ライフサイエンスコーパス: suppressor of cytokine signaling 3

1 oculated EC via a mechanism involving SOCS3 (suppressor of cytokine signaling 3).

2 cl-xL, cyclin D3, survivin, Mcl-1, c-Myc and suppressor of cytokine signaling 3.

3 nases and insensitive to the STAT3 inhibitor suppressor of cytokine signaling 3.

4 factors and the insulin resistance mediator, suppressor of cytokine signaling 3.

5 ion of suppressor of cytokine signaling-1 or suppressor of cytokine signaling-3.

6 of IL-10, its regulator/effector STAT-3, and suppressor of cytokine signaling 3 (a proinflammatory cy

7 synergized with IL-22 in upregulating SOCS3 (suppressor of cytokine signaling 3), a key regulator of

8 a mutation in gp130 at the binding site for suppressor of cytokine signaling 3, a critical negative

9 monstrate that both can induce expression of suppressor of cytokine signaling 3, a protein that tempe

10 sion of proinflammatory cytokines as well as suppressor of cytokine signaling-3, a negative regulator

11 ctly, and elevated TNFAIP3 suppressed SOCS3 (suppressor of cytokine signaling 3)-activated STAT3/VEGF

12 expression is constitutive, independent from suppressor of cytokine signaling 3 activity.

13 inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5.

14 ereas JAK2V617F can escape regulation by the suppressor of cytokine signaling 3 and p27/Kip1, JAK2R56

15 ed and previously documented targets such as suppressor of cytokine signaling-3 and IL-1 receptor ant

16 duced IR expression and with upregulation of suppressor of cytokine signaling-3 and phosphotyrosine p

17 ed STAT3 silencing, overexpression of SOCS3 (suppressor of cytokine signaling 3), and antioxidants su

18 sis of mRNA expression, we identified SOCS3 (suppressor of cytokine signaling-3) as a previously unre

19 d phosphorylation of Tyr(985) on LRb and the suppressor of cytokine signaling 3, attenuate leptin sig

20 actor), cytokine-mediated signaling pathway (suppressor of cytokine signaling 3, C-X-C ligand 8 [CXCL

21 -/-) mice had increased transcript levels of suppressor of cytokine signaling 3 compared with hTNF/Sp

22 Suppressor of cytokine signaling 3 elicited the immunosu

23 Conditional deletion in basal cells of suppressor of cytokine signaling 3, encoding a negative

24 cient macrophages was accompanied by reduced suppressor of cytokine signaling 3 expression and an ina

25 oduction of bioactive TGF-beta by inhibiting suppressor of cytokine signaling 3 expression and thereb

26 f transcription (STAT) 3 phosphorylation and suppressor of cytokine signaling 3 expression in wheel r

27 Restoring suppressor of cytokine signaling 3 expression under TAM

28 ased energy expenditure, and reduced arcuate suppressor of cytokine signaling 3 expression, indicativ

29 at IFN-beta-1a-mediated up-regulation of the suppressor of cytokine signaling 3 expression, induced v

30 man macrophages, which, in turn, upregulated suppressor of cytokine signaling 3 expression.

31 Retinoic acid acted on DCs to induce suppressor of cytokine signaling-3 expression, which sup

32 One potential contributor is the SOCS-3 (suppressor of cytokine signaling-3) gene, which regulate

33 e-rich high endothelial venule glycoprotein, suppressor of cytokine signaling 3, hematopoietic cell t

34 nocytes and B cells, IL-10 in monocytes, and suppressor of cytokine signaling 3 in monocytes and T ce

35 ncreased gene expression of IL-6, IL-10, and suppressor of cytokine signaling-3 in whole lung tissues

36 , mRNA of the postreceptor leptin inhibitor, suppressor of cytokine signaling-3, increased 22-fold in

37 Interestingly, suppressor of cytokine signaling 3 knockdown in GEnCs up

38 combined with Rosi-mediated upregulation of suppressor of cytokine signaling 3 leads to an altered r

39 horylation in muscle and liver and decreased suppressor of cytokine signaling-3 level in muscle, and

40 ulated by the IL-22/STAT3 axis, among others suppressor of cytokine signaling-3, lipocalin-2, and alp

41 6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition a

42 STAT3 and suppressor of cytokine signaling 3 protein levels were m

43 the expression of IkappaBalpha S32AS36A and suppressor of cytokine signaling 3, respectively, blocks

44 onist [IL-1ra], rs4251961; IL-10, rs1800871; suppressor of cytokine signaling-3, rs4969170; nucleotid

45 Because suppressor of cytokine signaling 3 (SOCS) controls the I

46 study IL-6 signaling and to analyze whether suppressor of cytokine signaling 3 (SOCS-3) proteins pla

47 tion of JAKs and STATs and the expression of suppressor of cytokine signaling 3 (SOCS-3), a downstrea

48 ment markedly induces the gene expression of suppressor of cytokine signaling 3 (SOCS-3), a known inh

49 IL-1 receptor-associated kinase M (IRAK-M), suppressor of cytokine signaling 3 (SOCS-3), and activat

50 ion of a candidate leptin resistance factor, suppressor of cytokine signaling 3 (SOCS-3), was compare

51 activity, AG 490, and overexpression of the suppressor of cytokine signaling 3 (SOCS-3), we show tha

52 Suppressor of cytokine signaling 3 (SOCS-3), which has p

53 d activator of transcription 3 (STAT-3), and suppressor of cytokine signaling 3 (SOCS-3).

54 ction of 2 significantly up-regulated genes, suppressor of cytokine signaling-3 (SOCS-3) and Kruppel-

55 rowth factor receptors induces expression of suppressor of cytokine signaling-3 (SOCS-3) and subseque

56 We identified Suppressor of Cytokine Signaling-3 (SOCS-3) as a gene th

57 As assessed by leptin-induced expression of suppressor of cytokine signaling-3 (SOCS-3) in fasted ra

58 Abundance and localization of suppressor of cytokine signaling-3 (SOCS-3) messenger RN

59 ress long form leptin-receptor mRNA, and the suppressor of cytokine signaling-3 (SOCS-3) mRNA after a

60 in the Arc did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA.

61 ukin (IL)-6 responses is due to induction of suppressor of cytokine signaling-3 (SOCS-3), a negative

62 , OnM transiently elevates mRNA encoding for suppressor of cytokine signaling-3 (SOCS-3).

63 IL-22BP also blocked induction of the suppressors of cytokine signaling-3 (SOCS-3) gene expres

64 mic inhibitors of leptin and CNTF signaling (suppressor of cytokine signaling 3 [SOCS-3]) and mediato

65 d tumor necrosis factor alpha (TNFalpha) and suppressor of cytokine signaling 3 (SOCS3) activities in

66 Putative targets of miR-203, suppressor of cytokine signaling 3 (SOCS3) and SOCS6, we

67 others have observed that hepatic levels of suppressor of cytokine signaling 3 (SOCS3) are significa

68 Suppressor of cytokine signaling 3 (SOCS3) binds cytokin

69 Here, we show that host suppressor of cytokine signaling 3 (SOCS3) can also bind

70 Suppressor of cytokine signaling 3 (SOCS3) down-regulate

71 permeability changes; and induction of lung suppressor of cytokine signaling 3 (SOCS3) expression th

72 STAT3 signaling, concomitant with increased suppressor of cytokine signaling 3 (SOCS3) expression.

73 Most notable were the TRIB1 and suppressor of cytokine signaling 3 (SOCS3) genes, which

74 Recently, suppressor of cytokine signaling 3 (SOCS3) has been show

75 mouse lines, we discovered that deletion of suppressor of cytokine signaling 3 (SOCS3) in adult reti

76 d is associated with increased expression of suppressor of cytokine signaling 3 (Socs3) in the hypoth

77 th T cell exhaustion; (3) elevated levels of suppressor of cytokine signaling 3 (SOCS3) in the liver;

78 3 (Stat3) and suppress the expression of the suppressor of cytokine signaling 3 (SOCS3) irrespective

79 Here we show that suppressor of cytokine signaling 3 (SOCS3) is a key regu

80 Suppressor of cytokine signaling 3 (SOCS3) is a major ne

81 Suppressor of cytokine signaling 3 (SOCS3) is a negative

82 Suppressor of cytokine signaling 3 (SOCS3) is an importa

83 Suppressor of cytokine signaling 3 (SOCS3) is expressed

84 Suppressor of cytokine signaling 3 (SOCS3) is known to b

85 onocyte chemoattractant protein 1 (MCP1) and suppressor of cytokine signaling 3 (SOCS3) mRNA, and we

86 3, phosphorylated Janus kinase 2 (JAK2), and suppressor of cytokine signaling 3 (SOCS3) protein abund

87 Here we demonstrate that suppressor of cytokine signaling 3 (SOCS3) regulated CXC

88 Suppressor of cytokine signaling 3 (SOCS3) regulates STA

89 Suppressor of cytokine signaling 3 (SOCS3) regulates the

90 was dependent on proteolytic degradation of suppressor of cytokine signaling 3 (SOCS3) resulting in

91 mponents and inhibitory regulators including suppressor of cytokine signaling 3 (SOCS3) were assessed

92 Epigenetic changes in suppressor of cytokine signaling 3 (SOCS3) were determin

93 e is an increased hypothalamic expression of Suppressor of cytokine signaling 3 (Socs3), a feedback i

94 omy model, we find that deletion of cortical suppressor of cytokine signaling 3 (SOCS3), a negative r

95 Suppressor of cytokine signaling 3 (SOCS3), a protein su

96 y activities of IL-6 is tightly regulated by suppressor of cytokine signaling 3 (SOCS3), a well-known

97 L-12, IL-23, and TNF-alpha) via induction of suppressor of cytokine signaling 3 (SOCS3), an effect me

98 We show here that suppressor of cytokine signaling 3 (SOCS3), an intrinsic

99 levels of macrophages, toll-like receptor 4, suppressor of cytokine signaling 3 (SOCS3), and cytokine

100 egulatory profile comprising upregulation of suppressor of cytokine signaling 3 (SOCS3), glycoprotein

101 C2/3 was found to decrease the expression of Suppressor of Cytokine Signaling 3 (SOCS3), leading to i

102 e expression of STAT target genes, including suppressor of cytokine signaling 3 (SOCS3), which inhibi

103 y of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3).

104 of the negative regulator of IL-6 signaling, suppressor of cytokine signaling 3 (SOCS3).

105 ine signaling of the JAK-STAT pathway is the suppressor of cytokine signaling 3 (SOCS3).

106 of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling 3 (SOCS3).

107 tive regulation by the intracellular protein suppressor of cytokine signaling 3 (SOCS3).

108 We discovered that CD37 interacts with suppressor of cytokine signaling 3 (SOCS3); therefore, a

109 dogenous inhibitor of the JAK/STAT3 pathway [suppressor of cytokine signaling 3 (SOCS3)].

110 We have previously identified suppressor of cytokine signaling-3 (Socs3) as a leptin-i

111 of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulating

112 ) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of

113 Suppressor of cytokine signaling-3 (SOCS3) is a key nega

114 Suppressor of cytokine signaling-3 (SOCS3) is an inducib

115 We hypothesized that suppressor of cytokine signaling-3 (SOCS3) is such a fac

116 In this response, suppressor of cytokine signaling-3 (Socs3) is upregulate

117 High-fat diet-induced up-regulation of suppressor of cytokine signaling-3 (SOCS3) occurs in AgR

118 l assays, we analyzed interleukin (IL)-6 and suppressor of cytokine signaling-3 (SOCS3), 2 key factor

119 reased visceral adipose tissue expression of suppressor of cytokine signaling-3 (Socs3), a target of

120 ecrosis factor (TNF), tristetraprolin (TTP), suppressor of cytokine signaling-3 (SOCS3), and brain-de

121 ation correlated with enhanced expression of suppressors of cytokine signaling 3 (SOCS3) in the prese

122 irectly suppressed the gene transcription of suppressors of cytokine signaling 3 (SOCS3), a critical

123 phosphorylation of STAT-3 and expression of suppressor of cytokine signaling 3 that positively or ne

124 al p38 mitogen-activated protein kinase, and suppressor of cytokine signaling-3; TLR2 and TLR4 messen

125 a transcription, which, in turn, may inhibit suppressor of cytokine signaling 3 transcription.

126 F-stimulated expression of c-fos, egr-1, and suppressor of cytokine signaling-3 was retained in SYF c

127 colitis revealed that levels of IL-10R1 and suppressor of cytokine signaling 3 were increased in the