ライフサイエンスコーパス: surrogate

1 enols with benzaldehyde oxime as a hydroxide surrogate.

2 oride serves as an enantioenriched bromonium surrogate.

3 quantitation of a thiophosphate nerve agent surrogate.

4 itation of a phosphoryl fluoride nerve agent surrogate.

5 tassium ethyl xanthate as an odorless sulfur surrogate.

6 ivatives of the steroids were used as oxygen surrogates.

7 expectations and goals of these patients and surrogates.

8 omy for prolonged mechanical ventilation, or surrogates.

9 ll long-term acute care hospital patients or surrogates.

10 Of 53 eligible surrogates, 32 (60%) consented to treatment allocation.

11 chain isotype are critical to generate ideal surrogate Abs for testing immuno-oncology mechanisms in

12 Immunogenicity of surrogate Abs may therefore represent an important obsta

13 d murinized (95% mouse sequence) DTA-1-based surrogate Abs with a murine IgG2c H chain isotype were c

14 g these two different fluorescent nucleoside surrogates advances the mechanistic understanding of the

15 re, these easily produced, non-lipidated Wnt surrogate agonists facilitate functional studies of Wnt

16 Our study provides the first selective surrogate agonists for the orphan GPR27.

17 PENK is a stable surrogate analyte of labile enkephalins that is correlat

18 ffects-measured by log hazard ratios-for the surrogates and OS were well correlated ( R(2), 0.73 [95%

19 rformance of rapid diagnostics as diagnostic surrogates, and better characterise the clinical phenoty

20 presented, based on UVA254 and fluorescence surrogates, and developed considering kinetic informatio

21 responses to otherwise suboptimal amounts of surrogate antigen.

22 interviews with surviving patients or their surrogates at 6 months.

23 care, and there is a capacitated patient or surrogate available.

24 In this study, the probe is the Met surrogate azidohomoalanine (Aha), which carries a reacti

25 rom the bacteria Streptomyces lividans) as a surrogate because it lacks a VSD and exhibits an activat

26 While biomimetic surrogates better model human disease, their complex com

27 utant was preferred, following assessment of surrogate binding affinity with LRRK2 inhibitors.

28 al urinary polyphenol (TUP) excretion, and a surrogate biomarker (plasma carotenoids).Dietary intake

29 f the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypot

30 gnostic aid for individual patients and as a surrogate biomarker in intervention trials.

31 l vasculature is easily imaged, and may be a surrogate biomarker of cerebral and systemic vascular ri

32 Surrogate biomarkers for clinical outcomes afford scient

33 sed metabolomics for the search of potential surrogate biomarkers of GHB consumption.

34 asma 2-tissue-compartment model to calculate surrogate biomarkers of tumor hypoxia (k3), perfusion (K

35 In addition, the surrogates can be systemically expressed and exhibit Wnt

36 Second, we showed that these surrogates can predict the proportion of genetic variati

37 e biological effectiveness (RBE) factors for surrogate cancer endpoints in cell culture models and tu

38 tIgE and IgE-FAB are considered as potential surrogate candidate biomarkers.

39 lue of expanded cardiac surveillance, use of surrogate cardiac biomarkers, and prophylactic cardiopro

40 of 32 nM and an EC50 value of 0.67 muM in a surrogate cellular biomarker assay.

41 ve value is too low to advocate its use as a surrogate clinical end point.

42 X-ray structures of the surrogates complexed with known LRRK2 inhibitors rationa

43 The mechanism of NO2 reduction on soil surrogates composed of HA and clay minerals was studied

44 Both UVA254 and fluorescence surrogates could be used to control DeltaTrOC, although

45 Here, we used alkenox, a clickable enoxacin surrogate, coupled with quantitative mass spectrometry,

46 ll 4 Prentice criteria for surrogacy for the surrogate covariate in the adjusted model for all-cause

47 Matching included age and surrogate DCIS subtypes.

48 Nearly 80% of patient and their surrogate decision makers identified going home as a goa

49 Surrogate decision makers involved in decisions to limit

50 illness and inform interventions to support surrogate decision-makers in intensive care units.

51 Surrogate-decision maker and patient self-reported estim

52 There was a lack of agreement between surrogate-decision maker and patient self-reported subje

53 Surrogate-decision makers, but not patient self-reported

54 These surrogates demonstrate that canonical Wnt signalling can

55 r natural organic matter (SRN) was used as a surrogate DOM standard.

56 itiation of induction therapy as a potential surrogate end point for PFS in first-line FL therapy.

57 notherapy trials demonstrates that CR30 is a surrogate end point for PFS in first-line FL treatment t

58 ction treatment with chemoimmunotherapy as a surrogate end point for progression-free survival (PFS)

59 from promising proof-of-concept trials with surrogate end points such as infarct size to larger clin

60 led, and most primary outcomes were based on surrogate end points.

61 red twenty-one primary end points (81%) were surrogate end points.

62 can monitor disease progression and serve as surrogate endpoint in clinical trials.

63 mes referred to as an intermediate variable, surrogate endpoint, or intermediate endpoint) is a third

64 highlight the potential limitations of using surrogate endpoints for vaccine efficacy studies of mid-

65 iology, drug class effects, and the value of surrogate endpoints in trials.

66 f COPD Longitudinally to Identify Predictive Surrogate Endpoints), and GenKOLS (Genetics of Chronic O

67 measurement of cardiac biomarkers and other surrogate endpoints, and in some cases initiation of car

68 To analyze these phenomena, surrogate fly ashes were synthesized to mimic the presen

69 ent from (90)Y-OPS201 and is therefore not a surrogate for (90)Y-OPS201 dosimetry studies.

70 AChE in red blood cells is a surrogate for AChE in the nervous system.

71 Cerium was used as a surrogate for actinide elements.

72 that the handler's intention is an adequate surrogate for actual knowledge of the odors cuing the ca

73 Responsiveness was used as a surrogate for consciousness.

74 ata suggest that BLN is suitable as a potent surrogate for conventional proteoliposomes or immunolipo

75 rom the ozonolysis of cyclohexene, acting as surrogate for cyclic terpenes, are followed as protonate

76 Here, using cyt c as a surrogate for cytP450, we report the effect of membrane

77 circumferential strain (Ecc) and T1 time, a surrogate for diffuse myocardial fibrosis, were assessed

78 ated negatively with antioxidant activity (a surrogate for electron donating capacity) for the collec

79 eloped bacteriophage Phi6 was evaluated as a surrogate for enveloped waterborne viruses.

80 Lymph node yield has been used as a surrogate for extent of lymphadenectomy.

81 Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional

82 We use Suwanee River Fulvic Acid (SRFA) as a surrogate for HULIS and investigate its effect on OH for

83 rsity panel (HMDP) of 83 inbred strains as a surrogate for human natural immune variation.

84 surements from OCT can serve as an effective surrogate for invasive intracranial pressure measurement

85 P16 positivity was a good surrogate for ISH+ tumor status among OPSCC, but not a g

86 epicardial activation-recovery intervals (a surrogate for local action potential duration; median, 2

87 change in proteinuria has been proposed as a surrogate for long-term prognosis in membranous nephropa

88 hinness (body mass index z-score < -2) was a surrogate for malnutrition.

89 Using metaplastic TNBC as a surrogate for mesenchymal TNBC, DAT and DAE had notable

90 epsy outcomes, suggesting that this may be a surrogate for more severe depression and that severity o

91 Thus, ECV is an effective surrogate for myocardial diffuse fibrosis on CMR imaging

92 xa-Albumin 647 nm fluorphore was chosen as a surrogate for nab-paclitaxel based on its similar molecu

93 ive PCa diagnostic sampling as an attractive surrogate for needle biopsies.

94 We measured levels of dsDNA, as a surrogate for NETs in 103 consecutive pediatric allogene

95 SH+ tumor status among OPSCC, but not a good surrogate for non-OP HNSCC.

96 Conclusion MFS is a strong surrogate for OS for localized prostate cancer that is a

97 formal homologation process that serves as a surrogate for other well-established alkyne syntheses.

98 ospital surgical volume is a frequently used surrogate for outcomes.

99 lmonary artery acceleration time (PAAT) as a surrogate for pulmonary artery pressure was found to be

100 including smoking, alcohol, education (as a surrogate for socioeconomic status), physical activity,

101 emographic pathways, or alternatively, are a surrogate for species' sensitivity to other environmenta

102 cardiovascular variable, pulse distension (a surrogate for stroke volume) was improved in the neuroki

103 is an early treatment response biomarker and surrogate for survival in patients with multifocal, bilo

104 ons in the urine of patients with NMIBC as a surrogate for the bladder tumor microenvironment.

105 The CF2H group, a potential surrogate for the OH group, can act as an unusual hydrog

106 pergillosis using changes in biomarkers as a surrogate for therapeutic response could significantly i

107 ylcysteine (NAC) thiol reactivity assay as a surrogate for thiol reactivity with biological proteins

108 eauville scale, have enabled PET to become a surrogate for treatment success or failure in common lym

109 imethoprim-sulfamethoxazole as an acceptable surrogate for trimethoprim-sulfadiazine with S. equi.

110 contrast enhancement serves as an imperfect surrogate for tumor volume and is influenced by agents t

111 neurofibroma-initiating cell self-renewal, a surrogate for tumour initiation, and activated P-Stat3.

112 tly predict post-LT recurrence, serving as a surrogate for underlying tumor biology which can be util

113 failure, diabetes mellitus, and stroke as a surrogate for vascular health.

114 ded meetings involving 51 intervention group surrogates for 43 patients were analyzed using grounded

115 AD signature regions from MRI and FDG-PET as surrogates for AD pathophysiology.

116 ctive esters have recently emerged as useful surrogates for alkyl halides in cross-coupling chemistry

117 entice criteria exist, but whether these are surrogates for all-cause mortality, and how their perfor

118 Conclusion L5HU and PsoasL4-5, which are surrogates for bone mineral density and muscle mass, res

119 ope to which synthetic chlorins can serve as surrogates for chlorophylls and be exploited in diverse

120 elevant and important for decision-making by surrogates for chronically critically ill patients on me

121 are limited with respect to their utility as surrogates for communities of shared environment-related

122 s to assess the relationship between imaging surrogates for diffuse fibrosis and myocardial dysfuncti

123 Typhimurium mutants as surrogates for expression of translocator orthologs iden

124 paves the way for widespread integration of surrogates for genetic variation into conservation plann

125 e to what extent mouse islets can be used as surrogates for human islets to study islet GPCR function

126 study validates and quantifies PR and CR as surrogates for long-term outcome in MGN.

127 el immunohistochemical markers that serve as surrogates for molecular genetic alterations and identif

128 priori defined excitation/emission pairs as surrogates for monitoring the behavior of emerging organ

129 e).Weight- and length-based indexes are poor surrogates for newborn adiposity.

130 Surrogates for overall survival (OS) could expedite the

131 the kinetic rate constants K1, K1/k2, and k3-surrogates for perfusion, (18)F-FMISO distribution volum

132 Several surrogates for prostate cancer-specific mortality satisf

133 cators evokes a repertoire of responses from surrogates for the chronically critically ill.

134 Surrogates for the LRRK2 kinase domain based on checkpoi

135 les a patient's own hands to serve as remote surrogates for the physician's in the screening of acute

136 In addition, they inhibit surrogates for trigeminovascular activation, including e

137 imaging phenotypes can serve as noninvasive surrogates for tumor genotypes and can provide important

138 toneal cell-derived mast cells were used as "surrogates" for mucosal and connective tissue mast cells

139 The top SNPs (or their surrogates) from discovery were advanced to a stage-2 ev

140 ficially tethering full-length viral RNAs or surrogate gag-pol mRNAs competent for Gag synthesis to n

141 s long-distance signals, (3) adults or their surrogate gamete dispersers are highly mobile, or (4) th

142 ns through introduction of the bulky leucine surrogate homoisoleucine.

143 [(11)C]AZ12204657 is a first-in-class surrogate imaging biomarker for pancreatic beta-cells by

144 e human pancreas and constitutes a tentative surrogate imaging biomarker in diabetes.

145 raphy of the pancreas has been shown to be a surrogate imaging biomarker of pancreatic islet mass.

146 e of chronically critically ill patients and surrogates in an long-term acute care hospital and the f

147 plication of convenient hydrogen halide (HX) surrogates in catalysis has lagged behind considerably.

148 The use of in vitro, engineered surrogates in the field of cancer research is of interes

149 the preparation of various Xaa-Gly dipeptide surrogates in the form of Xaa-psi[triazole]-F2Gly buildi

150 XCR6(-/-) mice were used as CXCL16-deficient surrogates) indicated that individual IFN-gamma-induced

151 , we discovered that solutions based only on surrogate information secured substantial amounts of ada

152 tolerability of storytelling among bereaved surrogates involved in a decision to limit life support

153 placed with (th) G, an emissive isomorphic G surrogate, is reported.

154 when IgLkappa genes are consumed, and 3) the surrogate L chain is necessary for selection of producti

155 o suggest that there is no dependency on the surrogate L chain, and thus the authentic IgL proteins m

156 However, the absence of endogenous or surrogate ligands for GPR27 complicates the examination

157 Fe(II) is a key player in ROS formation in surrogate lung fluid (SLF) containing antioxidants.

158 Importantly, the nucleobase surrogates marginally affected the structure of the dupl

159 terventions that reduced alert quantity as a surrogate marker for alert fatigue.

160 protein expression was tested as a potential surrogate marker for BRCA1/2 inactivation.

161 p16 is used as a surrogate marker for HPV infection.

162 Since the catatonic syndrome is likely a surrogate marker for other executive function defects, w

163 eptomeningeal enhancement may prove a useful surrogate marker for such pathology, perhaps improving o

164 pressed higher levels of cell surface CD5, a surrogate marker for TCR avidity for self-pMHC, as compa

165 5-HTP uptake and retention in pancreas, as a surrogate marker for the endogenous islet mass.

166 s an alternative or together with HbA1c as a surrogate marker indicator for glycemic control.

167 CCA test, which we consider to be a suitable surrogate marker of active infection.

168 c magnetic resonance have been shown to be a surrogate marker of diffuse myocardial fibrosis.

169 Microparticles (MPs) have emerged as a surrogate marker of endothelial dysfunction and cardiova

170 endothelium-dependent vasodilation and is a surrogate marker of endothelial function and NO bioavail

171 gm is lacking, the use of this paradigm as a surrogate marker of outcome is limited.

172 tes that the expression of p53R172H can be a surrogate marker of p53 gene transcription.

173 Circulating CLA(+) T cells may be a reliable surrogate marker of the inflammatory events occurring in

174 Using SOD2 as a surrogate marker of the UPR(mt), we found that in primar

175 igh-avidity Melan-A-specific clonotypes as a surrogate marker of treatment efficacy.

176 orrelation with PSA levels (P < 0.0001) as a surrogate marker of tumor burden, whereas SUVmax (P = 0.

177 DRIL is a robust and easily obtained surrogate marker of VA in participants with current or r

178 to be associated with T1 relaxation times, a surrogate marker of water content, but not with GABAA re

179 e of the improved CSF RT-QuIC is superior to surrogate marker tests for prion diseases such as 14-3-3

180 We present case studies of 2 well-accepted surrogate markers [blood pressure within sodium intake a

181 cle, we examine the challenges of evaluating surrogate markers and describe the framework proposed in

182 thrombosis, despite the lack of evidence of surrogate markers for atherosclerosis in primary APS.

183 and CRISP2 DMRs hold promise as novel blood surrogate markers for early risk stratification and CVD

184 The availability of surrogate markers for functional vascular proteins, such

185 r potential usefulness in the development of surrogate markers for vector delivery during the first w

186 The search for valid surrogate markers of arterial vascular inflammation led

187 afor uptake is significantly associated with surrogate markers of atherosclerosis and is linked to th

188 dothelial cell therapy showed mean levels of surrogate markers of hepatobiliary injury that were cons

189 chanistic link between fetal environment and surrogate markers of long-term health.

190 or monitoring disease progression and act as surrogate markers to identify underlying disease process

191 en FSR, suggesting applications as direct or surrogate markers, respectively, of hepatic fibrogenesis

192 d for future research that evaluates or uses surrogate markers.

193 Surrogates' mean age was 55.5 (SD, 11.8), and they were

194 t exposure to CO is not a consistently valid surrogate measure of exposure to PM2.5.

195 Sister chromatid exchanges, a surrogate measure of iHR, was significantly elevated in

196 at 60 months were additionally examined as a surrogate measure of research impact in a prespecified s

197 mpact Factor (JIF) should never be used as a surrogate measure of the quality of individual research

198 , whether BAT (18)F-FDG uptake is a reliable surrogate measure of UCP1-mediated heat production.

199 milar design elements, including reliance on surrogate measures as outcomes.

200 Although biomarkers are used as surrogate measures for drug targeting and approval and a

201 vitamin D-deficiency status, and the use of surrogate measures of body composition, insulin sensitiv

202 These dimensional approaches aim to provide surrogate measures of heterogeneous underlying pathologi

203 d skin reaction to prolonged sun exposure as surrogate measures of pigmentation among 49,323 white wo

204 rated approval based on showing an effect in surrogate measures that are only reasonably likely to pr

205 (42%) on the basis of trials that evaluated surrogate measures.

206 nderlines cefoxitin's status as the superior surrogate mecC-positive MRSA marker.

207 ay have the potential to serve as a possible surrogate method to evaluate the in vivo effects of heat

208 d-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population

209 The surrogate model is constructed by teaching a Gaussian pr

210 We used CTXs as a surrogate model of cold allodynia to dissect the framewo

211 occurring polymorphic NucS in a M. smegmatis surrogate model, suggests the existence of M. tuberculos

212 erogeneous catalysis reaction networks using surrogate models that are trained on the fly.

213 rovide valuable comparisons between hNoV and surrogate molecular signals that can begin the process o

214 These models require the use of (surrogate) mouse or rat antibodies to enable optimal int

215 s, cFAE can be used to efficiently generate (surrogate) mouse or rat bsAbs for pre-clinical evaluatio

216 generated by each system, spiked Ebola virus surrogates (MS2 and Phi6) into each system, and determin

217 monella enterica serovar Typhimurium, or the surrogate murine infection model for EHEC, Citrobacter r

218 Importantly, metabolome profiling in the Mtb surrogate, Mycobacterium bovis BCG, reveals significant

219 ken per day correlated with smartphone data (surrogates: n = 13, rho = 0.56, p < 0.05; n = 13, rho =

220 wn that stimulation of cultured neurons with surrogate NCAM ligands leads to the generation and nucle

221 signify the ability to elucidate a putative surrogate neurophysiologic signature that correlates wit

222 , and IIIb GII.17 strains were compared by a surrogate neutralization assay based on antibody blockad

223 A surrogate, non-imaging-based, method underestimated the

224 nce tomographic parameters showed promise as surrogate, noninvasive measures of intracranial pressure

225 with ischemic cardioplegic arrest is only a surrogate of acute myocardial infarction and confounded

226 n encoded by the ERG gene as the established surrogate of ERG fusion genes among 262 prostate cancer

227 evaluate the validity of exposure to CO as a surrogate of exposure to PM2.5 in studies of household a

228 o replace other heteroatoms and can act as a surrogate of functional groups such as olefin and amide

229 methylation of the CDH1 gene in AM may be a surrogate of GC.

230 ents with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking

231 RTS,S/AS01E-induced IL-5 may be a surrogate of lack of protection, whereas TH1-related res

232 T-cell response to brain metastases is not a surrogate of local tumor invasion, primary cancer type,

233 but not with GABAA receptor concentration, a surrogate of neuronal integrity.

234 The glucosamine disaccharide-as a backbone surrogate of the bacterial lipid A region-was synthesize

235 pyrimidines that associate with this soluble surrogate of the nicotinic acetylcholine receptor (nAChR

236 peripheral tissues, SUV is not a sufficient surrogate of VT from 2-tissue-compartment modeling.

237 tively targeted GNPs, using an external beam surrogate of Yb-169 created from an exotic filter materi

238 vely, these studies help to better establish surrogates of antigen-induced immunity against B. pseudo

239 To observe how surrogates of chronically critically ill patients respon

240 Bereaved surrogates of ICU patients.

241 respiratory criteria to include noninvasive surrogates of lung injury.

242 ve care physician and nurse practitioner for surrogates of patients in medical intensive care units w

243 igest them into peptides, which can serve as surrogates of the protein.

244 on of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act a

245 Growth of the surrogates over time was measured using optical in vivo

246 , and might therefore serve as an additional surrogate parameter for differentiating between malignan

247 aluate malignant LN infiltration, additional surrogate parameters, especially in cases with indetermi

248 a between the conventional approach based on surrogate peptide analysis and our proposed workflow wer

249 MS commonly relies on bottom-up or so-called surrogate peptide measurements to infer the whole-molecu

250 Targeted mass spectrometry of a surrogate peptide panel is a powerful method to study th

251 t form of the antibody is represented by the surrogate peptide.

252 psin digestion based LC-MS/MS analysis using surrogate peptides from different domains of the analyte

253 regardless of the retention time of targeted surrogate peptides.

254 hymic function has been mainly analyzed with surrogate peripheral markers affected by peripheral T-ce

255 rganisms were Escherichia coli and the Ebola surrogate Phi6.

256 when supplemented with the alpha-tocopherol surrogate, PMHC (2,2,5,7,8-pentamethyl-6-hydroxy-chroman

257 piprazole and the heterocyclic catecholamine surrogates present in the beta2-adrenoceptor agonists pr

258 Surrogate primary variable: presence of ICD behaviours a

259 n and compare the performance of 4 candidate surrogates (prostate-specific antigen [PSA] failure, PSA

260 -established agonist responses was used as a surrogate read-out for agonist dissociation kinetics, an

261 Six main categories of surrogate responses to prognostic information were ident

262 t with the fading of consciousness using its surrogate responsiveness.

263 cterization of patient, (5) consideration of surrogate role, and (6) mobilization of support.

264 levated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore investigated its

265 Suwannee river fulvic acid as a common HULIS surrogate shows a similar polarity range, but the sizes

266 individuals exposed to crude oil/fuel, only surrogate signatures derived from crude oil and fuel wer

267 A method using surrogate signatures to train the ANN was validated by c

268 determined from prior analysis of a purified surrogate standard that carries similar site-specific gl

269 bration and using 2-chloro-5-bromoanisole as surrogate standard.

270 e evidence is insufficient to validate their surrogate status.

271 ed: 1) poor quality of life for patients; 2) surrogate stress and anxiety; 3) optimistic health expec

272 Surrogate structures enable the rapid identification of

273 etermine the extent to which ICU patients or surrogates support a deferred consent process for a mini

274 Through the use of Drosophila genetics, surrogate systems and biochemistry, the field has begun

275 es with high NaV1.7 expression have led to a surrogate target strategy approach employing chimeras wi

276 For the 3 successful surrogates, the proportion of treatment effect values we

277 n it are frequently observed in tumor and/or surrogate tissues.

278 The in vivo use of the retina as a surrogate to evaluate brain injury following exposure to

279 t cancer serves as a clinically identifiable surrogate to evaluate potential regimens for mesenchymal

280 The laboratory rat has been used as a surrogate to study human biology for more than a century

281 now report the use of ammonium halides as HX surrogates to accomplish a Pd-catalyzed hydrohalogenatio

282 We evaluated the potential for Ebola virus surrogates to be aerosolized from three types of wastewa

283 tiated from pluripotent cells could serve as surrogates to test emerging therapies.

284 e outstanding sensitivity of both nucleobase surrogates to the small structural changes accompanying

285 sses have led to the development of chemical surrogates to these species.

286 Response of the surrogates to treatment with paclitaxel was measured by

287 em cell-derived endothelial cells are useful surrogates to uncover novel features related to disease

288 ed the genetic basis of timing of bud set, a surrogate trait for timing of yearly growth cessation th

289 e results suggest that the AH can serve as a surrogate tumor biopsy when Rb tumor tissue is not avail

290 The tissue-engineered surrogates used to demonstrate these methods consist of

291 pressed independent of infection or during a surrogate vaccinia virus infection to identify how MC159

292 imary tissues, we introduce a method-quality surrogate variable analysis (qSVA)-as a framework for es

293 programs, along with one approach utilizing surrogate variables (SVAs).

294 nd RT-qPCR reductions are also presented for surrogate viruses murine norovirus (MNV) and bacteriopha

295 nt suitability of Phi6 as an enveloped virus surrogate was dependent on the temperature and compositi

296 pacity at the time of ICU admission, or if a surrogate was readily available, consent was sought prio

297 A total of 50 subjects (30 patients and 20 surrogates) were enrolled.

298 oys a keto-oxetane motif as a 1,4-dicarbonyl surrogate, which can be synthesized using robust alkylat

299 ays for protein quantitation monitor peptide surrogates, which are easily multiplexed to target many

300 Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 hete