ライフサイエンスコーパス: suppressor of cytokine signaling

1 e negative immunoregulators CD274(PD-L1) and suppressors of cytokine signaling.

2 he previously described [proteolipid protein/suppressor of cytokine signaling 1 (PLP/SOCS1)] transgen

3 nhibitor peptide (Tkip) that is a mimetic of suppressor of cytokine signaling 1 (SOCS-1) and inhibits

4 The suppressor of cytokine signaling 1 (SOCS-1) protein modu

5 f BIC/microRNA 155 (miR-155) and its target, suppressor of cytokine signaling 1 (SOCS-1).

6 nhibitor peptide, Tkip, that is a mimetic of suppressor of cytokine signaling 1 (SOCS-1).

7 duced expression of the antifibrotic protein suppressor of cytokine signaling 1 (SOCS1) and upregulat

8 y mediated by the direct microRNA-155 target suppressor of cytokine signaling 1 (Socs1) because Socs1

9 ficiency in Treg cells resulted in increased suppressor of cytokine signaling 1 (SOCS1) expression ac

10 production of proinflammatory cytokines and suppressor of cytokine signaling 1 (SOCS1) in a human mo

11 that miR-155 differentially targets Noxa and suppressor of cytokine signaling 1 (SOCS1) in NK cells a

12 Suppressor of cytokine signaling 1 (SOCS1) is an obligat

13 Suppressor of cytokine signaling 1 (Socs1) is critical f

14 of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling 1 (SOCS1) mRNA, potenti

15 gp120-induced IL-23 upregulated suppressor of cytokine signaling 1 (SOCS1) protein in T

16 Here, we investigate the role of human suppressor of cytokine signaling 1 (SOCS1), a feedback i

17 Through the use of bioinformatics tools, suppressor of cytokine signaling 1 (SOCS1), a negative r

18 ction in macrophages leads to proteolysis of suppressor of cytokine signaling 1 (SOCS1), alleviating

19 trolled by the inducible negative regulators suppressor of cytokine signaling 1 (SOCS1), SOCS3, and u

20 No differential expression of suppressor of cytokine signaling 1 (SOCS1), SOCS3, or SO

21 d STAT1 activation only through induction of suppressor of cytokine signaling 1 (SOCS1), which increa

22 implicated in LPS desensitization, including suppressor of cytokine signaling 1 (SOCS1).

23 esponse correlates with a high expression of suppressor of cytokine signaling 1 (SOCS1).

24 These BM monocytes showed upregulation of suppressor of cytokine signaling 1 and 3 and IL-1R-"asso

25 n Stat1 and IL-6, induction of SOCS1 and -3 (suppressor of cytokine signaling 1 and 3) was markedly r

26 homa 6, dual specificity phosphatase 10, and suppressor of cytokine signaling 1 are direct targets of

27 tion, confirming that 1,25(OH)2D3 stimulates suppressor of cytokine signaling 1 by downregulating miR

28 els of IFNAR2 or STAT1 or enhanced levels of suppressor of cytokine signaling 1 or relevant protein t

29 rther studies demonstrating the induction of suppressor of cytokine signaling 1 via macrophage-stimul

30 ein kinase, inducible nitric oxide synthase, suppressor of cytokine signaling 1) beacons.

31 c mouse line [PLP/SOCS1 (proteolipid protein/suppressor of cytokine signaling 1)] that exhibits dimin

32 ) overproduction that excessively suppresses suppressor of cytokine signaling 1, a key regulator that

33 Furthermore, suppressor of cytokine signaling 1, an immune suppressiv

34 Kip1 ubiquitination-promoting complex 1, suppressor of cytokine signaling 1, and CD115 (M-CSFR) w

35 alpha also diminishes expression of CD95 and suppressor of cytokine signaling 1, both regulatory mole

36 y phosphatase 10, B cell CLL/lymphoma 6, and suppressor of cytokine signaling 1, respectively.

37 Suppressor of cytokine signaling 1-deficient (SOCS1(-/-)

38 tion is accompanied by dramatic induction of suppressors of cytokine signaling 1 (SOCS1), SOCS2, SOCS

39 IFN-beta induces suppressor of cytokine signaling-1 (SOCS-1) gene express

40 This led us to examine the possible role of suppressor of cytokine signaling-1 (SOCS-1) in this refr

41 es macrophage MyD88 expression by decreasing suppressor of cytokine signaling-1 (SOCS-1) mRNA stabili

42 munomodulators programmed death-1 (PD-1) and suppressor of cytokine signaling-1 (SOCS-1), the aim of

43 expression of a negative regulator of Stat3, suppressor of cytokine signaling-1 (SOCS-1), was reduced

44 2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 (SOCS1) and SOCS3, in

45 nhibited Blimp1 and also blocked LPS-induced suppressor of cytokine signaling-1 (SOCS1) expression, c

46 de mimicking the kinase-inhibitory region of suppressor of cytokine signaling-1 (SOCS1) regulatory pr

47 nd activator of transcription-3 (pSTAT3) and suppressor of cytokine signaling-1 (SOCS1)] were also el

48 -7Ralpha-chain expression and down-regulates suppressor of cytokine signaling-1 expression in thymocy

49 Thus, IFN-I-dependent suppressor of cytokine signaling-1 expression plays an i

50 nd activator of transcription-6 (STAT-6) and suppressor of cytokine signaling-1 in the pretreatment s

51 slets was prevented by overexpression of the suppressor of cytokine signaling-1 or inactivation of th

52 Increased activity of suppressor of cytokine signaling-1 was accompanied by re

53 downstream targets IFN regulatory factor-1, suppressor of cytokine signaling-1, CXCL9, and CXCL10.

54 diet was associated with increased levels of suppressor of cytokine signaling-1, implicating increase

55 miR-155 expression, with a resulting loss of suppressor of cytokine signaling-1.

56 o a loss in the IFN-I-dependent induction of suppressor of cytokine signaling-1.

57 of IFN-gammaR2, but not with IFN-gammaR1 or suppressor of cytokine signaling-1.

58 vestigations identified the ubiquitin ligase suppressor of cytokine signaling 2 (SOCS2) as a direct,

59 Suppressor of cytokine signaling 2 (SOCS2) is a regulato

60 validation of interleukin (IL)-8, IL-11, and suppressor of cytokine signaling 2 (SOCS2) messenger RNA

61 A screen for candidates revealed suppressor of cytokine signaling 2 (SOCS2), an inhibitor

62 f Stat5 target genes, such as those encoding suppressor of cytokine signaling 2 (SOCS2), Cish, and in

63 ctor aryl hydrocarbon receptor (AHR) and the suppressor of cytokine signaling 2 (SOCS2).

64 t that was significantly induced by TCDD was suppressor of cytokine signaling 2 (Socs2).

65 p7), plasma membrane proteolipid (Pllp), and suppressor of cytokine signaling 2 (Socs2).

66 the signaling proteins because of increased suppressors of cytokine signaling 2 expression that may

67 GH-stimulated suppressors of cytokine signaling 2 mRNA levels were sig

68 GH-regulated suppressor of cytokine signaling-2 (socs2) expression wa

69 ic in vitro and in vivo studies suggest that suppressor of cytokine signaling-2 (SOCS2) may normally

70 of IL-10, its regulator/effector STAT-3, and suppressor of cytokine signaling 3 (a proinflammatory cy

71 Because suppressor of cytokine signaling 3 (SOCS) controls the I

72 tion of JAKs and STATs and the expression of suppressor of cytokine signaling 3 (SOCS-3), a downstrea

73 ment markedly induces the gene expression of suppressor of cytokine signaling 3 (SOCS-3), a known inh

74 IL-1 receptor-associated kinase M (IRAK-M), suppressor of cytokine signaling 3 (SOCS-3), and activat

75 activity, AG 490, and overexpression of the suppressor of cytokine signaling 3 (SOCS-3), we show tha

76 d activator of transcription 3 (STAT-3), and suppressor of cytokine signaling 3 (SOCS-3).

77 d tumor necrosis factor alpha (TNFalpha) and suppressor of cytokine signaling 3 (SOCS3) activities in

78 Putative targets of miR-203, suppressor of cytokine signaling 3 (SOCS3) and SOCS6, we

79 others have observed that hepatic levels of suppressor of cytokine signaling 3 (SOCS3) are significa

80 Here, we show that host suppressor of cytokine signaling 3 (SOCS3) can also bind

81 Suppressor of cytokine signaling 3 (SOCS3) down-regulate

82 permeability changes; and induction of lung suppressor of cytokine signaling 3 (SOCS3) expression th

83 STAT3 signaling, concomitant with increased suppressor of cytokine signaling 3 (SOCS3) expression.

84 Most notable were the TRIB1 and suppressor of cytokine signaling 3 (SOCS3) genes, which

85 Recently, suppressor of cytokine signaling 3 (SOCS3) has been show

86 mouse lines, we discovered that deletion of suppressor of cytokine signaling 3 (SOCS3) in adult reti

87 d is associated with increased expression of suppressor of cytokine signaling 3 (Socs3) in the hypoth

88 th T cell exhaustion; (3) elevated levels of suppressor of cytokine signaling 3 (SOCS3) in the liver;

89 3 (Stat3) and suppress the expression of the suppressor of cytokine signaling 3 (SOCS3) irrespective

90 Suppressor of cytokine signaling 3 (SOCS3) is a major ne

91 Suppressor of cytokine signaling 3 (SOCS3) is a negative

92 Suppressor of cytokine signaling 3 (SOCS3) is an importa

93 Suppressor of cytokine signaling 3 (SOCS3) is expressed

94 Suppressor of cytokine signaling 3 (SOCS3) is known to b

95 onocyte chemoattractant protein 1 (MCP1) and suppressor of cytokine signaling 3 (SOCS3) mRNA, and we

96 3, phosphorylated Janus kinase 2 (JAK2), and suppressor of cytokine signaling 3 (SOCS3) protein abund

97 Here we demonstrate that suppressor of cytokine signaling 3 (SOCS3) regulated CXC

98 Suppressor of cytokine signaling 3 (SOCS3) regulates STA

99 Suppressor of cytokine signaling 3 (SOCS3) regulates the

100 was dependent on proteolytic degradation of suppressor of cytokine signaling 3 (SOCS3) resulting in

101 mponents and inhibitory regulators including suppressor of cytokine signaling 3 (SOCS3) were assessed

102 Epigenetic changes in suppressor of cytokine signaling 3 (SOCS3) were determin

103 e is an increased hypothalamic expression of Suppressor of cytokine signaling 3 (Socs3), a feedback i

104 omy model, we find that deletion of cortical suppressor of cytokine signaling 3 (SOCS3), a negative r

105 Suppressor of cytokine signaling 3 (SOCS3), a protein su

106 y activities of IL-6 is tightly regulated by suppressor of cytokine signaling 3 (SOCS3), a well-known

107 L-12, IL-23, and TNF-alpha) via induction of suppressor of cytokine signaling 3 (SOCS3), an effect me

108 levels of macrophages, toll-like receptor 4, suppressor of cytokine signaling 3 (SOCS3), and cytokine

109 egulatory profile comprising upregulation of suppressor of cytokine signaling 3 (SOCS3), glycoprotein

110 C2/3 was found to decrease the expression of Suppressor of Cytokine Signaling 3 (SOCS3), leading to i

111 e expression of STAT target genes, including suppressor of cytokine signaling 3 (SOCS3), which inhibi

112 ine signaling of the JAK-STAT pathway is the suppressor of cytokine signaling 3 (SOCS3).

113 of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling 3 (SOCS3).

114 tive regulation by the intracellular protein suppressor of cytokine signaling 3 (SOCS3).

115 of the negative regulator of IL-6 signaling, suppressor of cytokine signaling 3 (SOCS3).

116 We discovered that CD37 interacts with suppressor of cytokine signaling 3 (SOCS3); therefore, a

117 dogenous inhibitor of the JAK/STAT3 pathway [suppressor of cytokine signaling 3 (SOCS3)].

118 expression is constitutive, independent from suppressor of cytokine signaling 3 activity.

119 inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5.

120 ereas JAK2V617F can escape regulation by the suppressor of cytokine signaling 3 and p27/Kip1, JAK2R56

121 -/-) mice had increased transcript levels of suppressor of cytokine signaling 3 compared with hTNF/Sp

122 Suppressor of cytokine signaling 3 elicited the immunosu

123 cient macrophages was accompanied by reduced suppressor of cytokine signaling 3 expression and an ina

124 oduction of bioactive TGF-beta by inhibiting suppressor of cytokine signaling 3 expression and thereb

125 f transcription (STAT) 3 phosphorylation and suppressor of cytokine signaling 3 expression in wheel r

126 Restoring suppressor of cytokine signaling 3 expression under TAM

127 ased energy expenditure, and reduced arcuate suppressor of cytokine signaling 3 expression, indicativ

128 at IFN-beta-1a-mediated up-regulation of the suppressor of cytokine signaling 3 expression, induced v

129 man macrophages, which, in turn, upregulated suppressor of cytokine signaling 3 expression.

130 nocytes and B cells, IL-10 in monocytes, and suppressor of cytokine signaling 3 in monocytes and T ce

131 Interestingly, suppressor of cytokine signaling 3 knockdown in GEnCs up

132 combined with Rosi-mediated upregulation of suppressor of cytokine signaling 3 leads to an altered r

133 STAT3 and suppressor of cytokine signaling 3 protein levels were m

134 phosphorylation of STAT-3 and expression of suppressor of cytokine signaling 3 that positively or ne

135 a transcription, which, in turn, may inhibit suppressor of cytokine signaling 3 transcription.

136 colitis revealed that levels of IL-10R1 and suppressor of cytokine signaling 3 were increased in the

137 synergized with IL-22 in upregulating SOCS3 (suppressor of cytokine signaling 3), a key regulator of

138 ed STAT3 silencing, overexpression of SOCS3 (suppressor of cytokine signaling 3), and antioxidants su

139 ctly, and elevated TNFAIP3 suppressed SOCS3 (suppressor of cytokine signaling 3)-activated STAT3/VEGF

140 oculated EC via a mechanism involving SOCS3 (suppressor of cytokine signaling 3).

141 a mutation in gp130 at the binding site for suppressor of cytokine signaling 3, a critical negative

142 monstrate that both can induce expression of suppressor of cytokine signaling 3, a protein that tempe

143 d phosphorylation of Tyr(985) on LRb and the suppressor of cytokine signaling 3, attenuate leptin sig

144 actor), cytokine-mediated signaling pathway (suppressor of cytokine signaling 3, C-X-C ligand 8 [CXCL

145 Conditional deletion in basal cells of suppressor of cytokine signaling 3, encoding a negative

146 factors and the insulin resistance mediator, suppressor of cytokine signaling 3.

147 cl-xL, cyclin D3, survivin, Mcl-1, c-Myc and suppressor of cytokine signaling 3.

148 nases and insensitive to the STAT3 inhibitor suppressor of cytokine signaling 3.

149 ation correlated with enhanced expression of suppressors of cytokine signaling 3 (SOCS3) in the prese

150 irectly suppressed the gene transcription of suppressors of cytokine signaling 3 (SOCS3), a critical

151 ction of 2 significantly up-regulated genes, suppressor of cytokine signaling-3 (SOCS-3) and Kruppel-

152 We identified Suppressor of Cytokine Signaling-3 (SOCS-3) as a gene th

153 Abundance and localization of suppressor of cytokine signaling-3 (SOCS-3) messenger RN

154 ukin (IL)-6 responses is due to induction of suppressor of cytokine signaling-3 (SOCS-3), a negative

155 We have previously identified suppressor of cytokine signaling-3 (Socs3) as a leptin-i

156 of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulating

157 ) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of

158 Suppressor of cytokine signaling-3 (SOCS3) is a key nega

159 Suppressor of cytokine signaling-3 (SOCS3) is an inducib

160 We hypothesized that suppressor of cytokine signaling-3 (SOCS3) is such a fac

161 In this response, suppressor of cytokine signaling-3 (Socs3) is upregulate

162 High-fat diet-induced up-regulation of suppressor of cytokine signaling-3 (SOCS3) occurs in AgR

163 l assays, we analyzed interleukin (IL)-6 and suppressor of cytokine signaling-3 (SOCS3), 2 key factor

164 reased visceral adipose tissue expression of suppressor of cytokine signaling-3 (Socs3), a target of

165 ecrosis factor (TNF), tristetraprolin (TTP), suppressor of cytokine signaling-3 (SOCS3), and brain-de

166 duced IR expression and with upregulation of suppressor of cytokine signaling-3 and phosphotyrosine p

167 Retinoic acid acted on DCs to induce suppressor of cytokine signaling-3 expression, which sup

168 ncreased gene expression of IL-6, IL-10, and suppressor of cytokine signaling-3 in whole lung tissues

169 horylation in muscle and liver and decreased suppressor of cytokine signaling-3 level in muscle, and

170 sis of mRNA expression, we identified SOCS3 (suppressor of cytokine signaling-3) as a previously unre

171 One potential contributor is the SOCS-3 (suppressor of cytokine signaling-3) gene, which regulate

172 sion of proinflammatory cytokines as well as suppressor of cytokine signaling-3, a negative regulator

173 , mRNA of the postreceptor leptin inhibitor, suppressor of cytokine signaling-3, increased 22-fold in

174 ulated by the IL-22/STAT3 axis, among others suppressor of cytokine signaling-3, lipocalin-2, and alp

175 onist [IL-1ra], rs4251961; IL-10, rs1800871; suppressor of cytokine signaling-3, rs4969170; nucleotid

176 6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition a

177 al p38 mitogen-activated protein kinase, and suppressor of cytokine signaling-3; TLR2 and TLR4 messen

178 the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is requir

179 on of STAT3 as well as the expression of the suppressor of cytokine signaling 5 (SOCS5) in VSMCs.

180 nalysis indicates that DRD3 signaling evokes suppressor of cytokine signaling 5 expression, a negativ

181 2 (KLF2), Kruppel-like factor 4 (KLF4), and suppressor of cytokine signaling 5.

182 Here we show that suppressor of cytokine signaling 6 (SOCS6) and Cullin 5,

183 SOCS6 (suppressor of cytokine signaling 6) is a member of the S

184 NCK is carried into the nucleus by SOCS7 (suppressor of cytokine signaling 7), which possesses nuc

185 otably defective in the CIITA, class II HLA, suppressor of cytokine signaling and antiviral responses

186 (dUTX) maintains active transcription of the Suppressor of cytokine signaling at 36E (Socs36E) gene b

187 Here, we find that Suppressor of cytokine signaling at 36E (Socs36E) is a n

188 SPRY domain-containing suppressor of cytokine signaling box protein (SPSB) 2-de

189 fragment of Vif that consisted of the viral suppressor of cytokine signaling box showed decreased de

190 BC complex, which is mediated by Vif's viral suppressor of cytokine signaling box, is essential for V

191 The ankyrin and SOCS (suppressor of cytokine signaling) box (ASB) family of pr

192 and C (Cul5-EloB-EloC) through a novel SOCS (suppressor of cytokine signaling)-box that binds EloC.

193 ndau protein and p53 for degradation via its suppressor of cytokine signaling-box motif, which recrui

194 o show that IL-31 induces expression of four suppressor of cytokine signaling family members and prov

195 d not induce Shp-2 or several members of the suppressor of cytokine signaling family of Jak-Stat inhi

196 n-containing protein (CISH), a member of the suppressor of cytokine signaling family of negative feed

197 -containing protein (CIS), one member of the suppressors of cytokine signaling family of proteins, is

198 ort that genes encoding members of the SOCS (suppressor of cytokine signaling) family are critical ta

199 Th1 and Th2 cells, as do genes of the SOCS (suppressor of cytokine signaling) family, albeit indirec

200 study, we have shown that SOCS1, a member of suppressor of cytokine signaling, induces ASK1 degradati

201 that IFN-gamma acts through upregulation of suppressor of cytokine signaling molecules, which impair

202 urthermore, WT females expressed more of the suppressor of cytokine signaling protein 3 after I/R, wh

203 N-terminal kinase (JNK) and IKKbeta, and the suppressor of cytokine signaling protein 3, increased se

204 Evidence that suppressor of cytokine signaling protein induction by GH

205 The suppressor of cytokine signaling, protein inhibitor of S

206 in receptor substrate-1 and markedly induced suppressor of cytokine signaling proteins (1 and 3) coin

207 SCN/AML, prompting us to investigate whether suppressor of cytokine signaling proteins also down-modu

208 s the von Hippel-Lindau tumor suppressor and suppressor of cytokine signaling proteins, which are sub

209 ethanol-fed mice caused by the induction of suppressors of cytokine signaling proteins and the produ

210 Cul5 forms complexes with SOCS (suppressors of cytokine signaling) proteins, which bind

211 on and fibrosis, expression of AhR/cytokines/suppressor of cytokine signaling (SOCS) (spleen/heart),

212 ive immunity are critically regulated by the suppressor of cytokine signaling (SOCS) 1 in DCs.

213 IFN-gamma also induced expression of suppressor of cytokine signaling (SOCS) 1 in HSCs, and w

214 We sought to investigate the expression of suppressor of cytokine signaling (SOCS) 1 in tissues fro

215 inhibit innate immune signaling by inducing suppressor of cytokine signaling (SOCS) 2-dependent ubiq

216 Suppressor of cytokine signaling (SOCS) 3 attenuates pro

217 Finally, IL-22 treatment up-regulated the suppressor of cytokine signaling (SOCS) 3 expression in

218 oreover, we elucidated an important role for suppressor of cytokine signaling (SOCS) 3 in IL-17 enhan

219 Suppressor of cytokine signaling (Socs) 3 is a cytokine-

220 adiponectin augmented the expression of A20, suppressor of cytokine signaling (SOCS) 3, B-cell CLL/ly

221 Interestingly, expression of Suppressor of Cytokine Signaling (SOCS) domain-containin

222 ibitors of IL-2 signaling, including several suppressor of cytokine signaling (SOCS) family members a

223 We have found that Cish, a member of the suppressor of cytokine signaling (SOCS) family, is induc

224 To investigate the role of suppressor of cytokine signaling (SOCS) molecules in per

225 The suppressor of cytokine signaling (SOCS) protein family i

226 Suppressor of cytokine signaling (SOCS) proteins are fee

227 Suppressor of cytokine signaling (SOCS) proteins are inh

228 Suppressor of cytokine signaling (SOCS) proteins are key

229 Suppressor of cytokine signaling (SOCS) proteins are neg

230 The suppressor of cytokine signaling (SOCS) proteins are neg

231 ecade following their initial discovery, the suppressor of cytokine signaling (SOCS) proteins have be

232 Suppressor of cytokine signaling (SOCS) proteins have em

233 cription (STAT)-mediated signaling, E47, and suppressor of cytokine signaling (SOCS) proteins in a co

234 Suppressor of cytokine signaling (SOCS) proteins play a

235 Finally, I consider how the suppressor of cytokine signaling (SOCS) proteins regulat

236 Suppressor of cytokine signaling (SOCS) proteins serve a

237 We recently determined that AMs can secrete suppressor of cytokine signaling (SOCS) proteins within

238 be how these processes are controlled by the suppressor of cytokine signaling (SOCS) proteins, a fami

239 regulated by endogenous inhibitors, namely, suppressor of cytokine signaling (SOCS) proteins, phosph

240 or target of negative feedback inhibition by suppressor of cytokine signaling (SOCS) proteins.

241 these cells are negatively regulated by the Suppressor of cytokine signaling (Socs) proteins.

242 tudies test the hypothesis that GH induces a suppressor of cytokine signaling (SOCS), which inhibits

243 interleukin-10 (IL-10), IL-10 receptor, and suppressor of cytokine signaling (SOCS)-1 and SOCS-3.

244 Interestingly, suppressor of cytokine signaling (SOCS)-1 directly assoc

245 Suppressor of cytokine signaling (SOCS)-1 is a critical

246 Suppressor of cytokine signaling (SOCS)-1 protein modula

247 Moreover, the expression of suppressor of cytokine signaling (SOCS)-1, SOCS-3, and r

248 suppressed in preselection DP thymocytes by suppressor of cytokine signaling (SOCS)-1.

249 death in mice lacking the regulatory protein suppressor of cytokine signaling (SOCS)-1.

250 that this activation triggers expression of suppressor of cytokine signaling (SOCS)-2.

251 Suppressor of cytokine signaling (SOCS)-3 and protein-ty

252 Suppressor of cytokine signaling (SOCS)-3 expression is

253 IL-10 and LPS synergize to induce suppressor of cytokine signaling (SOCS)-3 gene expressio

254 Suppressor of cytokine signaling (SOCS)-3 is a potent in

255 mmunomodulators like cyclooxygenase (COX)-2, suppressor of cytokine signaling (SOCS)-3, and matrix me

256 PI3K activity and constitutively overexpress suppressor of cytokine signaling (SOCS)-3, which impairs

257 at and WD40 repeat families, but not for the suppressor of cytokine signaling (SOCS)-box-containing a

258 eukin-2, interferongamma, and IL-6 regulator suppressor of cytokine signaling (SOCS)1 expression in i

259 Suppressor of cytokine signaling (SOCS)1 is a cross-func

260 Following IL-4 exposure, suppressor of cytokine signaling (SOCS)1 is highly induc

261 one of the target genes induced by STAT5 is suppressor of cytokine signaling (SOCS)1-a surprising fi

262 Suppressor of cytokine signaling (SOCS)3 belongs to a fa

263 In adipocytes, suppressor of cytokine signaling (SOCS)3 deficiency incr

264 In murine splenic B cells, the suppressor of cytokine signaling (SOCS)3 is inducible by

265 ifferentiation, as well as the expression of suppressor of cytokine signaling (SOCS)3, a major negati

266 In this article, we show that Suppressor of Cytokine Signaling (SOCS)3, a molecular in

267 ed this question genetically by deleting the suppressor of cytokine signaling (SOCS)3, a negative reg

268 y understood but may involve upregulation of suppressor of cytokine signaling (SOCS-3) proteins that

269 Suppressors of cytokine signaling (SOCS) 1 and 3 protein

270 ion of the IL-6R signaling inhibitor protein suppressors of cytokine signaling (SOCS) 3 was also note

271 Suppressors of cytokine signaling (SOCS) are implicated

272 Suppressors of cytokine signaling (SOCS) are important r

273 Suppressors of cytokine signaling (SOCS) are negative fe

274 Proteins belonging to the suppressors of cytokine signaling (SOCS) family have bee

275 ularly and mechanistically distinct from the suppressors of cytokine signaling (SOCS) family of genes

276 IL-5 family cytokines induce members of the suppressors of cytokine signaling (SOCS) genes, CISH and

277 t decade, a family of host proteins known as suppressors of cytokine signaling (SOCS) have emerged as

278 Recent findings indicate that suppressors of cytokine signaling (SOCS) proteins are in

279 Suppressors of cytokine signaling (SOCS) proteins are ne

280 Suppressors of cytokine signaling (SOCS) proteins contro

281 Suppressors of cytokine signaling (SOCS) proteins functi

282 Suppressors of cytokine signaling (SOCS) proteins inhibi

283 The suppressors of cytokine signaling (SOCS) proteins play i

284 Suppressors of cytokine signaling (SOCS) proteins regula

285 e-inducible Src homology 2 (CIS) protein and suppressors of cytokine signaling (SOCS) proteins repres

286 be regulated by a family of proteins termed suppressors of cytokine signaling (SOCS) which can inhib

287 gy, but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of pr

288 ulators of innate and adaptive immunity, the suppressors of cytokine signaling (SOCS), in developing

289 The suppressors of cytokine signaling (SOCS), inhibitors of

290 Here we show that overexpression of suppressors of cytokine signaling (SOCS)-1 and SOCS-3 in

291 nfection in culture that can be inhibited by suppressors of cytokine signaling (SOCS)-3, a physiologi

292 lished STAT activity-dependent expression of suppressors of cytokine signaling (SOCS).

293 FN-gamma in cells occurs via proteins called suppressors of cytokine signaling (SOCS)1 and -3.

294 ed target gene transcription (e.g., IRF1 and suppressor of cytokine signaling [SOCS] 1) was strongly

295 is of prospective suppressive factors (e.g., suppressor of cytokine signaling [SOCS]), the effects of

296 itors (cytokine-inducible SH2-protein [CIS]; suppressor of cytokine signaling [SOCS]1, 2, 3; and SH2-

297 AngII infusion also stimulated the suppressor of cytokine signaling (SOCS3) in muscle, whic

298 Adiponectin also increased suppressor of cytokine signaling (SOCS3), a physiologic

299 identified a negative regulator of Brk, the suppressor of cytokine signaling, SOCS3.

300 Suppressors of cytokine signaling (SOCSs) are negative r