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1 on factor and member of the nuclear receptor superfamily.
2 ncluded that DddY should belong to the cupin superfamily.
3 ependent enzymes of the alpha/beta-hydrolase superfamily.
4 t cut-and-paste transposons are from the hAT superfamily.
5 the RAD2/XPG structure-specific 5'-nuclease superfamily.
6 exists within this diverse and heterogenous superfamily.
7 , a member of the ATP-binding cassette (ABC) superfamily.
8 lysophosphospholipid acyltransferase (LPLAT) superfamily.
9 sugar transporters of the major facilitator superfamily.
10 to the expansion of the grape homeobox gene superfamily.
11 member of the acyl-CoA oxidase/dehydrogenase superfamily.
12 s a member of the complement control protein superfamily.
13 functions remain to be uncovered within the superfamily.
14 -inflammatory cytokine belonging to the IL-1 superfamily.
15 ation, including the oncoproteins of the RAS superfamily.
16 of reactions catalyzed by the amidohydrolase superfamily.
17 the transforming growth factor-beta receptor superfamily.
18 tial future highlights of research on the NR superfamily.
19 ceptors, a subset of the TNF receptor (TNFR) superfamily.
20 mbers of the transforming growth factor beta superfamily.
21 nificantly differs from other members of the superfamily.
22 e protease inhibitor belonging to the serpin superfamily.
23 l model for the eukaryotic Cys-loop receptor superfamily.
24 ubstrate binding and recognition in the P450 superfamily.
25 esterase enzymes of the alpha/beta-hydrolase superfamily.
26 drug efflux protein of the major facilitator superfamily.
27 is homologous to, but distinct from the PAS superfamily.
28 are infamously oncogenic members of the PTP superfamily.
29 binding that is unparalleled within the FKBP superfamily.
30 onal analysis of proteins comprising the Prx superfamily.
31 espite absence of such enzymes within the AP superfamily.
32 ks the characteristic disulfide bonds of the superfamily.
33 o other nonpolymerizing members of the actin superfamily.
34 ylsugar acyltransferases (ASATs) of the BAHD superfamily.
35 and 2-oxoglutarate (2OG)-dependent oxygenase superfamily.
36 rs that are members of the major facilitator superfamily.
37 is shared by multiple cytokines in the IL-10 superfamily.
38 s of the pentameric ligand-gated ion channel superfamily.
39 o the identification of the nuclear receptor superfamily.
40 n the pancreatic-type ribonuclease (ptRNase) superfamily.
41 based drug discovery for this important gene superfamily.
42 ructure/function transitions in other enzyme superfamilies.
43 ovides a means to analyse trends across many superfamilies.
44 nistic data, for structurally defined domain superfamilies.
45 location along ssDNA that sheds light on how superfamily 1 and 2 helicases turn ATP hydrolysis into m
48 substates of the ATP hydrolysis cycle of the superfamily 2 helicase Hel308 during translocation on si
49 eral viruses of the NCLDV clade, which use a superfamily 3 helicase for replication, as do poxviruses
50 4-1BB (CD137, tumor necrosis factor receptor superfamily 9) is an inducible costimulatory receptor ex
54 tem-cell pluripotency, including the TGFbeta superfamily, all of which are aberrantly elevated in DND
55 ogenin (ANG), a member of the Ribonuclease A superfamily (also known as RNase 5) are known to be asso
56 ividual members of the glycyl radical enzyme superfamily among the microbiomes of healthy humans.
57 s into 15 functional classes, 689 structural superfamilies and 1404 families; (ii) 446 complexes of b
58 ridomorph clades, including the monophyly of superfamilies and families, except for Ascaridiidae, whi
59 and SsoMCM, these enzymes are from different superfamilies and unwind DNA with opposite polarities.
60 ors belong to the G protein-coupled receptor superfamily and are composed of eight members encoded by
61 mbers of the transforming growth factor beta superfamily and are often perceived to serve similar or
62 l analysis of similarities across the entire superfamily and computed a sequence similarity network t
63 e transforming growth factor-beta (TGF-beta) superfamily and has been implicated in various biologica
64 which belongs to the metallo-beta-lactamase superfamily and is a paralog of CPSF-73, the endonucleas
65 in (TRPML) channel family belongs to the TRP superfamily and is composed of three members: TRPML1-TRP
66 3 (INSL3) is a member of the relaxin/insulin superfamily and is expressed in testicular Leydig cells.
68 s have evolved within a structurally defined superfamily and provides a means to analyse trends acros
69 e and mechanism of an entire ABC transporter superfamily and the many diverse functions it supports.
70 DddY has not been classified into a protein superfamily, and its structure and catalytic mechanism a
71 s into the mechanistic design of the ptRNase superfamily, and presents a structural basis for evoluti
72 of the PdxA, class II aldolase, and RuBisCO superfamilies are phosphorylated, we postulated that the
74 ing data indicate that activation of the RAS superfamily are poor biomarkers of statin sensitivity, a
76 olecular basis of charge selectivity for the superfamily as a whole, we performed extensive mutagenes
77 eiodinase is a member of the same structural superfamily as many nitroreductases but does not directl
78 tructures of two members of the glucose EIIC superfamily, bcChbC in the inward-facing conformation an
79 a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depe
80 They belong to the voltage-gated ion channel superfamily but their activities are controlled by intra
82 the dimethylallyltryptophan synthase (DMATS) superfamily catalyze the attachment of prenyl or prenyl-
83 ick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropri
84 00348), a subgroup of the terpenoid synthase superfamily (CL0613) whose members have a characteristic
85 o the well-studied alkaline phosphatase (AP) superfamily, comparing three of its members, two evoluti
86 al calcium sensor subclass of the calmodulin superfamily, confers Ca(2+)-sensitive activation of reti
87 ever, DUI is not found in all three Unionida superfamilies (confirmed in Hyrioidea and Unionoidea but
89 led of the G protein-coupled receptor (GPCR) superfamily, constituting a key component of the Hedgeho
90 show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, s
93 c expression of different members of the RAS superfamily did not uniformly sensitize cells to fluvast
95 form is transported by the major facilitator superfamily domain containing 2A (MFSD2A) through the en
97 tein domains classified into 2737 homologous superfamilies, doubling the number of predicted protein
98 n chromosomal region 20p12 belongs to a gene superfamily encoding TGF-beta-signaling proteins involve
99 rRNA methylation mechanism by a radical SAM superfamily enzyme, indicating that two resistance mecha
101 tructure of the olfactory receptor (OR) gene superfamily: expansion or contraction of OR subfamilies
102 tebrate protein found to possess the RNase A superfamily fold, and homologs of this toxin are associa
105 ononucleotide-dependent nitroreductase (NTR) superfamily (>24,000 sequences from all domains of life,
106 (a pan-inhibitor of the Jumonji demethylase superfamily) had the opposite effect and was ~8-fold mor
107 gests that the carotenoid cleavage oxygenase superfamily has evolved in the "extremely high turnover"
108 eptor of the transforming growth factor-beta superfamily, has been reported to identify functional lo
109 f the tumour necrosis factor receptor (TNFR) superfamily, has the capacity to cause extensive apoptos
111 ins of the PR-1 (pathogenesis-related 1)/CAP superfamily have been implicated in fungal virulence and
112 model in which contemporary subgroups of the superfamily have diverged in a radial manner from a mini
113 ically inactive members of the rhomboid-like superfamily, have been shown to control the ER-to-Golgi
114 , the only known tumor necrosis factor (TNF) superfamily homolog in Drosophila, Coxiella-infected fli
115 Here we present an updated atlas of the Prx superfamily identified using a novel method called MISST
116 secreted proteins containing immunoglobulin superfamily (IgSF) domains discovered a network formed b
117 ine (SVM) to automatically assign domains to superfamilies; improved search facilities to return alig
118 transporters form one of the largest protein superfamilies in all domains of life, catalyzing the mov
119 (AIPL1) is a distinctive member of the FKBP superfamily in terms of its biochemical properties, and
120 e first genome-wide analysis of the expansin superfamily in the Arachis genus identified 40 members i
121 of FunTree that has expanded to include 2340 superfamilies including both enzymes and proteins with n
122 with several members of the nuclear receptor superfamily, including the human vitamin D receptor (hVD
123 s transforming growth factor beta (TGF beta) superfamily inhibitors of erythropoiesis, giving rise to
124 n-binding domain of LAIR1, an immunoglobulin superfamily inhibitory receptor encoded on chromosome 19
126 r and iron, in the heme-copper oxidase (HCO) superfamily is critical to the enzymatic activity of red
128 slation of the fundamental mechanisms of TNF superfamily is leading to the design of therapeutics tha
131 show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and
133 inine is conserved with the HerA/FtsK ATPase superfamily; (iv) a molecular docking model of the penta
134 P) shares no homology with the two other HPP superfamilies known previously in prokaryotes and resemb
136 a LTR-retrotransposons, members of the gypsy superfamily, led to genome expansion in C. baccatum.
138 pteran phylogeny since 1975, emphasizing the superfamily level, and discuss some resulting advances i
139 imerization upon binding to its trimeric TNF superfamily ligand (4-1BBL) to stimulate immune response
140 In this study, we demonstrate that the TNF superfamily ligand-receptor pair CD70/CD27 is expressed
142 yeast cells, indicating that members of this superfamily may generally bind sterols or related small
144 ed to upregulated expression of TNF receptor superfamily member 12a, also known as fibroblast growth
145 ron gamma (IFN-gamma), tumor necrosis factor superfamily member 14 (TNFSF14, also known as LIGHT), mo
146 AIMS: Variants in the tumor necrosis factor superfamily member 15 gene (TNFSF15, also called TL1A) h
150 ining protein 3 rs738409 nor transmembrane 6 superfamily member 2 rs58542926 polymorphisms influenced
151 and proteomics, we identified immunoglobulin superfamily member 21 (IgSF21) as a neurexin2alpha-inter
152 ifferentiation factor 8 (GDF8) is a TGF-beta superfamily member, and negative regulator of skeletal m
153 ame UL144 is an ortholog of the TNF receptor superfamily member, herpesvirus entry mediator (HVEM; TN
156 functions of the two most prominent TGF-beta superfamily members activin and TGF-beta in advanced col
159 ese dimeric voltage-gated ion channel (VGIC) superfamily members have a unique topology comprising tw
161 , provide clues for functional inference for superfamily members of unknown function, and facilitate
162 d and delineate new differences between GLTP superfamily members that are specific for C1P versus gly
164 hyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD(+)-dependent oxid
165 rmore conserved among additional coronavirus superfamily members, including lineage A betacoronavirus
166 Here we report that additional coronavirus superfamily members, including lineage A betacoronavirus
171 ulted in downregulation of Major Facilitator Superfamily (MFS) genes, while DEGs of the DEM treatment
173 ath one homolog (PD-1H) is an immunoglobulin superfamily molecule and primarily acts as a coinhibitor
174 levels of the tumor necrosis factor receptor superfamily molecule GITR, whose stimulation is closely
175 Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in
177 inct differences from the three metal ion AP superfamily monoesterase, from Escherichia coli AP (EcAP
178 igand-gated nicotinic acetylcholine receptor superfamily (namely alpha-amino-3-hydroxy-5-methyl-4-iso
180 discuss six publications that describe three superfamilies of T6SS proteins, each dedicated to mediat
184 redoxins (Prxs or Prdxs) are a large protein superfamily of antioxidant enzymes that rapidly detoxify
187 ionine (SAM) enzymes are emerging as a major superfamily of biological catalysts involved in the bios
191 afish Gdf3 (Dvr1) is a member of the TGFbeta superfamily of cell signaling ligands that includes Xeno
194 tory response, when self-limited, produces a superfamily of chemical mediators that stimulate resolut
196 Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes responsible for the faithful tran
197 er of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but it does not catalyze the for
198 e growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which use a reduced [4Fe-4S] clu
200 IA PI3Ks are activated downstream of the Ras superfamily of GTPases, and Ras-PI3K interaction plays a
201 zed by bioinformatics as a member of the FRD superfamily of heme-containing membrane proteins, which
203 mposed of arabinogalactan proteins (AGPs), a superfamily of hydroxyproline-rich glycoproteins present
205 -coupled receptors (GPCRs) belong to a large superfamily of membrane receptors mediating a variety of
206 (Trm10) is a member of the SpoU-TrmD (SPOUT) superfamily of methyltransferases, and Trm10 homologs ar
208 he DHH (Asp-His-His) phosphoesterase protein superfamily of molecules important for cell motility, an
209 Kinesins-13s are members of the kinesin superfamily of motor proteins that depolymerize microtub
210 ane X receptor (PXR, NR1I2), a member of the superfamily of nuclear receptors, is a transcription fac
211 Polynucleotide ligases comprise a ubiquitous superfamily of nucleic acid repair enzymes that join 3'-
215 ong neurotransmitter-gated ion channels, the superfamily of pentameric ligand-gated ion channels (pLG
216 ast, less is known about a second, extensive superfamily of PGTs that reveals a core structure with d
219 channel-like subunit (KdpA) belonging to the superfamily of potassium transporters and another pump-l
220 new and distinct subfamily within the broad superfamily of previously studied PII regulatory protein
222 g peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bac
223 led receptors (GPCRs) constitute the largest superfamily of proteins that compose approximately 4% of
226 , with each containing a member of the Omp85 superfamily of proteins: BamA in the BAM complex, TamA i
228 ppreciated that actin is a member of a large superfamily of structurally related protein families fou
229 usly, we found that DXPS is unique among the superfamily of thiamin diphosphate (ThDP)-dependent enzy
232 KCP) is a secreted regulator of the TGF-beta superfamily pathways that can inhibit both TGF-beta and
234 meningosepticum, indicate similarities to a superfamily phosphate diesterase [Xanthomonas citri nucl
236 members of the luciferase-like monooxygenase superfamily points toward an important role of these pro
237 al diversity displayed by the protein kinase superfamily poses unique challenges in fully defining th
239 sion molecule C (JAM-C) is an immunoglobulin superfamily protein expressed in epithelial cells, endot
240 a transforming growth factor-beta (TGF-beta) superfamily protein that has a role in cancer, obesity a
241 gCAM) BT-IgSF (brain- and testis-specific Ig superfamily protein) plays a major role in male fertilit
244 of other members of the pentameric receptor superfamily provide touchstones for an emerging alloster
245 emergence of functional diversity in enzyme superfamilies, provide clues for functional inference fo
246 VEM; TNFRSF14), a member of the TNF receptor superfamily, provides key signals for MPEC persistence.
247 functional evolution across a wide range of superfamilies, providing insights that will be useful in
249 kers of the transforming growth factor (TGF) superfamily, purinergic signaling in response to DL was
250 e demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint
251 DCs and identified Acvrl1, a type I TGF-beta superfamily receptor, as a gene strongly induced by Irf8
252 d potent agonists against two different TNFR superfamily receptors and mouse tumor model studies demo
253 ere, we focus attention on the subset of TNF superfamily receptors encoded in the immune response loc
256 this novel method is demonstrated by the Prx superfamily results, laying the foundation for potential
257 ent esterase MGS0169 from the amidohydrolase superfamily revealed a novel active site with a bound un
260 solution) of a mycetozoan peroxidase of this superfamily shows the presence of a post-translationally
261 and proteomic profiling reveal that TGFbeta superfamily signaling pathways are preferentially activa
262 dings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein can alter
265 nesis-related 1 proteins), also known as SCP superfamily (sperm-coating proteins), have been implicat
267 ups representing the other two cicadomorphan superfamilies supported the monophyly of Membracoidea, a
269 -18 (IL18), a cytokine belonging to the IL-1 superfamily that can induce synthesis of several other c
270 ANO5 is a member of the Anoctamin/TMEM16 superfamily that encodes both ion channels and regulator
271 GDF-15) is a member of the TGF-beta cytokine superfamily that is widely expressed and may be induced
272 sine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phosphat
273 eductase that is a member of the heme-copper superfamily that utilizes ubiquinol-8 (Q8H2) as a substr
274 (MVI) is the only known member of the myosin superfamily that, upon dimerization, walks processively
275 functional information about members of both superfamilies, the mechanism by which uphill potassium t
276 Despite extensive scrutiny of the myosin superfamily, the lack of high-resolution structures of a
286 way for quality control of major facilitator superfamily transporters that occurs before the first tr
288 shed that LigY belongs to the amidohydrolase superfamily, unlike previously characterized MCP hydrola
290 her factors may influence evolution across a superfamily, we turned to the well-studied alkaline phos
292 member of the PPAR nuclear hormone receptor superfamily, which can be activated by fibrate ligands.
293 ellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from t
294 aromyces cerevisiae belongs to the Ty1/Copia superfamily, which is present in every eukaryotic genome
295 member of the tumor necrosis factor receptor superfamily, whose activity has been linked to membrane
297 ecrosis factor (TNF) and immunoglobulin (Ig) superfamilies with diverse, and often opposing, outcomes
298 s both within and among the approximately 43 superfamilies, with unsolved problems now yielding to mu
299 e human cold shock domain-containing protein superfamily, with known functions in cell proliferation,
300 oup species representing other cicadomorphan superfamilies, yielded the same topology in which Scapho
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