ライフサイエンスコーパス: surmount

1 ntrast, cyclobutylidenecarbene only needs to surmount a barrier of 1.6 kcal mol(-1) to rearrange into

2 kcal/mol whereas the 1,2-methyl shift has to surmount a much larger barrier of 11.9 kcal/mol.

3 ossible, a biological catalyst would have to surmount a significantly higher activation barrier to fa

4 ts into the primary response of C. jejuni to surmount a sudden temperature upshift, allowing the bact

5 packed small squamous epithelial cells that surmounted a highly regimented basal layer with a picket

6 a process that would be expected to involve surmounting a considerable energy barrier.

7 ergo fragmentation to the lactone product by surmounting a second energy barrier of about 7 kcal/mol.

8 til recently, most of the strategies used to surmount ABC-transporter-mediated MDR have had limited s

9 ible peptidyl transfer and GTP hydrolysis to surmount activation barriers to large-scale conformation

10 oach for high-temperature nanophotonics that surmounts all of these difficulties.

11 emical reactions, reactant molecules need to surmount an energy barrier to allow their transformation

12 Many pathogens must surmount an epithelial cell barrier in order to establis

13 ate for the unguided residue-level search to surmount an initial kinetic barrier rather than for the

14 In these experiments, unfolding requires surmounting an energy barrier that separates the native

15 ce coverage appear to be a crucial factor in surmounting an ongoing but treatable chronic disease.

16 llenges and limitations which will be likely surmounted as our understanding of plant volatile networ

17 into two TCNE(-) anions that can be quickly surmounted at room temperature but not at 77 K.

18 ly used as pain relievers in the clinic, can surmount axon growth restrictions from myelin and proteo

19 thod, transition path sampling is capable of surmounting barriers in path phase space and focuses sim

20 a viruses into the human population requires surmounting barriers to cross-species infection.

21 There is growing interest in identifying and surmounting barriers to employment for people with schiz

22 design criteria and key hurdles that must be surmounted before clinical implementation.

23 ntial hurdles have also surfaced and must be surmounted before therapeutic RNAi applications can beco

24 g them from unrestricted pluripotency can be surmounted by a single reprogramming factor.

25 ive FA cells, this restriction was partially surmounted by antagonizing the DNA-dependent protein kin

26 urthermore, the effects of SCH23390 could be surmounted by co-administration of a sub-threshold dose

27 receptor antagonist whose inhibition can be surmounted by glycine.

28 ion was voltage-independent and could not be surmounted by increasing concentrations of either coagon

29 adenosine, and whether the antagonism can be surmounted by increasing the adenosine dose.

30 nce, and enzalutamide drug resistance can be surmounted by indomethacin a potent inhibitor of AKR1C3.

31 The obstacle can be surmounted by newly developed theoretical methods of car

32 ion polymer solar cells, this problem can be surmounted by solution-based incorporation of fulleropyr

33 This difficulty could be surmounted by the use of N-substituted pyrazoles.

34 Reaching this goal requires surmounting diverse challenges in nanofabrication and at

35 xpression of KRAS due to rare codons must be surmounted during drug resistance.

36 Provided potential barriers to success are surmounted, each achieves high efficacy at reducing tran

37 ce and temperature, a challenge that must be surmounted every time a cell divides.

38 while helpful in bacterial clearance and in surmounting excessive inflammatory tissue damage, could

39 teps in the aggregation pathway that must be surmounted for tau filaments to form in disease.

40 aps more natural responses scientists use to surmount impediments to research.

41 ranslational obstacle that is challenging to surmount in neurons, where primary tissue availability i

42 e of the challenges that CAR T cells have to surmount in the solid tumor microenvironment and new app

43 lly demanding challenge that must be met and surmounted in a short time if the patient is to survive.

44 These challenges have been surmounted in limited initiatives and now must be transl

45 g because of the energy barrier that must be surmounted in order to bring together and fuse the two e

46 nt of the energetic barriers that need to be surmounted in the motion, and as a by-product results in

47 decade to develop new antimalarial drugs to surmount increasing resistance to common therapies, chal

48 gene expression in the differentiated cells, surmounting issues of transgene silencing.

49 The synthetic route surmounts issues of individual step stereoselectivity an

50 -ALS) algorithm in confocal Raman imaging to surmount its instrumental limits and to characterize che

51 mbly in living cells offers the potential of surmounting many of the limitations inherent in other ap

52 t maintain nitric oxide (NO) homeostasis and surmount nitric oxide stress from host immune responses

53 ta support the notion that ImmSig assists in surmounting normal barriers related to oxidative and rep

54 have at least one PNS on its faculty and to surmount obstacles that currently impede the incorporati

55 e do-not-resuscitate policy is essential for surmounting obstacles to a well functioning perioperativ

56 al design and execution issues which, unless surmounted, predictably generate a distorted image of th

57 tial electron transfer in catalytic sites to surmount radical transition states without involving the

58 ce is high but teams have a critical role in surmounting residual vaccine resistance.

59 aditional therapeutics, present a pathway to surmount resistance within tumors that no longer respond

60 as an early targeting strategy to assist in surmounting resistance to pro apoptotic therapies.

61 Surmounting strong inhibition by CSPG-rich scar is an im

62 As barriers to xenotransplantation are surmounted, such as suppression of hyperacute rejection

63 en (LFA)-1 with costimulatory blockade could surmount the barrier posed by heterologous immunity in a

64 nase, both cofactor-independent enzymes that surmount the barriers to direct substrate/O2 reactivity

65 Creative and effective strategies that surmount the barriers to provision of mental healthcare

66 disorders, novel approaches are required to surmount the blood-brain barrier (BBB).

67 romiscuity of chemokines and CCR was able to surmount the deletion of CCR2, still resulting in full e

68 a large selective advantage to the vector to surmount the effects of a moderate dissociation rate and

69 ed fibroblasts into induced TSCs (iTSCs) and surmount the epigenetic barrier separating somatic from

70 s exploit DAF-mediated signaling pathways to surmount the epithelial barrier.

71 al priority for ECD, proponents will need to surmount the framing and governance challenges and lever

72 an opportunity to study molecules that might surmount the intrinsic limitations they share with mamma

73 How these enzymes surmount the kinetic barrier to reactions between single

74 at essentially has an unstructured region to surmount the noisy proximal region, a homomeric polyprot

75 COT sequences are designed to surmount the potential pitfalls stemming from sampling b

76 earch algorithm was applied in an attempt to surmount the problem of genetic heterogeneity.

77 h allowed for sufficient collision energy to surmount the reaction barrier.

78 to the high levels of activation required to surmount the threshold barriers.

79 ur findings uncover specific mechanisms that surmount the unique challenges of X-Y recombination.

80 equilibrium after a subset of reactants have surmounted the barrier to become products.

81 ing technologies and use of gene sets likely surmounted the limitations of previously inconsistent HD

82 tion of reactants is the main contributor to surmounting the barrier, since all transition states (TS

83 t reprogramming mouse fibroblasts into TSCs, surmounting the first lineage barrier established in dev

84 Surmounting the heart regeneration barrier would transfo

85 s enable mesotrypsin-BPTI complex formation, surmounting the predicted steric clash introduced by Arg

86 Integrated strategies are needed for surmounting the stringent experimental requirements of n

87 The routine use of MBR capably surmounts the difficulties brought about by the anatomic

88 performing carbohydrate epimerizations that surmounts the main disadvantages of current enzymatic an

89 Successful trisomy silencing in vitro also surmounts the major first step towards potential develop

90 itial pairing of Cys(A20) and Cys(B19), thus surmounting their wide separation in sequence.

91 ficant obstacles and suggested approaches to surmounting them are elaborated.

92 nd 10.4 kcal mol(-1) are much too high to be surmounted thermally under cryogenic conditions.

93 a developmental pipeline that may be able to surmount these challenges and bring novel biomarker solu

94 To surmount these challenges, we created a first-in-class,

95 ticles and siRNA conjugates, are designed to surmount these challenges.

96 To surmount these difficulties, we used probability analysi

97 scalable logic tiles for nanoprocessors that surmount these hurdles.

98 To surmount these impediments, we have adapted a costimulat

99 and speculating on the future strategies to surmount these impediments.

100 ial block-face electron microscopy (SBEM) to surmount these limitations and investigate the establish

101 To surmount these limitations, a paper-based biosensor was

102 To surmount these limitations, we introduce a two-step asse

103 emand alternative compounds that are able to surmount these limitations.

104 Finding ways to surmount these obstacles will provide opportunity for im

105 We surmounted these limitations by using saturating genomic

106 Only a few mucosal vaccines have surmounted these obstacles thus far.

107 This review focuses on identifying and surmounting these barriers.

108 Surmounting these challenges will require the cooperatio

109 To surmount this challenge, we extend traction force micros

110 main (S4) of voltage-gated ion channels must surmount this energy barrier to initiate channel activat

111 To surmount this inherent limitation, we developed an appro

112 Here we surmount this issue and report that spike shape and neur

113 d by leukocyte contamination; an approach to surmount this problem is single cell analysis.

114 To try and surmount this problem we have constructed a retroviral p

115 To surmount this problem, we conjugated a heptamer of argin

116 In an effort to surmount this problem, we have generated gene delivery v

117 To surmount this problem, we produced perceptual priming (i

118 To surmount this shortcoming, we devised a method for mucos

119 One potential approach to surmounting this impediment is to exploit MRI of magneti

120 by sequestering iron within haem, S. aureus surmounts this challenge by employing high-affinity haem

121 n a noncontractile state until term and then surmounts this state to enter labor.

122 s Ion-based Data Extraction Algorithm) which surmounts this void.

123 t a solvent-dependent energy barrier must be surmounted to access the singlet-to-triplet crossing reg

124 cell development and what obstacles must be surmounted to bring hematopoietic cell therapies from hu

125 evant funding agencies to support efforts to surmount today's data barriers and facilitate analytical

126 The first barrier is surmounted with the assistance of 2 conserved residues (