ライフサイエンスコーパス: sulfotransferase

1 Xanthomonas oryzae pv. oryzae, is a tyrosine sulfotransferase.

2 mmobilized HS chain using D-glucosaminyl 3-O-sulfotransferase.

3 racterize the Drosophila heparan sulfate 2-O-sulfotransferase.

4 similarity to vertebrate heparan sulfate 2-O-sulfotransferase.

5 imerase, heparan 6O-sulfotransferase, and 2O-sulfotransferase.

6 otic metabolism using dehydroepiandrosterone sulfotransferase.

7 hat the purified protein functions as an LPS sulfotransferase.

8 e oxidase, catechol O-methyltransferase, and sulfotransferase.

9 rate selection by SULT2A1 and possibly other sulfotransferases.

10 se/N-sulfotransferases and heparan sulfate O-sulfotransferases.

11 s encoding specific glycosyltransferases and sulfotransferases.

12 g heparan sulfate N-sulfotransferase and 6-O-sulfotransferases.

13 the least sequence conservation between TEG sulfotransferases.

14 ferases, heparan sulfate C(5)-epimerase, and sulfotransferases.

15 its homology to vertebrate glycosaminoglycan sulfotransferases.

16 producing the obligatory cosubstrate for all sulfotransferases.

17 in heparan sulfate generated by specific 3-O-sulfotransferases.

18 neral mechanism of action of heparan sulfate sulfotransferases.

19 in heparan sulfate generated by specific 3-O-sulfotransferases.

20 fotransferase (KSGal6ST) and chondroitin 6-O-sulfotransferase 1 (C6ST-1).

21 ied with 4-linked sulfate by either GalNAc-4-sulfotransferase 1 (GalNAc-4-ST1) (CHST8) or GalNAc-4-ST

22 ce deficient in both N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1) and GlcNAc6ST-2 and fou

23 Reduced HS 6-O-sulfotransferase 1 (HS6ST-1) or 6-O-sulfotransferase 2 (

24 We report here mutations in HS 6-O-sulfotransferase 1 (HS6ST1) in families with idiopathic

25 (HS) modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) exhibit severe developmental

26 the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-

27 we generated mice lacking Golgi-associated N-sulfotransferase 1 (Ndst1) that catalyzes sulfation of H

28 N-acetylglucosamine (GlcNAc) N-deacetylase-N-sulfotransferase 1 (Ndst1).

29 ith the levels of the enzyme N-deacetylase/N-sulfotransferase 1 (NDST1).

30 c enzyme N-acetylglucosamine N-deacetylase/N-sulfotransferase 1 (Ndst1).

31 Here we demonstrate that HS 6-O-sulfotransferases 1 and 2 (HS6ST-1 and HS6ST-2), which p

32 fation of glucosamine by heparan sulfate 3-O-sulfotransferase-1 (3-OST-1) is a key modification step

33 r sulfate addition to GalNAc on LH, GalNAc-4-sulfotransferase-1 (GalNAc-4-ST1) in mice.

34 Mice deficient in N-acetylglucosamine-6-O-sulfotransferase-1 (GlcNAc6ST-1) failed to synthesize su

35 ransferase (Hs2st(f/f)) and glucosaminyl 6-O-sulfotransferase-1 (Hs6st1(f/f)) and the bacterial Cre r

36 ivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the

37 mpted targeting of lymphatic N-deacetylase/N-sulfotransferase-1 (Ndst1), a major sulfate-modifying he

38 hat the sulfation activity of tyrosylprotein sulfotransferase-1 (TPST-1) is required for Xenopus dors

39 d at position 21 by expressed tyrosylprotein sulfotransferase-1 and unmodified peptide are both disor

40 ted a conditional allele for N-deacetylase/N-sulfotransferase-1 by using Cre-loxP technology.

41 Mammary tumor cells lacking N-deacetylase/N-sulfotransferase-1 exhibited reduced toxoplasma infectiv

42 lfation of HS resulting from elevated HS 6-O-sulfotransferase-1 expression in IPF HLF accounted, in p

43 enzyme N-acetyl glucosamine N-deacetylase-N-sulfotransferase-1 in endothelial cells and leukocytes,

44 heparan sulfate initiated by N-deacetylase/N-sulfotransferase-1, but 2-O sulfation and 6-O sulfation

45 d invasion were unchanged in N-deacetylase/N-sulfotransferase-1-inactivated cells as well, but replic

46 subjected to enzymatic modifications by 3-O-sulfotransferases-1 (3-OST1) to provide 3-O-sulfated der

47 re, we identified and validated carbohydrate sulfotransferase 10 (CHST10) as a novel RARgamma target

48 allele and the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) locus at 12q23, with a reci

49 s to serve as substrates for human cytosolic sulfotransferase 1A1 (hSULT1A1) was assessed by OH-PCB-d

50 DP-glucuronosyltransferase (UGT), and phenol sulfotransferase 1A1 (SULT1A1) were measured in brain of

51 P4501A2 (CYP1A2), N-acetyltransferase 2, and sulfotransferase 1A1 enzyme activity.

52 Cytosolic sulfotransferase 1C3 (SULT1C3) is the least characterize

53 show that heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 (HS3ST-2) is a marker for specific su

54 d HS 6-O-sulfotransferase 1 (HS6ST-1) or 6-O-sulfotransferase 2 (HS6ST-2) expression in endothelial c

55 Tyrosylprotein sulfotransferase 2 (TPST2) and solute carrier family 35

56 Here, we report that 2-O-sulfotransferase (2-OST) is an essential component of ca

57 hemopoietic PGD(2) synthase, N-deacetylase/N-sulfotransferase-2 (enzyme involved in heparin biosynthe

58 ncreased expression of bile acid-detoxifying sulfotransferase 2A (Sult2a) and selected bile acid tran

59 ), UDP-glucuronosyltransferase 1a1 (Ugt1a1), sulfotransferase 2a1 (Sult2a1), and organic anion-transp

60 HS 2-O-sulfotransferase (2OST) is a key enzyme in this pathway.

61 le specialized sulfotransferases such as 2-O-sulfotransferase (2OST) that transfers the sulfo group t

62 HS 2-O-sulfotransferase (2OST) transfers the sulfo group to the

63 ) heparan sulfate (HS)-generating enzyme 3-O sulfotransferase 3 (3-OST-3) but not nectin-1 or nectin-

64 We identified carbohydrate sulfotransferase 3 (CHST3), an enzyme that catalyzes pro

65 pathophysiological significance for the 3-O-sulfotransferase 3-OST3A (HS3ST3A), catalyzing the final

66 d demonstrate the clinical value of the HS-O-sulfotransferase 3-OST3A as a prognostic marker in HER2+

67 3-O-Sulfation of HS is catalyzed by the 3-O-sulfotransferase (3-OST) enzyme.

68 The 3-O-sulfotransferase (3-OST) family catalyzes rare modificat

69 mine residues in heparan sulfate (HS) by 3-O-sulfotransferase (3-OST) is a key substitution that is p

70 Heparan sulfate 3-O-sulfotransferase (3-OST) is an enzyme that transfers a s

71 f the rare 3-O sulfation catalyzed by HS 3-O-sulfotransferase (3-OST2) is predominantly restricted to

72 First, 3-O-sulfotransferase-3 (3-OST-3) expression in HIS cells pro

73 se genes, heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3A1 and hyaluronan synthase 2, are also

74 tidase 2, heparan sulfate d-glucosaminyl 3-O-sulfotransferase 3A1, and hyaluronan synthase 2) that ha

75 ated by heparan sulfate (HS) glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1).

76 plicated in human PE, encoding Galactose-3-O-sulfotransferase 4.

77 to be the only C. elegans cytosolic alcohol sulfotransferase, a family of enzymes that catalyze a su

78 l of the protease cascade relies on the Pipe sulfotransferase, a fly homolog of vertebrate glycosamin

79 cule 1 (GlyCAM-1), and high endothelial cell sulfotransferase, a PNAd-generating enzyme that is a tar

80 Here, we report that O-sulfotransferases, a class of enzymes that modify hepara

81 longs to the HNK1 family of Golgi-associated sulfotransferases, a group of glycosaminoglycan-modifyin

82 dues Gln255 and Lys368 are essential for the sulfotransferase activity and lie within hydrogen bondin

83 T carrying mutations of these residues lacks sulfotransferase activity and the ability to bind 3'-pho

84 of bacterially expressed SSU-1 demonstrates sulfotransferase activity and thus confirms the function

85 tations at these residues led to the loss of sulfotransferase activity but maintained the ability to

86 This work demonstrates sulfotransferase activity in C. elegans and indicates th

87 thelium can support the requirement for Pipe sulfotransferase activity in embryonic DV patterning.

88 cation of a gene, lpsS, which encodes an LPS sulfotransferase activity in S. meliloti.

89 mechanism through which spatially restricted sulfotransferase activity in the developing egg chamber

90 cking LpsS displayed an 89% reduction in LPS sulfotransferase activity in vitro.

91 regulator of HS-sulfation, increasing the N-sulfotransferase activity of HS-modifying N-deacetylase/

92 that embryonic DV polarity depends upon the sulfotransferase activity of Pipe.

93 O-sulfation in a C41C4.1 mutant and in vitro sulfotransferase activity of recombinant C41C4.1 protein

94 indicating the presence of an additional LPS sulfotransferase activity(ies) in S. meliloti that can c

95 propose to name lpsS), which encodes an LPS sulfotransferase activity.

96 and found to exhibit a 200-fold reduction in sulfotransferase activity.

97 by sulfate esters, consistent with bacterial sulfotransferase activity.

98 wed by modifications using heparan sulfate N-sulfotransferase and 6-O-sulfotransferases.

99 sed on their structural homology to estrogen sulfotransferase and HS 3-O-sulfotransferase isoform 3 (

100 , also exhibit concomitant expression of the sulfotransferase and luminal MECA-79 reactivity.

101 oduct of the gene C41C4.1 as a C. elegans CS-sulfotransferase and renamed it chst-1 (CarboHydrate Sul

102 e at LGS1 codes for an enzyme annotated as a sulfotransferase and show that functional loss of this g

103 this scheme the curacin A PKS employs tandem sulfotransferase and TE domains to form a terminal alken

104 ymes comprising the localization domain of a sulfotransferase and the catalytic domain of a glycosylt

105 proportion of 6-O-sulfation suggest that 6-O-sulfotransferase and/or 6-O-sulfatase enzymes may also b

106 Biosynthesis of HS involves sulfotransferases and an epimerase.

107 ncluding exostosin-2 (Ext2), N-deacetylase/N-sulfotransferases and heparan sulfate O-sulfotransferase

108 we found that the activities of only Gal 3-O-sulfotransferases and not sialyltransferases were advers

109 enzymes, glucuronyl C5-epimerase, heparan 6O-sulfotransferase, and 2O-sulfotransferase.

110 rXa21 activity if raxST, encoding a putative sulfotransferase, and raxA are provided in trans.

111 approach involving glycosyltransferases, HS sulfotransferases, and C(5)-epimerase.

112 glycosidases, nucleotide-sugar transporters, sulfotransferases, and glycan-bearing protein/lipid scaf

113 HS function is mainly controlled by sulfotransferases, and here we report a novel cellular a

114 The GlcNAc-6-sulfotransferases are a family of Golgi-resident enzymes

115 Sulfotransferases are an important class of enzymes that

116 Because the recombinant sulfotransferases are expressed in bacteria, and the met

117 Although tyrosylprotein sulfotransferases are known to exist as homodimers in th

118 Only two sulfotransferases are known to generate Gal6S, namely ke

119 tructures of HS that direct the action of HS sulfotransferases are pinpointed.

120 GPA-modifying sulfotransferases are promising tools for generating the

121 Gal6ST and C6ST-1 to determine whether these sulfotransferases are required for the generation of end

122 identify GlyCAM-1 and high endothelial cell sulfotransferase as new IKKalpha-dependent target genes,

123 The identification of sulfotransferases as candidate genes suggests that DO mi

124 We used a newly developed sulfotransferase assay and ultraviolet photodissociation

125 we show that Drosophila melanogaster HS 3-O sulfotransferase-b (Hs3st-B), which catalyzes HS 3-O sul

126 nsferase and renamed it chst-1 (CarboHydrate SulfoTransferase) based on loss of CS-4-O-sulfation in a

127 Asp-95 are conserved in heparan sulfate 3-O-sulfotransferases but not in heparan N-deacetylase/N-sul

128 ur data provide evidence that Pipe acts as a sulfotransferase, but argue against the hypothesis that

129 of the hormone-metabolizing enzyme estrogen sulfotransferase by certain BFRs.

130 ransferases, glutathione S-transferases, and sulfotransferases can protect cells against the toxic an

131 Sulfotransferases catalyze the transfer of a sulfuryl gr

132 effects have been measured for the estrogen sulfotransferase-catalyzed sulfuryl (SO3) transfer from

133 presence of corneal N-acetylglucosamine 6-O sulfotransferase (CGn6ST).

134 reased KSPG core protein genes and galactose sulfotransferase CHST1 expressions 2-fold; and reduced K

135 They also suggested that the sulfotransferase CHST1 regulates the abundance and inten

136 te with specific functions using immobilized sulfotransferases combined with a 3'-phosphoadenosine 5'

137 glucosamine, whereas chondroitin sulfate 2-O-sulfotransferase (CS-2OST) transfers the sulfo group to

138 evels for Gal3st1 (also known as cerebroside sulfotransferase [CST]), known to play a crucial role in

139 dysmyelinated mutants including the ceramide sulfotransferase deficient (CST-/-) mouse, which are mor

140 ansferase 1A1, 1A3, 1A4, 1A6, hydroxysteroid sulfotransferase enzyme 2A1, multidrug resistance protei

141 ike proteins sharing regulatory roles with a sulfotransferase enzyme.

142 ase activity of HS-modifying N-deacetylase/N-sulfotransferase enzymes.

143 e report an essential role for the oestrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme

144 his transfer reaction, catalyzed by estrogen sulfotransferase (EST), is investigated here in detail.

145 Estrogen sulfotransferase (EST), the enzyme responsible for the s

146 Estrogen sulfotransferase (EST, encoded by SULT1E1) catalyzes the

147 Estrogen sulfotransferase (EST/SULT1E1) is known to catalyze the

148 ities between members of the human cytosolic sulfotransferase family correlate with small-molecule bi

149 m 1A2 (SULT1A2) is a member of the cytosolic sulfotransferase family of phase II detoxification enzym

150 irst example of half-sites reactivity in the sulfotransferase family.

151 tly sulfates, which indicated conjugation by sulfotransferases followed by efflux from the enterocyte

152 g modes of TBBPA and 3-OH-BDE-47 to estrogen sulfotransferase for comparison with binding of the endo

153 Using the teicoplanin aglycone and the 3 sulfotransferases found in one of these gene clusters, m

154 These experiments identified one sulfotransferase, GAL3ST3, and one glycosyltransferase,

155 d kinetic properties of three cloned Gal:3-O-sulfotransferases (Gal3STs) ST-2, ST-3, and ST-4 along w

156 olgi transmembrane N-acetylgalactosamine-4-O-sulfotransferase (GalNAc4-ST1), which we show by immunof

157 on of Ndst1, the predominant N-deacetylase/N-sulfotransferase gene essential for the formation of mat

158 SULT2B1 gene is unique among steroid/sterol sulfotransferase genes in that it encodes for two isofor

159 ulfation of endothelial glycoproteins by the sulfotransferase GlcNAc6ST-2 is a regulatory modificatio

160 We applied this strategy to the GlcNAc-6-sulfotransferases GlcNAc6ST-1 and GlcNAc6ST-2, which col

161 re, mice lacking two N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 and GlcNAc6ST-2) demonstr

162 Two HEV-expressed sulfotransferases, GlcNAc6ST-1 and GlcNAc6ST-2, are esse

163 emicals, including cytochromes P450 (P450s), sulfotransferases, glutathione transferases, and UDP-glu

164 Bs, including OH-PCB3s, as the substrates of sulfotransferases have not been studied in many organism

165 GlcNAcT-I and high endothelial cell GlcNAc-6-sulfotransferase (HECGlcNAc6ST).

166 h substrate in the absence of a carbohydrate sulfotransferase; however, they produced extended GlcNAc

167 Heparan sulfate 2-O-sulfotransferase (HS-2OST) transfers the sulfo group fro

168 for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST (also known as HS2ST1) is importa

169 Mutant mouse embryos lacking the heparan sulfotransferases Hs2st or Hs6st1 have severe CC phenoty

170 e functions of the Drosophila HS 2-O and 6-O sulfotransferase (Hs2st and Hs6st) genes in FGF-mediated

171 vious study using Drosophila HS 2-O- and 6-O-sulfotransferase (Hs2st and Hs6st) mutants showed that l

172 xP-flanked conditional alleles of uronyl 2-O-sulfotransferase (Hs2st(f/f)) and glucosaminyl 6-O-sulfo

173 . elegans ortholog of vertebrate heparan 2-O-sulfotransferase (HS2ST) and the gene named hst-2.

174 Inactivation of heparan sulfate uronyl 2-O-sulfotransferase (Hs2st) in neutrophils substantially re

175 the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferase (Hs2st) leads to kidney agenesis.

176 Because HS 2-O-sulfotransferase (Hs2st) shows a strong substrate prefer

177 HS biosynthetic enzyme, heparan sulfate 2-O sulfotransferase (Hs2st; an enzyme which catalyzes the 2

178 etically ablated heparan sulfate 2-O and 6-O sulfotransferases (Hs2st, Hs6st1, and Hs6st2) in develop

179 Simultaneous block of Hsepi and HS 6-O-sulfotransferase (Hs6st) activity disrupted tracheoblast

180 We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cr

181 dues, which is generated by glucosaminyl-6-O-sulfotransferases (HS6STs) and selectively removed by ce

182 n of 6-O-sulfate is catalyzed by a family of sulfotransferases (HS6STs), and genetic manipulation of

183 that the HS C-5 epimerase hse-5, the HS 2-O-sulfotransferase hst-2, or the HS 6-O-sulfotransferase h

184 HS 2-O-sulfotransferase hst-2, or the HS 6-O-sulfotransferase hst-6 inhibit N-sulfation.

185 navigation phenotypes in two heparan sulfate sulfotransferase (Hst) mutant embryos, Hs2st-/- and Hs6s

186 C. elegans but also a mutant lacking two HS sulfotransferases (hst-6 hst-2), as we suspected that th

187 ified by co-expression of the human GalNAc 4-sulfotransferase I, which generates SO4-4GalNAcbeta1-4Gl

188 Here we show that inactivation of uronyl 2-O-sulfotransferase in endothelial cells (Hs2st), an enzyme

189 f Toll depends upon the activity of the Pipe sulfotransferase in the ventral region of the follicular

190 ults establish an essential function for the sulfotransferases in L-selectin ligand synthesis and may

191 Human SULT2A1 is one of two predominant sulfotransferases in liver and catalyzes transfer of the

192 The widespread role of sulfotransferases in modulating glycan function makes th

193 ps on HS, which are controlled by various HS sulfotransferases in the Golgi apparatus as well as extr

194 the downregulated genes were chondroitin-4-O-sulfotransferase involved in the synthesis of chondroiti

195 an-1 and hepatocyte-specific inactivation of sulfotransferases involved in heparan sulfate biosynthes

196 for the study of sialyltransferases and 3-O-sulfotransferases involved in the biosynthesis of O-glyc

197 Typical of its family, estrogen sulfotransferase is partially k(cat)-inhibited by its ac

198 ting that neither of the known galactose 6-O-sulfotransferases is required for ligand synthesis.

199 HEC-GlcNAc6ST, a HEV-localized sulfotransferase, is essential for the elaboration of fu

200 and kinetics of the interaction between 3-O-sulfotransferase isoform 1 (3-OST-1) and HS have been ex

201 tudy, we report the crystal structure of 3-O-sulfotransferase isoform 1 at 2.5-A resolution in a bina

202 Heparan sulfate 3-O-sulfotransferase isoform 1 performs the crucial last ste

203 Sulfotransferase isoform 1A2 (SULT1A2) is a member of th

204 We report a structural study of human HS 3-O-sulfotransferase isoform 3 (3-OST-3), a key sulfotransfe

205 logy to estrogen sulfotransferase and HS 3-O-sulfotransferase isoform 3 (3-OST3), for which crystal s

206 saccharide (3-OH octasaccharide) with HS 3-O-sulfotransferase isoform 3.

207 HS3st1 (heparan sulfate 3-O-sulfotransferase isoform-1) is a critical enzyme involve

208 on of both HS3st1 and NDST2 (N-deacetylase/N-sulfotransferase isoform-2) afforded HS with a very low

209 human SULT1A2 that differs from other known sulfotransferase isoforms was developed and used to scre

210 cDNAs for rat SULT2B1 steroid/sterol sulfotransferase isoforms were cloned, and the encoded p

211 The same vessels also expressed a GlcNAc-6-O-sulfotransferase known as HEC-GlcNAc6ST, which is known

212 Gal6S, namely keratan sulfate galactose 6-O-sulfotransferase (KSGal6ST) and chondroitin 6-O-sulfotra

213 ed a homolog of the S. meliloti carbohydrate sulfotransferase, LpsS, in Mesorhizobium loti.

214 orphisms in UDP-glucuronosyltransferases and sulfotransferases may contribute to variability in phyto

215 sequence and structural similarities, these sulfotransferases modify distinct side chains on the GPA

216 O-sulfotransferases modify heparan sulfate proteoglycans (

217 Unlike the wild type protein, 2-O-sulfotransferase mutant (2OST Y94I) transfers sulfate to

218 The glucosaminyl N-deacetylase/N-sulfotransferase (NDST) enzymes have a key role during b

219 y the action of glucosaminyl N-deacetylase/N-sulfotransferase (NDST).

220 ation of N-acetylglucosamine N-deacetylase-N-sulfotransferase (Ndst1) in endothelial cells.

221 women, indicating changes in N-deacetylase/N-sulfotransferases (NDSTs), the enzymes involved in the i

222 d at specific positions by heparan sulfate O-sulfotransferase (OST) families.

223 -47) have been suggested to inhibit estrogen sulfotransferase, potentially affecting estrogen metabol

224 form to high-toxicity forms through expanded sulfotransferases, probably as deterrence against predat

225 ediction results in the functionally diverse sulfotransferase protein family.

226 ided by plastids to serve as a substrate for sulfotransferase reactions in the cytosol and the Golgi

227 ay, the HS structures in the vicinity of the sulfotransferase recognition site are quickly determined

228 structure, we ablated the gene encoding the sulfotransferase responsible for sulfate addition to Gal

229 ession of an engineered human tyrosylprotein sulfotransferase, resulting in antigen-binding and virus

230 The sulfotransferases share similar overall architecture wit

231 t to the limited expression of the cytosolic sulfotransferase SSU-1 in the ASJ neuron pair.

232 chain termination module containing adjacent sulfotransferase (ST) and thioesterase (TE) catalytic do

233 tructure of the ternary complex of bacterial sulfotransferase StaL with the cofactor product 3'-phosp

234 Mycobacterial carbohydrate sulfotransferase Stf0 catalyzes the sulfuryl group trans

235 sphosulfate and a previously uncharacterized sulfotransferase, stf3.

236 Cytosolic sulfotransferases (STs) catalyze the sulfation of hydrox

237 res provide insights into the ability of the sulfotransferase substrate binding pocket to accommodate

238 S biosynthesis involves multiple specialized sulfotransferases such as 2-O-sulfotransferase (2OST) th

239 nsferases but not in heparan N-deacetylase/N-sulfotransferase, suggesting a role for these residues i

240 Sulfotransferase sulfonation of beta-hydroxy-acyl-ACP is

241 CH), on thyroid hormone deiodinase (DIO) and sulfotransferase (SULT) activity were investigated using

242 The superfamily of sulfotransferase (SULT) enzymes catalyzes the sulfate co

243 d mRNA expression levels of five major human sulfotransferase (SULT) enzymes in 10 matched pericarcin

244 osomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schist

245 Cytosolic sulfotransferase (SULT)-catalyzed sulfation regulates bi

246 Cytosolic sulfotransferase (SULT)-catalyzed sulfation regulates bi

247 Cytosolic sulfotransferase (SULT)-mediated sulfation plays an esse

248 Sulfotransferase (SULT)-mediated sulfation represents a

249 hether sulfonation of PAH catechols by human sulfotransferases (SULT) could intercept the catechol in

250 ofactors of N,O-acetyltransferases (NAT) and sulfotransferases (SULT) were added to cytosolic samples

251 In primates but not lower order animals, a sulfotransferase (SULT1A3) is present that can rapidly m

252 uced the expression and activity of estrogen sulfotransferase (SULT1E1 or EST), an enzyme important f

253 n by rifampicin (RIF) represses the estrogen sulfotransferase (SULT1E1) gene in human primary hepatoc

254 elopment of specific substrates for estrogen sulfotransferase (SULT1E1) to produce molecular imaging

255 PXR-mediated gene induction of the phase II sulfotransferase Sult2A1 in the livers of 4-month- and 2

256 Dehydroepiandrosterone sulfotransferase (SULT2A1) is a cytosolic enzyme that me

257 SNPs in the hydroxysteroid sulfotransferase, SULT2A1, have been identified in Afric

258 The cholesterol sulfotransferase SULT2B1b catalyzes the sulfoconjugation

259 allosteric regulation of the human cytosolic sulfotransferase (SULTs) family-13 disease-relevant enzy

260 Cytosolic sulfotransferases (SULTs) are phase II detoxification en

261 Human cytosolic sulfotransferases (SULTs) regulate the activities of hun

262 Human cytosolic sulfotransferases (SULTs) regulate the activities of tho

263 Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transf

264 Human cytosolic sulfotransferases (SULTs) transfer the sulfuryl moiety (

265 NSAIDs allosterically inhibit cytosolic sulfotransferases (SULTs) with high specificity and ther

266 roblem has now been solved for the cytosolic sulfotransferases (SULTs).

267 dary reactive intermediate by some mammalian sulfotransferases (SULTs).

268 road-specificity enzymes-the human cytosolic sulfotransferases (SULTs).

269 viii) Just like LNCaPalpha1,2-FT and Gal-3-O-sulfotransferase T2, the cloned alpha2,3(N)ST which modi

270 gene cluster contains three closely related sulfotransferases (Teg12, -13, and -14) that sulfate tei

271 CHST10 is a sulfotransferase that forms HNK-1 glycan on neural cell

272 work demonstrates that SSU-1 is a functional sulfotransferase that likely modifies endocrine signalin

273 -sulfotransferase isoform 3 (3-OST-3), a key sulfotransferase that transfers a sulfuryl group to a sp

274 ynthesis of HS includes numerous specialized sulfotransferases that generate a variety of sulfated sa

275 higher organization level of tyrosylprotein sulfotransferases that may serve for substrate selectivi

276 7 Mb) that contained a pair of overexpressed sulfotransferases that were inversely correlated with ge

277 alized glycosyl transferases, epimerase, and sulfotransferases, this approach should mimic the synthe

278 on by using recombinant human tyrosylprotein sulfotransferases TPST-1 and TPST-2 to modify a peptide

279 lfate (PAPS) synthase-coupled tyrosylprotein sulfotransferase (TPST) catalysis system that involves i

280 Tyrosyl protein sulfotransferase (TPST) is an enzyme required for produc

281 dification (PTM) catalyzed by tyrosylprotein sulfotransferases (TPST).

282 mediated by one of two Golgi tyrosylprotein sulfotransferases (TPST-1 and -2) expressed in all mamma

283 modification catalyzed by two tyrosylprotein sulfotransferases (TPST-1 and TPST-2) in the trans-Golgi

284 ion is mediated by two Golgi tyrosyl-protein sulfotransferases (TPST-1 and TPST-2) that are widely ex

285 mediated by one of two Golgi tyrosylprotein sulfotransferases (TPST1 and TPST2) that catalyze the tr

286 ed markedly by overexpression of the tyrosyl sulfotransferase TPST2.

287 Tyrosylprotein sulfotransferases (TPSTs) are enzymes that catalyze post

288 urylation is catalyzed by the tyrosylprotein sulfotransferases (TPSTs), and in humans there are two i

289 es mediated by purified human tyrosylprotein sulfotransferases (TPSTs), and unambiguously determined

290 ST followed by keratan sulfate galactose 6-O sulfotransferase treatment.

291 Recent evidence indicates that the same two sulfotransferases underlie the formation of functional P

292 for conditional activation of Golgi-resident sulfotransferases using a chemical inducer of dimerizati

293 A sulfotransferase was identified as the causative gene by

294 Remarkably these sulfotransferases were uniquely specific for sulfated su

295 1 (DS-epi1), together with the 6-O- and 4-O-sulfotransferases, were highly upregulated in ESCC biops

296 ggested that OH-PCB3s were the substrates of sulfotransferases which catalyzed the formation of PCB3

297 tion of ligand formation depends on the Pipe sulfotransferase, which is expressed in ventral cells of

298 dictated by sulfation patterns controlled by sulfotransferases, which add sulfate groups, and sulfata

299 is directly mediated by cytosolic and Golgi sulfotransferases, which use 3'-phosphoadenosine 5'-phos

300 that clearance of the nucleotide product of sulfotransferases within the Golgi plays an important ro