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1 PTE) explained are requisites for a suitable surrogate end point.
2 clinical events, and may not be a sufficient surrogate end point.
3 emission computed tomographic) imaging as a surrogate end point.
4 red twenty-one primary end points (81%) were surrogate end points.
5 led, and most primary outcomes were based on surrogate end points.
6 shed more quickly than those that focused on surrogate end points.
7 FS, suggesting that these biomarkers are not surrogate end points.
8 e needed for identifying the most predictive surrogate end points.
9 pancies in reporting, and an overreliance on surrogate end points.
10 were a focus on clinical events rather than surrogate end points (adjusted publication rate ratio, 2
11 enefits of earlier treatment access based on surrogate end points against the risks of clinical uncer
12 lesser albuminuria emphasized the fallacy of surrogate end points and argue against nephroprotective
14 ents in cardiovascular disease risk factors, surrogate end points, and mortality in blacks and other
15 ing access to new treatments on the basis of surrogate end points, and PFS in particular, likely vari
16 reserved ejection fraction (HFpEF), feasible surrogate end points are needed for phase II trials.
18 F, IGFBP-3, and IGF-I/IGFBP-3 could serve as surrogate end point biomarkers of 9-cis-RA treatment.
19 n development of prostate carcinogenesis and surrogate end point biomarkers related to prostate cance
20 ventive targets and drugs, risk markers, and surrogate end point biomarkers; new preclinical drug-tes
21 Here, we evaluate how analyses of certain surrogate end points can be used for inferring clinicall
26 nse to therapy has never been validated as a surrogate end point for clinical events in pulmonary art
27 atment effect, has only modest validity as a surrogate end point for clinical events, and may not be
29 ducible, this technique may provide a useful surrogate end point for clinical trials with appreciable
30 trials does not support the use of pCR as a surrogate end point for DFS and OS in patients with brea
31 30%-40% decline in eGFR after AKI could be a surrogate end point for ESRD in trials of AKI prevention
32 s has been widely accepted as an appropriate surrogate end point for HIV disease progression, and it
35 itiation of induction therapy as a potential surrogate end point for PFS in first-line FL therapy.
36 notherapy trials demonstrates that CR30 is a surrogate end point for PFS in first-line FL treatment t
37 ction treatment with chemoimmunotherapy as a surrogate end point for progression-free survival (PFS)
38 measurement of infarct size is an attractive surrogate end point for the early assessment of new ther
40 and partial remission (PR) of proteinuria as surrogate end points for a treatment effect on ESRD in p
42 ments during placental malaria might provide surrogate end points for interventional trials, but exis
43 pted as optimal, the utility and validity of surrogate end points for predicting clinical coronary ev
44 gest that resting hemodynamics are not valid surrogate end points for short-term events in PAH clinic
49 loss in AMD and could be used as an earlier surrogate end point in interventional trials targeting t
50 able data suggest that CR could be used as a surrogate end point in primary MN, whereas PR seems reas
52 Carotid B-mode ultrasound may serve as a surrogate end point in SLE intervention trials and clini
53 of mean maximum IMT in carotid arteries, the surrogate end point in this study, did not differ betwee
54 ffects on virus load and other postinfection surrogate end points in an efficacy trial is complicated
56 have analyzed the possible potentials of the surrogate end points in clinical studies of patients wit
57 upport the strategy of using EAP measures as surrogate end points in early-stage procognitive interve
58 d other pathologic measures may be useful as surrogate end points in evaluating and understanding new
61 es), gastric volume and pH have been used as surrogate end-points in many aspiration studies; however
63 g., mortality or quality of life), whereas a surrogate end point is one biologically closer to the di
64 perhaps more important, aspect of measuring surrogate end points is that they increase our understan
65 l modifications to PGs can serve as in vitro surrogate end point markers for chronological age, the e
66 ; use of molecular and histologic markers as surrogate end point markers; collection of epidemiologic
70 ould, therefore, be of value to have a rapid surrogate end point of tumor response that could be used
72 ions for new agents and to develop validated surrogate end points, so that novel agents can be tested
74 nodeficiency virus (HIV) disease, the use of surrogate end points such as HIV-1 RNA is becoming incre
75 from promising proof-of-concept trials with surrogate end points such as infarct size to larger clin
77 Regardless of funding source, trials using surrogate end points, such as quantitative angiography,
81 ct, MRD measurements might well be used as a surrogate end point, thereby significantly shortening th
82 ima-media thickness is used as a noninvasive surrogate end point to measure progression of atheroscle
85 ol excluded adults older than 80 years, used surrogate end points to evaluate microvascular outcomes
86 omatic and presymptomatic disease or provide surrogate end-points to demonstrate clinical efficacy of
87 this study serves to emphasize the need for surrogate end point validation in neoadjuvant endocrine
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