ライフサイエンスコーパス: sulfonyl

1 mical classes of sulfides, sulfonamides, and sulfonyls.

2 N-Sulfonyl 1,2,3-triazoles readily form rhodium(II) azavin

3 1,2-Bis(sulfonyl)-1-alkylhydrazines (BSHs) were conceived as mor

4 A series of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines (23-30) were sy

5 diverse rhodium vinylcarbenes from stable 1-sulfonyl-1,2,3-triazole precursors has been developed.

6 This methodology utilizes 4-aryl-1-sulfonyl-1,2,3-triazoles as carbenoid precursors and the

7 will describe the recent advances in using N-sulfonyl-1,2,3-triazoles as precursors for the formation

8 n of fused dihydroazepine derivatives from 1-sulfonyl-1,2,3-triazoles bearing a tethered diene is rep

9 re synthesized from 5-alkoxyisoxazoles and 1-sulfonyl-1,2,3-triazoles by tuning the Rh(II) catalyst a

10 a rhodium-catalyzed reaction of 4-alkenyl-1-sulfonyl-1,2,3-triazoles featuring an unusual 4pi electr

11 nsition-metal-catalyzed denitrogenation of 1-sulfonyl-1,2,3-triazoles has emerged as a powerful strat

12 produced from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of a rhodium ca

13 enerated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of chiral Rh(II

14 or the ring expansion and rearrangement of 1-sulfonyl-1,2,3-triazoles under rhodium(II)-catalyzed con

15 Rhodium-catalyzed transannulation of N-sulfonyl-1,2,3-triazoles with vinyl ether has been accom

16 inyl carbenes, conveniently generated from 1-sulfonyl-1,2,3-triazoles, undergo a facile, mild, and co

17 ective construction of the highly strained 2-sulfonyl-1,3-diazabicyclo[3.1.0]hexane structures in hig

18 erature asymmetric Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes is reported enlisting a se

19 e electron demand Diels-Alder reactions of N-sulfonyl-1-azabutadienes, while key elements of side cha

20 1-(Morpholine-4-sulfonyl)-1H-benzotriazole 3c reacts with piperidine, py

21 A method to prepare 1-substituted 3-sulfonyl-1H-pyrroles efficiently that relies on the gold

22 cation of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phen yl)-1,1,1

23 talyzed intramolecular aminooxygenation of N-sulfonyl-2-allylanilines and 4-pentenylsulfonamides to a

24 receptor antagonist (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2 -(2-(4-methyl-1-piperidinyl)ethyl)pyrrolidin

25 lar inhibitor of ALDH3A1, 1-[(4-fluorophenyl)sulfonyl]-2-methyl-1H-benzimidazole (CB7, IC50 of 0.2 mu

26 ility of a DH-specific probe that contains a sulfonyl 3-alkyne reactive warhead engineered to avoid h

27 antibiotic susceptibility, suggest that this sulfonyl 3-alkyne scaffold selectively targets a common

28 protein NMR spectroscopy to demonstrate that sulfonyl 3-alkynyl pantetheinamide is fully sequestered

29 ucts possessing a synthetically useful 1-bis-sulfonyl-3-nitroalkene moiety in good to excellent yield

30 A novel series of 1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 re

31 at C-9 methylene bridge is developed from N-sulfonyl-4-biaryl-1,2,3-triazole derivatives via Rh-cata

32 F-(N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-bi phenyl]-2-yl]methyl]-N,

33 C-(N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-bi phenyl]-2-yl]methyl]-N,

34 st N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl] -2-yl]methyl]-N,

35 F-(N-[[29-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,19-bi phenyl]-2-yl]methyl]-N,

36 anism of CCG-4986 [methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitro-benzenesulfinimidoate], a previously r

37 ounds screened, 1, methyl N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate (CCG-4986), inhib

38 a ((-)-3-(4-chlorophenyl)-N'-[(4-cyanophenyl)sulfonyl]-4-phenyl- 4,5-dihydro-1H-pyrazole-1-carboxamid

39 ulted in identification of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1

40 to the regiocontrolled domino formation of N-sulfonyl-6,7-dihydro-5H-dibenzo[c,e]azepines over the bi

41 Finally, sulfonyl acetylenes are efficient for alkyne transfer on

42 more extensive structural exploration of the sulfonyl acrylonitrile chemotype may result in useful in

43 Here, we describe a distinct set of sulfonyl acrylonitrile inhibitors that also emerged from

44 previously that (2E)-3-[(4-tert-butylphenyl)sulfonyl]acrylonitrile (1) induced cancer cell apoptosis

45 On the other hand, moving from an alkyl to a sulfonyl alkyl side chain led to reduced cytotoxicity.

46 e-pot transformation of the products to beta-sulfonyl-alpha,beta-unsaturated ketoximes has also been

47 y enantioselective addition of indole to the sulfonyl amide 50 with bifunctional aminothioureas 57 an

48 pyl) trimethylammonium][bis((trifluoromethyl)sulfonyl)amide] ((R)- and (S)-[CHTA]+[Tf2N]-) in optical

49 yl) trimethylammonium] [bis((trifluoromethyl)sulfonyl)amide] (S-[CHTA](+) [Tf(2)N](-)), is a novel ch

50 ction conditions were optimized, the desired sulfonyl amides (R)-55 and (S)-55 were obtained in 99% e

51 ddition/decarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted a

52 ing this simple protocol, a diverse range of sulfonyl amidines was obtained in moderate to excellent

53 decarboxylation, which liberates the desired sulfonyl amidines, generating N2 and CO2 as the only rea

54 l-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinyl methyl)-acetamide (EMPA),

55 (N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl) -1-piperazinyl]carbo

56 N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1 -piperazinyl]carbo

57 This study describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as pot

58 A series of N-sulfonyl-aminobiaryl derivatives have been examined as n

59 alyzed cycloisomerization of N-substituted N-sulfonyl-aminobut-3-yn-2-ols is described.

60 ore potent inhibitors then their sulfinyl or sulfonyl analogs.

61 palladium(II) acetate to afford the E-isomer sulfonyl analogues of cinnamoyl fluoride in 43-97 % yiel

62 ulfonylthymidine precursors, (4-methylphenyl)sulfonyl and (2,4,6-trimethylphenyl)sulfonyl, were prepa

63 s more ketenophilic bis-silyl ynamines and N-sulfonyl and N-phosphoryl ynamides serve as the reaction

64 Various sulfonyl and phosphoryl azides were screened for reactiv

65 d by the electron-withdrawing effects of the sulfonyl and sulfonamide groups, these media display an

66 In addition, 3-sulfonyl- and 3-sulfinylindoles have also been successfu

67 ives an easy entry to optically active alpha-sulfonyl- and alpha-phosphoryl oxyketones in respectable

68 wis acid-mediated [3 + 2] cycloaddition of N-sulfonyl- and N-sulfamoylaziridines with alkenes provide

69 The preparation and chemistry of novel sulfonyl- and phosphoryl-derived lambda(3)-iodanes are r

70 r of acetylenes, leading to hitherto unknown sulfonyl- and phosphoryl-substituted phosphinolines, pho

71 hlorosilane derivatives containing synthetic sulfonyl- and sulfonamide-substituted phenylboronic acid

72 Allylation of the intermediate alpha-sulfonyl anion is more rapid than racemization, leading

73 The corresponding alpha-sulfonyl anion reacts smoothly with diverse alkyl halide

74 ydrazone has been identified as an excellent sulfonyl anion surrogate in the DBU-catalyzed conjugate

75 nyl sulfone and in situ traping of the allyl sulfonyl anion with a CD ring allyl chloride.

76 synthesis of a novel ionic liquid-supported sulfonyl azide and its applications as diazotransfer rea

77 Imidazole-1-sulfonyl azide and salts thereof are valuable reagents f

78 ibe the development of lissamine rhodamine B sulfonyl azide as a sensitive click reagent for the dete

79 e recently reported bench-stable imidazole-1-sulfonyl azide as diazotransfer reagent, this new method

80 Imidazole-1-sulfonyl azide hydrochloride, an inexpensive and effecti

81 Imidazole-1-sulfonyl azide hydrogen sulfate is presented as an effic

82 Imidazole-1-sulfonyl azide hydrogen sulfate provides a considerable

83 gent, several different salts of imidazole-1-sulfonyl azide were prepared, and their sensitivity to h

84 Benzotriazol-1-yl-sulfonyl azide, a new crystalline, stable, and easily av

85 + 2 + 2]/[NC + CC + NC] cycloaddition, using sulfonyl azide, alkyne, and quinoline, to prepare pyrimi

86 st direct observation of the S(1) state of a sulfonyl azide, and this vibrational feature allows a me

87 late intermediate is allowed to react with a sulfonyl azide, resulting overall in N-arenesulfonyl 3-a

88 t formation of substituted sulfonamides from sulfonyl azides and amines via nucleophilic substitution

89 cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides at low CO pressur

90 sulfonyl carbamates and sulfonyl ureas from sulfonyl azides employing a palladium-catalyzed carbonyl

91 as an efficient reagent for the synthesis of sulfonyl azides from primary sulfonamides.

92 xo mode starting from 2-ethynylbiaryls and N-sulfonyl azides in one pot.

93 en readily accessible propargyl acetates and sulfonyl azides in the presence of CuI catalyst yields t

94 an amidation reaction between thio acids and sulfonyl azides is applicable for Bcl-XL-templated assem

95 2,3-triazoles from 2-cyanothioacetamides and sulfonyl azides is described.

96 e coupling of salicylaldehydes, propiolates, sulfonyl azides, and secondary amines.

97 etween indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regiosele

98 tive generation of sulfonyl isocyanates from sulfonyl azides, followed by a [2 + 2] cycloaddition wit

99 Using a two-chamber system, sulfonyl azides, PdCl2, and CO gas, released ex situ fro

100 tramolecular C-H bond amination reactions of sulfonyl azides.

101 pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amin

102 -catalyzed cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents is reported.

103 n reaction of a range of carbon acids with N-sulfonyl aziridines is reported.

104 N-Sulfonyl aziridines undergo oxidative addition to pallad

105 on of Grignard reagents to in situ-derived N-sulfonyl azoalkenes.

106 oromethyl)phosphonate, [(bromodifluoromethyl)sulfonyl]benzene, and ethyl 2-bromo-2-fluoroacetate were

107 the AMPAR antagonist 2,3-dihydroxy-6-nitro-7-sulfonyl-benzo[f]quinoxaline (NBQX) protected against th

108 eonatally with NBQX (2,3-dihydroxy-6-nitro-7-sulfonyl-benzo[f]quinoxaline) plus LY341495 [(2S)-2-amin

109 AR antagonists NBQX (2,3-dihydroxy-6-nitro-7-sulfonyl-benzo[f]quinoxaline), topiramate, or GYKI-53773

110 le, processes which introduce the most basic sulfonyl building block, sulfur dioxide, using catalytic

111 Taken together, styryl sulfonyls can cause a rapid decrease of cyclin D1 by blo

112 An efficient synthesis of sulfonyl carbamates and sulfonyl ureas from sulfonyl azi

113 d as nucleophiles to afford a broad range of sulfonyl carbamates and sulfonyl ureas.

114 atory Oxaprozin was prepared using the alpha-sulfonyl carbanion strategy along with optimized desulfo

115 d a beta-lactam, undergoes hydrolysis at the sulfonyl center rather than aminolysis at either the sul

116 C2-, and (13)C4-5-diethylamino-naphthalene-1-sulfonyl chloride (DensCl), in combination with liquid c

117 trazolopyridines by treatment with 4-toluene sulfonyl chloride and sodium azide in toluene at elevate

118 Heteroaromatic thiols may be oxidized to the sulfonyl chloride at low temperature (-25 degrees C) by

119 rivatization reagent 1,2-dimethylimidazole-5-sulfonyl chloride is its analyte-specific fragmentation

120 phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (

121 reaction protocol avoids the need to employ sulfonyl chloride substrates, thus removing the limitati

122 ed to several of its derivatives: anhydride, sulfonyl chloride, and sulfonyl fluoride, which provide

123 (1) and disulfides (2) to the corresponding sulfonyl chlorides (3) in excellent yields through oxida

124 Aryl sulfonyl chlorides (e.g. Ts-Cl) are beloved of organic c

125 solvolysis rate constants: (i) electron-rich sulfonyl chlorides and most carboxylic acid chlorides, i

126 with a significant negative slope; (ii) most sulfonyl chlorides and some chloroformates and thio deri

127 herein are generated from the corresponding sulfonyl chlorides by treatment with zinc dust.

128 [(18)F]Radiolabeling of sulfonyl chlorides in the presence of competing nucleoph

129 Sulfonyl chlorides substituted with functional groups ha

130 adicals were generated from their respective sulfonyl chlorides under mild, metal-free conditions lea

131 Sulfinamides were synthesized from sulfonyl chlorides using a procedure involving in situ r

132 ining functional groups, including sulfones, sulfonyl chlorides, and sulfonamides.

133 g a procedure involving in situ reduction of sulfonyl chlorides.

134 Here, we show that the prototypical styryl sulfonyl compound ON 01910.Na decreased cyclin D1 and c-

135 Styryl sulfonyl compounds have shown potent antitumor activity

136 Several chiral sulfonyl compounds were prepared using the iridium catal

137 Various sulfonyl-containing compounds (e.g. sulfonamides, sulfon

138 ucts are converted in situ into a variety of sulfonyl-containing functional groups, including sulfone

139 B(C6F5)3 activates N-sulfonyl cyanamides, thus leading to a formal cleavage o

140 ection of the 4-(dimethylamino)azobenzene-4'-sulfonyl derivative of l-methionine (dabsyl Met), the pr

141 apoptosis induction, while some sulfinyl and sulfonyl derivatives (5b, 5c, and 6a-c) were highly effi

142 cribe the formation of anionic 5,6-dihydro-6-sulfonyl derivatives by spontaneous addition of sulfite

143 However, despite being active sulfonyl derivatives, four-membered heterocyclic sulfona

144 Activated sulfonyl derivatives, similar to acyl ones, usually unde

145 Sulfonyl-derived functional groups populate a broad rang

146 first time, providing a workable access to N-sulfonyl dihydrophenanthridines in good to excellent yie

147 red dansyl chloride, 1,2-dimethylimidazole-4-sulfonyl (DMIS) chloride, pyridine-3-sulfonyl (PS) chlor

148 oselective synthesis of a wide range of beta-sulfonyl enamines without electron-withdrawing groups on

149 s and ArINTstBu (TstBu = (p-tert-butylphenyl)sulfonyl) establish the source of [NR] transfer as a "th

150 ument the failure of the previously reported sulfonyl ester pharmacophore to confer Tdp1 inhibition i

151 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), was characterized us

152 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a

153 d binding orientation and sheds light on the sulfonyl fluoride activation leading to the sulfonamide

154 We now report on later generation sulfonyl fluoride analogs that exhibit potent and select

155 firmed a chemoselective reaction between the sulfonyl fluoride and a conserved lysine in the ATP bind

156 s substituted at the 2 position with an aryl sulfonyl fluoride and at the 5 position with a substitut

157 h the members contain an amino acid inspired sulfonyl fluoride as the electrophilic trap.

158 oupling that is compatible with the aromatic sulfonyl fluoride functional group.

159 y, in which either the alkenyl moiety or the sulfonyl fluoride group can be the exclusive site of nuc

160 In total, 24 peptido sulfonyl fluoride inhibitors have been designed and synt

161 A number of the peptido sulfonyl fluoride inhibitors were found to be highly sel

162 Using a series of sulfonyl fluoride inhibitors with various lengths of acy

163 he membranes was achieved by reacting Nafion sulfonyl fluoride poly(perfluorosulfonyl fluoride) membr

164 highlighting the utility of lysine-targeted sulfonyl fluoride probes in demanding chemoproteomic app

165 Here, we report the design of sulfonyl fluoride probes that covalently label a broad s

166 rivatives: anhydride, sulfonyl chloride, and sulfonyl fluoride, which provide a good entry point for

167 Sulfonyl fluorides are known to inhibit esterases.

168 fers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reagents.

169 versatility and potential utility of [(18)F]sulfonyl fluorides as synthons for indirect radiolabelin

170 Additionally, sulfonyl fluorides can be converted to aryl sulfonamides

171 A few of the aryl sulfonyl fluorides efficiently form conjugates with TTR

172 lectfluor has been developed generating aryl sulfonyl fluorides in good to excellent yields.

173 the thyroxine binding site, most of the aryl sulfonyl fluorides react rapidly and chemoselectively wi

174 -catalyzed conversion of aryl iodide to aryl sulfonyl fluorides using DABSO and Selectfluor has been

175 lyl ethers and aryl fluorosulfates (or alkyl sulfonyl fluorides).

176 is lower than that of the corresponding aryl sulfonyl fluorides, which are better characterized with

177 The method allows the preparation of the sulfonyl fluorides, which are stable enough to be purifi

178 ion of electronically and sterically diverse sulfonyl fluorides.

179 on-withdrawing substituents, such as acyl or sulfonyl functionalities at nitrogen, are rather unreact

180 es are obtained with an electron-withdrawing sulfonyl group (left).

181 nal and internal alkynes bearing a 2-pyridyl sulfonyl group (SO2Py) at the propargylic position affor

182 onstrated that a small compound containing a sulfonyl group acts as inhibitor of catBoNT/A through co

183 The size of the substrate's N-sulfonyl group also influences the enantioselectivity of

184 Anthracene derivatives with an amino or sulfonyl group at the 1-position bind within the cavity,

185 ination mode, in which an oxygen atom of the sulfonyl group coordinates to Pd.

186 The sulfonyl group in the tail of compounds 1 and 2 is invol

187 The sulfonyl group is demonstrated to be an effective direct

188 Substituted anilines containing a sulfonyl group may be oxidized in situ in the presence o

189 s, whereas electron-rich substrates provided sulfonyl group migration products.

190 Use of an electron-donating sulfonyl group results in an unanticipated aza-Michael/a

191 rogen substituent at 2-position directed the sulfonyl group to the N-3 position, while alkylsulfanyl

192 elationship (SAR) studies indicated that the sulfonyl group, the piperidine ring and benzothiazole we

193 a longer perfluoroalkyl chain and a bulkier sulfonyl group, when compared to PFOAAmS.

194 the presence or absence of the N-(2-pyridyl)sulfonyl group.

195 eaction taking advantage of the N-(2-pyridyl)sulfonyl group.

196 of the tether and the presence or absence of sulfonyl groups.

197 cing the toluenesulfonyl sidearms with other sulfonyl groups.

198 ular amination of an N-guanidyl pyrrole by a sulfonyl guanidine.

199 inyl chloride, initiated with alkyl halides, sulfonyl halides, and N-halides.

200 toskeletal networks with 5-iodonaphthalene-1-sulfonyl homopiperazine and cytochalasin D abolished the

201 4-bromophenyl)-2-oxo-2,3-dihydro-1H-indole-5-sulfonyl hydrazide 40, which demonstrated 59% oral bioav

202 catalyst system, terminal alkynes react with sulfonyl hydrazides to produce branched allylic sulfones

203 aldehydes, respectively and (2) utilizing a sulfonyl hydrazine polymer treatment.

204 Ionic liquid-supported sulfonyl hydrazine was synthesized and reacted with a nu

205 Subsequent hydrolysis of the beta-hydroxy N-sulfonyl hydrazone products produces the corresponding b

206 We describe a family of sulfonyl-hydrazone (Shz) small molecules that can trigge

207 port here an asymmetric boronate addition to sulfonyl hydrazones catalyzed by chiral biphenols to acc

208 tuted diazo reagents, generated in situ from sulfonyl hydrazones in the presence of base, can serve a

209 The alpha-alkylation of N-sulfonyl hydrazones via in situ-derived azoalkenes provi

210 ive production of alpha-alkyl-beta-hydroxy N-sulfonyl hydrazones with alpha-quaternary centres.

211 dition of Grignard reagents to alpha-epoxy N-sulfonyl hydrazones-directed by the alkoxide of the 1-az

212 nd N-alkyl arylamines using NH2/NH(alkyl)-O-(sulfonyl)hydroxylamines as aminating agents; the relativ

213 uthyl-methylpyrolydinium bis (trifluromethyl sulfonyl) imide [C(4)mpyr][NTf(2)].

214 RILs, protonated betaine bis(trifluoromethyl sulfonyl)imide ([Hbet][Tf2N]) and choline bis(trifluorom

215 hyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide in an operating EDLC with electrodes comp

216 tyl-3-methylimidazolium bis(trifluoromethane-sulfonyl)imide, improves stability of the antibody.

217 hosphate (PF(6)(-)) and bis[(trifluoromethyl)sulfonyl]imide (NTf(2)(-)) anions, FAP-based ILs are sig

218 nyl-3-hexylimidazolium) bis[(trifluoromethyl)sulfonyl]imide [poly(VHIM-NTf(2))] and poly(1-vinyl-3-he

219 enzimidazolium)dodecane bis[(trifluoromethyl)sulfonyl]imide bromotrichloroferrate(III) ([(C16BnIM)2C1

220 ng of inhibitor by the enzyme generates an N-sulfonyl imine functionality that is tethered to Ser195,

221 The identity of the HNE-N-sulfonyl imine species was further corroborated using el

222 ordinate to the Cl, N, and O of alpha-chloro sulfonyl imine substrates is supported by computational

223 additions of alpha-isothiocyanato imides to sulfonyl imines are reported.

224 Cyclic sulfonyl imines derived from ketones were identified as

225 nonstabilized azomethine ylides and cyclic N-sulfonyl imines has been developed providing a workable

226 applied to the synthesis of N-sulfinyl and N-sulfonyl imines, but its general validity has been prove

227 carbonyl group in the parent compound with a sulfonyl in the PDK inhibitors.

228 (2(2,4-difluoro phenoxymethyl)-pyrrolidine-1-sulfonyl)isatin ((18)F-ICMT-11), has been developed for

229 -7-halogen-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins were developed as a new group of nonrad

230 ial Pd-catalyzed carbonylative generation of sulfonyl isocyanates from sulfonyl azides, followed by a

231 itu from Mo(CO)6, were assembled to generate sulfonyl isocyanates in situ, and alcohols and aryl amin

232 ound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits

233 s-alpha,beta-unsaturated N-tosylamides via N-sulfonyl ketenimine formation followed by a probable 1,3

234 tryptophans and 5-dimethylaminonaphthalene-1-sulfonyl-labeled crmAs occurred in protease complexes wi

235 Increasing the pK(a) of the acyl-sulfonyl linker yielded incremental enhancements, while

236 this transformation is ester << amide < H < sulfonyl < benzoyl << nitro.

237 ical properties of {(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]

238 An unexpected 1,3-sulfonyl migration was observed and further analyzed.

239 ate undergoes dehydration and deaurative 1,3-sulfonyl migration, a process that remains rare in gold

240 ization, thiophenol elimination, and N- to O-sulfonyl migration, giving 2-sulfonate-substituted pyrid

241 f prodrugs, increasing the pK(a) of the acyl-sulfonyl moiety, modulation of the lipophilicity, and st

242 Thermally persistent triplet sulfonyl nitrene, FSO(2)N, was produced in the gas phase

243 onyl, imidoyl, boryl, silyl, phosphonyl, and sulfonyl nitrenes are included.

244 The o-nitration process provides a series of sulfonyl o-nitrostyrenes.

245 -catalyzed aminooxygenation/cyclization of N-sulfonyl-O-butenyl hydroxylamines in the presence of (2,

246 n-withdrawing nonparticipating group, benzyl sulfonyl, on 2-O, an increase in beta-product was observ

247 center rather than aminolysis at either the sulfonyl or acyl center.

248 o excellent yield by heating in the presence sulfonyl or phosphoryl azides and pyridine in the absenc

249 three-component reaction of alkyne, azides (sulfonyl or phosphoryl azides), and N,N-dialkyloxyformam

250 ulfonyl residue could be replaced by various sulfonyl- or urethane-like protecting groups.

251 ones 1 and o-formyl allylbenzenes 2 provides sulfonyl oxabenzo[3.3.1]bicyclic core 4 in a cosolvent o

252 N-Sulfonyl oxaziridines are susceptible to electrophilic a

253 ntioselective oxyamination of alkenes with N-sulfonyl oxaziridines is catalyzed by a novel iron(II) b

254 In the presence of a copper(II) catalyst, N-sulfonyl oxaziridines participate in efficient intramole

255 We have discovered that N-sulfonyl oxaziridines react with a broad range of olefin

256 3) inhibitor 2-hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid (NSC74859).

257 for the first time that the presence of the sulfonyl oxygen atoms enhances receptor affinity.

258 etween the hypervalent iodine center and the sulfonyl oxygens in the tosyl group.

259 and 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf), three acid-labile protecting groups most

260 ated a 4-piperazinylquinoline scaffold and a sulfonyl phamarcophore.

261 -(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) was performed on pig brain s

262 12, (E)-3-(3-((1H-pyrrolo[2,3-b]pyridin-1-yl)sulfonyl)phenyl)-N-hydroxyacrylamide, which has a 7-azai

263 yl)amino)-6-(4-((4-methyl-1,4-diazepan-1- yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) f

264 603 [(8-[4-[4-((4-chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine].

265 b]pyridin-2-yl)-2-[4-(4-methyl-piperazine -1-sulfonyl)-phenyl]-propionamide (17c).

266 -methoxy-2-[(4methoxyphenyl)sulfonyl] phenyl]sulfonyl] phenyl]ethyl]methane-sulfonamide (Sch225336),

267 t, N-[1(S)-[4-[[4-methoxy-2-[(4methoxyphenyl)sulfonyl] phenyl]sulfonyl] phenyl]ethyl]methane-sulfonam

268 nd 2,4-dichloro-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}benzamide (ChemBridge ID5217941)] sharin

269 f symmetrical ureas of [(7-amino(2-naphthyl))sulfonyl]phenylamines were designed, synthesized, and te

270 by accumulation of N-(lissamine rhodamine B sulfonyl)phosphatidylethanolamine (N-Rh-PE), a lipid mar

271 nd p-toluenesulfonyl azide gives access to N-sulfonyl phosphoramidines in good to excellent yields.

272 azole-4-sulfonyl (DMIS) chloride, pyridine-3-sulfonyl (PS) chloride, and 4-(1H-pyrazol-1-yl)benzenesu

273 ive S(N)Ar substitution of the corresponding sulfonyl pyridines.

274 mGluR1, (S)-2-(4-fluorophenyl)-1-(toluene-4-sulfonyl)pyrrolidine (Ro 67-7476).

275 ion of the terminal alkyne and addition of a sulfonyl radical to the resultant vinyl azide.

276 catalyst-free approach for the generation of sulfonyl radicals from aryldiazonium tetrafluoroborates

277 id H2O adsorption takes place at hydrophilic sulfonyl/salt groups on domain surfaces at low RH, while

278 While attempts to render this 1,3-sulfonyl shift stereoselective failed, we uncovered anot

279 An observation of N-to-C 1,3-sulfonyl shift was made when examining these aza-Claisen

280 key C7 and C8 stereocenters and a tandem 1,3-sulfonyl shift/intramolecular Mannich cyclization to for

281 addition of a keto sulfone and a tandem 1,3-sulfonyl shift/Mannich cyclization to construct the tric

282 lladium catalysis is required, as facile 1,3-sulfonyl shifts dominate under thermal conditions.

283 substitution on the substrate backbone and N-sulfonyl substituent affect the level of enantioselectiv

284 Epoxidation of N-sulfonyl substituted allenamides with dimethyldioxirane

285 methylphosphonate- and (difluoromethylphenyl)sulfonyl-substituted alkyl acetals.

286 The use of chiral N-sulfonyl-substituted allenamides provided minimal diaste

287 te, whether generated from N-carbamoyl- or N-sulfonyl-substituted allenamides.

288 pyridinium ylides 3, sulfonium ylide 4, and sulfonyl-substituted chloromethyl anion 5.

289 ntrast to acyl transfer reactions, those for sulfonyl transfer appear to show an inverse reactivity-s

290 s and ketone derivatives, thus rendering the sulfonyl triazole traceless.

291 Stable and readily available 1-sulfonyl triazoles are converted to the corresponding im

292 r, N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine (11q) is a high affinity, potent ful

293 ntioselective oxyamination of alkenes with N-sulfonyl ureas employing chiral, lactic acid-based hyper

294 ficient synthesis of sulfonyl carbamates and sulfonyl ureas from sulfonyl azides employing a palladiu

295 ubstituted amide nucleophiles to afford acyl sulfonyl ureas in good yields.

296 ord a broad range of sulfonyl carbamates and sulfonyl ureas.

297 ylphenyl)sulfonyl and (2,4,6-trimethylphenyl)sulfonyl, were prepared and analyzed for their stabiliti

298 irecting groups, such as benzyl, ketone, and sulfonyl, were shown to give good enantioselectivity und

299 ed study of amidine synthesis from N-allyl-N-sulfonyl ynamides is described here.

300 With N-sulfonyl ynamides, the use of palladium catalysis is req