsistent with the initial formation of a C2-sulfonium[bond]C1-oxosulfonium pyranosyl species upon ac

20 ection from dimethyl(2-hydroxy-5-nitrobenzyl)sulfonium bromide (DHNBS) oxidation.

21 reaction of dimethyl(2-hydroxy-5-nitrobenzyl)sulfonium bromide (HNSB) with tryptophan (Trp) residues

22 se charged interactions formed by the AdoMet sulfonium cation are stronger than typical CH...O hydrog

23 Molecular mechanics parameters for the sulfonium center have been developed for the AMBER force

24 that all three carbon atoms attached to the sulfonium center in SAM can serve as precursors to carbo

25 s initiated by the reductive cleavage of the sulfonium center of S-adenosyl-L-methionine (AdoMet), ge

26 s spontaneously degraded by inversion of its sulfonium center to form the R,S diastereomer.

27 ymes that transfer the methyl group from the sulfonium center, but is more folded in complexes with p

28 on of 3-dimethylsulfoniopropionate (DMSP), a sulfonium compound produced by many marine algae.

29 beta-sp(2) carbon and flexible, medium-sized sulfonium-delta-substituents are crucial for SAM analogs

30 y reaction of silane with tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF) or crypt[2.1.

31 reagents and 1.5 equiv of tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF).

32 termediate 65 with TAS-F (tris(dimethylamino)sulfonium difluorotrimethylsilicate), thereby completing

33 arbamidomethylation of Met residues leads to sulfonium ether formation, and the resulting fixed posit

34 the high reaction efficiency and the lack of sulfonium formation.

35 mechanism involving the formation of the C2-sulfonium glycosyl imidate 39 as well as oxazoline 37 as

36 tic interactions with the positively charged sulfonium group of SAM, thereby providing a basis for di

37 Met for uptake required a positively charged sulfonium group on the 5' position of the ribose.

38 first of which is racemization of the chiral sulfonium group, which takes place in a pH-independent m

39 ol (TG, 71%) and a minor amount of the CH-TG sulfonium ion (12%), although some elimination of HCl is

40 for this enzyme yielding methyl ethyl vinyl sulfonium ion (MEVS+) upon reaction with S-adenosylmethi

41 a hydrogen-bonded complex is formed between sulfonium ion and acceptor that undergoes SN2-like glyco

42 Displacement of the sulfonium ion by a hydroxyl leads to the stereoselective

43 boronate was converted to the corresponding sulfonium ion by treatment with methyl iodide and subseq

44 Under physiological conditions, however, the sulfonium ion can spontaneously racemize to the R form,

45 our different inhibitors: acarbose and three sulfonium ion compounds.

46 ophosphoserine lipids using a "fixed charge" sulfonium ion containing, d(6)-S,S'-dimethylthiobutanoyl

47 city of the amido anion contained within the sulfonium ion intermediate and facilitates the rate of t

48 observations support a mechanism by which a sulfonium ion intermediate is formed as a trans-decalin

49 convincingly the presence of the beta-linked sulfonium ion intermediate.

50 Due to steric and electronic factors, the sulfonium ion is formed as a trans-decalin ring system.

51 vidence for the formation of an intermediate sulfonium ion is provided, as are data from nucleophilic

52 rrole rings A and C of the heme as well as a sulfonium ion linkage between the sulfur atom of Met(243

53 results in the formation of a bicyclic beta-sulfonium ion that after addition of an alcohol undergoe

54 mpted preparation of dimethyl(trimethylsilyl)sulfonium ion under similar conditions failed as a resul

55 t of covalent reaction of methyl ethyl vinyl sulfonium ion with the enzyme as shown by comigration of

56 ich yields the nonreactive product trimethyl sulfonium ion, protected the enzyme from inactivation by

57 initial evaluation of a novel "fixed charge" sulfonium ion-containing crosslinking reagent, S-methyl

58 diastereoisomeric states with respect to its sulfonium ion.

59 articipation to give a quasi-stable anomeric sulfonium ion.

60 attacks the methylene carbon adjacent to the sulfonium ion.

61 Anomeric sulfonium ions are attractive glycosyl donors for the st

62 Since vinyl sulfonium ions are reactive toward nucleophiles, the ina

63 The sulfonium ions are sufficiently stable at a temperature

64 d easily be converted into bicyclic anomeric sulfonium ions by oxidization to sulfoxides and arylated

65 The resulting sulfonium ions gave high 1,2-cis-anomeric selectivity wh

66 S-Adenosylmethionine (AdoMet) and other sulfonium ions play central roles in the metabolism of a

67 The reactivities of acylated and unacylated sulfonium ions that were analogues of S-adenosylmethioni

68 AdoMet and two other biologically important sulfonium ions, S-methylmethionine and dimethylsulfoniop

69 ethers by methylation to form reactive vinyl sulfonium ions.

70 -ium triflate, a weak partial agonist with a sulfonium isostere of the ammonium pharmacophore.

71 se of myeloperoxidase, through an additional sulfonium link from the Cbeta of the 2-vinyl group to a

72 To duplicate the sulfonium link in myeloperoxidase and to obtain informat

73 o this reaction revealed a novel process for sulfonium-mediated oxidation of glycal enol ethers in wh

74 styryl]benzene core with covalently attached sulfonium moieties, has been synthesized.

75 ive charge at the position equivalent to the sulfonium of S-adenosylmethionine.

76 Further, sulfonium PEG polyelectrolytes can be obtained via alkyl

77 e (ACC) synthases and is positioned near the sulfonium pole of (S,S)-S-adenosyl-L-methionine (SAM) in

78 upport a role for Glu47 as an anchor for the sulfonium pole of (S,S)-SAM, and consequently a role as

79 3)C-methyl]-SAM complex show that the target sulfonium positioning varies with the cation, while the

80 1-hydroxy glycosyl donors employing dialkyl sulfonium reagents is described.

81 presence of DBU, is dehydrated by activated sulfonium reagents to generate the corresponding isocyan

82 cation mechanism leading to the formation of sulfonium salt 18.

83 PAH-sulfonium salts 1Me+, 1Et+, 10Me+, 10Et+, 12Me+, and 14M

84 oratories, was employed utilizing the chiral sulfonium salts 22 and 23.

85 Sulfonium salts 3 and 4 do not appear to interconvert, a

86 These azulene sulfonium salts are bench-stable species that may be emp

87 The corresponding sulfonium salts are formed in a highly regio- and stereo

88 tudies demonstrate that these triphenylamine sulfonium salts are highly efficient cationic photoiniti

89 ghly functionalized aromatic compounds using sulfonium salts as leaving groups.

90 Interestingly, only mono- or disubstituted sulfonium salts can be prepared.

91 These oligomeric sulfonium salts exist as free-flowing powders and are st

92 rived from readily available camphor-derived sulfonium salts for the synthesis of glycidic amides hav

93 The alpha-effects for the series of sulfonium salts in completion reactions for 3-ClNMBH ani

94 The propargyl sulfonium salts obtained by alkylation of thioethers 7,

95 S-alkyl and S-aryl orbitals of the starting sulfonium salts provide additional insight.

96 The formation of these sulfonium salts represents additional products in the di

97 To address this, we prepared sulfonium salts that produced a pH drop within HCT 116 c

98 On the other hand, the efficiencies of the sulfonium salts toward the photopolymerization of cycloh

99 The sulfonium salts with tertiary alkyl and vinyl substituen

100 pture nucleophiles and electrophiles to give sulfonium salts, which subsequently enable the formation

101 The chiral sulfonium spontaneously racemizes to form a mixture of S

102 exene oxide depend on the counterion and the sulfonium substituents.

103 tal hydroxyl to the S(IV)-center of putative sulfonium sulfonate 6.

104 ith an electrostatic interaction between the sulfonium sulfur and the carboxylate group is not notice

105 The sulfonium sulfur is in van der Waals contact with a prot

106 conformation in which the positively charged sulfonium sulfur is near an electronegative oxygen in th

107 s involving the sulfur and which can use the sulfonium sulfur solely as a binding site.

108 ared via the reaction of dimethyl(methylthio)sulfonium tetrafluoroborate (DMSTF) with beta-alkoxy-gam

109 tituted thioacetals with dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF) produces synthetical

110 ared via the reaction of dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF) with beta-alkoxy-gam

111 carbonyl compounds with dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF).

112 OBr, HOCl, CH(3)SCl, and dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF)/NaN(3) with a variet

113 t of cycloadduct 17 with dimethyl(methylthio)sulfonium tetrafluoroborate gave 2,5,6,7-tetrahydropyrro

114 philes provided facile access to pyridinium, sulfonium, thiol, carbonitrile, acetoxy, and amino deriv

115 hanesulfonic acid- and dimethyl (thiomethyl) sulfonium trifluoromethanesulfonate-promoted systems.

116 e two vinyl groups of heme b but lacks the 2-sulfonium-vinyl linkage of heme m.

117 Interactions of the sulfonium with aromatic rings are rarely observed.

118 tal lineCH-Acc, 2) with pyridinium ylides 3, sulfonium ylide 4, and sulfonyl-substituted chloromethyl

119 presented that suggests that the hydroperoxy sulfonium ylide exists in both diradical and zwitterioni

120 in terms of partitioning of the hydroperoxy sulfonium ylide intermediate.

121 is formed via rearrangement of a hydroperoxy sulfonium ylide intermediate.

122 have low BDEs, unless the sulfilimine or S,C-sulfonium ylide is stabilized by an electronegative subs

123 orged through the Stevens rearrangement of a sulfonium ylide, generated in situ from the coupling of

124 d acrylates with high ee and that stabilized sulfonium ylides (e.g., ester-stabilized) reacted with c

125 d previously been found that semi-stabilized sulfonium ylides (e.g., Ph-stabilized) reacted with cycl

126 Photolysis of S,C-sulfonium ylides derived from thioanisol, thiophene, ben

127 N-H sulfilimines and CH2-S,C-sulfonium ylides have low BDEs, unless the sulfilimine o

128 rsulfoxides, thiadioxiranes, and hydroperoxy sulfonium ylides were located and their structures analy

129 y has focused on the reactions of stabilized sulfonium ylides with acyclic enones which unexpectedly

130 the following: sulfoxides, sulfilimines, S,C-sulfonium ylides, and selenoxides.

131 ions were carried out with deuterium-labeled sulfonium ylides, higher ee's were observed in all cases