ライフサイエンスコーパス: surface ectoderm

1 luding retinal cells, lens cells, and ocular-surface ectoderm.

2 mouse line, which expresses Cre in the head surface ectoderm.

3 m depends on its interaction with overlaying surface ectoderm.

4 gression in the urethral endoderm and in the surface ectoderm.

5 m, neural crest, ocular-surface ectoderm, or surface ectoderm.

6 r midline transition between neural tube and surface ectoderm.

7 imary mechanism for lens separation from the surface ectoderm.

8 In the mouse, the lens forms from the head surface ectoderm.

9 ation of beta-catenin expression in the head surface ectoderm.

10 ed in an overlapping manner with Wise in the surface ectoderm.

11 ese tissues, a crucial source of Edn1 is the surface ectoderm.

12 with more focused QSulf1 expression in r2/3 surface ectoderm.

13 on arising from the border of the neural and surface ectoderm.

14 maintained independently of r5, but requires surface ectoderm.

15 a tissue explant containing neural plate and surface ectoderm.

16 antagonistic signals from the notochord and surface ectoderm.

17 pheral nervous system, developing liver, and surface ectoderm.

18 the lens fails to detach completely from the surface ectoderm.

19 istent adhesion of the lens to the overlying surface ectoderm.

20 tocols were used to replace FGF secretion by surface ectoderm: (1) implantation of FGF-secreting fibr

21 To test this hypothesis in vivo we removed surface ectoderm, a rich source of FGFs.

22 teins mediate the dorsalizing effects of the surface ectoderm and dorsal neural tube on somites.

23 irecting sclerotome development, whereas the surface ectoderm and dorsal neural tube provide a dorsal

24 y the sclerotome, while the dorsally located surface ectoderm and dorsal neural tube provide the dors

25 at the surrounding extraocular tissues - the surface ectoderm and extraocular mesenchyme - are necess

26 th factors, which emanate from the overlying surface ectoderm and induce the adjacent neuroepithelium

27 cial tissue-specific functions in patterning surface ectoderm and its appendages by controlling divis

28 gnals from the axial tissues, as well as the surface ectoderm and lateral plate mesoderm, together ac

29 g their activation by Wnt signaling from the surface ectoderm and neural tube.

30 araxial mesoderm and in arch epithelia, both surface ectoderm and pharyngeal endoderm, but not in ske

31 development proceeds, including those of the surface ectoderm and placental vasculature.

32 the lens vesicle fails to separate from the surface ectoderm and the maturing lens is smaller and sh

33 inductive interactions between the embryonic surface ectoderm and the underlying neuroepithelium of t

34 g is ectopically activated in central ocular surface ectoderm and underlying mesenchyme in Pitx2- and

35 d, Brn-3.0 neurons develop in the absence of surface ectoderm and ventral midline tissue, suggesting

36 A levels are detected in somites, the dorsal surface ectoderm, and in vertebral cartilage primordia.

37 Par1 and Par2 were expressed in surface ectoderm, and Par2 was expressed selectively alo

38 The lens vesicle failed to separate from the surface ectoderm, and prospective lens and corneal epith

39 tic FGF10 with progressive maturation of the surface ectoderm, and show that full expression of somit

40 ad domain, including tissues in the foregut, surface ectoderm, and the head ganglion of the central n

41 ally exit it, thereby colonizing the ventral surface ectoderm anterior to the VER.

42 expressed in both the dorsal neural tube and surface ectoderm are also potent inhibitors of myogenesi

43 nterface between the neuroepithelium and the surface ectoderm, are required for completion of neural

44 d that PAA formation requires the pharyngeal surface ectoderm as a key signalling centre from which G

45 phalic neuroblasts which delaminate from the surface ectoderm as individual cells, cells of the dorso

46 hpf, before separation of the lens from the surface ectoderm, as evidenced by cell elongation, exit

47 strong regional expression in ventrolateral surface ectoderm at E10.5, much earlier than previously

48 is patterned molecularly, with dorsolateral surface ectoderm at the levels of r2/3 and r7 expressing

49 rsal neural tube and of Wnt4 and Wnt6 in the surface ectoderm at the time of dermomyotome specificati

50 crest cells that arise at the neuroectoderm/surface ectoderm border, but not for their initial forma

51 ting in a lateral shift of the neuroectoderm/surface ectoderm border.

52 have ablated the lens precursor cells of the surface ectoderm by generation of transgenic mice that e

53 Attachment of surface ectoderm cells to the neural plate is required f

54 ese results indicate that, in the absense of surface ectoderm, cells of the optic vesicles display bo

55 tgrowth involve coordinated morphogenesis of surface ectoderm, cloacal mesoderm and hindgut endoderm.

56 t contact between pharyngeal pouches and the surface ectoderm coincides with the onset of neurogenesi

57 During skin development, the single-layered surface ectoderm covering the mouse embryo must initiate

58 ed cranial neural tissue and reduced cranial surface ectoderm culminating in a lateral shift of the n

59 corneal morphogenesis, we deleted Cited2 in surface ectoderm derived ocular structures including cor

60 we deleted the Klf4 gene selectively in the surface ectoderm-derived structures of the eye (cornea,

61 porters, we showed that Wnt ligands from the surface ectoderm directly or indirectly elicit a Wnt/bet

62 F can mimic one of the earliest functions of surface ectoderm during eye development, namely the dema

63 The surface ectoderm expresses BMP-4 and we show that it is

64 The surface ectoderm expresses FGFs and the optic vesicles e

65 NC development, while blocking placodal and surface ectoderm fates.

66 chyme/BMP specifies pigmented epithelium and surface ectoderm/FGF specifies neural retina.

67 however, from the hindbrain forward, little surface ectoderm forms and the forebrain is enlarged and

68 and weakly in the surrounding mesenchyme and surface ectoderm, has crucial roles during lens inductio

69 vative, while the dorsal neural tube and the surface ectoderm have been shown to direct somite cells

70 Cells lacking Bmpr1a also contribute to surface ectoderm; however, from the hindbrain forward, l

71 General ocular surface ectoderm identity is maintained during developme

72 on by signals from neural tube/notochord and surface ectoderm in cultured presomitic mesoderm (PSM),

73 inhibits separation of the lens vesicle from surface ectoderm in mice heterozygous or homozygous for

74 Thus, BMP-4 signaling can substitute for the surface ectoderm in supporting nephric duct morphogenesi

75 d in the arch mesenchyme, pouch endoderm and surface ectoderm in the pharyngeal region of Eya1(-/-) e

76 ally fated to give rise to neuroectoderm and surface ectoderm, in a serum-free, chemically defined me

77 te that r3 neuroepithelium and its overlying surface ectoderm independently help maintain the NCC-fre

78 Finally, we demonstrate that avian cranial surface ectoderm is patterned molecularly, with dorsolat

79 to the nephric duct and demonstrate that the surface ectoderm is required for its differentiation.

80 tissue explants in vitro and confirmed that surface ectoderm is sufficient to induce paraxis express

81 gest that inductive interactions between the surface ectoderm, lateral mesoderm and intermediate meso

82 s indicative of lineage, spanning the ocular surface ectoderm, lens, neuro-retina, and retinal pigmen

83 ults also suggest that the lens cells of the surface ectoderm may be critical for the proper differen

84 gonistic signals from the dorsal neural tube/surface ectoderm, mediated by WNTs, and from the ventral

85 sensory neurons originate in placodes in the surface ectoderm, migrating to form ganglia that connect

86 c basis for the known synergistic actions of surface ectoderm/neural tube and notochord signaling in

87 This surface ectoderm/neural tube Wnt signaling has both nega

88 mesenchyme, pouch endoderm, and possibly the surface ectoderm of 3rd pharyngeal clefts.

89 RA) synthesized by Raldh3 in the frontonasal surface ectoderm of chick embryos has been suggested to

90 Acvr1 was deleted from the surface ectoderm of mouse embryos on embryonic day 9 usi

91 Finally, we found that the surface ectoderm of the 3rd and 4th pharyngeal region sh

92 placode which normally invaginates from the surface ectoderm of the embryo and gives rise to two sep

93 hat associated with Raldh3 expression in the surface ectoderm of the eye field.

94 ion of five pairs of mammary placodes in the surface ectoderm of the mouse embryo.

95 amined the influence of axial structures and surface ectoderm on paraxis expression by performing mic

96 sembling neuroectoderm, neural crest, ocular-surface ectoderm, or surface ectoderm.

97 that Wise, a Wnt modulator expressed in the surface ectoderm overlying the trigeminal ganglion, play

98 lly programmed events involving induction of surface ectoderm, preliminary morphogenesis, specificati

99 trix (ECM) between the optic vesicle and the surface ectoderm prevents the prospective lens cells fro

100 that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the

101 signals from the neural tube, notochord, and surface ectoderm promote somitic myogenesis.

102 We showed that the surface ectoderm region that includes the lens placode e

103 ung mice (<P30), which derive from embryonic surface ectoderm remain undifferentiated and serve as co

104 Following surface ectoderm removal, mainly r4 NCCs enter r3 mesenc

105 f a BMP-4-coated bead to embryos lacking the surface ectoderm restored normal levels of Sim-1 and Pax

106 Removal of the surface ectoderm resulted in decreased levels of Sim-1 a

107 Conversely, the removal of the surface ectoderm results in the maintenance of MITF in t

108 Surface ectoderm (SE) cells give rise to structures incl

109 re key epigenomes of cell types derived from surface ectoderm (SE), including keratinocytes and breas

110 ation by signals from dorsal neural tube and surface ectoderm stimulates the development of the dermo

111 the neuroectoderm that forms the retina and surface ectoderm that forms the lens.

112 riginate from Pax3-expressing regions of the surface ectoderm that normally contribute to the ophthal

113 synergise with dorsalising signals from the surface ectoderm to induce the formation of the hypaxial

114 ns with the commitment of the single-layered surface ectoderm to initiate a stratification program, a

115 AP-2alpha is required for signaling from the surface ectoderm to the underlying mesoderm for proper d

116 it, in conjunction with DiI labeling of the surface ectoderm, to analyze some of the mechanisms unde

117 En1-expressing cells directly underneath the surface ectoderm transduce Wnt signals.

118 e co-Smad Smad4 were deleted from the ocular surface ectoderm using Cre recombinase.

119 mbryos, the persistent connection of lens to surface ectoderm was associated with aborted lens develo

120 actor, Pax6 was conditionally deleted in the surface ectoderm was associated with greatly diminished

121 es, but Raldh3 expression in the frontonasal surface ectoderm was found to be needed for normal Fgf8

122 to the ECM between the optic vesicle and the surface ectoderm was sufficient to explain lens placode

123 e of separation of the lens vesicle from the surface ectoderm was the earliest structural defect obse

124 c42 in the dorsal neuroepithelium, or in the surface ectoderm, we show that these protrusions origina

125 ess of somite formation and signals from the surface ectoderm, whereas upregulation of patched and ac

126 patial development of cells derived from the surface ectoderm, which become corneal epithelium and le

127 le, the corneal epithelium is descended from surface ectoderm, while the iris and collagen-rich strom

128 Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt s

129 r plate (Shh), dorsal neural tube (Wnt1) and surface ectoderm (Wnt1-like signalling activity) but neg