ライフサイエンスコーパス: sulfonylurea receptor

1 inward rectifier, plus SUR2A, a low-affinity sulfonylurea receptor.

2 or family, in keeping with the presence of a sulfonylurea receptor.

3 enzymes, beta-cell-specific glucokinase and sulfonylurea receptor.

4 ATP-sensitive K(+) (K(ATP)) channels is the sulfonylurea receptor.

5 inwardly rectifying Kir channel (Kir6.x) and sulfonylurea receptors.

6 nnels, with SUR 1 and SUR 2, probably SUR2B, sulfonylurea receptors.

7 Recent studies demonstrated that sulfonylurea receptor 1 (SUR 1) regulated nonselective c

8 otassium (K(ATP)) channel, a complex of four sulfonylurea receptor 1 (SUR1) and four potassium channe

9 ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1) and inwardly rectifying p

10 tive potassium (K(ATP)) channels composed of sulfonylurea receptor 1 (SUR1) and Kir6.2 regulate insul

11 h defects in ABCC8 and KCNJ11 genes encoding sulfonylurea receptor 1 (SUR1) and Kir6.2 subunits, whic

12 ATP-sensitive K(+) (K(ATP)) channel proteins sulfonylurea receptor 1 (SUR1) and Kir6.2, encoded by AB

13 caused by mutations in the channel proteins: sulfonylurea receptor 1 (SUR1) and Kir6.2, results in lo

14 sitive potassium (KATP) channels composed of sulfonylurea receptor 1 (SUR1) and Kir6.2.

15 Recessive mutations of sulfonylurea receptor 1 (SUR1) and potassium inward rect

16 ensitive potassium (K(ATP)) channel subunits sulfonylurea receptor 1 (SUR1) and the inwardly rectifyi

17 tive potassium (KATP) channels consisting of sulfonylurea receptor 1 (SUR1) and the potassium channel

18 ed glucose sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse.

19 outward current that was antagonized by the sulfonylurea receptor 1 (SUR1) channel blocker tolbutami

20 Sulfonylurea receptor 1 (SUR1) is a molecule with more d

21 tions in ABCC8 or KCNJ11, genes encoding the sulfonylurea receptor 1 (SUR1) or the inwardly rectifyin

22 tudies using transfected COSm6 cells, mutant sulfonylurea receptor 1 (SUR1) protein was expressed on

23 s to nucleotide binding fold-1 (NBF1) of the sulfonylurea receptor 1 (SUR1) subunit of the KATP chann

24 ctifying potassium channel (Kir6.2) and four sulfonylurea receptor 1 (SUR1) subunits.

25 Mutations in the sulfonylurea receptor 1 (SUR1), a subunit of ATP-sensiti

26 in ischemic astrocytes that is regulated by sulfonylurea receptor 1 (SUR1), is opened by depletion o

27 The sulfonylurea receptor 1 (Sur1)-NC(Ca-ATP) channel plays

28 scovery of a disease-causing mutation in the sulfonylurea receptor 1 (SUR1)/ABCC8 from a patient with

29 Diazoxide, a sulfonylurea receptor 1 (SUR1)selective KATP-channel ope

30 racellular calcium in islets from normal and sulfonylurea receptor 1 knockout (SUR1-/-) mice.

31 ns in ABCC8 or KCNJ11, genes that encode the sulfonylurea receptor 1 or the inward rectifier Kir6.2 s

32 ATP-sensitive K(+) channel (K(ATP) channel) sulfonylurea receptor 1 subunit, and decreased inhibitor

33 ying potassium channel Kir6.2 assembles with sulfonylurea receptor 1 to form the ATP-sensitive potass

34 cases are associated with mutations in SUR1 (Sulfonylurea receptor 1) or KIR6.2 (Inward rectifier K(+

35 Kir6.2 or its associated regulatory subunit, sulfonylurea receptor 1, causes congenital hyperinsulini

36 K(ATP) channel, a functional complex of the sulfonylurea receptor 1, SUR1, and an inward rectifier p

37 cervical SCI, we tested the hypothesis that sulfonylurea receptor 1-regulated (SUR1-regulated) Ca(2+

38 Sulfonylurea receptor- 1 was quantified by enzyme-linked

39 inemic hypoglycemia, similar channel loss in sulfonylurea receptor-1 (SUR1) and Kir6.2 null mice yiel

40 he absence of nucleotide stimulation through sulfonylurea receptor-1 (SUR1).

41 There was no association between mean/peak sulfonylurea receptor-1 and mean/peak intracranial press

42 There was a temporal delay between peak sulfonylurea receptor-1 and peak intracranial pressure i

43 is available, assessing cerebrospinal fluid sulfonylurea receptor-1 in larger studies is warranted t

44 Because a therapy inhibiting sulfonylurea receptor-1 is available, assessing cerebros

45 We hypothesized that sulfonylurea receptor-1 is measurable in human cerebrosp

46 However, decreasing sulfonylurea receptor-1 trajectories between 48 and 72 h

47 Sulfonylurea receptor-1 trajectories between 48 and 72 h

48 Sulfonylurea receptor-1 was detected in severe traumatic

49 Mean and peak sulfonylurea receptor-1 was higher in patients with CT e

50 MAIN Sulfonylurea receptor-1 was present in all severe trauma

51 Sulfonylurea receptor-1-transient receptor potential cat

52 report quantifying human cerebrospinal fluid sulfonylurea receptor-1.

53 nes were generated and independently bred to sulfonylurea receptor 2 (SUR2) null mice to generate mic

54 tations in the genes encoding the regulatory sulfonylurea receptor 2 (SUR2) subunits of the ATP-sensi

55 The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channel

56 T-PCR) using primers specific for Kir6.2 and sulfonylurea receptor 2A (SUR2A) subunits was performed

57 The sulfonylurea receptor 2B (SUR2B) forms the regulatory su

58 Sulfhydration of sulfonylurea receptor 2B (SUR2B) was induced by NaHS and

59 kidney 293 cell-attached patches expressing sulfonylurea receptor 2B and Kir6.2, we found K(ATP) sti

60 ed equivalent of this channel comprising the sulfonylurea receptor 2B and the inward rectifier 6.1 su

61 The high-affinity sulfonylurea receptor, a novel member of the ATP-binding

62 in the second nucleotide-binding fold of the sulfonylurea receptor, a subunit of the pancreatic-islet

63 iant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S) promotes closure

64 se, two insulin-dependent diabetes loci, the sulfonylurea receptor, and ataxia telangiectasia.

65 l beta-cells, including rat insulin, amylin, sulfonylurea receptor, and glucokinase, are stably expre

66 both nucleotide-binding-fold regions of the sulfonylurea receptor are required for normal regulation

67 Superfusion of tolbutamide, a K(ATP) channel sulfonylurea receptor blocker, elicited identical glucos

68 a transgenic strategy where the full-length sulfonylurea receptor containing exon 40 was expressed u

69 osinophils do express mRNA homologous to the sulfonylurea receptor family, in keeping with the presen

70 effective after procedures that decouple the sulfonylurea receptor from the K(ATP) channel.

71 in the first nucleotide-binding fold of the sulfonylurea-receptor gene.

72 lurea 1 and 2 failed to show expression of a sulfonylurea receptor in the parietal cell, thus further

73 Transgenic expression of the sulfonylurea receptor in vascular smooth muscle cells wa

74 Administration of the sulfonylurea-receptor inhibitor glibenclamide promptly r

75 The sulfonylurea receptor is present in membranes from a num

76 o disrupt the normal splicing pathway of the sulfonylurea-receptor mRNA precursor.

77 ce probe BODIPY-FL-glyburide labeling of the sulfonylurea receptor of mitoK(ATP) from brain and liver

78 ct with ABC proteins beyond the subfamily of sulfonylurea receptors provides an intriguing explanatio

79 inwardly rectifying potassium channel and a sulfonylurea receptor regulatory subunit (SUR1 or SUR2).

80 yeast cadmium resistance transporter and the sulfonylurea receptor share a conserved topology disting

81 aining a pore-forming subunit (Kir6.1) and a sulfonylurea receptor subunit (SUR2B).

82 he potentiatory effects are conferred by the sulfonylurea receptor subunit, SUR.

83 pore-forming subunit (Kir6.2) but different sulfonylurea receptor subunits (SUR1 and SUR2A, respecti

84 r6.2 subunits complexed with four regulatory sulfonylurea receptor subunits (SUR1 in pancreatic beta-

85 ed from pore-forming (Kir6.x) and regulatory sulfonylurea receptor subunits, are critical electrical

86 , an inwardly rectifying K+ channel, and the sulfonylurea receptor SUR, an ATP binding cassette prote

87 e components of KATP channels in beta-cells, sulfonylurea receptor (SUR) 1 and Kir6.2, have operation

88 he ATP-gated K(+) (K(ATP)) metabolic sensor [sulfonylurea receptor (SUR) 1 and potassium inwardly rec

89 rd rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 critically regulate pancre

90 Mutations in either the Kir6.2 or sulfonylurea receptor (SUR) 1 subunit of the channel hav

91 The ability of the sulfonylurea receptor (SUR) 1 to suppress seizures and e

92 eter regulation of wild-type [SUR2(+/+)] and sulfonylurea receptor (SUR) 2-deficient [SUR2(-/-)] mous

93 These channels are heteromultimers of sulfonylurea receptor (SUR) and KIR6.X subunits associat

94 The sulfonylurea receptor (Sur) and somatostatin receptor ty

95 ultimers assembled by an ion conductor and a sulfonylurea receptor (SUR) ATPase.

96 Using putative sulfonylurea receptor (SUR) coiled-coil domains as baits

97 timeric structures formed by a member of the sulfonylurea receptor (SUR) family and a member of the i

98 The sulfonylurea receptor (SUR) gene, now known to encode an

99 (HBB) and markers D11S899/D11S1324 near the sulfonylurea receptor (SUR) gene.

100 The sulfonylurea receptor (SUR) is a member of the ATP-bindi

101 The sulfonylurea receptor (SUR) is another atypical ABC prot

102 second nucleotide-binding fold (NBF2) of the sulfonylurea receptor (SUR) of an individual diagnosed w

103 a member of the ATP binding cassette family (sulfonylurea receptor (SUR) or cystic fibrosis transmemb

104 e KATP channel is formed from four each of a sulfonylurea receptor (SUR) regulatory subunit and an in

105 el subunit (Kir6.1, Kir6.2) and a regulatory sulfonylurea receptor (SUR) subunit, an ATP-binding cass

106 ATP), channels are comprised of K(IR)6.x and sulfonylurea receptor (SUR) subunits that assemble as oc

107 -forming Kir6.2 subunits and four modulatory sulfonylurea receptor (SUR) subunits.

108 Compounds acting on the pancreatic sulfonylurea receptor (SUR) to increase (e.g., glibencla

109 ssion of the inward rectifier Kir6.2 and the sulfonylurea receptor (SUR), a member of the ATP-binding

110 The sulfonylurea receptor (SUR), an ATP-binding cassette (AB

111 transmembrane conductance regulator (CFTR), sulfonylurea receptor (SUR), and heavy metal tolerance f

112 rectifying K(+) channel 6.2 (Kir6.2) and the sulfonylurea receptor (SUR), now renamed SUR1, subunits

113 -dependent stimulatory action of the ATPase, sulfonylurea receptor (SUR), on K(IR) sufficient to elic

114 It is comprised of sulfonylurea receptor (SUR)-1 and Kir6.2 proteins.

115 Mutations in the high-affinity sulfonylurea receptor (SUR)-1 cause one of the severe re

116 provides a template for the MDR-like core of sulfonylurea receptor (SUR)-1.

117 nsitive K+ (KATP) channel and its associated sulfonylurea receptor (SUR).

118 glybenclamide from its binding sites on the sulfonylurea receptor (SUR).

119 ATP/ADP-sensing (sulfonylurea receptor (SUR)/K(IR)6)(4) K(ATP) channels r

120 novo L225P mutation in the L0 region of the sulfonylurea receptor (SUR)1, the regulatory subunit of

121 sized that the mitoK(ATP) channel contains a sulfonylurea receptor (SUR)2 regulatory subunit and aime

122 They comprise four sulfonylurea receptors (SUR) and four potassium channel

123 els (K(ATP) channels) are heteromultimers of sulfonylurea receptors (SUR) and inwardly rectifying pot

124 mponent gene expression including regulatory sulfonylurea receptors (SUR) SUR1 and SUR2B but not SUR2

125 channels are heteromultimers of KIR6.2 and a sulfonylurea receptor, SUR, an ATP binding cassette (ABC

126 s tissues contain subtypes of the regulatory sulfonylurea receptor, SUR, and pore-forming, K(+) inwar

127 itive potassium (K(ATP)) channel composed of sulfonylurea receptor SUR1 and potassium channel Kir6.2

128 The sulfonylurea receptor SUR1 associates with Kir6.2 or Kir

129 ective opener for K(ATP) channels containing sulfonylurea receptor SUR1 subunits, but not with cromak

130 Sulfonylurea receptors SUR1 and SUR2 are the regulatory

131 , is composed of two types of subunits: 1) a sulfonylurea receptor (SUR1) and 2) an inwardly rectifyi

132 are an octameric assembly of two proteins, a sulfonylurea receptor (SUR1) and an ion conducting subun

133 channel, composed of the beta-cell proteins sulfonylurea receptor (SUR1) and inward-rectifying potas

134 These channels comprise the sulfonylurea receptor (SUR1) and Kir6.2, a member of the

135 probands were screened for mutations in the sulfonylurea receptor (SUR1) gene by single-strand confo

136 Mutations in both the Kir6.2 and sulfonylurea receptor (SUR1) genes have been associated

137 l membranes indicated that the high affinity sulfonylurea receptor (SUR1) is not present on eosinophi

138 tween them and a nearby pancreatic beta-cell sulfonylurea receptor (SUR1) missense variant (S1370A),

139 complex of pore-forming Kir6.2 subunits and sulfonylurea receptor (SUR1) subunits with two nucleotid

140 m (KATP) channels, which comprise Kir6.2 and sulfonylurea receptor (SUR1) subunits.

141 r6.2) and four regulatory beta-subunits, the sulfonylurea receptor (SUR1, SUR2A or SUR2B).

142 ore-forming subunit (Kir6.1 or Kir6.2) and a sulfonylurea receptor (SUR1, SUR2A, or SUR2B).

143 The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its a

144 no evidence for the presence of either known sulfonylurea receptors (SUR1 or SUR2) in the mitochondri

145 mily (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of

146 l KATP (surfaceKATP) channels encoded by the sulfonylurea receptor SUR2A and the pore-forming subunit

147 rmed from pore-forming Kir6.2 and regulatory sulfonylurea receptors (SUR2A in heart and skeletal musc

148 ssium inward rectifier (Kir6.x) subunits and sulfonylurea receptors (SURs).

149 rvations and the unexpected partnership with sulfonylurea-receptors (SURs) makes the TRPM4 channel a

150 ifier potassium (K(ir)6.x) subunits and four sulfonylurea receptor (SURx) subunits.

151 K(ATP) channels are formed as a complex of a sulfonylurea receptor (SURx), a member of the ATP-bindin

152 Sulfonylurea receptors (SURx) are multi-spanning transme

153 Sulfonylurea receptors (SURx) are required subunits of t

154 Sulfonylurea receptors (SURx), members of the ATP bindin

155 d of a pore-forming protein, Kir6.x, and the sulfonylurea receptor, SURx.

156 osynthesis and were thought to interact with sulfonylurea receptors that mediate chitin vesicle trans

157 rough association of the Kir6.2 pore and the sulfonylurea receptor, the stress-responsive ATP-sensiti

158 ck by adenine nucleotides similar to that of sulfonylurea receptor type 1 (SUR1).

159 ; however, the evidence is strong that SUR1 (sulfonylurea receptor type 1) subunits are also expresse

160 K(ATP) channels, (SUR1/Kir6.2)(4) (sulfonylurea receptor type 1/potassium inward rectifier

161 -rectifier potassium channel 6.2) and SUR2A (sulfonylurea receptor type 2A) subunits; however, the ev

162 The gene sulfonylurea receptor was eliminated as a candidate gene

163 ic ATP-binding cassette regulatory subunits (sulfonylurea receptors), which counterbalance the nearly

164 The gene responsible (SUR1) encodes the sulfonylurea receptor, which maps to chromosome 11p15.1.