ライフサイエンスコーパス: suprabasal

1 IgGs caused gross skin blisters with PV-like suprabasal acantholysis and stained perilesional epiderm

2 shown that inhibiting AP1 factor function in suprabasal adult epidermis leads to reduced filaggrin le

3 and temporally precedes the other, which is suprabasal and arises only after the start of the first

4 ransgenic mice overexpressing C2beta in both suprabasal and basal epidermal layers.

5 was not detected, and the morphology of the suprabasal and basal layers were similar.

6 endent, utilizing multiple steps within both suprabasal and cornified layers.

7 yte compartment and premature acquisition of suprabasal and granular differentiation markers, whereas

8 SRC3 was detected in the suprabasal and granular layer of the skin, similar to ca

9 the expression of K12 was restricted to the suprabasal and/or superficial cells of the corneal epith

10 dendritic cells situated adjacent to basal, suprabasal, and follicular infundibular keratinocytes th

11 To test this, we inactivated suprabasal AP1 factor function in mouse epidermis by tar

12 netic background, indicating that suppressed suprabasal AP1 factor function is sufficient to drive th

13 also show that the phenotype regresses when suprabasal AP1 factor signaling is restored.

14 and MK2 inhibit spontaneous but not induced suprabasal blisters by PV mAbs in mouse passive transfer

15 rm expressed in the basal epidermis, develop suprabasal blisters in skin that are histologically iden

16 in HK1.bcl-2 and control epidermis although suprabasal BrdUrd incorporating cells were present only

17 tially differentiated, clonal populations of suprabasal bulge region cells can regenerate skin and ha

18 atch force at pCa > 8 and decreases force at suprabasal but submaximum [Ca2+].

19 plakoglobin or coexpression of its companion suprabasal cadherin, Dsc1 (desmocollin 1).

20 ivide asymmetrically, generating a committed suprabasal cell and a proliferative basal cell.

21 antigen (PCNA) expression in both basal and suprabasal cell layers and by expression of keratin 6 in

22 vealed that hr expression was present in the suprabasal cell layers of the epidermis, whereas the bas

23 Both the basal cell layer and the suprabasal cell layers were expanded in treated Cav-1 nu

24 ic mice, as evidenced by increased number of suprabasal cell layers, elevated proliferating cell nucl

25 r antigen Ki67(+) cells in the basal and the suprabasal cell layers, increased loricrin expression, a

26 dominantly expressed by keratinocytes in the suprabasal cell layers.

27 Tracer transfer occurred in both basal and suprabasal cell layers.

28 ion of the K3 and K14 genes in the basal and suprabasal cell layers.

29 igh risk of malignant progression, including suprabasal cell proliferation and heterogeneous expressi

30 ed the proliferative compartment by inducing suprabasal cell proliferation.

31 omal dominant skin disorder characterized by suprabasal cell separation (acantholysis) of the epiderm

32 Shh-dependent suprabasal cell shape suggests convergent migration and

33 ubset of cells at the interface of basal and suprabasal cells above and around the hair germ.

34 ipheral localization of CLP in the basal and suprabasal cells adjacent to and immediately over the wo

35 inct mechanisms: terminal differentiation of suprabasal cells and a spatial gradient of apoptosis of

36 rs of normal skin, staining the periphery in suprabasal cells and exhibiting nuclear localization in

37 ced by positive expression of K10 keratin in suprabasal cells and filaggrin in superficial cells-ensu

38 2:1 mixtures (NHK:II-4) were stripped of all suprabasal cells and regrown, all beta-gal cells were lo

39 xpression is up-regulated in Ovol1-deficient suprabasal cells and that Ovol1 represses c-myc transcri

40 E7 protein, which induces S phase reentry in suprabasal cells by destabilizing the p130 pocket protei

41 deoxyuridine incorporation in differentiated suprabasal cells compared to that seen in wild-type raft

42 kinetics of the appearance of doubly labeled suprabasal cells demonstrate that E7 expression did not

43 een differentiation and immature programs in suprabasal cells during epidermal development.

44 However, suprabasal cells had a more complex pattern of keratin e

45 ch1, we mapped Notch1 activation strictly to suprabasal cells in epidermis, nail matrix, and other sk

46 cause keratin 14 mRNA expression persists in suprabasal cells in Skn-1/Tst-1 double knockout mice.

47 ctor beta type II receptor mRNA in basal and suprabasal cells in the epidermis and dermal cells.

48 e central cornea and to the lower and middle suprabasal cells in the limbal region.

49 ll proliferation in normally growth arrested suprabasal cells in vivo.

50 In embryonic epidermis, suprabasal cells induce whn expression at the same time

51 eptor heterodimers located in differentiated suprabasal cells mediate retinoid induction of HB-EGF, w

52 ranscription of late genes occur only in the suprabasal cells of a differentiated epithelium.

53 tense and nuclear in stromal keratocytes and suprabasal cells of corneal and limbal epithelia; p107,

54 Ralpha mutant (dnRARalpha) to differentiated suprabasal cells of mouse epidermis.

55 gnaling is strongly activated in luminal and suprabasal cells of several epithelia, but suppressed in

56 to PPE mRNA were detected in both basal and suprabasal cells of the central and peripheral cornea, l

57 is responsible for the sustained survival of suprabasal cells of the epidermis in the absence of PTEN

58 e restricted to the basal and most immediate suprabasal cells of the epidermis, whereas both proteins

59 DNA and capsid antigens were detected in the suprabasal cells of the epithelium.

60 ta have been localized in both the basal and suprabasal cells of the epithelium.

61 Basal and suprabasal cells of the limbus and conjunctiva exhibited

62 were associated with both the basal and the suprabasal cells of the ocular surface epithelium.

63 real-time PCR, we localized cyclin D1 to the suprabasal cells of the telogen bulge and anagen outer r

64 s there were alterations in the frequency of suprabasal cells supporting DNA synthesis, the levels of

65 found that the ability of HPV16 to reprogram suprabasal cells to support DNA synthesis correlates wit

66 quantitative reduction in the percentage of suprabasal cells undergoing DNA synthesis, compared to c

67 The LIs of suprabasal cells were increased at 24 h and 36 h; these

68 A wide zone of suprabasal cells were misaligned and coexpressed keratin

69 ng marked hyperplasia of less-differentiated suprabasal cells, angiogenesis and overt papillomatosis.

70 ing at the cell periphery in the majority of suprabasal cells, confirming a peripheral distribution o

71 l progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouri

72 In suprabasal cells, microtubules concentrate at cell-cell

73 7- and 17-fold increase of labeled basal and suprabasal cells, respectively, in the epithelium adjace

74 idermis, C2beta was found to be localized in suprabasal cells, suggesting a potential role for C2beta

75 cells and then to localize in the nuclei of suprabasal cells, suggesting a role for NF-kappaB in the

76 populations, and was expressed in epidermal suprabasal cells, the inner root sheath, and the innermo

77 Cx26 staining was limited to the lower suprabasal cells, whereas Cx31.1 localized to the apical

78 and tumors, integrins are also expressed by suprabasal cells, with concomitant up-regulation of Erk

79 bular keratin structures in the cytoplasm of suprabasal cells.

80 n as a desmosomal cadherin both in basal and suprabasal cells.

81 This induction occurred exclusively in suprabasal cells.

82 se in numbers and stability of desmosomes in suprabasal cells.

83 ageal basal cells but not the differentiated suprabasal cells.

84 ic accumulation of cyclin B1 and cdc2 in the suprabasal cells.

85 nduce productive replication of viral DNA in suprabasal cells.

86 ng from an increased number of proliferating suprabasal cells.

87 toplasm and cell nuclei in basal, as well as suprabasal, cells of adult rat corneal epithelium.

88 Once suprabasal, cells stop dividing and enter a differentiat

89 f keratin 4 (K4) to the early differentiated suprabasal compartment and having previously demonstrate

90 EGFR, cycling tumor cells migrated into the suprabasal compartment and initiated the differentiation

91 In the suprabasal compartment of organotypic raft cultures harb

92 eratinocyte protein that is expressed in the suprabasal compartment of the epidermis and other strati

93 elative to the wound and location within the suprabasal compartment of the epidermis.

94 sis and inhibit their differentiation in the suprabasal compartment of the epithelia, where cells nor

95 re silenced when keratinocytes move into the suprabasal compartment.

96 ulation by upstream signals in the basal and suprabasal compartments of the epidermis, providing a po

97 Displaced WNT(lo) suprabasal daughters become SCs that respond to paracrin

98 ile E7 promoted S-phase re-entry in numerous suprabasal differentiated cells, HPV DNA unexpectedly am

99 e epidermis selectively induces apoptosis in suprabasal differentiating keratinocytes while sparing b

100 um between the basal proliferative layer and suprabasal differentiating layers forming the skin barri

101 l, giving rise to one basal daughter and one suprabasal, differentiating daughter.

102 crin (Inv) promoter targeted the receptor to suprabasal, differentiating keratinocytes.

103 e the transition from basal proliferation to suprabasal differentiation.

104 Based on the suprabasal distribution of Bmi-1 in epidermis, we propos

105 Additional studies identify a DRR immediate suprabasal element (ISE).

106 fected regions exhibited an expansion of the suprabasal epidermal cells.

107 pression of alpha9beta1 is seen in basal and suprabasal epidermal keratinocytes in wounds.

108 Cell-cycle exit and differentiation of suprabasal epidermal keratinocytes require nuclear Ikapp

109 genic mice expressing beta1 integrins in the suprabasal epidermal layers have sporadic skin hyperprol

110 expressed constitutively active MEK1 in the suprabasal epidermal layers of transgenic mice.

111 nvolucrin is expressed in the differentiated suprabasal epidermal layers, and an AP1 transcription fa

112 1 mRNAs localized in the basal and immediate suprabasal epidermal layers, whereas VEGF mRNA was predo

113 ated, differentiating cells of the first few suprabasal epidermal layers.

114 n which beta1 integrins are expressed in the suprabasal epidermal layers.

115 CGI-58 is essential for lipid metabolism in suprabasal epidermal layers.

116 om a keratin 10 promoter, exclusively in the suprabasal epidermis (the cells in which Connexin 26 is

117 ber, desmoglein 4, which is expressed in the suprabasal epidermis and hair follicle.

118 Ras blockade in post-mitotic suprabasal epidermis exerts no effect.

119 t suppression of AP1 factor signaling in the suprabasal epidermis is a key event in the pathogenesis

120 ression of epilysin protein in the basal and suprabasal epidermis of intact skin.

121 We show that activation of c-MycER in adult suprabasal epidermis rapidly triggers proliferation and

122 CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentia

123 tors have distinct roles in the basal versus suprabasal epidermis, confirm that AP1 factor function i

124 elevated RAC activity that extended into the suprabasal epidermis, deeper into the dermis, and was ma

125 xpressed in the hair follicle as well as the suprabasal epidermis, have been found to underlie LAH.

126 lated and found expressed in fetal and adult suprabasal epidermis, osteoblasts, small intestine, and

127 ters and acantholysis in the superficial and suprabasal epidermis, respectively, to the same degree i

128 keratoderma phenotype in mice in response to suprabasal epidermis-specific inhibition of activator pr

129 sal epidermis and increased apoptosis in the suprabasal epidermis.

130 regulatory protein that is expressed in the suprabasal epidermis.

131 , or developmental abnormalities of basal or suprabasal epidermis.

132 (TPA) induced strong VEGF-GFP expression in suprabasal epidermis.

133 factors function differently in basal versus suprabasal epidermis.

134 genesis and, in particular, formation of the suprabasal epithelial cell layer were impaired.

135 We identified keratin 10 as a marker of suprabasal epithelial cells in teeth.

136 the zeta receptor were detected in basal and suprabasal epithelial cells.

137 3 (miR-203), which is expressed primarily in suprabasal epithelial cells.

138 ation of M phase cells in both the basal and suprabasal epithelium adjacent to the wound showed incre

139 n, we generated transgenic mice in which the suprabasal expression of an inducible form of the ODC pr

140 pressed NOTCH signal transduction, including suprabasal expression of integrins, talin and basal type

141 dose-dependently inhibited tRA induction of suprabasal HB-EGF and subsequent basal cell hyperprolife

142 t p38 delta is the major p38 isoform driving suprabasal hINV gene expression and that p38 delta direc

143 These results suggest that de novo suprabasal induction of ODC activity in adult mouse skin

144 We conclude that suprabasal integrin expression leads to Erk activation a

145 follicles and only becomes expressed in the suprabasal intrafollicular regions when the epidermis is

146 cal signaling partner RBP-J act at the basal/suprabasal juncture to induce spinous and down-regulate

147 n and substrate phosphorylation in the first suprabasal KCs of normal human epidermis, suggesting act

148 spaces, and perinuclear condensation of the suprabasal keratin intermediate filament network.

149 However, these lesions had significant suprabasal keratinocyte cytotoxicity.

150 We previously showed that suprabasal keratinocyte expression of a Fatp4 transgene

151 ropose that Bmi-1 may promote maintenance of suprabasal keratinocyte survival to prevent premature de

152 e filament assembly, leading to cytolysis of suprabasal keratinocytes and secondary hyperkeratosis an

153 is expressed in the nuclei and cytoplasm of suprabasal keratinocytes and weakly expressed in a perin

154 studies show that intermediate filaments of suprabasal keratinocytes are finer than those of the bas

155 ttern of p110alpha and p110beta in basal and suprabasal keratinocytes as well as differential PI3K re

156 In general, K10 was expressed in suprabasal keratinocytes at the wound edge, but not in k

157 cell DNA synthesis in replication-activated suprabasal keratinocytes by suppressing licensing of cel

158 ansduction of dividing basal and nondividing suprabasal keratinocytes could be demonstrated, which wa

159 ggest that increasing expression of FATP1 in suprabasal keratinocytes could normalize the skin of IPS

160 keratin-filament aggregates were observed in suprabasal keratinocytes from both probands, suggesting

161 ut its expression is markedly upregulated in suprabasal keratinocytes in psoriasis.

162 ns the integrity and differentiated state of suprabasal keratinocytes in the epidermis.

163 ncy indicate an involvement of matriptase in suprabasal keratinocytes in the maintenance of the epide

164 s is counterbalanced by the growth arrest of suprabasal keratinocytes in the stratified epidermis by

165 with an intact acyl-CoA synthetase domain in suprabasal keratinocytes is necessary for normal skin de

166 Importantly, loss of Fra-2 in suprabasal keratinocytes is sufficient to cause skin bar

167 wever, a significant portion of K2-deficient suprabasal keratinocytes lacked a regular cytoskeleton a

168 We expressed activated H-RAS(V12G) in suprabasal keratinocytes of adult mice and observed rapi

169 strongly localized to cell membranes in the suprabasal keratinocytes of human epidermis, suggesting

170 , MycER(TAM), is targeted to the postmitotic suprabasal keratinocytes of murine epidermis via the inv

171 type 1 keratin expressed exclusively in the suprabasal keratinocytes of palmoplantar epidermis, have

172 Transgenic expression of FATP1 in suprabasal keratinocytes rescued the phenotype of Fatp4

173 ive to the nuclei of a three-cell cluster of suprabasal keratinocytes that is morphologically consist

174 specifically activate E2F2 transcription in suprabasal keratinocytes through its ability to bind HDA

175 We observed H. ducreyi inside suprabasal keratinocytes using transmission electron mic

176 ed at the cell surface of psoriatic involved suprabasal keratinocytes whereas it was restricted to ba

177 uclear localization of NFAT1 was observed in suprabasal keratinocytes within lesional and to a lesser

178 elanin pigment from melanocytes to basal and suprabasal keratinocytes, an event critical to epidermal

179 progenitor cells, in the basal layer, and in suprabasal keratinocytes, and the level, timing, and dis

180 enous FATP4 either widely or specifically in suprabasal keratinocytes, and we bred the transgenes ont

181 proliferation and delayed differentiation of suprabasal keratinocytes, culminating in papillomatosis.

182 wed a perinuclear localization of keratin in suprabasal keratinocytes, suggesting a collapsed interme

183 specifically by thymic epithelial cells and suprabasal keratinocytes.

184 ontrol the cell cycle, triggering S phase in suprabasal keratinocytes.

185 ficient amplification of the viral genome in suprabasal keratinocytes.

186 yte antigen 6 protein family, is secreted by suprabasal keratinocytes.

187 s, Kdap was expressed more widely throughout suprabasal keratinocytes.

188 ed in proliferative basal and differentiated suprabasal keratinocytes.

189 overexpression of MMP-2 in the cytoplasm of suprabasal keratinocytes.

190 lumping, cytolysis, and blister formation in suprabasal keratinocytes.

191 characterized histologically by cytolysis of suprabasal keratinocytes.

192 ediated growth inhibition, and quiescence of suprabasal keratinocytes.

193 rescued by transgene expression of FATP4 in suprabasal keratinocytes.

194 ansgene-driven expression of FATP4 solely in suprabasal keratinocytes.

195 SLURP2 is produced by suprabasal keratinocytes.

196 e effects of mutations in the end domains of suprabasal keratins and so contribute to understanding o

197 The terminal domains of suprabasal keratins of the skin epithelium are very resi

198 rresponds to the fact that LCs reside in the suprabasal layer (stratum germinativum).

199 the dorsal epidermis does not interfere with suprabasal layer differentiation or maintenance of the b

200 Suprabasal layer KCs underwent apoptosis at much later t

201 Instead of basal keratinocytes, the suprabasal layer of keratinocytes migrated into the woun

202 as more abundant than Ki-67 in the basal and suprabasal layer of newborn foreskins, suggesting that h

203 ris, with mucosal-dominant blistering in the suprabasal layer of the epidermis.

204 the brightest cells present in the basal and suprabasal layer of the epithelium.

205 manchette as well as in keratinocytes of the suprabasal layer of the rat and human footpad/sole epide

206 ter activity is found primarily in the first suprabasal layer, which contains keratinocytes in the ea

207 ers, and spots of CK 13 were detected in the suprabasal layer.

208 levels were dramatically up-regulated in the suprabasal layer.

209 asal keratinocytes and essentially lost from suprabasal layers adjacent to the wound (i.e., within 20

210 er of human epidermis, with a decline in the suprabasal layers and a reemergence of expression at the

211 here was a marked reduction in the number of suprabasal layers and basal keratinocytes.

212 relative to TGF-beta1, the latter induced in suprabasal layers and up-regulated in outer layers.

213 ion was due to significant cell death in the suprabasal layers and was alleviated by caspase inhibiti

214 bited podoplanin expression in the basal and suprabasal layers and were classified as podoplanin posi

215 ation, was restricted to basal and immediate suprabasal layers at the wound edge.

216 to more extensive distribution in basal and suprabasal layers by 48 h.

217 g expression of AKR1C3 in the differentiated suprabasal layers compared with the basal layer.

218 rmis results in the delayed reduction of its suprabasal layers in late embryogenesis and to the ultim

219 e structural integrity required of the early suprabasal layers in the context of development, adult h

220 myoepithelial cells, in epithelial basal and suprabasal layers in the distal endbud region of develop

221 Increased CALML3 expression in suprabasal layers is characteristic for differentiating

222 Epithelial cells at the basal or suprabasal layers move centripetally in these mice at an

223 odes are stratified into a basal and several suprabasal layers of cells.

224 ak staining of NT3 and TrkC was noted in the suprabasal layers of corneal and limbal epithelia but wa

225 Desmocollin-1 is strictly confined to suprabasal layers of epidermis, but it is absent in mito

226 CARD14 is localized mainly in the basal and suprabasal layers of healthy skin epidermis, whereas in

227 However, ILK expression is lost in the suprabasal layers of keratinocytes that are undergoing t

228 h K4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia.

229 dant expression of BRAK protein was found in suprabasal layers of normal tongue mucosa but consistent

230 appeared in the cytoplasm in differentiated suprabasal layers of skin, next in a more peripheral web

231 a predominantly productive infection in the suprabasal layers of stratified epithelium, similar to t

232 pithelially denuded AM and in basal and some suprabasal layers of stratified HLE transplanted in nude

233 of keratinocytes in the basal and immediate suprabasal layers of stratified squamous epithelia.

234 velope that is specifically expressed in the suprabasal layers of stratifying squamous epithelia.

235 nfection, late gene expression occurs in the suprabasal layers of the cervical epithelium.

236 cells were dissociated either upward to the suprabasal layers of the epidermis or downward into the

237 21 is normally expressed in the post-mitotic suprabasal layers of the epidermis, overlapping with Grh

238 defensin-2 immunoreactivity was found in all suprabasal layers of the epidermis, the distal outer roo

239 with interleukin-1 express keratin 6 in all suprabasal layers of the epidermis, throughout the tissu

240 zed by abnormal keratinocyte adhesion in the suprabasal layers of the epidermis.

241 tion in MK6a(-/-) mice was restricted to the suprabasal layers of the epidermis.

242 layer and more diffusely upregulated in the suprabasal layers of the epidermis.

243 Suprabasin was detected in the suprabasal layers of the epithelia in the tongue, stomac

244 HPV-16 life cycle occurs in the postmitotic suprabasal layers of the epithelium, where the virus amp

245 layers of central corneal epithelium and the suprabasal layers of the limbus stained positively for R

246 protein whose expression is confined to the suprabasal layers of the palmoplantar epidermis.

247 inocytes in normal skin and to the basal and suprabasal layers of the psoriatic epidermis, coincident

248 to differentiating sebocytes located in the suprabasal layers of the sebaceous gland.

249 r, became dispersed throughout the basal and suprabasal layers of the skin at 48 hours and paralleled

250 Expression of K8 + 18 persisted in the suprabasal layers of the stratified epithelium for sever

251 al hyperplastic lesions were detected in the suprabasal layers of ZD esophagi.

252 A consequent increase in cell density of suprabasal layers results in a thicker than normal CE.

253 Smad2 through -5 exhibited greater levels in suprabasal layers than basal keratinocytes.

254 Suprabasal layers upregulated desmosomal cadherins, but

255 fraction of total labeled nuclei detected in suprabasal layers was increased from 19 to 39%.

256 rmis, TIG3 is present in the differentiated, suprabasal layers, and it regulates terminal differentia

257 Ks 5/6 and 14 were detected in the basal and suprabasal layers, and spots of CK 13 were detected in t

258 helia; it becomes membrane associated in the suprabasal layers, coincident with up-regulation of peri

259 urine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous

260 mber of S-phase competent cells in the upper suprabasal layers, while the opposite was seen with the

261 n epidermis it is expressed in the basal and suprabasal layers.

262 The expression of Glis1 is restricted to the suprabasal layers.

263 oss of transgene expression in the immediate suprabasal layers.

264 expression of Cx43 and -30 in the basal and suprabasal layers.

265 repaired DNA damage more rapidly than KCs in suprabasal layers.

266 as restricted to the proliferating basal and suprabasal layers.

267 of detachment occurs in the basal and lower suprabasal layers.

268 reactivity in the terminally differentiating suprabasal layers; this pattern was similar to that seen

269 as shown by the absence of expression of the suprabasal markers loricrin and involucrin.

270 The effects of suprabasal MEK1 on basal keratinocytes and leukocytes, c

271 but epidermis displayed hyperproliferation, suprabasal mitoses, and multinucleated cells.

272 so supports keratinocyte differentiation and suprabasal morphogenesis.

273 The presence of Bmi-1 in suprabasal non-proliferative cells of the epidermis and

274 ion of activated MAPK kinase 1 (MEK1) in the suprabasal, nondividing, differentiated cell layers (Inv

275 ermis connexin 26 was also located mainly in suprabasal, nonproliferating cells.

276 l warts connexin 26 was restricted mainly to suprabasal, nonproliferating cells.

277 l and in nonlesional psoriatic skin, but was suprabasal or completely absent in lesional psoriatic sk

278 -transgene expression often is restricted to suprabasal or follicular epithelial cells that may lack

279 erentiated transient amplifying cells in the suprabasal ORS.

280 Therefore, TGF-beta1 in suprabasal/outer epidermal layers might inhibit LC activ

281 the proliferative basal and differentiating suprabasal populations of the mouse epidermis.

282 sed II-4 cells had been actively sorted to a suprabasal position where their clonal expansion was lim

283 hough transgene expression was restricted to suprabasal, postmitotic cells.

284 ic epidermis resulted in increased basal and suprabasal proliferation marker expression, decreased di

285 with opposite effects on gene expression of suprabasal proteins.

286 apical cell layers of the cornea and to the suprabasal region of the conjunctival epithelium.

287 essed on particular epithelia, including the suprabasal region of the epidermis, the basal layer of b

288 ntiation, which was expressed throughout the suprabasal region.

289 pressed in epidermis, may play a role in the suprabasal repression of the keratin 5 and 14 genes beca

290 Driven by the suprabasal-specific keratin-10 gene promoter, expression

291 curately recapitulates the normal pattern of suprabasal (spinous and granular layer) expression in tr

292 the ML.myc2 epidermis were also found to be suprabasal, suggesting an inhibition of terminal differe

293 matrix-deficient, these cells are capable of suprabasal survival and proliferation.

294 As basal cells become suprabasal, they lose proliferative potential and embark

295 We present a model in which FGF generates suprabasal tissue by asymmetric cell division, while Shh

296 cessary for, and promotes, invagination once suprabasal tissue is generated.

297 Here we show that suprabasal type II keratins, K1 and K2, are expressed in

298 functional tight junctions (TJ) to the most suprabasal viable layer.

299 nfected keratinocytes migrate up through the suprabasal wart layers.

300 led cell in the corneal epithelium (basal or suprabasal) was determined.