コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 phatase and by purinergic receptor blockade (suramin).
2 -naphthylazo-6-nitro-4',8'-disulfonate), and suramin.
3 (s) underlying the antimitogenic activity of suramin.
4 tidase apyrase and the P2 receptor inhibitor suramin.
5 ure-assisted design of improved analogues of suramin.
6 arable or significantly improved relative to suramin.
7 nt made a complete recovery after 5 weeks of suramin.
8 ere then directly assessed in the absence of suramin.
9 ring raw beef, and successfully treated with suramin.
10 sphate 6-azophenyl-2',4'-disulfonic acid and suramin.
11 or in activation of RyR2 channels by Ca2+ or suramin.
12 d lysyl oxidase expression in the absence of suramin.
13 imal activity at pH 8--9 and is inhibited by suramin.
14 -specific P2X receptor antagonists, PPADS or suramin.
15 ith apyrase or blockade of P2 receptors with suramin.
16 nists XAMR 0721, periodate-oxidized ATP, and suramin.
17 tive randomized comparison of three doses of suramin.
18 nergistic interaction between paclitaxel and suramin.
19 ibition of SHP-1 by the reversible inhibitor suramin.
20 plete reversal in the presence of <20 microM suramin.
21 arbohydrate elicitors were also inhibited by suramin.
22 (33% v 16%; P =.01) in patients who received suramin.
23 ation, but neither response was inhibited by suramin.
24 eparin interact with elicitor receptors like suramin.
25 of systemin was inhibited in the presence of suramin.
26 curve to increases in CO2 was reduced after suramin.
27 rine cytokines but can still be inhibited by suramin.
28 ch was blocked in the presence of 100 microM suramin.
29 hat was additive to insulin and inhibited by suramin.
30 on is sensitive to the purinergic antagonist suramin.
31 -) mice and C57BL/6 mice given injections of suramin.
32 ch is antagonistic to another anti-HAT drug, suramin.
33 re blocked by the P2Y(2) receptor antagonist suramin.
34 o eflornithine and increasing sensitivity to suramin.
35 as did treatment with the purinergic blocker suramin.
36 sphate 6-azophenyl-2',4'-disulfonic acid and suramin.
37 c application of the P2 receptor antagonists suramin (0.02 M) and pyridoxal-phosphate-6-azophenyl-2',
38 ts were abolished by the P2 receptor blocker suramin (0.02 M, 80 nA), which also reduced the baseline
39 n the presence of the P2-receptor antagonist suramin (0.1 mM), the amplitude of vasoconstrictions to
40 disulfonic acid (PPADS) (0.1-100 microM) and suramin (1-300 microM) inhibited contractions evoked by
41 treated i.v. with paclitaxel (15 mg/kg) and suramin (10 mg/kg) administered twice weekly for 3 weeks
43 Pretreatment of Galpha12WT-NIH3T3 cells with suramin (100 microM), a receptor-uncoupling agent, inhib
53 e insensitive to block by the P2X antagonist suramin (300 microM) but were prevented by incubation in
60 The G-protein G(beta)gamma subunit blockers suramin (8,8'-[carbonylbis[imino-3,1-phenylen ecarbonyli
61 , 4'-disulphonic acid (20 mg kg-1, i.v.) and suramin (80 mg kg-1, i.v. ) each antagonised both the ea
63 h higher than CM-cholesterol (P < 0.01), and suramin (a lipoprotein receptor antagonist) decreased ch
66 enhanced their sensitivity to cisplatin; 3) suramin, a growth factor receptor antagonist that greatl
68 d by the polysulfonated naphtylurea compound suramin, a known inhibitor of cytokine and growth factor
74 netic analysis of the inhibition of SIRT5 by suramin, a potent sirtuin inhibitor previously shown by
75 APAP in insulin signaling were prevented by suramin, a PTP1B inhibitor, or rosiglitazone that decrea
83 ase (MLCK) in smooth muscles, the effects of suramin/alpha,beta-methylene ATP (alpha,beta-meATP) (pur
85 ment with the purinergic receptor antagonist suramin also partly suppressed early regenerative signal
88 d this response was blocked by coaddition of suramin, an inhibitor of FGF ligand-receptor interaction
89 um chemoresistance in solid tumors, and that suramin, an inhibitor of multiple growth factors includi
92 P-induced vasodilation was inhibited by both suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP)
93 Further, it is blocked by pre-incubation in suramin and by a selective protein kinase A inhibitor (H
95 that can be inhibited by pertussis toxin and suramin and can be desensitized by ATP and ADP, suggesti
102 hosphate-6-azophenyl-2',4'-disulphonic acid, suramin and kynurenic acid) significantly decreased base
105 mouse receptor, the sensitivity to block by suramin and NF449 was much increased for E138K, but not
107 by the purported close binding proximity of suramin and nicotinamide, we prepared two sets of fragme
108 A, B, and C, and sulfated compounds such as suramin and pentosan efficiently extract TIMP-3 from the
109 ytes with P2 receptor antagonists, including suramin and periodate oxidized ATP (oATP), resulted in a
110 llular adhesion molecule-1 (ICAM-1), whereas suramin and PPADS decreased both ATPgammaS-induced and b
112 potentiated by ivermectin but insensitive to suramin and PPADS, and it permeated the large cation N-m
114 -induced currents were blocked by 100 microm suramin and pyridoxal phosphate 6-azophenyl-2',4'-disulf
116 re was little or no effect on sensitivity to suramin and pyridoxal-phosphate-6-azophenyl-2,4-disulfon
123 her investigation, and two known inhibitors, suramin and SirReal2, were profiled against substrates c
124 and nuclear influx of Myb3 were inhibited by suramin and SQ22536, respective inhibitors of the Galpha
125 enhancement of the efficacy of paclitaxel by suramin and support the use of nontoxic doses of suramin
127 ATP signaling by the P2Y1 blockers, MRS2176, suramin, and apyrase, reduces Ca(2+) transients and reta
130 P2X1 receptor, which is inhibited by NF449, suramin, and pyridoxal-phosphate-6-azophenyl-2,4-disulfo
131 g bicuculline-resistant mPSCs are blocked by suramin, and their decay phase is briefer than that of G
132 phylline, but not the P2-receptor antagonist suramin, antagonized the effect of AP4A, suggesting that
138 he basis of the feasibility of administering suramin, as judged by the number of patients who develop
139 habeta-MethyleneADP enhanced the fade, while suramin at 50 micrometer prevented the early component o
141 e significantly inhibited by oATP but not by suramin; ATP-induced apoptosis was significantly inhibit
142 f a suramin molecule, could not compete with suramin binding and oligomerization suggesting that the
143 n bound to protein provided evidence for two suramin-binding sites on each C9 and three on each C8 in
145 Results of the NMR experiments reveal that suramin binds to residues in the heparin binding pocket
149 y genistein, but not G-protein inhibition by suramin, blocked FN-induced intracellular Ca(2+) signali
150 r HC067047 or purinergic receptor antagonist suramin blunted flow/pressure-evoked vasoconstriction, w
152 (oATP) but not by the P2 receptor antagonist suramin; both ATP and BzATP increase intracellular Ca(2+
154 tment with the growth factor receptor poison suramin but was sensitive to treatment with the PI 3-K i
155 y chemoreceptor stimulation was depressed by suramin, but convergent excitatory inputs from pharyngo-
156 by the purinergic receptor (P2X) antagonist suramin, but they are totally unaffected by the alpha1 a
158 e axonal neuropathies, tacrolimus and rarely suramin can result in a demyelinating neuropathy that ma
162 philic medications (amiodarone, chloroquine, suramin, clofazimine, etc.) may produce a drug-induced l
163 er adjusting for treatment arm, the measured suramin concentration was not associated with clinical r
166 Oligomerization could be reversed by high suramin concentrations, but 8-aminonaphthalene-1,3,6- tr
168 s BBG and oxidized ATP, but not by 30 microM suramin, consistent with the actions of the P2X(7) recep
169 erally long-term release and, in the case of suramin, cross-linked hydrogels that can modulate cellul
175 sphate-6-azophenyl-2',4'-disulfonic acid and suramin) did not block adenosine- or AMP-evoked activati
179 ethylene ATP, and the purinergic antagonist, suramin, effectively inhibited the local Ca2+ transients
180 rther showed that an inhibitor of aFGF/bFGF (suramin) enhanced the in vitro and in vivo activity of c
181 the determination of the binding affinity of suramin for PTPases and several catalytically impaired m
184 e patient who "progressed" after 12 weeks of suramin had a subsequent marked reduction in tumor size
189 cid hexasodium salt), a structural analog of suramin, has an increased affinity for TIMP-3 and increa
192 hropathy, administration of a single dose of suramin immediately after ureteral obstruction abolished
198 city, while some patients with tacrolimus or suramin-induced demyelinating neuropathy may respond to
199 trypsin digestion analysis data suggest that suramin-induced oligomerization of hFGF-1 occurs in two
200 ing excitation-contraction coupling and that suramin-induced potentiation of voltage-gated Ca(2+) rel
204 cultured renal interstitial fibroblasts with suramin inhibited their activation induced by TGF-beta1
205 s the molecular interactions responsible for suramin inhibition of heparin binding, which could be of
208 th factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is un
209 knowledge, this is the first study in which suramin interaction sites on FGF have been characterized
210 in this structure, and other details of VCP-suramin interactions, might provide useful structural in
211 Using a radioreceptor assay, we show that suramin interfered with the binding of the systemin anal
217 Collectively, these findings indicate that suramin is a potent antifibrotic agent that may have the
222 monstrating the generality of this approach, suramin led to the formation of the best hydrogels per u
223 The larger than anticipated flexibility of suramin manifested in this structure, and other details
225 n, cAMP/protein kinase A pathway inhibitors, suramin, MDL12330A, or H89 suppressed bile acid-mediated
226 trisulfonate (ANTS2- ), which mimics half a suramin molecule, could not compete with suramin binding
227 y relevant doses of the other anti-HAT drugs suramin, nifurtimox or melarsoprol, but a significant in
228 ze-exclusion chromatography data reveal that suramin oligomerizes hFGF-1 to form a stable tetramer.
229 ls), we sought to investigate the effects of suramin on the phenotype of transformed cells and the ro
230 with this, TF up-regulation was inhibited by suramin or by siRNA silencing of P2Y(2) receptor, but no
233 photoreceptors with the G protein uncoupler suramin or pertussis toxin, which inactivates Gi/o/z pro
234 apyrase and blockade of P2Y-purinoceptors by suramin or reactive blue 2 inhibited both beta-blocker-i
235 addition of an anti-FGF-2 blocking antibody, suramin, or treatment with either sodium chlorate or hep
237 ved raise questions regarding the utility of suramin, particularly high-dose suramin, as administered
241 460 HRPC patients were randomized to receive suramin plus hydrocortisone (n = 229) or placebo plus hy
243 , and TTPP, both in the entire group and the suramin plus hydrocortisone group at all three landmarks
244 data from a multicenter randomized trial of suramin plus hydrocortisone versus hydrocortisone alone.
245 In this prospective, randomized trial of suramin plus hydrocortisone versus placebo plus hydrocor
246 provement in a randomized phase III trial of suramin plus hydrocortisone versus placebo plus hydrocor
251 TP, were blocked by P2Y receptor antagonists suramin, pyridoxal-phosphate-6-azophenyl-2',4'-disulfona
253 ished by antagonism of purinergic receptors (suramin+RB2) or TXA2 receptor (SQ29548), or by intratrac
255 cells with high salt, protamine, heparin, or suramin released significant VEGF, suggesting that hepar
256 01), and duration of response was longer for suramin responders (median, 240 v 69 days; P =.0027).
259 duces PKB/Akt activation in an SB203580- and suramin-sensitive manner, suggesting p38 MAPK-dependent
261 e parasite population lead to differences in suramin sensitivity, a drug commonly used to treat this
262 urintricarboxylic acid (ATA) (IC50=1.4 muM), suramin sodium salt (IC50=3.6 muM), NF 023 hydrate (IC50
264 adenosine 3',5'-bisphosphate (MRS-2179), and suramin, suggesting that ATP released by neural cells ac
265 in a higher proportion of patients receiving suramin than placebo (43% v 28%; P =.001), and duration
271 with the non-selective purinergic antagonist suramin to test the role of purinergic signaling in C57B
273 to receive low-, intermediate-, or high-dose suramin (total doses 3.192, 5.320, and 7.661 g/m(2), res
275 8-day fixed dosing schedule (one cycle), and suramin treatment cycles were repeated every 6 months fo
277 life nor performance status was decreased by suramin treatment, and overall survival was similar.
278 surface glycoprotein (ISG75) family mediates suramin uptake, and the AP1 adaptin complex, lysosomal p
279 Analysis of the experimental results of suramin using quantitative pharmacology (QP) modeling in
280 d in vivo interaction between paclitaxel and suramin, using human PC3-LN cells which, upon i.v. injec
281 rmore, because only EDG-3 was antagonized by suramin, variations in receptor structure may determine
282 in the uptake of the antitrypanosomal drug, suramin, via invariant surface glycoprotein 75, and in t
288 The inhibition of medium alkalinization by suramin was reversible in the presence of high concentra
291 was used to hydrolyze extracellular ATP, and suramin was used to block apical P2Y ATP receptors.
292 phosphate, heparin, clodronate, trypan, and suramin, we demonstrate the utility of this strategy.
293 and also of the fluorescence enhancement of suramin when bound to protein provided evidence for two
294 mycin SV, doxycycline, and another molecule, suramin, which binds but does not inhibit Cu(II)-induced
299 min and support the use of nontoxic doses of suramin with paclitaxel in the treatment of lung cancer.
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。