ライフサイエンスコーパス: sultam

1 aturated lactam or an alpha,beta-unsaturated sultam.

2 lishing the ring contraction of a bridgehead sultam.

3 droxide-ion-catalyzed hydrolysis of the beta-sultam.

4 lution gives rise exclusively to tetracyclic sultam 20.

5 nt strategy has allowed access to bridgehead sultam 9 and the related carboxamides 10 and 11.

6 A practical synthesis of the bicyclic dienyl sultam 9 has been developed.

7 We report that chiral 3-substituted gamma-sultam alpha-carbanions undergo diastereoselective alkyl

8 thyl-3-oxo-beta-sultam, which is both a beta-sultam and a beta-lactam, undergoes hydrolysis at the su

9 d beta value of +0.9 for both N-benzoyl beta-sultam and N-benzyl-4,4-dimethyl-3-oxo-beta-sultam, indi

10 and 1.9 for the hydrolysis of N-benzoyl-beta-sultam and N-benzyl-4,4-dimethyl-3-oxo-beta-sultam, resp

11 Syntheses of the first bridgehead sultams and the only known bridgehead disulfonimide are

12 lides, providing a workable access to biaryl sultams annulated into a six-membered ring that are othe

13 l analogues of beta-lactams, and N-acyl beta-sultams are novel inactivators of the class C beta-lacta

14 Beta-sultams are the sulfonyl analogues of beta-lactams, and

15 N-Acyl-beta-sultams are time-dependent, irreversible active site-dir

16 e site serine being sulfonylated by the beta-sultam as shown by ESI-MS analysis and by X-ray crystall

17 gn and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chemical reactions

18 the template, customized reactions of vinyl sultams at C horizontal lineC bond or involving N-S bond

19 was achieved through the use of the Oppolzer sultam chiral auxiliary.

20 The most advanced delta-sultam compound, GNE-3500 (27, 1-{4-[3-fluoro-4-((3S,6R)

21 tivation is first order with respect to beta-sultam concentration, and the second-order rate constant

22 gely controlled over the formation of biaryl sultams containing a seven member ring.

23 s protocol including the synthesis of biaryl sultams containing a seven-membered ring and analogous s

24 idoisoindolones and their previously unknown sultam counterparts.

25 our-membered heterocyclic sulfonamides, beta-sultams, do not undergo aminolysis in aqueous solution b

26 yclic, 10- to 11- and 7-membered benzo-fused sultams for broad-scale screening.

27 ydro-5H-dibenzo[c,e]azepines over the biaryl sultam formation.

28 er utilized to construct the tricyclic fused-sultam framework.

29 Using an appropriate substrate, a biaryl sultam has been obtained exclusively.

30 e design, synthesis, and evaluation of novel sultam hydroxamates 4 as MMP-2, -9, and -13 inhibitors.

31 The rate of the reaction of beta-sultams in buffered solutions of simple primary amines s

32 s carried out to obtain different polycyclic sultams in good yields.

33 -sultam and N-benzyl-4,4-dimethyl-3-oxo-beta-sultam, indicating that the general base amine is almost

34 Moreover, we report the selective beta-sultam-induced dehydroalanine formation of the active si

35 for the alkaline hydrolysis of N-aroyl beta-sultams is -0.73, similar to that for the beta-lactams,

36 K(m), and those of sulfonylation by the beta-sultams, measured by the second-order rate constant for

37 for programming chemical reactions on vinyl sultam periphery or (hetero)aryl ring is described.

38 nantly produce trans-3,5-disubstituted gamma-sultam products.

39 -sultam and N-benzyl-4,4-dimethyl-3-oxo-beta-sultam, respectively, compatible with a general base-cat

40 modate additional substituents on the lactam/sultam ring and allows late stage sequential functionali

41 The lack of reactivity of beta-sultams toward amine nucleophiles appears to be related

42 e moiety in living S. aureus cells upon beta-sultam treatment.

43 While the latter sultam undergoes extensive polymerization, 9 is transfor

44 ereochemically rich medium-sized benzo-fused sultams via complementary pairing of heretofore-unknown

45 Even N-benzyl-4,4-dimethyl-3-oxo-beta-sultam, which is both a beta-sultam and a beta-lactam, u

46 reaction of N-benzyl-4,4-dimethyl-3-oxo-beta-sultam with carboxylate anions based on a SKIE of 1.7-1.

47 ted to the mechanism of ring opening of beta-sultams with a decreased reactivity toward amines relati