ライフサイエンスコーパス: suppressor

1 Z1 to function as a neuroblastoma (NB) tumor suppressor.

2 tif that mimics the binding of the p53 tumor suppressor.

3 also implicates Importin-11 as a novel tumor suppressor.

4 ion factor postulated to function as a tumor suppressor.

5 2 protein, which in turn degrades TP53 tumor suppressor.

6 quence of CD82 molecule (CD82), a metastasis suppressor.

7 ependent on its interaction with BRCA1 tumor suppressor.

8 6 (KLF6) is a transcription factor and tumor suppressor.

9 selenocysteine tRNA and may function as opal suppressor.

10 ers, reflecting its critical role as a tumor suppressor.

11 g the function of Tet2, a dioxygenase tumour suppressor.

12 g that CCAR2 may in fact function as a tumor suppressor.

13 y active center, but also as a dealumination suppressor.

14 cyhmal transition, thereby acting as a tumor suppressor.

15 le, acting either as a mitogen or as a tumor suppressor.

16 ides its well-established function as tumour suppressor.

17 al mechanisms, blocks these important tumour suppressors.

18 e to epistasis, which breeders overcame with suppressors.

19 suppressors and propose 27 candidate tumour suppressors.

20 negative Rac regulators solely act as tumor suppressors.

21 h level of DNA methylation of putative tumor suppressors.

22 nal mutational processes affecting key tumor suppressors.

23 us deletions, aiming to identify rare tumour suppressors.

24 dentified the scaffolding protein metastasis suppressor 1 (MTSS1) as a novel Akt2-regulated gene.

25 work indicates that GPS2 (G-protein Pathway Suppressor 2) is a multifunctional protein regulating TN

26 ream from the mir-35 family in this process, suppressor-26 (sup-26) and NHL (NCL-1, HT2A, and LIN-41

27 stem cell marker, is known to exhibit tumor suppressor activity in colon cancer, the mechanism of wh

28 nd control tumors suggests that TRIM14 tumor suppressor activity may depend on cell death signaling p

29 C1 with focal adhesions and attenuates tumor suppressor activity.

30 terized the mechanistic basis by which these suppressors alleviated Deltahda cold sensitivity.

31 iated with activation of the metabolic tumor suppressor AMPKalpha1/2-LKB1, and a reduction in mTOR si

32 er a role in senescence for the potent tumor suppressor and ATM substrate USP28.

33 vations uncover a novel mitochondrial tumour suppressor and demonstrate a connection between mitochon

34 n, facilitates the accumulation of the tumor suppressor and HR effector BRCA1 at replication forks to

35 at MRN cannot be considered a standard tumor suppressor and instead imply that nuclease activities of

36 gase, is a potent inhibitor of the p53 tumor suppressor and is elevated in many human cancers that re

37 ctor 2 (EAF2) is an androgen-regulated tumor suppressor and its intracellular localization can be mod

38 PML is a tumour suppressor and regulator of cell differentiation.

39 We identify UBC9 and RAD50 as suppressors and 53BP1, DDB1 and poly(ADP)ribose polymera

40 We find 16 established tumour suppressors and propose 27 candidate tumour suppressors.

41 an ongoing molecular arms race between viral suppressors and the immune system they target.

42 easing the expression of E-cadherin, a tumor suppressor, and decreasing the expression of mesenchymal

43 data showed that Mdm2 acts as a translation suppressor, and FMRP is required for its ubiquitination

44 nstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic environmental and

45 c genetic alterations in oncogenes and tumor suppressors are highly context-dependent and are predomi

46 ave identified a critical role for the tumor suppressors BRCA1 and BRCA2 in preventing the degradatio

47 Mutations in the tumor suppressor BRCA2 predominantly predispose to breast canc

48 y to recognize RPA-coated ssDNA to the tumor suppressor BRCA2, which is complexed with RAD51.

49 ations truncating a single copy of the tumor suppressor, BRCA2, cause cancer susceptibility.

50 ocytic leukemia (PML) is a pleiotropic tumor suppressor, but its role in tumor microenvironment regul

51 ociated macrophage (TAM) and myeloid-derived suppressor cell (MDSC) infiltration in tumors via chemok

52 indicate that denileukin diftitox and other suppressor cell-depleting therapies may be useful adjunc

53 ve an increased frequency of myeloid derived suppressor cells (MDSC) and are at increased risk for ca

54 cells allowed generation of myeloid-derived suppressor cells (MDSC) from precursors in mouse bone ma

55 Accumulation of myeloid-derived suppressor cells (MDSC) in melanoma microenvironment is

56 cy may be the recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment.

57 ave previously reported that myeloid-derived suppressor cells (MDSC), which are a heterogeneous popul

58 Myeloid-derived suppressor cells (MDSC), which expand during states of e

59 expression is a hallmark of myeloid-derived suppressor cells (MDSC).

60 ncreased in myeloid cells as myeloid-derived suppressor cells (MDSCs) accumulated, which was associat

61 Myeloid-derived suppressor cells (MDSCs) are known to play important rol

62 Myeloid-derived suppressor cells (MDSCs) described in cancer and inflamm

63 cells, accumulation of donor myeloid-derived suppressor cells (MDSCs) mediated by ILC2 production of

64 and massive accumulation of myeloid-derived suppressor cells (MDSCs), which actively suppressed anti

65 Human monocytic myeloid-derived suppressor cells (MO-MDSCs) within the hepatic compartme

66 acterized by an abundance of myeloid-derived suppressor cells and inhibition of cytotoxic T-cell infi

67 equency of immunosuppressive myeloid-derived suppressor cells in a syngeneic TNBC mouse model.

68 neutrophils and granulocytic myeloid-derived suppressor cells in the tumor microenvironment.

69 nulocytic (gMDSC) subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and di

70 ygen species in granulocytic myeloid-derived suppressor cells, whereas the antioxidant N-acetylcystei

71 d granulocytic and monocytic myeloid-derived suppressor cells.

72 ne suppressive activities of myeloid-derived suppressor cells.

73 to induce the generation of CD8(+)CD28(-) T suppressor cells.

74 -DC, DC-10, and PGE2-induced myeloid-derived suppressor cells.

75 Such suppressor changes resulted in decreased proteolytic sta

76 us recombination, an attribute of the tumour suppressor complex that could be targeted in cancer ther

77 Although tumor suppressor CtIP is critical for DSB end resection, a key

78 tivation by binding and inhibiting the tumor suppressor DAB2IP (DAB2-interacting protein) in the cyto

79 gets in cancers that harbour specific tumour-suppressor deficiencies.

80 at the induction of the post-transcriptional suppressor DND1 synergizes with concurrent transcription

81 he TCV CP also serves as the viral silencing suppressor, early translation of the CP from the viral g

82 s were actin regulators, including the tumor suppressor eplin.

83 y putative 'escape from X-inactivation tumor-suppressor' (EXITS) genes, we examined somatic alteratio

84 peroxide reduced thrombospondin 2 (an MMP-3 suppressor) expression in prostate cancer cells by upreg

85 tors of basal bud initiation, SPL4 acts as a suppressor for the formation of both aerial and basal bu

86 multispecific transcription factor and tumor suppressor FOXO3 is an important mediator of apoptosis,

87 These latter findings support a tumor suppressor function for KIND1, and identify c-Jun N-term

88 mia.Significance: This study defines a tumor suppressor function for the protein tyrosine phosphatase

89 ulation exhibited diminished homeostasis and suppressor function in vivo.

90 ediated gene regulation as a principal tumor-suppressor function of ARID1A.

91 ism explaining, at least in part, the tumour suppressor function of FLCN.

92 egitimate concerns associated with the tumor suppressor function of nontargeted Notch pathway inhibit

93 Four of the six BDs abrogated PBRM1 tumor suppressor function, gene regulation, and chromatin affi

94 f p53 target genes, which confer p53's tumor suppressor function, has led to increasingly complex mod

95 down of GRM3 enhances TGFbeta-mediated tumor suppressor function.

96 wnregulation, suggesting an important tumour suppressor function.

97 in stability of HIPK2 and enhances its tumor suppressor function.

98 llular contexts, such as oncogenic and tumor-suppressor functions and hematopoietic and cardiac diffe

99 the molecular mechanism underlying the tumor suppressor functions of FANCJ remains obscure.

100 have found that KANK1 was a candidate tumor suppressor gene (TSG) for human MPNSTs.

101 phosphorylated state mediated by large tumor suppressor gene 1 and 2 (LATS1/2).

102 DAC) frequently contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homoz

103 channel catfish, Ictalurus punctatus, muscle suppressor gene MSTN.

104 nslation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1.

105 own that miRNA-based regulation of the tumor suppressor gene PTEN can be modulated by the expression

106 tion, differential gene expression and tumor suppressor gene status.

107 complex (TSC) is an autosomal dominant tumor-suppressor gene syndrome caused by inactivating mutation

108 Mutations at CpG sites on the p53 tumor suppressor gene that can result from these adductions ar

109 sociated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogene

110 ults suggest that VGLL4 is a candidate tumor suppressor gene which acts by selectively antagonizing Y

111 CTCF is a haploinsufficient tumour suppressor gene with diverse normal functions in genome

112 three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control

113 tion as a traditional loss-of-function tumor suppressor gene, and they provide a fully penetrant anim

114 of both the RAD52 gene, and the HR and tumor suppressor gene, BRCA2, in human cells synergistically r

115 used by a germline mutation in the NF1 tumor suppressor gene, individuals with NF1 are prone to optic

116 s are associated with mutations in NF1 tumor suppressor gene, resulting in activation of Ras and its

117 ted by somatic inactivation of the VHL tumor suppressor gene.

118 cers, as widely documented for the p53 tumor suppressor gene.

119 those predicted to target oncogenes or tumor suppressor gene.

120 ssible explanation why Parkin may be a tumor suppressor gene.

121 two broad categories: inactivation of tumor suppressor genes (hypomorph, antimorph or amorph) or act

122 able to simultaneously inactivate five tumor suppressor genes (TP53, PTEN, APC, BRCA1, and BRCA2) and

123 ly mutated, and the identity of key 8p tumor-suppressor genes (TSG) is unknown.

124 the replacement of single, functional tumor suppressor genes by the mutant alleles.

125 Comutated, myeloid tumor-suppressor genes contribute to phenotypic variability, p

126 reens in multiple cancer types, as new tumor suppressor genes in prostate cancer.

127 We observed that hypermethylation of tumor suppressor genes is a frequent event in ocular tumors, b

128 esis of cancer either by silencing key tumor suppressor genes or by activating oncogenes.

129 program several hypoxia associated and tumor suppressor genes such as MAT2A and PDK-1, in addition to

130 Known oncogenes and tumor suppressor genes, beyond those engineered, are mutated,

131 ity that, in the absence of functional tumor suppressor genes, can contribute to tumorigenesis.

132 ion (H3K27me3), and (ii) activation of tumor suppressor genes, including BRCA1.

133 on and increased expression of several tumor suppressor genes, including Src homology region 2 domain

134 G1-S phase arrest and act as potential tumor suppressor genes, we aimed to study potential methylatio

135 of which are associated with putative tumor suppressor genes.

136 vation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised as necessary for the

137 ave arisen from accumulation of unidentified suppressors, highlighting the importance and power of st

138 growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive

139 The protein expression of the tumor suppressor HNF4alpha may be inhibited by interactions of

140 We investigated effector and suppressor immune responses in CML patients at diagnosis

141 that has been recently identified as a tumor suppressor in colorectal cancer, yet its potential role

142 OXP3 is also a cell-cycle inhibitor and onco-suppressor in different cell types.

143 s suggest that KANK1 may function as a tumor suppressor in human MPNSTs, and thus it may be useful fo

144 p53 is a critical tumor suppressor in humans.

145 otein INO80C was identified as a novel tumor suppressor in KRAS(MUT) colorectal and pancreatic tumor

146 mary, miR-193b not only functions as a tumor suppressor in liposarcoma but also promotes adipogenesis

147 ferase, which has been implicated as a tumor suppressor in mammals.

148 in some cellular backgrounds, and as a tumor suppressor in others, and the molecular mechanism respon

149 vidence that ABHD5 acts as a metabolic tumor suppressor in PCa that prevents EMT and the Warburg effe

150 eceptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs).

151 lex serves as a previously undescribed tumor suppressor in the liver, restraining TNFR1-independent a

152 regulates the proteolysis of FOXO3A/4 tumour suppressors in the context of cancer and illustrates how

153 ides a functional landscape of gliomagenesis suppressors in vivo.

154 phosphorylation of the retinoblastoma tumour suppressor, inducing G1 cell cycle arrest in tumour cell

155 Additionally, an iron-regulated metastasis suppressor interacts with the epidermal growth factor re

156 condition and transform caspases from tumor suppressors into tumor promotors.

157 f the adenomatous polyposis coli (APC) tumor suppressor is frequently found in colorectal cancer.

158 ammed cell death 4 (Pdcd4), a tumor invasion suppressor, is frequently downregulated in colorectal ca

159 ermline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorige

160 C-induced p53 and p73 axes converge on tumor-suppressor LKB1 which is transcriptionally upregulated b

161 nt growth in the context of concurrent tumor suppressor loss.

162 6) downstream of common oncogenes, and tumor suppressors may provide a potent way to defeat intratumo

163 escence (OIS) is considered a powerful tumor suppressor mechanism.

164 influence for 15,798 genes, including tumor suppressor, mitochondrial, and mismatch repair genes.

165 demonstrate that atypical E2Fs act as tumor suppressors, most likely via transcriptional repression

166 ynthetic precursor coproporphyrinogen III; a suppressor mutant of this strain harbours a mutation in

167 By studying DeltaireK suppressor mutants that recovered the ability to coloniz

168 Two suppressor mutants were found to harbor mutations in AP2

169 Furthermore, we show how a second suppressor mutation (E247Q) cooperates with H80R in prot

170 Further, suppressor mutations can then be easily acquired to rest

171 gella rotated freely by Brownian motion, and suppressor mutations in MotA that were immune to MotI in

172 In this work, we identified suppressor mutations in the M1 protein which complement

173 Strikingly, all suppressor mutations increased the hydrophobicity of the

174 od shape, revertant alleles with second-site suppressor mutations supported lysis events that were pr

175 The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has

176 dy identified complex PTEN-cooperating tumor suppressor networks in different cancer types, with pote

177 protein (NS) 5B, directly binds to the tumor suppressor, NORE1A (RASSF5), and promotes its proteosoma

178 in CLL was found to be driven by Deltex1, a suppressor of antigen receptor signaling in lymphocytes.

179 uced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activation, and we found that TNFAIP3

180 our work has uncovered a novel component and suppressor of Ca(2+)-dependent cell egress during Toxopl

181 st cells that harbored mutations in the gene Suppressor of Ca(2+)-dependent Egress 1 (SCE1).

182 creen, our laboratory identified PTPN23 as a suppressor of cell motility and invasion in mammary epit

183 f BIC/microRNA 155 (miR-155) and its target, suppressor of cytokine signaling 1 (SOCS-1).

184 C2/3 was found to decrease the expression of Suppressor of Cytokine Signaling 3 (SOCS3), leading to i

185 inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5.

186 xpression, we identified miR-100 as a potent suppressor of endothelial adhesion molecule expression,

187 -female conversion, whereas loss of a single suppressor of female development drives male-to-hermaphr

188 omoter-deletion studies and identified SUF4 (SUPPRESSOR OF FRIGIDA4), a C2H2 transcription factor, as

189 cal analysis shows that A2BP1 is part of the Suppressor of Hairless [Su(H)] complex in the presence a

190 uced by the transcription factor CSL, called Suppressor of Hairless [Su(H)] in Drosophila.

191 broadly expressed repressors, Runt (Run) and Suppressor of Hairless [Su(H)], in patterning the Drosop

192 Matriptase-2 (MT2) is a protease and key suppressor of hepatic hepcidin expression and cleaves HJ

193 s the hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based sil

194 These findings implicate AIM1 as a key suppressor of invasive phenotypes that becomes dysregula

195 Here we show that the genes SUPPRESSOR OF MAX2 1-LIKE3 (SMXL3), SMXL4, and SMXL5 act

196 Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-b

197 oncogenic AR signaling pathway but also as a suppressor of metastasis-related phenotypes.

198 nscription factor Nkx2-1, a well-established suppressor of metastatic progression.

199 P-1) and MCP-1 induced protein-1 (MCPIP1), a suppressor of miR-146a, suggesting an autocrine loop.

200 The Arabidopsis thaliana suppressor of quenching1 (soq1) mutant exhibits enhanced

201 findings identify CIB2 as a novel endogenous suppressor of SK1 signaling and potential prognostic mar

202 anscription factors Msn2 and Msn4 (multicopy suppressor of SNF1 mutation proteins 2 and 4) bind the s

203 V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory

204 overed NCRs is VISTA (V-domain Ig-containing Suppressor of T cell Activation).

205 The Suppressor of TCR signaling proteins (Sts-1 and Sts-2) a

206 DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Lei

207 As a result, two suppressor of tic40 loci, stic1 and stic2, were identifi

208 These include natriuretic peptides, soluble suppressor of tumorgenicity 2, highly sensitive troponin

209 radation pathway, we screened for extragenic suppressors of a temperature-sensitive fission yeast str

210 ere we performed a mutant screen to identify suppressors of agb1-2 (sgb) that restore susceptibility

211 We used a genetic approach to isolate 9 suppressors of Deltahda cold sensitivity, and characteri

212 Regulatory T type 1 (TR1) cells are potent suppressors of immune responses and can be induced in vi

213 tions genetically and identified second-site suppressors of lethal mutations in SP.

214 We review the use of S1QELs and S3QELs, suppressors of mitochondrial O2()/H2O2 generation that d

215 ncodes an H3K36 methyltransferase, as potent suppressors of morc-1(-) and nuclear RNAi mutant phenoty

216 cts the expression of highly effective viral suppressors of RNAi.

217 h provides evidence that these two genes are suppressors of tumor metastasis.

218 Suppressor-of-cytokine-2 (SOCS2) protein, a conserved pr

219 e has been proposed to act either as a tumor suppressor or as an oncogene in different human cancers,

220 tion and/or tumorigenesis, as either a tumor suppressor or tumor promoter, is complex and may be depe

221 ethylation, restores the expression of tumor suppressor p15(INK4B) through promoter demethylation; in

222 The tumor suppressor P19(ARF) is strongly activated in the nerves

223 Loss of the tumor suppressor p53 (encoded by TP53) provides cancer cells w

224 Human TP53 gene encodes the tumor suppressor p53 and, via alternative splicing, the p53bet

225 M2, and leads to re-activation of the tumour suppressor p53 in various cancers.

226 and its related cancers.IMPORTANCE The tumor suppressor p53 is a critical cellular protein in respons

227 The tumor suppressor p53 is a well-characterized transcription fac

228 rces, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression

229 Mutations in the tumor suppressor p53 occur in a majority of human cancers.

230 Tumour suppressor p53 or proto-oncogene MYC is frequently alter

231 Tumor suppressor p53 plays a central role in tumor suppression

232 ytes in vitro and possibly in vivo The tumor suppressor p53 plays a seminal role in cancer developmen

233 Many oncogenic mutants of the tumor suppressor p53 rapidly aggregate but form amorphous fibr

234 Mutations in tumor suppressor p53 remain a vital mechanism of tumor escape

235 r stem cells (CSCs) by suppressing the tumor suppressor p53.

236 c tumors or changing the status of the tumor suppressors p53, p16(Ink4a) and p19(Arf).

237 wo BRCA proteins are linked by a third tumor suppressor, PALB2, in the HR pathway.

238 The Hippo tumor suppressor pathway is essential for development and tiss

239 votal MOB1 signal transducer.The Hippo tumor suppressor pathway is essential for development and tiss

240 The core LATS kinases of the Hippo tumor suppressor pathway phosphorylate and inhibit the downstr

241 nflammation, through loss of the same tumour-suppressor pathways and eventual sporadic development of

242 CCs are clonal, with alteration of key tumor-suppressor pathways in stem cells as the primary cause o

243 The suppressor phenotype was not caused by compensatory effe

244 els, decreasing both Treg numbers and immune suppressor phenotype while enhancing effector responsive

245 We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support

246 25A led to reduction in retinoblastoma tumor suppressor protein (pRb) phosphorylation.

247 p53 is an important tumor-suppressor protein deactivation of which by mdm2 results

248 The p53 tumour suppressor protein is a short-lived transcription factor

249 a novel Myst2-associated protein, the tumour suppressor protein Niam (Nuclear Interactor of ARF and M

250 Under normal cellular conditions, the tumor suppressor protein p53 is kept at low levels in part due

251 The tumor suppressor protein p53, the "guardian of the genome", is

252 The p53 tumor suppressor protein plays a critical role in orchestratin

253 of an SCF ubiquitin ligase and a major tumor-suppressor protein that is altered in several human mali

254 In contrast, CYLD (cylindromatosis tumor-suppressor protein), a K63-specific deubiquitinase enric

255 We found induction of tumor suppressor protein, p53, and apoptosis with suppression

256 binding of inhibitors such as the p27 tumor suppressor protein.

257 nificant role in the regulation of the tumor suppressor protein.

258 key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancer

259 The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles

260 as remarkably downregulated, while the tumor suppressor proteins p53 and p21 were substantially upreg

261 opment of small molecule activators of tumor suppressor proteins.

262 The tumor suppressor PTEN controls cell proliferation by regulatin

263 al. show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protect

264 Dictyostelium cells lacking the tumor suppressor PTEN show strongly impaired migratory activit

265 inosa clearance through activating the tumor suppressor PTEN.

266 21/222 in regulating expression of the tumor suppressor PTEN.

267 p53 tumor suppressor responds to various cellular stresses and reg

268 Two of the suppressors restore growth without restoring soluble phe

269 ne cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a tra

270 of the phenylpropanoid pathway, and that the suppressors reverse many of these changes.

271 Our results establish a tumor suppressor role for PTP1B in the myeloid lineage cells,

272 Our results show a tumor suppressor role of AKT-phosphorylated FOXO1 in the cytop

273 Therefore, our results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it a

274 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is on

275 Overall, our findings show how the tumor suppressor SIRT6 is regulated in hepatocellular carcinom

276 Alterations in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HI

277 rrying mutations in the major emerging tumor suppressor STAG2 across different cancer contexts.

278 cross-linking experiments indicate that the suppressor substitutions induce conformational change in

279 feron regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of in

280 P53 is a major tumor suppressor that is mutated and inactivated in 50% of al

281 ound that knock-down of KLF9, an axon growth suppressor that is normally upregulated 250-fold in RGC

282 Unlike other tumor suppressors that are frequently deleted or acquire loss-

283 Synonymous codon suppressors that corrected the effect of a translation-d

284 es miR-452, which acts as a novel metastasis suppressor to directly target the SNAI2 3'-untranslated

285 The switch converting TGF-beta from a tumor-suppressor to tumor-promoter has not been identified.

286 amined the potential translation function of suppressor tRNA species in Escherichia coli; tRNAs with

287 ctures may function as missense and nonsense suppressor tRNAs and/or regulatory noncoding RNAs.

288 ic screen to identify and validate new tumor suppressors (TS) in this disease.

289 The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis co

290 onal deletion of the von Hippel-Lindau tumor suppressor (VHL) protein in the forkhead box FOXD1 cell

291 hat Mig-6 has an important function of tumor suppressor via inhibition of STAT3 phosphorylation in ut

292 One suppressor was in a gene encoding a single KH-domain pro

293 hotspot in miR-200b, a key tumor metastasis suppressor, we found that the miR-200b editing level cor

294 many cancer types, TGF-beta acts as a tumor suppressor, whereas in the advanced stages of these canc

295 e B1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoi

296 therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic functio

297 Association of undruggable tumour suppressors with drug targets informs therapeutic option

298 Six intragenic ouf suppressors with near wild-type (WT) JA pathway activity

299 53,54) TAD2 mutant behaves as a "super-tumor suppressor," with an enhanced capacity to both suppress

300 hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucid