ライフサイエンスコーパス: superoxide radical

1 sfer and can reduce molecular oxygen forming superoxide radical.

2 al aconitase, suggesting they react with the superoxide radical.

3 bly through metabolic pathways involving the superoxide radical.

4 t antioxidant capacity, particularly against superoxide radical.

5 lecular O(2), facilitating the generation of superoxide radical.

6 ction via photosynthesis and the disposal of superoxide radicals.

7 ling the NADPH oxidase complex and producing superoxide radicals.

8 sed sensitivity to intracellularly generated superoxide radicals.

9 hin a few minutes at neutral pH and produces superoxide radicals.

10 lls in blood vessels to produce an excess of superoxide radicals.

11 clinical therapies for diseases mediated by superoxide radicals.

12 ucigenin-derived chemiluminescence evoked by superoxide radicals.

13 the tyrosine kinase-dependent generation of superoxide radicals.

14 ys against 2,2-diphenyl-1-picrylhydrazyl and superoxide radicals.

15 sion-controlled reaction of nitric oxide and superoxide radicals.

16 tance to H(2)O(2) have the highest levels of superoxide radicals.

17 ing the scavenging of DPPH, nitric oxide and superoxide radicals.

18 d to be the scavenging and detoxification of superoxide radicals.

19 ctivities as well as increased production of superoxide radicals.

20 D1 and chloroplastic CSD2) that can detoxify superoxide radicals.

21 generation, NOS is also capable of producing superoxide radicals.

22 zing the formation of hydrogen peroxide from superoxide radicals.

23 gen deprivation, a donor of nitric oxide and superoxide radicals (3-morpholinosydnonimine), an inhibi

24 Superoxide radical adducts were observed in both WT and

25 In this way, two toxic species, superoxide radical and hydrogen peroxide, are converted

26 producer of reactive oxygen species such as superoxide radical and hydrogen peroxide, which may cont

27 When MnSOD is deficient, superoxide radical and its resulting reactive oxygen spe

28 bination with PUT-CAT may eliminate both the superoxide radical and the H2O2 produced from the dismut

29 ns is exposed to a range of stresses such as superoxide radicals and cationic fluxes.

30 ocytosis of GBS was unaltered, production of superoxide radicals and hydrogen peroxide was markedly d

31 g reactions with molecular oxygen, producing superoxide radicals and hydrogen peroxide.

32 LIT1-null promastigotes accumulated superoxide radicals and initiated amastigote differentia

33 mitochondrial antioxidant enzyme, scavenges superoxide radicals and its overexpression provides neur

34 Hydroethidine was used to identify superoxide radicals and lipid peroxidation was visualize

35 ilar fashion, epithelial cells produced more superoxide radicals and were more susceptible to cytotox

36 oles for STAR-derived peroxysulfate radical, superoxide radical, and sulfo-NAD(P) in the mechanism of

37 the channel for electrostatic recognition of superoxide radical, and the connectivity of the intrasub

38 prevent reduction of cytochrome C(FeIII) by superoxide radical, and they reverse an age-dependent de

39 reactive oxygen species (ROS), specifically superoxide radicals, and induced apoptosis through the m

40 ases (SODs) are metalloenzymes that detoxify superoxide radicals, and occur in cytosolic (Cu,Zn-SOD)

41 Sanguinarine-induced production of superoxide radicals, and the addition of MnTBAP, a scave

42 nown agent of oxidative stress and source of superoxide radical anion (and indirectly, a causative of

43 d oxidation reaction mechanisms initiated by superoxide radical anion (O(2)()) and nitric oxide ((*)N

44 NO/O(2) (via nitrogen dioxide, (*)NO(2)) and superoxide radical anion (O(2)(*)(-)) promote Ras guanin

45 enge three specific reactive oxygen species (superoxide radical anion (O(2)(-)), hydroxyl radical (HO

46 n be reoxidized by O2to Fe(III)-CBS, forming superoxide radical anion (O2 ()).

47 ing CDNMPO shows distinctive EPR spectra for superoxide radical anion (O2(*-)) compared to other biol

48 in trap that incorporates high reactivity to superoxide radical anion (O2(*-)), more persistent super

49 radical ((*)OH), singlet oxygen ((1)O2) and superoxide radical anion (O2(*-)).

50 reactivity of functionalized spin traps with superoxide radical anion (O2*-).

51 s with HPLC-based simultaneous monitoring of superoxide radical anion and hydrogen peroxide provides

52 gulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a

53 assays for monitoring cellular production of superoxide radical anion and hydrogen peroxide using hyd

54 cating involvement of enhanced generation of superoxide radical anion as an upstream signal.

55 gen species suggest a nucleophilic attack of superoxide radical anion followed by TNT denitration thr

56 lective NO synthase inhibitor), and Tiron (a superoxide radical anion scavenger) on the development o

57 ctions with water, molecular oxygen, and the superoxide radical anion support the experimental findin

58 athway requiring Src kinases, NADPH oxidase, superoxide radical anion, and hydrogen peroxide.

59 mediated photogeneration of singlet oxygen, superoxide radical anion, and photo-oxidation of added l

60 which is produced by the reaction of NO with superoxide radical anion.

61 udies prove that the reaction progresses via superoxide radical anions (.O2(-)).

62 NAD(P)H/O2 system revealed the generation of superoxide radical anions (O2 *-).

63 secretory product from Necator americanus on superoxide radical anions generated by xanthine/xanthine

64 shown to depend markedly on the presence of superoxide radical anions.

65 High levels of the superoxide radical are still toxic.

66 vant to several neurological disorders where superoxide radicals are generated in the vicinity of gli

67 Reactive oxygen species (ROS) such as superoxide radicals are responsible for the pathogenesis

68 superoxide dismutase-deficient astrocytes to superoxide radicals artificially produced by paraquat tr

69 g hydrogen peroxide as the major product and superoxide radical as a minor product.

70 pe, surB1, and delta(cydAB) strains produced superoxide radicals at the same rate in vitro.

71 d in detail for their capability to generate superoxide radicals both in isolated enzymatic one- and

72 OD), the mitochondrial enzyme that catalyzes superoxide radical breakdown, in brain mitochondria from

73 The trapping of the superoxide radical by cytochrome c in the reaction of BH

74 The superoxide radical can scavenge endothelium-derived rela

75 , in addition to being a potential source of superoxide radical, CBS constitutes a previously unrecog

76 posing, concentration-dependent roles of the superoxide radical comprise a form of hormesis and show

77 n signaling and PLETHORA gradient as well as superoxide radical content, resulting in reduction of ce

78 n of 6-OHDA by COX-2 triggered production of superoxide radicals critical for both propagation of 6-O

79 hypothesis, we first used in situ imaging of superoxide radical distribution by hydroethidine oxidati

80 , and the addition of MnTBAP, a scavenger of superoxide radicals, efficiently inhibited sanguinarine-

81 spectrum produced implies that, besides the superoxide radical expected to be formed during autoxida

82 The amount of superoxide radicals formed during oxidation was investig

83 he primary cellular defense against damaging superoxide radicals generated by aerobic metabolism and

84 Consistently, superoxide radicals generated by hypoxanthine and xanthi

85 IV deficiency and elevated nitric oxide and superoxide radical generation precede neuronal death in

86 function was associated with a reduction in superoxide radical generation, vascular cell adhesion mo

87 s cells sensitive to H(2)O(2) but not to the superoxide radical generator menadione.

88 cells and dopaminergic neurons by modifying superoxide radical handling in these selectively vulnera

89 The superoxide radical has not previously been directly dete

90 rite, a reaction product of nitric oxide and superoxide radicals, has been implicated in N-methyl-D-a

91 reases in levels of mitochondrially produced superoxide radicals have a protective effect during H(2)

92 uction of reactive oxygen species, including superoxide radical, hydrogen peroxide, and hypochlorous

93 active oxygen species (ROS; peroxyl radical, superoxide radical, hypochlorous acid), cytotoxicity ass

94 assays performed, a remarkable inhibition of superoxide radicals i.e. 94.25% observed with extracts o

95 he class of metalloenzymes that detoxify the superoxide radical in aerobic organisms.

96 s, a single MnSOD caters to the reduction of superoxide radical in both cytosol and thylakoid lumen/p

97 ismutases (SODs) catalyze the dismutation of superoxide radicals in a broad range of organisms, inclu

98 Manganese superoxide dismutase removes superoxide radicals in mitochondria, and thus protects m

99 ced the NADPH oxidase-mediated production of superoxide radicals in neurons that was involved in the

100 induce NADPH oxidase-mediated production of superoxide radicals in neurons, which was involved in th

101 ntravenous injection of hydroethidine due to superoxide radicals in photoreceptors, greater photorece

102 Involvement of superoxide radicals in selenomethionine toxicity in vivo

103 sults provide further evidence for a role of superoxide radicals in the long-term effects of METH.

104 2-MPTP-induced toxicity, thereby implicating superoxide radicals in the mechanism of action of a neur

105 ty and generated reactive oxygen species and superoxide radicals in vitro.

106 we show that H/R enhances the generation of superoxide radicals in wt CA (25.8 +/- 0.7 relative ligh

107 eural debris and prevented the production of superoxide radicals induced by challenge with neural deb

108 MPO-OOH adduct converts the very short-lived superoxide radical into a more stable spin adduct.

109 The SODs convert superoxide radical into hydrogen peroxide and molecular

110 iron-oxygen bond resulting in the release of superoxide radical into the heme pocket.

111 e dismutase (SOD) is an enzyme that converts superoxide radicals into hydrogen peroxide and molecular

112 agnetic resonance spectroscopy, we show that superoxide radical ions (O2-) form directly on Mars-anal

113 latter observation strongly supports that a superoxide radical is involved in the maturation mechani

114 anine lesions via combination of guanine and superoxide radicals is greatly reduced in the presence o

115 SOD), which catalyzes the dismutation of the superoxide radical, is present in the cytosol and mitoch

116 (2)-sensitive mutant strains have the lowest superoxide radical levels, and strains with the highest

117 s of the primary defense of the cell against superoxide radicals, manganese superoxide dismutase.

118 A mechanism of superoxide radical-mediated dimerization of EGCG and H2O

119 Quantitation of superoxide radical (O(2)(*)(-)) production at the site o

120 , whereas increasing levels of extracellular superoxide radical (O(2)(*-)) using xanthine/xanthine ox

121 t enzymes responsible for the elimination of superoxide radical (O(2)(-)).

122 Cellular superoxide radicals (O(2)(-)) are mostly generated durin

123 fense against oxidative damage by converting superoxide radicals (O(2)(-)) to O(2) and H(2)O(2).

124 iplasm to offer protection from host-derived superoxide radicals (O(2)(-)).

125 iving tissues under inflammatory conditions, superoxide radicals (O(2)*)) are generated and are known

126 cCer stimulated the endogenous generation of superoxide radicals (O-2) about 5-fold compared with the

127 Rate constants of superoxide radical (O2(*-)) reactions with nitrones were

128 s (SOD) are essential enzymes that eliminate superoxide radical (O2-) and thus protect cells from dam

129 roxynitrite is formed by the reaction of the superoxide radical (O2.-) with the nitric oxide radical

130 Superoxide radicals (O2( *-)) and their protonated form

131 (NO) in combination with singlet oxygen and superoxide radicals (O2(*-)) as reactive oxygen species

132 When C60 and HA were present as a mixture, superoxide radicals (O2(*-)) were 2.2-2.6 times more tha

133 known, mainly in non-neuronal systems, that superoxide radicals (O2-) activate these (and other) kin

134 ombination reaction between the 8-oxoGua and superoxide radicals occurs with the rate constant of (1.

135 The deleterious effect of superoxide radicals on cell growth and survival is predo

136 he conclusion that this new radical is not a superoxide radical or a mixture of superoxide and biopte

137 ing cells from oxidative damage arising from superoxide radical or reactive oxygen species produced f

138 they are sensitive to degradation induced by superoxide radicals or increased temperatures.

139 These results suggest that superoxide radicals play a role in the delayed ischemic

140 otocin, 3-morpholinosydnonimine (SIN-1), and superoxide radical produced by xanthine/xanthine oxidase

141 entify xanthine oxidase as a major source of superoxide radical production causing these toxic effect

142 to H(2)O(2), the wild-type strain increases superoxide radical production to activate this defense m

143 orting the notion that doxorubicin increases superoxide radical production.

144 reatment, yeast cells significantly increase superoxide radical production.

145 aintain iron in soluble form, EDDS acts as a superoxide radical-promoting agent, enhancing the genera

146 tem for reliable and continuous detection of superoxide radical release from cell culture was develop

147 Addition of the superoxide radical scavenger tempol restored the ability

148 Thus, we propose that superoxide radical scavenging activity is a useful metho

149 f the trypsin hydrolysate showed the highest superoxide radical scavenging activity.

150 these heat products were studied by ABTS and superoxide radical scavenging assays.

151 Superoxide radical scavenging, lipid peroxidation inhibi

152 Superoxide radicals seem to participate in AMPH-induced

153 tion of reduced oxygen intermediates such as superoxide radicals, singlet oxygen, hydrogen peroxide,

154 respiration generates a proton gradient and superoxide radicals, suggesting a possible link between

155 o be correlated with their ability to quench superoxide radicals suggests that the regulation of phas

156 in the absence of MnTBAP either formation of superoxide radicals suppressed NO production or part of

157 ations GD3 recruits nitric oxide to scavenge superoxide radicals that triggered signaling events that

158 cellular microenvironment (formation of the superoxide radical), the chemistry of NO will turn into

159 te that, under identical ratios of enzyme to superoxide radical, the dismutation efficiencies scaled

160 g) caused conversion of approximately 70% of superoxide radical to a novel radical, explaining how l-

161 Nitric oxide reacts with superoxide radical to form peroxynitrite, which generate

162 ial primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular ox

163 ial primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular ox

164 D1 ), which catalyses the dismutation of the superoxide radical to hydrogen peroxide and oxygen.

165 dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide.

166 of approximately 15 s(-1), the time for the superoxide radical to leave the heme pocket and reach th

167 ble for catalyzing the disproportionation of superoxide radical to oxygen and hydrogen peroxide.

168 superoxide dismutase catalyzes conversion of superoxide radicals to H(2)O(2), with catalase neutraliz

169 dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and oxygen.

170 reactive oxygen species (ROS), specifically superoxide radicals, to induce apoptosis through both mi

171 The thermodynamic quantities for superoxide radical trapping by various nitrones have bee

172 t react with molecular oxygen and produce no superoxide radical under the typical settings of inhibit

173 haride (glycan) of N. commune DRH1 generated superoxide radicals upon exposure to UV-A or -B irradiat

174 BH(4)-free eNOS(ox) produced the superoxide radical very efficiently in the absence of L-

175 In vivo oxidation of dihydroethidium by superoxide radical was also significantly lower in brain

176 Scavenging of superoxide radical was generally weak, except for the <1

177 lhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated.

178 The superoxide radicals were spin-trapped via reaction with

179 nfection in part by issuing a burst of toxic superoxide radicals when challenged.

180 reactions with PFOA showed that hydroxyl and superoxide radicals, which are typically the primary pla

181 venging activity towards ABTS, hydroxyl, and superoxide radicals, which might explain their excellent

182 As MnSOD has been shown to remove superoxide radical with varying efficiency depending upo

183 ls on blood vessels to produce and excess of superoxide radicals, with attendant alterations in endot