ライフサイエンスコーパス: sumoylation

1 MOs (small ubiquitin-like modifier proteins; SUMOylation).

2 velopment of parasite-specific inhibitors of SUMOylation.

3 r the experimentally observed low fractional sumoylation.

4 /6 in recruiting and activating Sgs1 through SUMOylation.

5 , and that rab17 prenylation is required for sumoylation.

6 ue to perturbation of the dynamics of target SUMOylation.

7 fied to interact with Wor1 and regulate Wor1 SUMOylation.

8 TA for probing the cellular consequences of sumoylation.

9 Crm1, Imp beta, Transportin, and NTF2 on Ran sumoylation.

10 ual functions, including a role in replisome sumoylation.

11 ed lysines in the polyQ AR that are sites of SUMOylation.

12 clease-generated ssDNA promote Siz2-mediated sumoylation.

13 GTPase Ran is a target for RanBP2-dependent sumoylation.

14 Surprisingly, all inhibited Ran sumoylation.

15 ations of PIASy for their ability to mediate SUMOylation.

16 d demonstrated that it can mediate effective SUMOylation.

17 nslationally modified by phosphorylation and sumoylation.

18 of topotecan as a novel inhibitor of global SUMOylation.

19 il segment and is predicted to disrupt STAT1 sumoylation.

20 er post-translational modifications, such as sumoylation.

21 ubiquitin-like modifier E3 ligase for FOXP2 sumoylation.

22 the graft endothelium due to increased GATA2 SUMOylation.

23 Ns largely prevent heat shock-triggered poly-SUMOylation.

24 eins results primarily from inhibition of de-SUMOylation.

25 nsights into the mechanism of PIASy-mediated SUMOylation.

26 anner, while GEI-17 undergoes extensive auto-sumoylation.

27 he first proteins reported to be modified by SUMOylation, a ubiquitin-like posttranslational modifica

28 associated protein 1 (KAP1) and inhibits its sumoylation activity, impairing KAP1-mediated chromatin

29 Here we show that sumoylation acts in parallel with phosphorylation to pro

30 ponsive transcription factor OsbZIP23 for de-SUMOylation affecting its stability.

31 In other cases, SUMOylation alters transcriptional mechanisms through se

32 This 'SUMOylation' alters the behavior of the target protein,

33 In vitro studies indicated that Sf1 SUMOylation, although not directly influencing DNA bindi

34 ponse modeled as a closed system, where e.g. sumoylation always decreases with increasing SENP levels

35 As a consequence of CRMP2 loss of SUMOylation and binding to NaV1.7, the channel displays

36 s define a crucial repressor function of Sf1 SUMOylation and Dax1 in the physiological cessation of F

37 a suggest that active SnRK1 triggers its own SUMOylation and degradation, establishing a negative fee

38 s(447), obviated Hsp27-mediated F508del NBD1 SUMOylation and degradation.

39 ciferase (FLuc), to quantitatively image p53 sumoylation and desumoylation in cells and living mice.

40 Here, we have examined the function of Sf1 SUMOylation and its interaction with Dax1 on FAdE functi

41 the Drosophila beta-arrestin 2, inhibits Smo sumoylation and prevents Smo accumulation through Krz re

42 -ORF3 targets specific cellular proteins for sumoylation and proteasomal degradation and provide sign

43 in controlling homeostasis of intracellular sumoylation and show that sumoylation of MCM is controll

44 through the use of TDG mutants defective for sumoylation and Small Ubiquitin-like Modifier (SUMO) bin

45 Our findings indicate that sumoylation and SUMO binding are not essential for TDG-m

46 ere, we show that E1B-55K and E4-ORF3 induce sumoylation and the assembly of SUMO2/3 viral genome rep

47 pensable for ATRIP (ATR-interacting protein) SUMOylation and the ATR-ATRIP interaction, it is require

48 show that SUMO overexpression leads to STAT1 SUMOylation and to a decrease in IFN-induced STAT1 phosp

49 Sumoylation and translocation are required for the AtBAG

50 Taken together, these results indicate that sumoylation and ubiquitination play crucial roles in the

51 olves regulated nuclear transport as well as SUMOylation and ubiquitination.

52 omerase activity is compromised by K391/K436 SUMOylation, and this provides the first in vivo evidenc

53 nd repurposed small molecules that alter p53 sumoylation, and to preclinically evaluate candidate ant

54 g acetylation, methylation, phosphorylation, SUMOylation, and ubiquitylation, have emerged as importa

55 t pathways depending on either mono- or poly-SUMOylation are largely missing.

56 These data reinforce sumoylation as a key posttranslational regulatory modifi

57 Here, we identify SUMOylation as a major mechanism that counteracts ubiqui

58 Our data identified SUMOylation as a previously undescribed post-translation

59 apical plasma membrane and further implicate sumoylation as an important mediator of protein-protein

60 with ginkgolic acid, a drug that reduces p53 sumoylation, as well as trichostatin A, a potential indu

61 psipsiKDxxxxSY-83) of WASp, compromises WASp-SUMOylation, associates with COMMD1 to attenuate NF-kapp

62 unexpectedly, displays a pattern of protein SUMOylation at 25 degrees C that is essentially identica

63 These mice have an increased level of SUMOylation at baseline and, in confirmation of the data

64 Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the

65 We identified that SUMOylation at the lysine 451 site facilitated STAT3 bin

66 , we summarise our emerging understanding of SUMOylation both as a distinct modification and as a coo

67 We find that Hh stimulates Smo sumoylation by dissociating it from a desumoylation enzy

68 s trichostatin A, a potential inducer of p53 sumoylation by enhancement of its nuclear export.

69 Conversely, increasing Drp1 SUMOylation by knocking down SENP3 reduces both Drp1 bin

70 Consistent with this, preventing Drp1 SUMOylation by mutating the SUMO acceptor sites enhances

71 tion calorimetry revealed that NTF2 prevents sumoylation by reducing RanGDP's affinity to RanBP2's RB

72 We also provide evidence that inhibition of SUMOylation by topotecan is associated with reduced leve

73 Because protein sumoylation can promote transcriptional repression, we h

74 dependent manner that requires SUMOylated or SUMOylation-competent PML.

75 Deregulation of ID complex SUMOylation compromises cell survival following replicat

76 g region in GFI1 contains a conserved type I SUMOylation consensus element, centered on lysine-239 (K

77 In summary, our findings suggest that SUMOylation could be a target to inhibit CSCs and ultima

78 suggest that parasite-specific inhibitors of SUMOylation could be developed and used in combination t

79 Mice expressing a SUMOylation-defective mutant of LRH-1 (LRH-1 K289R mice)

80 -La(WT)) grow faster than cells expressing a sumoylation-deficient mutant La (GFP-La(SD)), suggesting

81 adoxically increased in TH1 cells expressing SUMOylation-deficient WASp.

82 al cortex (X-zone) were detected in both the SUMOylation-deficient-Sf1(2KR/2KR) and Dax1 knockout mou

83 SUMOylation depends on the sequential activities of E1 a

84 Disruption of the sumoylation/desumoylation equilibrium is associated with

85 riments indicate a critical role of balanced SUMOylation/deSUMOylation for proper cardiac development

86 Here, we review the current knowledge about SUMOylation/deSUMOylation in the heart and provide an in

87 pon inflammation, endothelial SENP1-mediated SUMOylation drives GA by regulating the synergistic effe

88 human bacillary dysentery, switches off host sumoylation during epithelial cell infection in vitro an

89 the calnexin cytoplasmic domain and UBC9, a SUMOylation E2 ligase, which modified the calnexin cytop

90 st-translational modification of proteins or SUMOylation ensures normal cell function.

91 However, the participating SUMOylation enzymes are not fully characterized.

92 However, the participating SUMOylation enzymes are not known.

93 iral effects, the enzymes that mediate these SUMOylation events remain to be defined.

94 Second, SUMOylation facilitates alpha-synuclein aggregation by b

95 Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/Ube2i/Sae1/Uba2/Senp6), and c

96 in transfected cells confirmed absent STAT1 sumoylation for E705V, whereas it was present in wild-ty

97 SUMOylation has also been shown to play a role in the pa

98 Mitotic SUMOylation has an essential role in faithful chromosome

99 and their role in controlling intracellular sumoylation homeostasis.

100 ptation to stress involves changes in global SUMOylation in C. glabrata Importantly, loss of the deSU

101 ever, non-toxic chemical tools that modulate sumoylation in cells are lacking.

102 spite this importance, little is known about SUMOylation in crop species.

103 As2O3 exposure increased MTHFD1 SUMOylation in cultured cells and in in vitro SUMOylatio

104 igases, as essential for mitotic chromosomal SUMOylation in frog egg extracts and demonstrated that i

105 e, we investigate the role of SENP1-mediated SUMOylation in graft arteriosclerosis (GA), the major ca

106 uantifying the effects of these drugs on p53 sumoylation in living mice using bioluminescence imaging

107 al communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.

108 sing this assay, we investigated the role of sumoylation in regulating TDG activity through the use o

109 , our results demonstrate a pivotal role for SUMOylation in septin filament bundling and cell divisio

110 erlying the up-regulation of alpha-synuclein SUMOylation in the disease.

111 tudy, we have investigated the importance of SUMOylation in the human pathogen, Candida glabrata We i

112 udy thus demonstrates a key role for protein SUMOylation in the life cycle and pathobiology of C. gla

113 ted proteins in HS and the role of chromatin SUMOylation in the regulation of transcription.

114 el roles for Pif1, Rad52, and Siz1-dependent sumoylation in the spatial exclusion of telomerase from

115 rified E4-ORF3 protein stimulates TIF-1gamma sumoylation in vitro, demonstrating that E4-ORF3 acts as

116 ation with small ubiquitin-related modifier (SUMOylation) in Sox11, which suppresses Sox11's nuclear

117 P1, the major protease of post-translational SUMOylation, in cardiovascular disorders.

118 We present the first mathematical model for sumoylation including enzyme mechanism details such as a

119 n, we hypothesized that LMP1-induced protein sumoylation induces the repression of EBV lytic promoter

120 of the SUMO E1 enzyme SAE2, thus leading to sumoylation inhibition.

121 phenol, tannic acid (TA) emerged as a potent sumoylation inhibitor in vitro (IC50 = 12.8 microM) and

122 was reproduced by ginkolic acid, a specific SUMOylation inhibitor.

123 Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen

124 This activity requires the sumoylation-interacting motif within p150N, which is als

125 Protein SUMOylation is a dynamic post-translational modification

126 Sumoylation is a multistep, multienzymatic post-translat

127 Sumoylation is a post-translational modification (PTM) p

128 Sumoylation is a post-translational modification mediate

129 Sumoylation is a posttranslational reversible modificati

130 tion of p53 tumor suppressor protein through sumoylation is a promising new strategy for improving ca

131 SUMOylation is a ubiquitin-related transient posttransla

132 revisiae and C. glabrata We demonstrate that SUMOylation is an essential process and that adaptation

133 Recent studies show that SUMOylation is an integral part of the ubiquitin proteas

134 Accordingly, SUMOylation is critical in maintaining cellular homeosta

135 We determined that CRMP2 SUMOylation is enhanced by prior phosphorylation by cycl

136 SUMOylation is essential for cell growth, division, and

137 Multisite protein group sumoylation is known to promote HR in yeast.

138 PIAS1-mediated promoter SUMOylation is likely to regulate Pol2-associated factor

139 offered via the selective control of global SUMOylation is readily apparent.

140 ural studies and in vitro biochemistry, that sumoylation is required for efficient TDG enzymatic turn

141 We demonstrated that FOXP2 sumoylation is required for regulation of cerebellar mot

142 However, whether sumoylation is required for TDG activity in vivo has not

143 The data showed that increased UBC9-mediated SUMOylation is sufficient to induce relatively high leve

144 agy, suggesting that increased UBC9-mediated SUMOylation is sufficient to upregulate cardiac autophag

145 FOXP1 SUMOylation is tightly controlled by neuronal activity,

146 reversible post-translational modification, SUMOylation, is widely conserved in the eukaryotic kingd

147 P concentration at which steady state target sumoylation level is maximum.

148 eled as an open system: (i) the steady state sumoylation level is robust to variation in several enzy

149 ults in equal or higher activity, the target sumoylation levels are lower; and (iii) there is an opti

150 from specific substrates and how curtailing sumoylation levels can regulate transcription in this nu

151 igher SUMO activating enzyme (E1) and global SUMOylation levels than non-CSCs.

152 calpains as powerful modulators of cellular sumoylation levels with potentially broad implications i

153 Hinokiflavone increases protein SUMOylation levels, both in in vitro splicing reactions

154 Furthermore, silencing of SUMOylation machinery either by depletion of UBC9 or PIA

155 ng plant development, mutations of the basic SUMOylation machinery in Arabidopsis (Arabidopsis thalia

156 ultured cells, consistent with the idea that SUMOylation may govern PIM1 substrate specificity under

157 Finally, we tested the protective role of SUMOylation-mediated autophagy by expressing UBC9 in a m

158 Our findings indicate that a SUMOylation-mediated mechanism regulates nuclear localiz

159 n of recombination, potentially dependent on SUMOylation, Mer2 mediates global chromosome compaction

160 its DNA binding capability, indicating that SUMOylation might regulate its DNA-dependent ATPase acti

161 SUMOylation modifies the interactome, localization, acti

162 This sumoylation modifies transcriptional regulation by FOXP2

163 Furthermore, SUMOylation modulated the interaction of ErbB4 with chro

164 independent sites: K169, within a consensus SUMOylation motif (IK(169)DE(171)) in the active site of

165 The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch o

166 the first report of a mutation in the STAT1 sumoylation motif associated with clinical disease.

167 dues downstream of the consensus Psi-K-x-E/D sumoylation motif.

168 Protein SUMOylation, N-terminal acetylation, and phosphorylation

169 Upon genome damage, large-scale protein sumoylation occurs from yeast to humans to promote DNA r

170 ndings indicated that Hsp27-Ubc9 targets the SUMOylation of a transitional, non-native conformation o

171 Our observations suggest that SUMOylation of alpha-synuclein by PIAS2 promotes alpha-s

172 We report that PIAS2 promotes SUMOylation of alpha-synuclein, leading to a decrease in

173 odulated by the SUMO protease SENP1 and that sumoylation of both proteins is required for their inter

174 activating region-3 (CTAR3) and induces the sumoylation of cellular proteins.

175 ng Xenopus laevis egg extract, we found that SUMOylation of DNA topoisomerase IIalpha (TOP2A) CTD reg

176 Furthermore, we demonstrated that sumoylation of Foxp1 affects neuronal differentiation an

177 ht into Foxp1 function by demonstrating that sumoylation of Foxp1 during embryonic brain development

178 ylatable FOXP1-K670R mutant, indicating that SUMOylation of FOXP1 is essential for regulation of prop

179 hese results suggest that activity-dependent SUMOylation of FOXP1 may be an important mediator of ear

180 We identified sumoylation of FOXP2 at K674 (K673 in mice) in the cereb

181 We characterized sumoylation of FOXP2 biochemically and analyzed the regi

182 Sumoylation of FOXP2 in neonatal mouse cerebellum regula

183 nd analyzed the region-specific function and sumoylation of FOXP2 in the developing mouse cerebellum.

184 We also show that coordinated sumoylation of Gcn4 and Tup1 enhances Gcn4 promoter evic

185 ur studies provide evidence that coordinated sumoylation of Gcn4, Tup1 and likely other factors dampe

186 lly, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the

187 SUMOylation of KCNQ1 is KCNE1 dependent and determines t

188 is study, we address the question of whether sumoylation of La contributes to cell proliferation of H

189 our study support a novel mechanism whereby sumoylation of La promotes cell proliferation by avertin

190 Sumoylation of La regulates not only the trafficking of

191 These findings suggest that compromised SUMOylation of LRH-1 promotes the development of NAFLD u

192 We demonstrate here that SUMOylation of lysine K293 (mouse K310) located within a

193 We also provide evidence that Shh stimulates sumoylation of mammalian Smo (mSmo) and that sumoylation

194 s of intracellular sumoylation and show that sumoylation of MCM is controlled in a subunit-specific a

195 ome maintenance, preferentially controls the sumoylation of Mcm3 during DNA replication.

196 bstantial accumulations of GCRs and elevated sumoylation of most proteins except for Ulp2 targets.

197 e shown that the Ad5 E4-ORF3 protein induces sumoylation of multiple cellular proteins and subsequent

198 at cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases INa.

199 Here we show that sumoylation of NPR1 by SUMO3 activates defense gene expr

200 have previously shown that d-flow increases SUMOylation of p53 and ERK5 through downregulation of se

201 with the observation that E1B-55K-dependent SUMOylation of p53 is required for efficient cell transf

202 onger capable of mediating E1B-55K-dependent SUMOylation of p53, inhibition of p53-mediated transacti

203 decreased compared with phyB-YFP, and (iii) SUMOylation of phyB inhibits binding of PHYTOCHROME INTE

204 Taken together, we conclude that SUMOylation of phyB negatively regulates light signaling

205 Finally, the SUMOylation of PICH significantly reduced its DNA bindin

206 from this study demonstrate that inhibiting SUMOylation of polyQ AR restores much of its transcripti

207 proteins, hardly anything is known about the SUMOylation of proteins targeted to membrane-enclosed or

208 1), which in turn inhibits SENP1-mediated de-SUMOylation of Rac1 to activate Rac1.

209 tion of the SUMO isopeptidase SENP1 enhances sumoylation of Ran in semi-permeabilized cells.

210 nclusion, our data show that TORC1-dependent sumoylation of Rpc82 bolsters the transcriptional capaci

211 TORC1-dependent sumoylation of Rpc82 in particular is required for robus

212 Mechanistically, sumoylation of Rpc82 is important for assembly of the RN

213 skeletal integrity, it significantly reduced SUMOylation of S100A4, a critical posttranslational modi

214 rize a small molecule, N106, which increases SUMOylation of SERCA2a.

215 rized this biosensor by successfully imaging sumoylation of several target proteins, achieving signif

216 Second, Smc5/6-dependent SUMOylation of Sgs1 and Top3 is required for the efficie

217 ts demonstrate a function of RanBP2-mediated SUMOylation of SHP in maintaining BA homoeostasis and pr

218 nBP2, in maintaining BA homoeostasis through SUMOylation of SHP.

219 The time-course for SUMOylation of single NaV1.2 channels at the cell surfac

220 First, auto-SUMOylation of Smc5/6 subunits leads to recruitment of S

221 Sumoylation of Smo in turn recruits a deubiquitinase UBP

222 Notably, sumoylation of Srs2 itself specifically stimulates recom

223 the NDSM and renders a selective decrease in sumoylation of substrates with the NDSM motif.

224 We determined that mono-sumoylation of the 25-kDa rab17 is responsible for the s

225 function as an intramolecular E3 ligase for SUMOylation of the cell cycle regulatory domain 1 (CRD1)

226 We recently reported that SUMOylation of the GR at position K293 in humans (K310 i

227 ersensitive to red light, (ii) light-induced SUMOylation of the mutant phyB is drastically decreased

228 w that SENP1 deletion in adipocytes enhances SUMOylation of the NF-kappaB essential molecule, NEMO, a

229 is delocalized and can no longer antagonize sumoylation of the PIAS family SUMO E3 ligase, Pli1.

230 Mono- and poly-SUMOylations of target proteins provide docking sites fo

231 Consistent with the effects of SUMOylation on other classes of nuclear receptors, dexam

232 However, the precise role of SUMOylation on other protein degradation pathways, parti

233 sitions could be controlled by levels of PML SUMOylation or cellular mRNA concentration, respectively

234 proteasome-deficient cells, suggesting that SUMOylation participates in cellular protein quality con

235 and-activated polyQ AR and indicate that the SUMOylation pathway may be a potential target for therap

236 rapid and massive rearrangement of chromatin SUMOylation pattern: SUMOylation was gained at active pr

237 m of this protein, but it is unclear whether SUMOylation plays a pathogenic or protective role in SBM

238 Here, we provide evidence that SUMOylation plays a role in the parasite response to oxi

239 Maize SUMOylation primarily impacts nuclear substrates, is str

240 e, we investigate the role of E4-ORF3 in the sumoylation process by using transcription intermediary

241 Mechanistically, SUMOylation promoted ubiquitin-mediated degradation of P

242 sumoylation of mammalian Smo (mSmo) and that sumoylation promotes ciliary localization of mSmo and Sh

243 Therefore, inhibitors of alpha-synuclein SUMOylation provide a strategy to reduce alpha-synuclein

244 UMOylation in cultured cells and in in vitro SUMOylation reactions, and increased MTHFD1 ubiquitinati

245 We found that SUMOylation regulates CSCs through Oct-1, a transcriptio

246 Sumoylation regulates many cellular processes, but its r

247 bcellular localization and shed light on how sumoylation regulates membrane protein trafficking.

248 LMP1 CTAR3-mediated sumoylation regulates the function of KAP1.

249 Interestingly, SUMOylation regulates the functional activity of many of

250 SUMOylation-resistant derivatives of GFI1 fail to comple

251 pression by GFI1 are profoundly impaired for SUMOylation-resistant GFI1 derivatives, while enforced e

252 Wild-type FANCA was also subject to SUMOylation, RNF4-mediated polyubiquitination, and degra

253 We further determined that sumoylation selectively promotes interactions with synta

254 E171 (within the consensus motif) abolished SUMOylation, significantly increased the half-life of PI

255 Mutation of the SUMOylation site compromised neither ErbB4-induced phosp

256 ow demonstrate that the integrity of this GR SUMOylation site is mandatory for the formation of a GR-

257 nterestingly, 1 mutation damaged a predicted sumoylation site, and another disrupted a predicted CK1

258 Mutation of the consensus SUMOylation site, Lys(447), obviated Hsp27-mediated F508

259 cated GR isoform GRalpha-D3 lacking the K310 SUMOylation site, revealed a more severe skin inflammati

260 Conserved CTD SUMOylation sites are required for Ipl1 recruitment.

261 development, it is important to identify the sumoylation sites in proteins.

262 Proteome-wide detection of SUMOylation sites on target proteins typically requires

263 Mapping Ran sumoylation sites revealed that transport receptors may

264 We then map SUMOylation sites to the C-terminal domain of septins be

265 We further show that Hh-induced-sumoylation stabilizes Smo, whereas desumoylation by Ulp

266 g in utero electroporation to manipulate the sumoylation state of FOXP2 as well as Foxp2 expression l

267 la promotes its own invasion by altering the sumoylation state of RhoGDIalpha, a master negative regu

268 A molecular tool that monitors p53 sumoylation status and expedites screening for drugs tha

269 rovide a mechanistic explanation for how the SUMOylation status of Drp1 acts as a key switch in cell

270 demonstrated the utility of the approach in SUMOylation studies, but, in principle, it may be adapte

271 on of SUMOylation that can be applied to any SUMOylation substrate and SUMO isoform.

272 SUMOylation targets a wide variety of cellular regulator

273 mal consensus criteria for the validation of SUMOylation that can be applied to any SUMOylation subst

274 We have identified a target of LMP1-mediated sumoylation that contributes to the maintenance of laten

275 ered a novel mechanism for Smo activation by sumoylation that is regulated by Hh and Smo interacting

276 ome-wide, site-level detection of endogenous SUMOylation that uses alpha-lytic protease, WaLP.

277 Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PI

278 B4 kinase activity was not necessary for the SUMOylation, the SUMOylated ErbB4 ICD was tyrosine phosp

279 Modifier (SUMO) binding and by altering TDG sumoylation through SUMO and SUMO protease overexpressio

280 cterization of the host factors that rely on SUMOylation to exert their antiviral effects, the enzyme

281 n Arabidopsis (Arabidopsis thaliana) linking SUMOylation to stress tolerance via its modification of

282 , we have assessed the contribution of LRH-1 SUMOylation to the development of nonalcoholic fatty liv

283 borates with Ubc9, the E2 enzyme for protein SUMOylation, to selectively degrade F508del CFTR via the

284 Chromatin SUMOylation was further correlated with HS-induced globa

285 rrangement of chromatin SUMOylation pattern: SUMOylation was gained at active promoters and enhancers

286 ibit poly-SUMO chain formation, whereas mono-SUMOylation was not impaired.

287 In contrast, SUMOylation was required for nuclear accumulation of the

288 omoting ubiquitin-dependent degradation, and sumoylation was required for this process.

289 To address how PIASy catalyzes SUMOylation, we examined various truncations of PIASy fo

290 A, interact with other proteins, and undergo sumoylation were all necessary to selectively repress If

291 his, we bypassed the inhibitory effect of AR SUMOylation (where SUMO indicates small ubiquitin-like m

292 Intriguingly, SUMOylation (where SUMO indicates small ubiquitin-like m

293 horylation, ubiquitination, acetylation, and SUMOylation, which affect PTEN localization and protein

294 Cardiolipin induces PPARgamma SUMOylation, which causes recruitment of a repressive NC

295 estrogen E2 program appears to depend on GR SUMOylation, which leads to stable trans-recruitment of

296 Preventing CRMP2 SUMOylation with a SUMO-impaired CRMP2-K374A mutant trig

297 point to tissue/cell-specific functions for SUMOylation, with potentially significant roles during e

298 These findings suggest that SUMOylation within the GFI1 linker favors LSD1/CoREST re

299 ntal Cell, Ma et al. (2016) demonstrate that sumoylation works in parallel with phosphorylation to st

300 pedites screening for drugs that enhance p53 sumoylation would be beneficial.