ライフサイエンスコーパス: susceptibility loci

1 nked to >30 insulin-dependent diabetes (Idd) susceptibility loci.

2 8 cases and 13,970 controls) to identify new susceptibility loci.

3 :03 (Pcombined=1.83 x 10(-9)) as independent susceptibility loci.

4 ysis using Immunochip data have uncovered 36 susceptibility loci.

5 ified numerous common prostate cancer (PrCa) susceptibility loci.

6 wer, leading to the discovery of six new EOC susceptibility loci.

7 mmary, we provide evidence of five novel SLE susceptibility loci.

8 cinoma may be attributable to shared genetic susceptibility loci.

9 heterogeneity to discover additional obesity susceptibility loci.

10 ltiple biologically relevant lupus nephritis susceptibility loci.

11 mapping for detecting previously overlooked susceptibility loci.

12 -1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci.

13 tent not previously observed in other cancer susceptibility loci.

14 tive phenotypes to identify putative disease-susceptibility loci.

15 rlap with previously reported SLE-associated susceptibility loci.

16 reveals a strong enrichment for DMRs in T2D-susceptibility loci.

17 ping studies in the search for CCLE specific susceptibility loci.

18 0(-8), OR 0.89), confirming that both are RA susceptibility loci.

19 mosome 9q21.32 are true diabetic nephropathy susceptibility loci.

20 are causally linked to specific mutagens or susceptibility loci.

21 AS) have identified 140 Crohn's disease (CD) susceptibility loci.

22 dies (GWAS) have reported several suggestive susceptibility loci.

23 ful tool in the investigation of new disease susceptibility loci.

24 nformation has been used to identify genetic susceptibility loci.

25 multiplex families to identify possible rare susceptibility loci.

26 teraction between AXIN2 and additional cleft susceptibility loci.

27 crease statistical power to identify disease susceptibility loci.

28 tion studies, and identification of numerous susceptibility loci.

29 sms, previously confirmed as type 1 diabetes susceptibility loci.

30 D2 signaling pathway and are Crohn's disease susceptibility loci.

31 ions have now been identified as scleroderma susceptibility loci.

32 ments in the fine-mapping resolution at many susceptibility loci.

33 entified multiple renal cell carcinoma (RCC) susceptibility loci.

34 enia (SCZ) in Han Chinese identified several susceptibility loci.

35 eract with the 92 DRE that were found at IBD susceptibility loci.

36 nderstanding the biology of specific disease susceptibility loci.

37 ncorporating information from common genetic susceptibility loci.

38 heterogeneous, with evidence for hundreds of susceptibility loci.

39 We identify an additional four susceptibility loci: 11q23.3 CADM1, a metastasis suppres

40 y proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with sch

41 Here we show the discovery of four new BCC susceptibility loci: 2p24 MYCN (rs57244888[C], OR=0.76,

42 We identified 25 new susceptibility loci, 3 of which contain integrin genes t

43 gies have led to the discovery of 242 common susceptibility loci, 45 of which have been fine-mapped t

44 We identified 14 new susceptibility loci, 9 of which were associated with rhe

45 We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance,

46 We identified 18 susceptibility loci achieving genome-wide significance,

47 Genome-wide significant susceptibility loci affecting biomarker levels were foun

48 ls, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci.

49 m six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci.

50 Given previous evidence that certain susceptibility loci and carcinogens are associated with

51 tion between 12 GWAS-identified hypertension-susceptibility loci and cardiotoxicity in a cohort of lo

52 We identified shared susceptibility loci and commonalities in pathways betwee

53 to determine the association between obesity susceptibility loci and dietary intake.

54 ociations between inflammatory bowel disease susceptibility loci and gene expression.

55 we used an alternative approach to annotate susceptibility loci and identify candidate genes for hum

56 s and Epidemiology (PAGE) study, we identify susceptibility loci and investigate pleiotropy among gen

57 pport for potential type 2 diabetes mellitus susceptibility loci and may be useful in identifying new

58 Our results highlight several promising new susceptibility loci and reinforce the importance of lyso

59 We identify new CBD susceptibility loci and show that CBD and PSP share a ge

60 table psychiatric disorders with overlapping susceptibility loci and symptomatology.

61 udies, we estimated the number of undetected susceptibility loci and the distribution of effect sizes

62 k alleles carried at 27 validated common CRC susceptibility loci), and history of endoscopic examinat

63 our of these regions are known breast cancer susceptibility loci, and four additional regions were fo

64 iously published loci, we discovered six new susceptibility loci, and further gene prioritization ana

65 e 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processin

66 pped and examined for enrichment for disease susceptibility loci annotated in the genome-wide associa

67 ; P = .02) and CD2AP (rs9349407; P = .03) AD susceptibility loci are associated with neuritic plaque

68 olymorphisms or aggregations of these 36 T2D susceptibility loci are associated with PCa.

69 ether genotypes of 10 recently identified RA susceptibility loci are associated with radiologic sever

70 Many low-penetrance breast cancer susceptibility loci are found to be located in non-prote

71 y the scientific community investigating SLE susceptibility loci as they are more powerful than simpl

72 ciation (GWA) studies-identified lung cancer susceptibility loci assessed, a variant (rs2808630) of t

73 tudies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk.

74 smoking women have previously identified six susceptibility loci associated with lung cancer risk.

75 n and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-m

76 We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 x 10

77 04 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595

78 This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31.

79 P<5.0 x 10(-8)) evidence of 4 additional CHD susceptibility loci at 4q31.22 (rs1400558, upstream of E

80 We also identified two novel susceptibility loci at 5q15 near ERAP2 (rs7705093; OR =

81 rited susceptibility to BCP-ALL, identifying susceptibility loci at 7p12.2, 9p21.3, 10q21.2, and 14q1

82 Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(

83 We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 x

84 ,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 x 1

85 ween the immune system, psoriasis-associated susceptibility loci, autoantigens, and multiple environm

86 y is unexplained, indicating that additional susceptibility loci await identification.

87 d IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci

88 reveals that several diseases share multiple susceptibility loci, but there are many nuances.

89 ested in mapping common and uncommon disease susceptibility loci by focusing on output linking correl

90 ng to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have pr

91 or which the goal is to discover new genetic susceptibility loci by leveraging G-E interaction when p

92 eth cells associated with particular genetic susceptibility loci can be used to define specific subty

93 genetic basis of the disease, the identified susceptibility loci can only account for a small portion

94 ts at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1

95 Many disease susceptibility loci colocalize with DNA regulatory eleme

96 These new TGCT susceptibility loci contain biologically plausible genes

97 Most vitiligo susceptibility loci encode immunoregulatory proteins or

98 -associated loci, suggesting that additional susceptibility loci exist.

99 nts; in addition, known rheumatoid arthritis susceptibility loci explain only a portion of familial c

100 More than 70 prostate cancer susceptibility loci, explaining approximately 30% of the

101 also confirmed the association of the known susceptibility loci FCER1A, STAT6, and IL13 for the dysr

102 some 19p13.11 (p = 1.0 x 10(-11) ) as shared susceptibility loci for ALS and FTD-TDP.

103 ociation studies have identified a number of susceptibility loci for Alzheimer disease (AD).

104 vances have been made in identifying genetic susceptibility loci for autoimmune diseases, but evidenc

105 s have driven the discovery of more than 300 susceptibility loci for autoimmune diseases.

106 To discover new susceptibility loci for Behcet's disease, we performed a

107 High-penetrance susceptibility loci for breast cancer usually result fro

108 To identify functional susceptibility loci for breast cancer, we interrogated t

109 East Asian women to search for novel genetic susceptibility loci for breast cancer.

110 The recent identification of over 60 susceptibility loci for CAD confirms not only the import

111 ed in future functional studies as candidate susceptibility loci for cardiovascular disease mediated

112 d with lupus, potentially harboring distinct susceptibility loci for CCLE.

113 We discuss genetic susceptibility loci for CD and how these affect Paneth c

114 te antigen (HLA) genes are candidate genetic susceptibility loci for childhood acute lymphoblastic le

115 ation studies (GWAS) have identified several susceptibility loci for childhood acute lymphoblastic le

116 Several susceptibility loci for classical Hodgkin lymphoma have

117 ion studies (GWASs) have identified multiple susceptibility loci for colorectal cancer, but much of h

118 To identify additional susceptibility loci for colorectal cancer, here we perfo

119 ociation Studies (GWAS) have identified many susceptibility loci for common diseases, they only expla

120 y productive for the discovery of additional susceptibility loci for common diseases.

121 ssociation studies (GWAS) have revealed many susceptibility loci for complex genetic diseases.

122 wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) i

123 gulatory elements that colocalize with known susceptibility loci for coronary artery disease (CARDIoG

124 Genetic susceptibility loci for Crohn's disease (CD) are numerou

125 assessed using genetic risk scores based on susceptibility loci for Crohn's disease, type 1 diabetes

126 ome-wide association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at M

127 ieve the large sample sizes needed to detect susceptibility loci for depression.

128 We identified nine new susceptibility loci for different EOC histotypes: six fo

129 To identify genetic susceptibility loci for DLBCL, we conducted a meta-analy

130 In humans, these genes reside in susceptibility loci for epilepsy, and, in flies, we obse

131 ociation studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC),

132 ome-wide association studies have identified susceptibility loci for esophageal squamous cell carcino

133 nduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.

134 vious candidate gene studies suggested a few susceptibility loci for food allergy, but no study inves

135 wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo.

136 Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; thes

137 ) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14.

138 nal candidate-gene annotation for 37 disease susceptibility loci for human atherosclerotic disease th

139 city, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predic

140 We also observe considerable overlap between susceptibility loci for IBD and mycobacterial infection.

141 nochip genotyping array expand the number of susceptibility loci for IBD in Caucasians to 163, but th

142 We correlated these regions with susceptibility loci for IBD.

143 tion studies (GWAS) have identified multiple susceptibility loci for immunoglobulin A nephropathy (Ig

144 Twenty-two previously identified susceptibility loci for individual MetS component traits

145 the discriminatory attributes of the 14 CRC susceptibility loci for individual risk prediction are p

146 Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, most

147 Major susceptibility loci for islet autoantibodies are separat

148 and to investigate relationships with known susceptibility loci for kidney function and lipids.

149 (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, pr

150 To identify genetic susceptibility loci for MacTel, we performed a genome-wi

151 iation (GWA) studies have identified several susceptibility loci for metabolic syndrome (MetS) compon

152 ubstantially increases the number of genetic susceptibility loci for NSCLP and provides important ins

153 ome-wide interaction study to identify novel susceptibility loci for occupational exposure to biologi

154 ermine whether the identified genes are true susceptibility loci for occupational exposures and wheth

155 ly several other genomic regions, may harbor susceptibility loci for OCD.

156 udies (GWAS) have identified multiple common susceptibility loci for pancreatic cancer.

157 idence for SMAP1, B3GAT2, and RIMS1 as novel susceptibility loci for pediatric VTE and warrant future

158 We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12

159 dies (GWAS) have identified >100 independent susceptibility loci for prostate cancer, including the h

160 in UC patients with the aim of detecting new susceptibility loci for PSC.

161 or, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 x 10(-10) and P =

162 Only two common susceptibility loci for RCC have been confirmed to date.

163 ve facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA).

164 the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human can

165 ion studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been condu

166 tion (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT

167 We conducted a meta-analysis to identify new susceptibility loci for testicular germ cell tumor (TGCT

168 ighted SNP-scores were built involving known susceptibility loci for the aforementioned traits (53, 7

169 IoGRAM and METASTROKE, are ongoing to reveal susceptibility loci for their underlying disease-atheros

170 To identify additional susceptibility loci for this common cancer, we conducted

171 To identify further susceptibility loci for this common, complex skin diseas

172 Known genetic susceptibility loci for type 2 diabetes (T2D) explain on

173 studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most

174 to the CF disease-causing gene) and at four susceptibility loci for type 2 diabetes in the general p

175 To identify susceptibility loci for visceral leishmaniasis, we under

176 hort of 1,481 individuals and identified two susceptibility loci: for lobar ICH, chromosomal region 1

177 h as discoveries of large numbers of disease susceptibility loci from genome-wide association studies

178 r risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, a

179 dies have had limited success in identifying susceptibility loci, genome-wide association studies (GW

180 lay between lifestyle risk factors and these susceptibility loci has not been fully elucidated.

181 ry diseases in recent years: several hundred susceptibility loci have been discovered in genome-wide

182 For type 1 diabetes, >40 susceptibility loci have been discovered.

183 To date, 22 common breast cancer susceptibility loci have been identified accounting for

184 While numerous genetic susceptibility loci have been identified for clinical Al

185 Over 40 susceptibility loci have been identified for type 1 diab

186 More than 200 susceptibility loci have been identified in populations

187 ory skin disorder for which multiple genetic susceptibility loci have been identified, but few resolv

188 Although several lung cancer susceptibility loci have been identified, much of the he

189 cing dyslipidemia and currently; 157 genetic susceptibility loci have been reported to be associated

190 Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of

191 Thirteen common susceptibility loci have been reproducibly associated wi

192 have identified common risk variants in >100 susceptibility loci; however, the contribution of rare v

193 Additional susceptibility loci identified at genome-wide significan

194 To further investigate susceptibility loci identified by genome-wide associatio

195 Susceptibility loci identified by GWAS generally account

196 ion to prioritize candidate genes in disease susceptibility loci identified by GWAS.

197 ed networks can inform functional studies of susceptibility loci identified from genome-wide associat

198 Overall, the association of most CRC susceptibility loci identified in initial GWAS seems to

199 on in a subset of the 72 known breast cancer susceptibility loci identified through genome-wide assoc

200 Intriguingly, two PBC susceptibility loci identified through genome-wide assoc

201 tudy, we aimed to investigate whether the OA susceptibility loci identified to date are functioning a

202 eritability for PsA, the majority of genetic susceptibility loci identified to date are shared with p

203 ntribution to prostate cancer, with over 100 susceptibility loci identified to date that can explain

204 Exploration of the enlarged set of susceptibility loci implicates several processes, includ

205 MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls

206 to investigate established RA, IBD, and T1D susceptibility loci in AD.

207 olism (VTE) and identified a number of novel susceptibility loci in adults.

208 e we identified a role for nine genes in IBD susceptibility loci in antibacterial autophagy and chara

209 We recently identified ten novel SLE susceptibility loci in Asians and uncovered several addi

210 sing the Immunochip to determine whether IBD susceptibility loci in Caucasians also affect risk in AA

211 Here we map common genetic susceptibility loci in European ancestry women for the N

212 ing regulatory biofeatures at 17 known HGSOC susceptibility loci in FTSECs (P = 3.8 x 10(-30)), OSECs

213 spots" may provide new targets for defining susceptibility loci in future studies.

214 s have been reproducibly identified as major susceptibility loci in large-scale genome-wide associati

215 (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry.

216 NXB, and ERBB3, which had been identified as susceptibility loci in previous genome-wide association

217 nd Behcet's disease and exploring additional susceptibility loci in the human leukocyte antigen (HLA)

218 We identify four novel inguinal hernia susceptibility loci in the regions of EFEMP1, WT1, EBF2

219 have not previously been identified as TGCT susceptibility loci in these GWA scans, demonstrating th

220 diovascular phenotypes, we identify novel AD susceptibility loci, including 2 genome-wide significant

221 s of this study identify three candidate LSL susceptibility loci, including one that appears to be as

222 We have mapped 43 susceptibility loci, including ten new associations.

223 We identified ten previously unreported T2D susceptibility loci, including two showing sex-different

224 We identified 15 new susceptibility loci, increasing to 36 the number associa

225 Each of the 14 susceptibility loci independently influences CRC with th

226 additive interactions between smoking and 12 susceptibility loci, individually and combined as a poly

227 50-IL13 and IL4), and 12q13 (STAT6) as major susceptibility loci influencing the regulation of total

228 cidating how the repercussions of individual susceptibility loci integrate to yield dysregulation of

229 cellular structure affected by schizophrenia susceptibility loci is the actin cytoskeleton, an organe

230 spite the large number of identified disease-susceptibility loci, it is not known which loci influenc

231 entified nearly 40 different type 2 diabetes susceptibility loci, mainly in European populations, but

232 determine whether, similarly, common cancer susceptibility loci map to genes that have altered frequ

233 A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14

234 A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1

235 xistence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited

236 o date, but the identification of additional susceptibility loci might be important to enhance our un

237 pots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-

238 addition to PLG, the currently known shared susceptibility loci of CAD and periodontitis, ANRIL and

239 Several susceptibility loci of differentiated thyroid cancer (DT

240 , including SLC25A39 and SLC25A40, reside in susceptibility loci of severe forms of epilepsy.

241 ned interactions between smoking and obesity susceptibility loci on BMI.

242 In addition to revealing two new TGCT susceptibility loci, our results continue to support the

243 Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus uniqu

244 Furthermore, among 21 breast cancer susceptibility loci previously established in European p

245 These susceptibility loci provide deeper insight into the path

246 We describe six new susceptibility loci reaching a genome-wide threshold of

247 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P

248 hisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide a

249 These observations suggest that OA susceptibility loci regulate the level of DNA methylatio

250 ty and function of the causal genes in these susceptibility loci remain, however, elusive.

251 diabetes predisposition at most established susceptibility loci remains poorly understood.

252 Ultimately, we identified a NSCL/P susceptibility loci (rs17095681 at 10q25.3, intron of SH

253 Two GVHD susceptibility loci (rs17114803 and rs17114808) within t

254 ormatics using all 82 loci revealed that SLE susceptibility loci share many gene regulatory features,

255 -DR2 and HLA-DR3, two well established lupus susceptibility loci, showed evidence of association with

256 ar germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding prot

257 To identify susceptibility loci specific to ER-negative disease, we

258 MS Genetics Consortium) that identified new susceptibility loci, taking the total number of risk all

259 dies (GWAS) in PSC have detected a number of susceptibility loci that also show associations in UC an

260 and we discover novel etiologically relevant susceptibility loci that are invisible to standard singl

261 y identified four novel diabetic nephropathy susceptibility loci that have subsequently been shown to

262 ically analyze chromatin-interactions at IBD susceptibility loci that localize to regulatory DNA.

263 , our integrated analyses highlight a set of susceptibility loci that might subserve a shared molecul

264 and progression of DR, the identification of susceptibility loci through candidate gene approaches, l

265 f colorectal cancer (CRC) have identified 23 susceptibility loci thus far.

266 renal cell cancer (RCC) have identified four susceptibility loci thus far.

267 P<5x10(-8)), increasing the number of known susceptibility loci to 25.

268 WAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33.

269 thnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethni

270 studies have identified not only hundreds of susceptibility loci to immune-mediated diseases but also

271 cts demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunit

272 nt with previous genetic mapping of teratoma susceptibility loci to the region containing Gfra1.

273 but have had variable success in identifying susceptibility loci to the syndrome as an entity.

274 Known susceptibility loci together can only explain about 6-8%

275 NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SE

276 ly, the aggregated effect of all 170 disease susceptibility loci was not associated with disease prog

277 To identify new susceptibility loci, we carried out a genetic study of m

278 To identify additional CLL susceptibility loci, we conducted a GWAS and performed a

279 To identify additional BCP-ALL susceptibility loci, we conducted a GWAS and performed a

280 To identify additional FL susceptibility loci, we conducted a large-scale two-stag

281 To identify new glioma susceptibility loci, we conducted a meta-analysis of fou

282 To identify novel CRC susceptibility loci, we conducted a new GWAS and perform

283 To identify additional RCC common susceptibility loci, we conducted an independent genome-

284 To identify additional CLL susceptibility loci, we conducted the largest meta-analy

285 tter understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,6

286 To further discover new susceptibility loci, we imputed data from four GWAS of A

287 To identify new susceptibility loci, we performed a meta-analysis of 11

288 In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11

289 To identify new susceptibility loci, we performed meta-analysis on genom

290 gle nucleotide polymorphisms (SNPs) at these susceptibility loci were associated with diabetic nephro

291 Six new atrial fibrillation susceptibility loci were identified and replicated in an

292 Twenty-three new susceptibility loci were identified at association P < 5

293 Twenty-three new prostate cancer susceptibility loci were identified at genome-wide signi

294 Four novel susceptibility loci were identified with genome-wide sig

295 After adjusting for these factors, 100 susceptibility loci were identified.

296 n the allele frequencies and effect sizes of susceptibility loci, which we use to interpret the volum

297 The identification of SIX1 and CDKN2B as susceptibility loci will assist in understanding the pat

298 We identified 16 shared susceptibility loci with association P<5x10(-8), includi

299 We increased the number of susceptibility loci with genome-wide significant associa

300 Opportunities exist to identify susceptibility loci with modest effect by meta-analyzing