ライフサイエンスコーパス: supraphysiological

1 These levels could be considered as supraphysiological.

2 both physiological (300 pM or 70 pg/mL) and supraphysiological (10 nM or 2.3 ng/mL) concentrations o

3 armacological targeting of MEK1/2 results in supraphysiological activity of the ERK5 pathway.

4 increase in systemic FIX protein levels and supraphysiological activity over a range of vector doses

5 mal function (K(d) = 5 to 1 muM), those with supraphysiological affinity (K(d) = 1 muM to 15 nM) show

6 ering B-vitamin treatment regimens featuring supraphysiological amounts of FA or the reduced folate,

7 e cultures to proliferate in the presence of supraphysiological amounts of p27(kip1) but did not stim

8 rite selectively dilates conduit arteries at supraphysiological and near-physiological concentrations

9 Supraphysiological Ca(2+) levels diminished stimulation

10 layer studies had been commonly conducted at supraphysiological [Ca2+] and [K+], we determined the ef

11 lar myocardium, mouse cardiac muscle resists supraphysiological [Ca2+]o.

12 host cell cytosol where it rapidly generates supraphysiological cAMP concentrations, which inhibit ho

13 us derivative of whole blood that contains a supraphysiological concentration of platelets, is though

14 fter 7 days of elevated resistin levels at a supraphysiological concentration, the animals displayed

15 d DnaJ was observed, but the requirement for supraphysiological concentrations makes it unlikely that

16 ivo at physiological levels (pg/ml), whereas supraphysiological concentrations of 17-beta E(2) (ng/ml

17 h betaAPP-expressing HEK293 cells triggering supraphysiological concentrations of Abeta peptides, NF-

18 By contrast, supraphysiological concentrations of Adn resulting from

19 By contrast, supraphysiological concentrations of Adn resulting from

20 We postulate that media containing supraphysiological concentrations of chloride or other i

21 nzymatic activity and is induced in vitro by supraphysiological concentrations of citrate (> 5 mM).

22 emonstrate that when evaluated individually, supraphysiological concentrations of either E2 (200 nM)

23 arterial smooth muscle cells are exposed to supraphysiological concentrations of glucose, and this e

24 Supraphysiological concentrations of IL3 or SCF prevent

25 rrow microenvironment and in the presence of supraphysiological concentrations of interleukin-3 (IL3)

26 by partial proteolysis or by the binding of supraphysiological concentrations of polyunsaturated lon

27 Many in vitro reports use supraphysiological concentrations of these drugs to demo

28 f various cancer cells; however, significant supraphysiological concentrations of this compound are r

29 ne formation after injury; however, the high supraphysiological concentrations required for desired o

30 Plasma triiodothyronine levels increased to supraphysiological concentrations with hormonal therapy.

31 etic Abeta peptides of one defined length at supraphysiological concentrations, but the existence of

32 ngle-channel analysis, we show that, even at supraphysiological concentrations, flecainide did not in

33 At supraphysiological concentrations, glucocorticoids alone

34 re effective against CHIKV as monotherapy at supraphysiological concentrations.

35 However, under supraphysiological conditions, upon infusion with increa

36 ty stems mainly from studies performed under supraphysiological conditions.

37 embryos, 9-cis-RA was undetectable unless a supraphysiological dose of all-trans-RA was administered

38 ther restated or challenged the conventional supraphysiological doses of 'stress steroids', while oth

39 ned oral B-vitamin supplementation featuring supraphysiological doses of folic acid.

40 Supraphysiological doses of insulin enhance total limb b

41 ected with P. berghei inocula incubated with supraphysiological doses of NO (< or =150 microM) or wit

42 Effective bleeding control requires supraphysiological doses of rFVIIa, posing both high exp

43 When administered to rodents at supraphysiological doses, ghrelin activates hypothalamic

44 ase insulin sensitivity when administered at supraphysiological doses, we determined the effect of 6

45 ed an attenuated trabecular bone response to supraphysiological E2 treatment.

46 ion or differentiation, but IL-2 can promote supraphysiological expansion when supplied exogenously.

47 Sustained and supraphysiological expression of 770% normal was observe

48 Supraphysiological expression of DKF-1 limited C. elegan

49 metabolite biomarkers readily discriminates supraphysiological glucocorticoid replacement doses in p

50 ally, we observed that prolonged exposure to supraphysiological glucose concentration impaired SOCs f

51 idation, and via hexosamine metabolism under supraphysiological glucose concentrations, we hypothesiz

52 m the adverse effects of chronic exposure to supraphysiological glucose concentrations.

53 insulin gene transcription in conditions of supraphysiological glucose levels.

54 rowth of gmps null cells was only rescued by supraphysiological guanine concentrations (100 muM) or b

55 e, at concentrations generally thought to be supraphysiological, has the potential for disrupting glu

56 treatment consisting of administration of a supraphysiological heat dose in the presence of an antip

57 Supraphysiological IGF-I concentrations were maintained

58 lly produce IDUA, and resulted in a >10-fold supraphysiological increase in IDUA activity.

59 Both a postprandial and supraphysiological insulin clamp significantly increased

60 ke in excess of energy expenditures, chronic supraphysiological intake of dietary sodium, excessive a

61 Supraphysiological leptin levels were necessary to resto

62 Further increase in dietary selenium to supraphysiological levels (0.4 ppm) had very little or n

63 ficantly induce the release of HMGB1 even at supraphysiological levels (up to 200 ng/ml).

64 (V600E)BRAF, expressed at supraphysiological levels because of (V600E)BRAF ultra-a

65 dequate (0.08 ppm; sodium selenite), and two supraphysiological levels in the form of Se-supplemented

66 differentially regulated at physiological or supraphysiological levels of amyloid beta (Abeta) peptid

67 ivated by endogenous calmodulin, it produces supraphysiological levels of cAMP.

68 We hypothesize that supraphysiological levels of CSO(4) in keratinocyte memb

69 Here we show that supraphysiological levels of D-mannose safely achievable

70 Supraphysiological levels of estrogens act as antioxidan

71 ent mice treated with the hgAI vector showed supraphysiological levels of expression of human APOA-I

72 not observed in physiological or even highly supraphysiological levels of fluid flow.

73 MglA-dependent proteins was repressed by the supraphysiological levels of free amino acids present in

74 Although AAV2/5 alone provided supraphysiological levels of GALC activity and reduced p

75 stinct from canonical responses generated by supraphysiological levels of H2O2.

76 Supraphysiological levels of LXA4 are generated during i

77 How cells discriminate physiological from supraphysiological levels of Myc is largely unknown.

78 mediator Stat5 in the presence of normal and supraphysiological levels of PRL.

79 ine suggested increased oxidation of PGE2 at supraphysiological levels of Se that also correlated wel

80 a phenomenon relevant to the requirement for supraphysiological levels of this hormone in differentia

81 Furthermore, supraphysiological levels of uridine are required to pro

82 n deliver a lysosomal enzyme continuously at supraphysiological levels to the bloodstream and can cor

83 eeks later when oestrogen production reached supraphysiological levels.

84 Our results imply that relatively small (but supraphysiological) levels of dATP increase the number o

85 timulatory effect (22-27%) was observable at supraphysiological maximal ADP-stimulated respiration at

86 Supraphysiological mechanical stretching in smooth muscl

87 formation, its clinical applications require supraphysiological milligram-level doses that increase p

88 o short telomeres, DNA damage, oncogenes and supraphysiological mitogenic signals, and overexpression

89 tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise ar

90 eptide that contains both nuclear import and supraphysiological nuclear export signals.

91 isease, tumor-bearing mice treated i.v. with supraphysiological numbers of syngeneic gammadelta T cel

92 maximum deformability when equilibrated with supraphysiological O(2) concentrations.

93 Ventilator treatment with supraphysiological O2 concentrations (hyperoxia) contrib

94 of MLL leukemia pathogenesis, but often use supraphysiological oncogene expression with uncertain im

95 hile most cartilage research is performed in supraphysiological oxygen levels (19-21%), culturing cho

96 MLL-ENL target loci showed supraphysiological PAF1 binding, hyperubiquitination of

97 proximately 1.0 mmol/L and as much as 60% at supraphysiological plasma lactate concentrations when th

98 CONCLUSIONS; GIP, given to achieve supraphysiological plasma levels, still had an early, sh

99 ican culture frequently leads to exaggerated supraphysiological post-prandial spikes in blood glucose

100 This triple agonist demonstrates supraphysiological potency and equally aligned constitue

101 an be evoked by depolarization of a rod to a supraphysiological potential (-20 mV) that activates a l

102 re of rabbit aorta, longitudinal stretch and supraphysiological pressure applied for 3 hours during i

103 At supraphysiological release rates (>2 micrometer/s) NO( s

104 dulate Myc activity from essentially null to supraphysiological resulted in a significantly increased

105 heories offer different explanations for the supraphysiological rFVIIa dosing requirement: (1) the ne

106 R regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal

107 o this affinity support, and are released at supraphysiological salt concentrations in a relatively p

108 ype of Sepp1(-/-) mice, as these mice needed supraphysiological selenium supplementation to survive,

109 0(9) transducing particles of either vector, supraphysiological serum levels of hFIX were obtained, w

110 and dehydrated state, which is maintained at supraphysiological temperatures.

111 Daily supraphysiological vitamin K supplementation restores cl