ライフサイエンスコーパス: suppressive

1 vities that may be either oncogenic or tumor suppressive.

2 tated in cancer and hypothesized to be tumor suppressive.

3 ion indicate that Notch signalling is tumour suppressive.

4 hether various miRNAs are oncogenic or tumor suppressive.

5 breast cancer cells in which RAB25 is tumor suppressive.

6 Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted c

7 lls from well-controlled patients had better suppressive abilities.

8 e effect, confirming their important role in suppressive acitivity.

9 DHA, and letrozole completely inhibited this suppressive action.

10 o general anesthesia is widely attributed to suppressive actions of anesthetic molecules distributed

11 Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose pro

12 (hi) tTregs and Teffs, whereas modulation of suppressive activities by PKC-theta and Dlgh1 signaling

13 outcomes, and how might we restore its tumor-suppressive activities in cancer?

14 ressions on TFH cells and B cells, and their suppressive activities involved CD40, CD80, CD86, and in

15 els of proteins that are critical for immune suppressive activities of myeloid-derived suppressor cel

16 activation domain isoforms, which have tumor-suppressive activities, and the DeltaN isoforms, which a

17 n of regulatory T cells, leading to enhanced suppressive activity and diminished lesions.

18 g cells, CCR6(+) Treg cells exhibit stronger suppressive activity and display higher FOXP3 expression

19 Treg cell suppressive activity and Foxp3 methylation in MLN CD4(+)

20 s, at which point they exerted potent immune suppressive activity by inhibiting CD8 T cells, enhancin

21 immunoregulatory mechanisms, and the higher suppressive activity correlates to their capacity to tri

22 ctor or memory Treg phenotypes with superior suppressive activity in humans.

23 e2/3 has an important and selective leukemia-suppressive activity in this genetic context.

24 tolerogenic activity in vivo, but sustained suppressive activity in vitro.

25 enesis, which highlights an unexpected tumor-suppressive activity of MIF in murine skin.-

26 Here, we provide evidence of tumor suppressive activity of PPARD in prostate cancer through

27 as to prominent reduction in the number and suppressive activity of regulatory T cells.

28 ed epigenetic mechanism underlying the tumor-suppressive activity of SMARCB1.

29 IL-10, and granzyme B, resulting in enhanced suppressive activity of these cells.

30 ostate cancer cell lines validated the tumor suppressive activity of this gene in vitro and in vivo M

31 1 phosphorylation is required to relieve its suppressive activity to potentiate egress.

32 To clarify phenotype, suppressive activity, origin, and clinical impact of MDS

33 tial immunologic profile, upon ongoing AdMSC suppressive activity, promoting: (i) early correlated in

34 totic phosphorylation inhibits Vgll4's tumor-suppressive activity.

35 kinase 3) is critical for KLF9's axon-growth-suppressive activity.

36 production, which ultimately mediated their suppressive activity.

37 Also, RNAi of miR-17 resulted in enhanced suppressive activity.

38 ucible regulatory T (iTreg) cells exhibiting suppressive activity.

39 However, conventional immune suppressive agents have limited clinical efficacy in chr

40 on corticosteroids and other broadly immune suppressive agents.

41 ergens by expanding populations of naturally suppressive allergen-specific regulatory T cells (Tregs)

42 LncRNAs may exhibit tumor-suppressive and -promoting (oncogenic) functions.

43 atitis B reactivation associated with immune-suppressive and biological therapies is emerging to be a

44 ne response, including creation of an immune-suppressive and hostile tumor environment.

45 yer in stress pathways exhibiting both tumor-suppressive and oncogenic functions.

46 summary, ARID1A has context-dependent tumor-suppressive and oncogenic roles in cancer.

47 in MDSCs enhanced the pro-angiogenic, immune suppressive and pro-tumorigenic behavior of these cells

48 how that Notch signalling can be both tumour suppressive and pro-tumorigenic in small-cell lung cance

49 had increased Foxp3 expression, became more suppressive, and were resistant to Th17 skewing in vitro

50 Despite years of fully suppressive antiretroviral therapy (ART), HIV persists i

51 HIV-infected persons on suppressive antiretroviral therapy (ART), including thos

52 als with viremia or individuals on long-term suppressive antiretroviral therapy (ART).

53 a single chronically HIV-infected patient on suppressive antiretroviral therapy who underwent allo-SC

54 V-1-infected adults aged >18 to <70 years on suppressive antiretroviral therapy with CD4+ counts >350

55 s and in cells from HIV-infected patients on suppressive antiretroviral therapy with undetectable vir

56 nt in HIV-infected individuals despite fully suppressive antiretroviral therapy.

57 ful for treating HIV-infected individuals on suppressive antiretroviral therapy.

58 lls (PBMCs) from HIV-infected individuals on suppressive antiretroviral therapy.

59 breakthrough reactivation can occur despite suppressive antiviral therapy.

60 rophage reservoir in infected individuals on suppressive antiviral therapy.

61 Low-level HIV-1 RNA in CSF is common during suppressive ART and is associated with low-level HIV-1 R

62 ured over time in the presence or absence of suppressive ART and were compared to the HIV reservoir s

63 and across multiple time points in donors on suppressive ART consistent with constitutive expression

64 fic role in HIV persistence during long-term suppressive ART has not been established.

65 from 220 HIV-positive adults who were taking suppressive ART.

66 of considering protein context when pursuing suppressive avenues.

67 To measure suppressive binocular interactions directly, we recorded

68 cells lacking this pathway were functionally suppressive but failed to migrate to skin allografts and

69 e number of Treg cells, but it reduced their suppressive capacity and Foxp3 expression.

70 CD28-deficient TFR cells showed a diminished suppressive capacity as assessed by their ability to inh

71 y lower IDO1 expression and a weaker Th cell suppressive capacity compared with osteoarthritis SF.

72 from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehen

73 immunotherapy, but also to restore the tumor-suppressive capacity of NK cells.

74 these conditions, whereas the frequency and suppressive capacity of regulatory T cells were unaffect

75 Suppressive capacity of Tregs on effector cells and cyto

76 Although CD45RA Treg retained a greater suppressive capacity when expanded with TAC, the marked

77 e revealed unaltered cytokine production and suppressive capacity.

78 isplayed a more stable phenotype with better suppressive capacity.

79 uggested to provide Treg cells with enhanced suppressive capacity.

80 g was dispensable for Treg proliferation and suppressive capacity.

81 Circulating exosomes can deliver suppressive cargos to immune recipient cells, inhibiting

82 fractional anisotropy) in 134 PLWH receiving suppressive cART and 79 comparable HIV-negative controls

83 stained elevations in IFN-I signaling during suppressive cART.

84 l integrates in patients' blood during fully suppressive cART.

85 detected, notably elevated numbers of immune suppressive CD16BRIGHT CD62LDIM neutrophils (82.07 x 106

86 s infection promotes the expansion of immune-suppressive cells and consequently the development of re

87 in vivo to the in situ recruitment of immune-suppressive cells.

88 ymph nodes maintained similar phenotypic and suppressive characteristics ex vivo as did their counter

89 and human tumor models to identify the tumor-suppressive checkpoint role of TEC-expressed insulin gro

90 mplete response (CR) to standard light chain suppressive chemotherapy, and almost all patients eventu

91 ficiency virus (HIV; PLWH) who are receiving suppressive combination antiretroviral therapy (cART), b

92 IL-35 is an immune-suppressive cytokine mainly produced by regulatory T cel

93 increased levels of inflammatory and immune-suppressive cytokines (C-X-C motif chemokine ligand 10 a

94 cell-mediated ILC2 suppression alongside the suppressive cytokines TGF-beta and IL-10.

95 Second, the excitatory edges have nearby suppressive edges with orthogonal orientations.

96 The autofluorescence suppressive effect does not substantially diminish durin

97 The suppressive effect of 2-AG on TRPV1 activation was emula

98 suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was fou

99 The results indicated suppressive effect of gga-miR-219b on MD tumorigenesis.

100 hat integrin beta3 signaling intensifies the suppressive effect of IFNgamma on HSCs, which indicates

101 f energy by high-fat diet feeding dampen the suppressive effect of leptin on synaptic transmission.

102 Augmenting WNT signaling attenuated the suppressive effect of p53 and enhanced ectopic progenito

103 We show that the suppressive effect of peptide boronic acids on hyperacti

104 suring, in human subjects (three males), the suppressive effect of static masks on the ocular followi

105 reatic cancer, supporting a potential tumour-suppressive effect of the pathway in Ras-driven human ca

106 ions within the ORF1p C-C domain abolish the suppressive effect of truncated proteins on L1 retrotran

107 subthalamic nucleus, with a putative global suppressive effect on basal-ganglia output.

108 monstrated that PTH/PTH1R signaling exerts a suppressive effect on Cldn14.

109 ot the negative control, PP3, blocked BDNF's suppressive effect on context-induced relapse after 1 we

110 y and TrkB signaling is imperative to BDNF's suppressive effect on drug-seeking.

111 d that wild-type p53 exerts a dominant tumor-suppressive effect on mutant tumors, as all genotypes we

112 ecretion compared with a control but have no suppressive effect on subsequent ad libitum energy intak

113 C(++)-expressing cells exerted a significant suppressive effect on T cell proliferation.

114 ated whether alpha9beta1 has a similar cross-suppressive effect on the ability of alpha3beta1 to prom

115 hether this molecule could exhibit a similar suppressive effect on TLR-stimulation and inflammatory c

116 ivary exosomes from mice with PDAC exhibit a suppressive effect that results in reduced tumor-killing

117 KLR1 expression and lack of phenotypic tumor-suppressive effect with exogenous RARRES2 treatment, RAR

118 2/9 inhibition significantly decreased AdMSC suppressive effect, confirming their important role in s

119 of bases apart from the WRE, and exhibits a suppressive effect.

120 e disrupting PKM releases CGNPs from a tumor-suppressive effect.

121 ivity, whereas the loss of SUN2 had a modest suppressive effect.

122 one of the Notch ligand, and that its tumor suppressive effects are mediated through inhibition of J

123 beta-catenin in MDSCs, thus exerting immune suppressive effects during tumor progression.

124 creases in central parasympathetic drive and suppressive effects evoked by direct stimulation of para

125 hown to have potent antitumor and metastasis-suppressive effects in multiple animal models and to be

126 odiesterase 4 (PDE4) inhibition restores the suppressive effects of 3',5'-cyclic adenosine monophosph

127 MTSS1 was also shown to mediate suppressive effects of Akt2 deficiency on CRC cell viabi

128 tes attenuates the anorectic and body weight-suppressive effects of intra-NTS GLP-1R activation.

129 The suppressive effects of NLRP3 signaling were IL-10 depend

130 for autoimmune disease, are resistant to the suppressive effects of TGFbeta.

131 MK-4166 decreased induction and suppressive effects of Tregsin vitro In human TIL cultur

132 into B cell-deficient mice revealed that the suppressive effects on Ag-specific humoral immune respon

133 at it controls the generation of type II IFN-suppressive effects on normal and malignant hematopoiesi

134 circulating soluble CD163 can elicit direct suppressive effects on the adaptive immune system, as se

135 Furthermore, such suppressive effects were also observed on the growth of

136 in a relative increase in Tregs, and immune suppressive efficacy was abolished in the absence of Tre

137 l metastatic sites, thus promoting an immune suppressive environment.

138 To conclude, we describe a subset of suppressive eosinophils expressing CD16 that may escape

139 inct hubs of the circuit to produce multiple suppressive events that create the proper tempo and sequ

140 nalyses show that adenosine, but not typical suppressive factors such as PD-L1, CTLA-4, TGF-beta, IL-

141 s in vitro However, only STINGa reversed the suppressive FcgammaR profile in vivo, providing strong a

142 tic protocols through generation of strongly suppressive forkhead box P3(+) Treg cells.

143 -mediated phosphorylation of FOXO3a, a tumor suppressive forkhead transcription factor, leading to it

144 ns in which NIK is activated, Tregs may lose suppressive function and may actively contribute to infl

145 ) Treg cells exhibited significantly reduced suppressive function compared with polyclonal Treg cells

146 We demonstrated a disease-suppressive function for CNS-specific CD8 T-cells in a m

147 ion of the FOXP3 transcription factor, lower suppressive function in peripheral CD4(+)CD25(+)FOXP3(+)

148 Although we observed normal suppressive function in peripheral polyclonal Treg cells

149 tory T cells contributed to their autoimmune-suppressive function in this model.

150 rp-1 and CTLA-4, coupled with a loss of Treg suppressive function in vitro and in vivo.

151 r findings support a model for SIRT2's tumor-suppressive function in which somatic mutations in SIRT2

152 ry 1 cells in health and in AIH/AISC, though suppressive function is lost in patients upon proinflamm

153 FLCN H255Y mutant protein has lost it tumour suppressive function leading to the clinical manifestati

154 lts provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and

155 The suppressive function of both iTreg and nTreg, however, i

156 The suppressive function of CD4(+) CD127(+) CD25(high) cells

157 ur findings thus further elucidate the tumor-suppressive function of FBXO32 in breast cancer.

158 iation between the metabolic fitness and the suppressive function of Foxp3-expressing Treg cell subse

159 Tr1 cell development and suppressive function of Itk deficient cells can be resto

160 -13 induced the preferential recruitment and suppressive function of monocytes.

161 corepressor TOPLESS that contributes to the suppressive function of NaJAZi on floral defenses.

162 Therefore, we investigated the tumor-suppressive function of PTPN23 in an orthotopic transpla

163 rall, this mechanistic analysis of the tumor-suppressive function of PTPN23 in breast cancer supports

164 ation of galectin-10 partially abrogated the suppressive function of the eosinophils.

165 oid receptors augments the number and immune suppressive function of the regulatory CX3CR1(hi) macrop

166 g growth factor-beta partially abrogated the suppressive function of therapy-induced regulatory T cel

167 nstream pathways are essential for the tumor suppressive function of TP53.

168 We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.

169 ated mutp53 proteins not only lose the tumor-suppressive function of wild-type p53 but also gain new

170 Foxp3+ Tregs lacking HDAC11 showed increased suppressive function, and increased expression of Foxp3

171 ory networks in mesodermal cells with growth-suppressive function, exposing the conserved and selecti

172 ten-specific CD4(+) T cells but had impaired suppressive function, indicating that Treg cell dysfunct

173 Beyond its recognized tumor suppressive function, p53 controls several immunoregulat

174 ayed enhanced migratory activity but similar suppressive function, while conventional T cells were un

175 ate factors that affect Treg homeostasis and suppressive function.

176 stem cell transplantation, suggesting normal suppressive function.

177 essential for maintaining Treg stability and suppressive function.

178 that are known to display the most powerful suppressive function.

179 ere combined immunodeficiency mice to assess suppressive function.

180 , and USP44) show prior evidence of a tumour suppressive function.

181 enriched with FrIII Treg cells had deficient suppressive functions (P = 0.0017) compared to healthy v

182 tional program with highly distributed tumor suppressive functions acting in diverse cellular context

183 scribe context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) co

184 g ETS2 to switch between oncogenic and tumor suppressive functions in a cell-type specific manner.

185 Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments a

186 interaction performs crucial oncogenic/tumor suppressive functions in glioblastoma multiforme (GBM).

187 pansion as well as pro-angiogenic and immune suppressive functions in MDSCs.

188 IL10 and ICOS up-regulation and impairs the suppressive functions of human activin-A-induced Tr1-lik

189 ing understanding of the oncogenic and tumor suppressive functions of JARID1 proteins, which are cont

190 ther, these findings not only identify tumor-suppressive functions of RB that are distinct from cell

191 Mutants of p53 have lost the tumour-suppressive functions of wild type p53.

192 otein (LAG-3), and CD49b, and exert strongly suppressive functions toward allergic responses induced

193 Genes involved in MDSC suppressive functions, including S100A12, S100A9, MMP8,

194 A suppressive hedonic coldspot was also found in the form

195 We here show that highly suppressive human adipose tissue-derived MSC (AdMSC) dis

196 ent transcriptional network, which generates suppressive human Tr1 cells that may be harnessed for th

197 eg cells that develop from naive precursors, suppressive IL-17A(+)Foxp3(+) and ex-Th17 Foxp3(+) cells

198 hanisms by which injured myocardium recruits suppressive immune cells remain largely unknown.

199 nd apoptotic cell interactions and developed suppressive immune functions, including production of in

200 ogic etiology), and impact of select AEs and suppressive immune-modulating agents (IMs) on antitumor

201 gulators of these events and therefore tumor suppressive in nature.

202 polyclonally expanded in culture were highly suppressive in vitro and maintained high expression of F

203 generated CD4(+)LAP(+)Foxp3(-) T cells were suppressive in vitro, inhibiting proliferation of naive

204 on of pancreatic oncogenesis requires immune-suppressive inflammation in cooperation with oncogenic m

205 The STING/type I interferon pathway enhances suppressive inflammation in tumors by recruiting myeloid

206 CF sites shield a widely expressed gene from suppressive influences of a silent locus.

207 ication rates, indicating that there were no suppressive interactions operating between parasites.

208 s and a reduced tumor mass, implying a tumor-suppressive-like function of the AhR in MCF7 xenograft t

209 ound that NLRP3 promotes expansion of immune-suppressive macrophages in PDA.

210 intenance and suggest that release from this suppressive mechanism is a fundamental requirement for s

211 In an effort to overcome this suppressive mechanism, we evaluated NK cell responses to

212 ls a previously unrecognized extrinsic tumor-suppressive mechanism, whereby epithelial polarity prote

213 We investigated the immune-suppressive mechanisms of the human pregnancy hormone, c

214 g alternative inhibitory receptors (IRs) and suppressive mechanisms within the tumor microenvironment

215 Simultaneously, use of gastric acid suppressive medications is increasing.

216 Recent increases in the use of gastric acid-suppressive medications might contribute to the increasi

217 i and HDACi, respectively) reduce the immune suppressive microenvironment through type I IFN signalin

218 n cancer (EOC) is characterized by an immune suppressive microenvironment, and response of ovarian ca

219 antitumor responses due to the Treg-enriched suppressive microenvironment.

220 t improvement of hepatic BA retention, tumor-suppressive microRNA expressions, microbial gut communit

221 roved as a direct target of miR-708, a tumor-suppressive microRNA.

222 As and decreased hepatic expression of tumor-suppressive microRNAs.

223 coring the importance of FRCs in shaping the suppressive milieu of lymphoid organs during homeostasis

224 00c, miR-206, and miR-335) known to be tumor suppressive miRNAs in breast cancer were investigated in

225 ever, whether the expressions of these tumor suppressive miRNAs translate to patient survival were no

226 Here we report a tumor-suppressive mode of action for growth-differentiation fa

227 lower trimethylation of histone H3 lysine 27 suppressive modification, relaxes chromatin, and promote

228 show that galectin-10 functions as a T cell-suppressive molecule in eosinophils.

229 om fresh BC tissues displayed high levels of suppressive molecules, including Arg1, iNOS, ROS, PDL-1

230 , partly at least, by recruiting this global suppressive network.

231 tex, the fixation onset was accompanied with suppressive neural signal, and duration of neuronal resp

232 ng populations of oppositely tuned, mutually suppressive neurons explains these changes and also expl

233 When stimuli were unattended, adding a suppressive, nonpreferred stimulus beside a preferred st

234 SCs, in part via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1.

235 MDSCs were suppressive of autologous T-cell responses as evidenced

236 latory influenza-reactive environment into a suppressive one.

237 ule selectivity regardless of whether it had suppressive or excitatory effects on these neurons.

238 y mediates cell fate decisions and is tumour suppressive or oncogenic depending on the context.

239 f 51 dysregulated miRNA regulating 719 tumor suppressive or oncogenic mRNA associated with increased

240 Disruption of the tumor-suppressive p53 network is a key event in human malignan

241 e processed downstream and activate multiple suppressive pathways in NK-92 cells.

242 ancers are able to grow by subverting immune suppressive pathways, to prevent the malignant cells as

243 ulating rejection-type processes or blocking suppressive pathways.

244 ssion signatures revealed a consistent tumor suppressive pattern for TAp63.

245 panded using soluble OX40 L and JAG1 were of suppressive phenotype and delayed the onset of diabetes

246 , with the remaining Tregs exhibiting a less suppressive phenotype.

247 d microRNAs involved in Treg homeostasis and suppressive phenotype.

248 sms underlying mesenchymal stem cells' (MSC) suppressive potency are largely unknown.

249 Nrf2 regulates the generation, survival, and suppressive potency of MDSC, and that a feedback homeost

250 ly, suggesting that extrusion may be a tumor-suppressive process.

251 Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in so

252 d that CD71(+) cells have distinctive immune-suppressive properties and suppress innate immune respon

253 CD4+ T cell ratio, and diminished the immune-suppressive properties of CLL cells through BTK-dependen

254 e the ability of the feature to transfer its suppressive properties to a separately rewarded cue is l

255 though typically considered as having tumour-suppressive properties, transforming growth factor (TGF)

256 gated TGFbeta-induced upregulation of growth suppressive pSMAD2 and p21, prevented downregulation of

257 nother epidermal integrin, alpha9beta1, as a suppressive regulator of alpha3beta1-dependent wound ang

258 signal the emergence and expansion of highly suppressive regulatory CD4 T cells.

259 Use of a patient's own suppressive regulatory T cells (Tregs) is an attractive

260 no differences in the percentages of immune-suppressive regulatory T cells, pro-inflammatory Th17 ce

261 ndicate that they mediate homeostatic immune-suppressive responses during gestation.

262 , keratinocytes also directly support immune-suppressive responses that are critical for re-establish

263 In addition to its suppressive role during spontaneous cardiac fibrosis in

264 our findings indicate an unanticipated tumor-suppressive role for HIF2alpha in neuroblastoma.

265 s are slow growing, consistent with a tumour-suppressive role for Notch, but these cells are also rel

266 hile these prior studies highlighted a tumor suppressive role for stromal PTEN, how the adjacent norm

267 ional data therefore establish a novel tumor suppressive role for TRIM14 in NSCLC progression.

268 our data suggest that p85alpha plays a tumor-suppressive role in transformation, and suggest that p11

269 This opposition underlies the tumor-suppressive role of BAF subunits and is expected to cont

270 ptosis in human melanoma cells, suggesting a suppressive role of NLRP1 in caspase-3/7 activation and

271 Here, we show that, rather than a cross-suppressive role, alpha9beta1 has an opposing role in ba

272 Despite this perceptible tumor-suppressive role, MDM2-ALT1 is also associated with seve

273 g a set of significant species that can take suppressive roles across different environments.

274 umors correlated with oncogenic versus tumor suppressive roles of ETS2.

275 connection between oncogenic SPOP and tumor suppressive SETD2 in the dynamic regulation of gene expr

276 suggest a delicate balance of enhancing and suppressive signals.

277 First, a myeloid suppressive signature was identified by gene expression

278 nistic insights into regulation of the tumor suppressive sirtuin SIRT6 and its implications for the d

279 ylates and triggers degradation of the tumor-suppressive sirtuin SIRT6 in hepatocellular carcinoma.

280 hage phenotype from tumor-promoting to tumor-suppressive status; using cellular-based therapies, such

281 The interactions between preferred and suppressive stimuli are often quite complex and vary acr

282 show that Myc extensively programs an immune suppressive stroma that is obligatory for tumor progress

283 the differentiation and expansion of immune-suppressive stromal cells, and remodels the metabolic la

284 s suggest that ERK is a key factor in growth suppressive TGFbeta signals, yet may also contribute to

285 pecifically activated and significantly more suppressive than polyclonal or DeltaCAR Tregs in the pre

286 ncreased inflammation and may be amenable to suppressive therapeutics.

287 tivation of persistent viruses during immune-suppressive therapies targeting B cells in multiple scle

288 tency and are a crucial target for long-term suppressive therapy or viral clearance.

289 Immune suppressive therapy was maintained for 48 months in 29 r

290 Higher levels of HIV antibodies during suppressive therapy were associated with later initiatio

291 ficacy in chronic GVHD, and prolonged immune suppressive treatments result in additional toxicities t

292 tumor-specific vaccine decreased numbers of suppressive Treg and increased numbers of vaccine-induce

293 tability of Foxp3(+) Tregs and maintaining a suppressive Treg phenotype.

294 modulatory regimen that enhances the pool of suppressive Treg subsets while effectively controlling c

295 AzaC, instead focusing on the generation of suppressive Tregs (CD4(+)CD25(+)FOXP3(+)) through the in

296 Mutant mice exhibited fewer suppressive Tregs in the injured myocardium and decrease

297 , likely due to the development of an immune-suppressive tumor microenvironment (TME).

298 -regulation of TNFalpha to promote an immune-suppressive tumor microenvironment characterized by an a

299 aling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibito

300 ILs, MK-4166 may attenuate the Treg-mediated suppressive tumor microenvironment.