ライフサイエンスコーパス: survivin

1 e of androgen and consequent upregulation of survivin.

2 oteins FLIP, Mcl-1, Bcl-2, cIAP1, cIAP2, and survivin.

3 of activated T cells, B-cell lymphoma 2, and Survivin.

4 ocytes did suppress proliferation and reduce survivin.

5 ion by controlling the cellular abundance of survivin.

6 of activated T cells, B-cell lymphoma 2, and Survivin.

7 r HuR, and the cell-cycle regulators p21 and survivin.

8 p-regulation of CHK1, CHK2, H2AX, BRCA1, and survivin.

9 ors (CHK1 and CHK2), and anti-apoptosis gene survivin.

10 hway, was implicated in the up-regulation of survivin.

11 phorylated form of the antiapoptotic protein survivin.

12 iated transcription to promote expression of survivin.

13 orylation and key survival factors, Mdm2 and Survivin.

14 its down-stream targets Aurora kinase B and survivin.

15 arian cancer cells through downregulation of survivin.

16 the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-spec

17 cent findings showing that Notch2 suppresses survivin (a key inhibitor of apoptosis), FIH targeting i

18 a concomitant drop in the protein levels of survivin, a member of anti-apoptotic proteins and a know

19 NA encoded by KSHV upregulates expression of survivin, a member of the inhibitor of apoptosis (IAP) f

20 epithelia decreases the protein abundance of survivin, a member of the inhibitor of apoptosis family.

21 Survivin, a member of the inhibitor of apoptosis protein

22 In a previous study, we showed that survivin, a member of the inhibitor of apoptosis protein

23 In addition, we identify survivin, a member of the inhibitor-of-apoptosis family

24 onversely, siRNA-mediated down-regulation of survivin activated caspases and enhanced the sensitivity

25 Anti-apoptotic survivin, along with other inhibitor of apoptosis (IAP)

26 tion to its role in inhibition of apoptosis, survivin also regulates mitosis.

27 The subsequent increase in survivin among transit amplifying cells promotes epithel

28 The target gene was survivin, an anti-apoptotic protein induced by chemother

29 The target gene was survivin, an inducible chemoresistance gene.

30 Survivin, an inhibitor of apoptosis (IAPs) family member

31 Survivin, an inhibitor-of-apoptosis protein, was also do

32 Survivin, an overexpressed anti-apoptotic protein in can

33 (CD31 and VE-cadherin) expression, increased survivin and Ajuba expression, and a reduction in Hippo

34 Combined blockade of survivin and application of chimeric T cells in vivo sup

35 T/mTOR pathways and stimulating proapoptotic survivin and BAX pathways.

36 AmEpCs up-regulated anti-apoptotic proteins survivin and Bcl-xL by mechanisms dependent and independ

37 Amniotic membranes naturally expressed both survivin and Bcl-xL, indicating that fetal membranes cou

38 on of INCENP forms a three-helix bundle with Survivin and Borealin, directing the CPC to the inner ce

39 Here, we reveal that in addition to Survivin and Borealin, the single alpha-helix (SAH) doma

40 ated the latter in H. pylori-induced loss of survivin and cell viability.

41 These demonstrated that the mRNA of survivin and CUG-BP1 each contain two functional miR-214

42 pithelial cells leads to an increase in both survivin and CUG-BP1 mRNA and protein.

43 , using miR target prediction programs, both survivin and CUG-BP1 mRNA were found to contain potentia

44 rease in the mRNA and protein levels of both survivin and CUG-BP1.

45 in esophageal cancer cells by targeting both survivin and CUG-BP1.

46 se-3 cleavage, and upregulated expression of survivin and cyclin B1.

47 sed expression of p-Akt, VEGF, Ang-1, Bcl-2, survivin and DNA binding activity of NF-kappaB were obse

48 n completely reversed the paclitaxel-induced survivin and enhanced the paclitaxel activity (p<0.05).

49 R reduces p85alpha and TP53, which increases survivin and intestinal epithelial cell expansion during

50 omotes the ubiquitylation and degradation of survivin and is inhibited by CUL7.

51 issue were assessed immunohistochemically by survivin and Ki-67 staining.

52 Survivin and p16(INK4a) were functionally linked by assa

53 /Akt/mTORC1 mechanism elevates expression of Survivin and promotes growth of prostate epithelial cell

54 of adherens junction molecule modulation of survivin and the Hippo pathway in the proliferation and

55 omplex ClpXP associates with the oncoprotein survivin and the respiratory chain Complex II subunit su

56 6(INK4a) contributes to the up-regulation of survivin and thereby provides a survival advantage to ce

57 sed a siRNA against the chemoresistance gene survivin and two model polyanion drugs (suramin, heparin

58 cules, including c-myc, axl, CTGF, cyr61 and survivin and upregulation of the tumor growth inhibitor

59 tment induced reduction of CK2alpha, Bcl-xL, survivin and xIAP protein expression along with suppress

60 urvival pathway-involving AKT, CREB, Bcl-xL, survivin, and Bcl-2-downstream of Mer, which is differen

61 ed regulation of c-MYC, GSK3beta, p27(KIP1), survivin, and components of the RB pathway, resulting in

62 rgets of STAT3, including cyclin D1, bcl-XL, survivin, and micro-RNA-21.

63 -induced Notch-2 activation, upregulation of survivin, and phosphorylation of STAT3, but STAT3 kinase

64 nal epithelial cells had less Trp53 and more survivin, and relative responses to resection were blunt

65 pha, nuclear factor of activated T cells and survivin, and signal transducers and activators of trans

66 tical survival pathways, including RAS, p53, survivin, and the BCL2 family of cell death regulators.

67 ukin-13 receptor alpha 2 (IL-13Ralpha2), and survivin, and their peptide epitopes were emulsified in

68 Finally, Survivin antagonists impede growth of MB cells in vivo.

69 sensor with covalently bound monoclonal anti-survivin antibody can detect Sur with the limit of detec

70 e-potential barrier layer structure and anti-survivin antibody.

71 NF-kappaB and survivin are coordinately up-regulated in GBM patient tu

72 a cells, and two siRNAs specific to EGFR and survivin are fused between two aptamers.

73 Consistently, both alphavbeta6 and survivin are significantly increased in prostatic adenoc

74 ll cycle regulators, including cyclin D1 and survivin, are downregulated in the germinative zone of t

75 es IGF-I-stimulated cell growth, implicating Survivin as a mediator of this growth response.

76 a lines in vitro, supporting the validity of survivin as an attractive therapeutic target for high-gr

77 insulted CA1 neurons and identify STAT3 and survivin as potentially important therapeutic targets in

78 uction of phosphorylation of the oncoprotein survivin at residue T34.

79 nase B (AK-B) and induces phosphorylation of survivin at residue T34.

80 orced expression of ectopic FLIP(S), but not survivin, attenuated augmented apoptosis induced by PP24

81 ther cell cycle regulators such as Aurkb and survivin, Aurka is required for hematopoiesis, but is di

82 s of the inner-centromere-targeting proteins survivin (Bir1), borealin (Nbl1), Bub1 and Sgo1.

83 mmals/yeasts as Aurora B/Ipl1, INCENP/Sli15, Survivin/Bir1, and Borealin/Nbl1.

84 endent expression of the prosurvival protein survivin (BIRC5) and attenuation of sensitivity to EGFR

85 gulation of several survival factors such as survivin (BIRC5) and Bcl-xL (BCL2L1) when cells were exp

86 n of transcription of the antiapoptosis gene survivin (BIRC5) and the CSC-associated cytokine interle

87 ression profiling, the antiapoptotic protein survivin (BIRC5) demonstrated a striking increase in ATL

88 anti-apoptotic and proliferation-associated survivin (BIRC5) gene generates six isoforms, which regu

89 STAT3 target genes, such as Bcl-xL (BCL2L1), survivin (BIRC5), cyclin D1 (CCND1), and matrix metallop

90 short form of c-FLIP (FLIP(S), CFLAR(S)) and survivin (BIRC5).

91 downregulated transcriptional expression of survivin (BIRC5a).

92 vated apoptotic proteins BAD, cytC, c-casp3, Survivin, BIRC7.

93 Together, our results suggest that survivin blockade is required for therapeutic responses

94 In conclusion, survivin blockade provides a strategy to sensitize RMS c

95 mposed of inner centromere protein (INCENP), Survivin, Borealin, and the kinase Aurora B, contributes

96 ynamics of Stapled Peptides derived from the survivin-borealin protein-protein interface and predicts

97 over, our data support that the induction of Survivin by IGF-I occurs through a transcriptional mecha

98 ces while mTORC2 represses the expression of Survivin by IGF-I.

99 biquitylation and proteasomal degradation of survivin by interacting with Glu-126 within its carboxyl

100 uces Survivin expression, and that silencing Survivin by lentiviral-mediated small hairpin RNA (shRNA

101 Down-regulation of survivin by siRNA or pharmacologically in RMS cells incr

102 cumventing ciliary function by re-expressing survivin can rescue polycystic kidney disease phenotypes

103 n of known p53-repression targets, including survivin, CDC25C, and CDC25B in response to p53 inductio

104 Compared with wild-type survivin, cellular expression of a survivin mutant prote

105 eased expression of anti-apoptotic proteins (survivin, cIAP-2, XIAP), induced apoptosis, and arrested

106 tory vesicles containing the HSP90alpha-AHA1-survivin complex toward the leading edge.

107 and a codon-optimized form of the human TAA survivin (coSVN), an oncoprotein that is overexpressed i

108 Survivin could be detected in the small intestine and as

109 f anti-apoptotic molecules Bcl-2, Bcl-xL and survivin, coupled with down-regulation of signaling path

110 mediates Gas6/Axl-mediated overexpression of survivin, cyclin D1 and FAK, leading to enhanced surviva

111 ed in the lesions of mice with compound PTEN/survivin deficiency throughout the time points examined.

112 ery, B cell homeostasis is not affected, but survivin-deficient B cells are unable to mount humoral r

113 LQZ-7F induced proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and

114 l for stimulating apoptosis through XIAP and survivin degradation.

115 e compound that induced proteasome-dependent survivin degradation.

116 as, the most severe lesions in the biallelic survivin deleted mice were high-grade prostatic intra-ep

117 of the animals with wild-type or monoallelic survivin deletion developed adenocarcinomas, the most se

118 Survivin deletion was also associated with reduced tumor

119 as a cellular marker for proliferation, and survivin demonstrated a coincidental localization of the

120 ets of eIF4E-mediated translation, including survivin, demonstrated that eIF4E(S209) phosphorylation

121 , understanding the mechanisms that regulate survivin DEx3 mRNA AS is clearly important.

122 ance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform.

123 the first clues regarding the regulation of survivin DEx3 mRNA splicing.

124 One of the isoforms is survivin DEx3, in which the exclusion of exon 3 generate

125 , but the clinical pathology associated with survivin downregulation or knockout has never been studi

126 a role in cystic kidney and aneurysm through survivin downregulation.

127 lts of this study indicated that the loss of survivin due to H. pylori infection involves proteasome-

128 In this article, we show that deletion of survivin during early B cell development results in a co

129 immunodominant epitope (Sur20-28) of murine survivin during early stages of thymopoiesis.

130 The up-regulation of survivin during immortalization likely contributes to th

131 This study shows that up-regulation of survivin during immortalization of human myofibroblasts

132 Survivin (encoded by BIRC5), the smallest member of the

133 to get deeper insights in the regulation of survivin expression after tissue damage, we also studied

134 chanistically, [pIC](PEI) repressed XIAP and survivin expression and activated an immune response by

135 Furthermore, survivin expression and ciliary localization are regulat

136 ed upregulation of STAT3 phosphorylation and survivin expression and delayed recovery.

137 otch-2 signaling, STAT3 phosphorylation, and survivin expression and delayed recovery.

138 of PCat-siSurvivin reversed the TPM-induced survivin expression and enhanced the antitumor activity

139 s also rescued cells from down-regulation of Survivin expression and growth suppression by pharmacolo

140 itors or by silencing Smads 2 and 3, induced Survivin expression and promoted cell growth similar to

141 dherin expression correlating with increased survivin expression and YAP nuclear localization, consis

142 d understanding of the mechanisms regulating survivin expression in different cancer cells will be cr

143 However, there is also evidence of survivin expression in differentiated tissues, including

144 e the role of microRNAs (miRs) in regulating survivin expression in esophageal cancer cells.

145 I induces the renoprotective upregulation of survivin expression in kidney epithelial cells, but the

146 Elevated survivin expression in primary canine osteosarcoma tissu

147 ls, consistent with TCR signaling induced by survivin expression in the murine thymus.

148 There is rather limited information on survivin expression in the small intestine.

149 ed animal survival and, as expected, induced survivin expression in tumors.

150 Renal survivin expression increased substantially in response

151 sion analysis found an increase in bcl-2 and survivin expression induced by 4-1BB that was associated

152 vels of survivin from cancer cells with high survivin expression levels.

153 osphorylation and subsequent upregulation of survivin expression mediated by Notch-2 signaling in ren

154 a more detailed and thus complete picture of survivin expression patterns in the gastrointestinal tra

155 pletion by antimycin A treatment upregulated survivin expression through a phospho-STAT3-dependent pa

156 ults suggest that there is already a maximal survivin expression under normal conditions.

157 whether the observed effect of miR-214-3p on survivin expression was direct, mediated through CUG-BP1

158 PCNA Cyclin D1 Cyclin E and Survivin expression was measured by Western blot.

159 tentiates apoptotic cell death by inhibiting survivin expression, a member of the inhibitor of apopto

160 ine as a model, we showed that IGF-I induces Survivin expression, and that silencing Survivin by lent

161 thway involving cilia function or structure, survivin expression, cytokinesis, cell ploidy, symmetric

162 Bcl-2, Bcl-xL, Mcl-1, cyclin D1, c-Myc, and survivin expression.

163 eening of small-molecule inhibitors of human survivin expression.

164 racterized by chromosome instability and low survivin expression.

165 an cancer cells to PTX and DOX by inhibiting survivin expression.

166 Moreover, we show that PDT inhibited survivin expression.

167 guish healthy cells expressing low levels of survivin from cancer cells with high survivin expression

168 shown that E2F1 directly interacted with the survivin gene (BIRC5) promoter in cells that spontaneous

169 onal mouse and zebrafish models confirm that survivin gene deletion in the kidneys results in a cysti

170 First, we demonstrated that mice lacking the survivin gene in prostate epithelium were fertile and ha

171 line in which the Sam68 binding site in the survivin gene was mutated with the CRISPR/Cas system.

172 level of expression in many types of cancer, survivin has long been regarded as a promising therapeut

173 ly overexpressed in cancer cells; therefore, survivin has potential as a target for cancer immunother

174 The inhibitor of apoptosis protein, survivin, has been implicated in many adaptive responses

175 Treatment with small-molecule antagonists of Survivin impairs proliferation and survival of both muri

176 sis through downregulating the expression of survivin in breast cancer.

177 This further supports the decisive role of survivin in cell division.

178 g in HUVECs leads to selective repression of survivin in endothelial cells, thus promoting cell apopt

179 he bacterial factors responsible for loss of survivin in gastric cells exposed to H. pylori.

180 f STAT3 and STAT3-dependent transcription of survivin in insulted CA1 neurons and identify STAT3 and

181 The current study examines survivin in intestinal epithelial cells after ileocecal

182 reases activation of STAT3 and expression of survivin in intestinal epithelial cells and expression o

183 omoted activation of STAT3 and expression of survivin in intestinal tumor cells.

184 Restoration of survivin in melanoma cells partially rescued the growth-

185 A study with human colon specimens exhibited survivin in most basal crypt epithelial cells of normal

186 in E, maspin, polo-like kinase 1 (Plk1), and survivin in patients with stage Ta and T1 urothelial car

187 Here we evaluated the functional role of survivin in prostate tumor growth.

188 Genetic deletion of survivin in Ptch mutant tumor cells significantly inhibi

189 To determine the role of survivin in renal recovery from AKI, we generated mice w

190 These studies highlight the importance of Survivin in SHH-driven MB, and suggest that it may repre

191 r cells and post-transcriptionally regulates survivin in these cells.

192 13: to IL-13Ralpha2 in 10, EphA2 in 11, and survivin in three.

193 In infant small bowel, survivin in transit amplifying cells increased 71% after

194 A reduced expression of Ki-67 and survivin in tumor tissues accompanied the observed effec

195 er ileocecal resection, epithelial levels of survivin increased relative to sham-operated on mice, wh

196 Survivin increases proliferation and blunts apoptosis.

197 ads 2 and 3 with kinetics similar to that of Survivin induction.

198 n vivo suppressed tumor proliferation during survivin inhibition.

199 deliver survivin inhibitors, co-delivery of survivin inhibitors with chemotherapeutic agents, synchr

200 cation of nanoparticulate systems to deliver survivin inhibitors, co-delivery of survivin inhibitors

201 helial neoplasia to adenocarcinoma, and that survivin interference at the prostatic intraepithelial n

202 Survivin is a member of the inhibitor of apoptosis famil

203 Survivin is a tumor-associated antigen (TAA) that inhibi

204 Survivin is a unique member of the inhibitor of apoptosi

205 n promoting cell survival and proliferation, survivin is an attractive candidate for targeted therapy

206 Survivin is an essential component of the chromosomal pa

207 Survivin is an inhibitor of apoptosis protein that regul

208 Down-regulation of survivin is at the translational level and is probably m

209 Thus, survivin is essential for proliferation of B cell progen

210 The inhibitor of apoptosis protein survivin is expressed in most cancers.

211 Here we show that Survivin is overexpressed in tumors from patched (Ptch)

212 Correspondingly, we show that survivin is required for cell division in response to mi

213 It was also shown previously that survivin is up-regulated during telomerase-mediated immo

214 nfant small-bowel sections were analyzed for survivin, Ki-67, and TP53 by immunohistochemistry.

215 The finding that in vivo survivin knockdown by PCat-siSurvivin was successful onl

216 Despite the modest effect of survivin knockdown on tumor growth, reduction of the tra

217 parison, PCat-siSurvivin alone did not yield survivin knockdown or antitumor activity, indicating the

218 Survivin knockout also contributes to abnormal oriented

219 Depletion of CUL7 decreases survivin level, and overexpression of survivin rescues t

220 ion mouse model, we previously reported that survivin levels increase with prostate tumor growth.

221 s exposed to 100 mGy exhibited elevations in survivin levels, reductions in apoptosis frequencies, an

222 Therefore, we hypothesized that Survivin may have a critical role in growth and survival

223 acrylate nanoparticles (PMMA-NPs) to promote survivin MB uptake in human A549 cells was investigated.

224 e the ability of the PMMA-NPs to promote the survivin-MB internalization, suggesting that this comple

225 This survivin-mediated adaptive response has the potential fo

226 be induced in vascular-specific normotensive survivin mice.

227 ate of mice with PTEN deletion combined with survivin mono- or bi-allelic gene deletion.

228 vin) was active in cultured cells (decreased survivin mRNA and protein levels, reduced cell clonogeni

229 apy and a Molecular Beacon (MB) specific for survivin mRNA is available.

230 portantly, these LNA nanoparticles knockdown survivin mRNA, an established target for cancer therapy,

231 activity in a vector carrying the 3'-UTR of survivin mRNA.

232 wild-type survivin, cellular expression of a survivin mutant protein deficient in its ability to inte

233 poly(ADP ribose) polymerase, and suppressed survivin, myeloid cell leukemia 1, Bcl-xL, cyclin D1, an

234 ffect is abrogated with rescue expression of survivin or CUG-BP1.

235 that showed that either the up-regulation of survivin or repression of p16(INK4a) rendered telomerase

236 therapeutic agents, synchronous targeting of survivin, other drug resistant molecules, and survivin r

237 ancer samples analyzed showed BRCA1-IRIS and survivin overexpression and lacked nuclear FOXO3a expres

238 Survivin overexpression is associated with cancer, but t

239 target gene expression, activated caspase-3, survivin, p85alpha, and Trp53.

240 Our findings suggest that survivin participates in the progression of prostatic in

241 We propose a 3M-CUL9-survivin pathway in maintaining microtubule and genome i

242 rived TCRs had tighter interactions with the survivin peptide than did fratricidal TCRs.

243 CR-Tg mice, which cannot effectively present survivin peptides on class I major histocompatibility co

244 The expression of survivin proceeds during embryonic development and in ad

245 , reduction of the translationally regulated survivin profoundly inhibited motility and metastasis of

246 PR, AR, Bcl-2, HER2, p53, E-cadherin, Ki67, survivin, prolactin, FOXA1) for survival impact.

247 ponse elements in the proximal region of the Survivin promoter are involved in this IGF-I response.

248 ation assay, we demonstrate occupancy of the survivin promoter by CBP that is decreased by ICG-001 in

249 n antisurvivin drug that interferes with Sp1-survivin promoter interactions, and survivin small inter

250 a, which lowers TP53 activation and releases survivin promoter repression.

251 minicircles that use the pan-tumor-specific Survivin promoter to drive expression of a secretable re

252 Use of various Survivin promoter-luciferase constructs revealed that th

253 nd identified in the screen, can bind to the survivin protein at the intended target site.

254 or growth but also significantly induced the survivin protein level in residual tumors, whereas addit

255 way of a collective result of suppression of survivin protein, beta-catenin, and mammalian target of

256 sponsible for the procancerous properties of survivin proteins.

257 indicated similar degrees of renal injury in survivin(ptKO) and control mice 24 hours after reperfusi

258 fusion, but recovery was markedly delayed in survivin(ptKO) mice.

259 control littermates but remained minimal in survivin(ptKO) mice.

260 oximal tubule-specific deletion of survivin (survivin(ptKO)).

261 esents an overview of the mechanism by which survivin regulates cell function, followed by a discussi

262 urvivin, other drug resistant molecules, and survivin regulators.

263 reases survivin level, and overexpression of survivin rescues the defects caused by CUL7 depletion.

264 ence-mediated or pharmacologic inhibition of survivin restored sensitivity to trastuzumab in resistan

265 tuzumab, higher pretreatment tumor levels of survivin RNA correlated with poor response to therapy.

266 lotinib and the small-molecule antagonist of survivin, S12.

267 Furthermore, both Lys-90 and Lys-91 within survivin serve as ubiquitin acceptor sites.

268 ) breast cancer by inhibiting HER2-PI3K-FOXO-survivin signaling.

269 The chimera is able to inhibit EGFR and survivin simultaneously and induce apoptosis effectively

270 PCat-loaded with survivin siRNA (PCat-siSurvivin) was active in cultured

271 e-specific membrane antigen, and loaded with survivin siRNA, inhibited prostate cancer xenograft.

272 Likewise, survivin siRNA-loaded and folate-displaying extracellula

273 of an adaptive response if transfected with survivin siRNA.

274 with Sp1-survivin promoter interactions, and survivin small interference RNA (siRNA) transfection eli

275 Application of HLA-A2-restricted survivin-specific T cell receptors (TCRs) isolated from

276 Here, we identified an HLA-A2-restricted survivin-specific TCR isolated from autologous TCR reper

277 Phosphorylation of survivin specifically on residue T34 enhances the activi

278 Phosphorylation of survivin specifically on residue T34 upregulates the act

279 Phosphorylation of survivin specifically on residue T34 upregulates the act

280 Moreover, a small-molecule inhibitor of survivin strongly impaired the growth of representative

281 d the antitumor activity of a small-molecule survivin suppressant YM155 alone and in combination with

282 The anti-apoptotic protein survivin (Sur) plays an important role in the regulation

283 h renal proximal tubule-specific deletion of survivin (survivin(ptKO)).

284 ting the current limitations associated with survivin-targeted therapies and speculating on the futur

285 owed by a discussion of the current state of survivin-targeted therapies.

286 providing preclinical proof of concept for a survivin-targeting anticancer agent, our work offers nov

287 We generated mice (survivin-TCR-transgenic [Sur-TCR-Tg]) expressing a TCR r

288 y inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with s

289 omplex that regulates CUL9 and its substrate survivin to link mitosis to cell survival.

290 ion, as evidenced by the ability of shRNA to survivin to reverse neuroprotection.

291 get of rapamycin complex 1 (mTORC1)-mediated survivin translation by ERK and AKT signaling.

292 ng siRNAs (Bcl-2, P-glycoprotein [P-gp], and survivin) via encapsulation and surface coordination, re

293 Likewise, expression of survivin was detected in the ischemically damaged small

294 The expression of survivin was downregulated by TP.

295 Survivin was expressed strongly in epithelial cells of s

296 extracellular signal-related kinase 1/2, and survivin were determined by enzyme-linked immunosorbent

297 pathway, and the downstream targets MMP7 and survivin were down-regulated upon BMVC or BMVC4 treatmen

298 egrin, alphavbeta3, promotes upregulation of survivin, which in turn supports anchorage-independent g

299 ining Aurora B kinase, borealin, INCENP, and survivin, which orchestrates chromosome dynamics.

300 Lewis lung carcinoma, vaccination of the TAA survivin with SA-4-1BBL/MPL yielded superior efficacy ag