ライフサイエンスコーパス: supraphysiologic

1 Reconstitution of MBLdS with supraphysiologic (24 microg/ml) concentrations of MBL-MA

2 lation of Nf1 in bone-forming cells leads to supraphysiologic accumulation of pyrophosphate (PPi), a

3 activity levels of CD8(+) T cells expressing supraphysiologic affinity TCR were gradually restored.

4 re was a gradual attenuation in activity for supraphysiologic affinity TCR with K(D) < approximately

5 ical, region of acinar cells observed during supraphysiologic agonist stimulation were dependent on R

6 This work addresses mechanisms by which supraphysiologic alphaTOC may contribute to stroke-induc

7 t show noticeable complement cleavage unless supraphysiologic amounts of enzymes were used.

8 lls isolated from tumors stably overproduced supraphysiologic amounts of IL-12, and the therapeutic e

9 This can result in supraphysiologic amounts of NO and cause oxidative injur

10 Initially, we investigated the effects of supraphysiologic amounts of ProCT administered to animal

11 th a wide range of C. albicans inocula under supraphysiologic and near-physiologic (at estrus) concen

12 A moderately supraphysiologic androgen regimen that included an anabo

13 in injury was exacerbated in the presence of supraphysiologic brain alphaTOC levels.

14 e myelogenous leukemias when administered at supraphysiologic but nontoxic doses.

15 However, when stimulated with supraphysiologic CCK-8 levels to mimic pancreatitis, Mun

16 y enhancing BCR signaling, only B cells with supraphysiologic CD45 expression became anergic, whereas

17 Although both E613R B cells and those with supraphysiologic CD45 expression exhibited hyperresponsi

18 However, supraphysiologic cFVIII levels correlated with the forma

19 Supraphysiologic changes in extracellular pH (pHo) modul

20 gic concentrations of carbachol (1 muM) to a supraphysiologic concentration (1 mM) that leads to prot

21 otoxic effects caused by chronic exposure to supraphysiologic concentration of glucose are only minim

22 Supraphysiologic concentrations of 17beta-estradiol, est

23 titis models is created by administration of supraphysiologic concentrations of caerulein, an ortholo

24 Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes advers

25 overwhelmed by oxidative insults, including supraphysiologic concentrations of O2 (hyperoxia).

26 Prolonged exposure of isolated islets to supraphysiologic concentrations of palmitate decreases i

27 In contrast, supraphysiologic concentrations of TGF-beta had no effec

28 imulated innate cytokine production, even at supraphysiologic concentrations.

29 nerve agent poisoning will likely need both supraphysiologic doses and frequent re-dosing of atropin

30 Supraphysiologic doses induced formation of cytoplasmic

31 patients with high doses of oral calcium and supraphysiologic doses of 1 alpha,25-dihydroxyvitamin D(

32 in isolated pancreatic acini stimulated with supraphysiologic doses of cholecystokinin (CCK-8), remai

33 mone agonist leuprolide acetate, adding back supraphysiologic doses of estradiol and progesterone for

34 In Hfe(-/-) mice, supraphysiologic doses of exogenous BMP6 improved hepcid

35 fortification but remain very responsive to supraphysiologic doses of folic acid-based supplementati

36 ed in the analysis because they had received supraphysiologic doses of GCs (doses above the lowest te

37 Adding supraphysiologic doses of levothyroxine (L-T4) to standa

38 Supraphysiologic doses of testosterone, especially when

39 ansgenic overexpression or administration of supraphysiologic doses, rather than in a physiologic set

40 tly contrasts with previous reports based on supraphysiologic dosing.

41 An absolute, supraphysiologic elevation in GFR is observed early in t

42 ed cell-surface epitopes despite recognizing supraphysiologic exogenously added epitopes.

43 Moreover, supraphysiologic expression of BAFF in the setting of on

44 Although "supraphysiologic" expression of human complement regulat

45 This resulted in sustained supraphysiologic FIX activity (400%), correction of the

46 asmid into hemophilia A (HemA) mice achieved supraphysiologic FVIII expression, but triggered product

47 ases or in normal aging, or about the use of supraphysiologic GH doses to treat catabolic states.

48 Chronic exposure of HIT-T15 cells to supraphysiologic glucose concentration diminishes insuli

49 ulture of HIT-T15 cells in medium containing supraphysiologic glucose concentrations (11.1 mmol/l) ca

50 ly that chronic exposure of HIT-T15 cells to supraphysiologic glucose concentrations causes decreased

51 osure of pancreatic islet beta-cell lines to supraphysiologic glucose concentrations causes defects i

52 stimulates NHE3 transport activity, whereas, supraphysiologic glucose concentrations inhibit this exc

53 Chronic exposure of beta-cells to supraphysiologic glucose concentrations results in decre

54 The supraphysiologic gonadal steroid levels of pregnancy and

55 tly packaged within AAV virions and mediated supraphysiologic hFVIII expression (732 +/- 162% of norm

56 s heparin or glycerol during physiologic and supraphysiologic hyperinsulinemia, by combining microdia

57 No adverse effects of supraphysiologic hyperosmolarity such as renal failure,

58 However, at supraphysiologic inputs, large quantities of vitamin D(3

59 ng glucose transport without insulin or with supraphysiologic insulin.

60 With supraphysiologic K(+) intake (5% K(+)), AS(-/-) mice dec

61 , renal adaptation to a physiologic, but not supraphysiologic, K(+) load can be achieved in aldostero

62 scAAV particles led to expression of hFIX at supraphysiologic levels (8I U/mL) and correction of the

63 pg/mL), whereas the E2 50 group still showed supraphysiologic levels 360 min after administration (24

64 lls has been attributed to the production of supraphysiologic levels of cyclic AMP by the toxin.

65 As expected, the animals developed supraphysiologic levels of EPO and polycythemia.

66 It also caused resistance to supraphysiologic levels of erythropoiesis-stimulating ag

67 Exposure to supraphysiologic levels of glucocorticoid drugs is known

68 ays a major role in scavenging exogenous and supraphysiologic levels of H2O2, although this enzyme ca

69 We found that supraphysiologic levels of insulin or insulin-like growt

70 ussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAM

71 c macrophages were activated with H. pylori, supraphysiologic levels of L-Arg were required to permit

72 In contrast, supraphysiologic levels of plasma FFA (4,111 +/- 1,709 n

73 Only supraphysiologic levels of sEPCR could influence protein

74 i in vitro by an NO-dependent mechanism, but supraphysiologic levels of the iNOS substrate l-arginine

75 Serum MIS in the mice rose to supraphysiologic levels over time.

76 of elevated brain alphaTOC establish that at supraphysiologic levels, alphaTOC potentiates neuroinfla

77 , peripheral concentrations are increased to supraphysiologic levels, with likely effects on diverse

78 evidence of adverse effects of Ca2+ even at supraphysiologic levels.

79 me a strong activator only when expressed at supraphysiologic levels.

80 characterize the effects of physiologic and supraphysiologic loads of intraduodenal leucine on eatin

81 sion is induced by airway hyperinflation and supraphysiologic lung volumes.

82 We conclude that although supraphysiologic Notch signaling in HSCs promotes LSC ac

83 atural affinity range, along with an extreme supraphysiologic one having 1400-fold enhanced affinity,

84 besity body-fat depletion by leptin requires supraphysiologic plasma concentrations that exceed the l

85 Exogenous IFN-alpha induces supraphysiologic restriction factor expression associate

86 representing diseases with undetectable and supraphysiologic serum CA19.9 levels.

87 ir initial reinforcing effects by triggering supraphysiologic surges of dopamine in the nucleus accum

88 ited robust T-cell recoveries by day 14 with supraphysiologic T-cell counts accompanied by a sustaine

89 Supraphysiologic T-cell proliferation, a hallmark of thi

90 CD8 T cells transduced with this supraphysiologic TCR produced a greater range of soluble

91 Both sub- and supraphysiologic testosterone levels may influence bone

92 surgery (SHAM), gonadectomy (GX), or GX plus supraphysiologic testosterone-enanthate (TE) administrat

93 ings provide evidence that administration of supraphysiologic thyroid hormone improves depressive sym

94 Thus, supraphysiologic Yap polypeptide levels are necessary to