ライフサイエンスコーパス: susceptibility loci

1 entified multiple renal cell carcinoma (RCC) susceptibility loci.

2 enia (SCZ) in Han Chinese identified several susceptibility loci.

3 eract with the 92 DRE that were found at IBD susceptibility loci.

4 nderstanding the biology of specific disease susceptibility loci.

5 ncorporating information from common genetic susceptibility loci.

6 heterogeneous, with evidence for hundreds of susceptibility loci.

7 nked to >30 insulin-dependent diabetes (Idd) susceptibility loci.

8 d by fixed-effect meta-analyses, to identify susceptibility loci.

9 :03 (Pcombined=1.83 x 10(-9)) as independent susceptibility loci.

10 as likely causative genes at respective AMD susceptibility loci.

11 ysis using Immunochip data have uncovered 36 susceptibility loci.

12 ified numerous common prostate cancer (PrCa) susceptibility loci.

13 wer, leading to the discovery of six new EOC susceptibility loci.

14 cinoma may be attributable to shared genetic susceptibility loci.

15 heterogeneity to discover additional obesity susceptibility loci.

16 ltiple biologically relevant lupus nephritis susceptibility loci.

17 mapping for detecting previously overlooked susceptibility loci.

18 -1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci.

19 tent not previously observed in other cancer susceptibility loci.

20 tive phenotypes to identify putative disease-susceptibility loci.

21 e provided strong evidence for 3 genome-wide susceptibility loci.

22 rlap with previously reported SLE-associated susceptibility loci.

23 reveals a strong enrichment for DMRs in T2D-susceptibility loci.

24 ping studies in the search for CCLE specific susceptibility loci.

25 0(-8), OR 0.89), confirming that both are RA susceptibility loci.

26 ncluded 94 437 individuals and discovered 24 susceptibility loci.

27 mosome 9q21.32 are true diabetic nephropathy susceptibility loci.

28 are causally linked to specific mutagens or susceptibility loci.

29 AS) have identified 140 Crohn's disease (CD) susceptibility loci.

30 ful tool in the investigation of new disease susceptibility loci.

31 nformation has been used to identify genetic susceptibility loci.

32 ere associated with novel, to our knowledge, susceptibility loci.

33 and annotated several cardiovascular disease susceptibility loci.

34 ich is genetically associated with different susceptibility loci.

35 have identified more than 170 breast cancer susceptibility loci.

36 confound attempts to identify additional T1D susceptibility loci.

37 on of PBT heritability attributable to these susceptibility loci.

38 is, revealing new targets that map to asthma susceptibility loci.

39 (IFIH1, STAT1, and IRF7) encompassed in SLE susceptibility loci.

40 tifying traits or diseases that share common susceptibility loci.

41 udies (GWASs) of vitiligo have identified 50 susceptibility loci.

42 ariant and effector transcripts at T2DM GWAS susceptibility loci.

43 8 cases and 13,970 controls) to identify new susceptibility loci.

44 mmary, we provide evidence of five novel SLE susceptibility loci.

45 dies (GWAS) have reported several suggestive susceptibility loci.

46 ry loci for a total of 85 cutaneous melanoma susceptibility loci.

47 ments in the fine-mapping resolution at many susceptibility loci.

48 We identify an additional four susceptibility loci: 11q23.3 CADM1, a metastasis suppres

49 y proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with sch

50 Here we show the discovery of four new BCC susceptibility loci: 2p24 MYCN (rs57244888[C], OR=0.76,

51 We identified 25 new susceptibility loci, 3 of which contain integrin genes t

52 gies have led to the discovery of 242 common susceptibility loci, 45 of which have been fine-mapped t

53 -9) for the leading rs259919) and two cancer susceptibility loci 6p21.32 (rs3135001, HLA-DQB1) and 6p

54 We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance,

55 We identified 18 susceptibility loci achieving genome-wide significance,

56 ave led to the identification of hundreds of susceptibility loci across cancers, but the impact of fu

57 We found that up to 35% of the susceptibility loci affect in vitro cytokine production

58 ls, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci.

59 sociation between genetic variants at 21 T2D-susceptibility loci and all-cause mortality in an elderl

60 m six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci.

61 Given previous evidence that certain susceptibility loci and carcinogens are associated with

62 tion between 12 GWAS-identified hypertension-susceptibility loci and cardiotoxicity in a cohort of lo

63 We identified shared susceptibility loci and commonalities in pathways betwee

64 ociations between inflammatory bowel disease susceptibility loci and gene expression.

65 we used an alternative approach to annotate susceptibility loci and identify candidate genes for hum

66 s and Epidemiology (PAGE) study, we identify susceptibility loci and investigate pleiotropy among gen

67 Our results highlight several promising new susceptibility loci and reinforce the importance of lyso

68 We identify new CBD susceptibility loci and show that CBD and PSP share a ge

69 to examine the molecular mechanisms of known susceptibility loci and to detect and interpret pleiotro

70 k alleles carried at 27 validated common CRC susceptibility loci), and history of endoscopic examinat

71 our of these regions are known breast cancer susceptibility loci, and four additional regions were fo

72 iously published loci, we discovered six new susceptibility loci, and further gene prioritization ana

73 e 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processin

74 pped and examined for enrichment for disease susceptibility loci annotated in the genome-wide associa

75 ; P = .02) and CD2AP (rs9349407; P = .03) AD susceptibility loci are associated with neuritic plaque

76 ether genotypes of 10 recently identified RA susceptibility loci are associated with radiologic sever

77 ciation (GWA) studies-identified lung cancer susceptibility loci assessed, a variant (rs2808630) of t

78 tudies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk.

79 smoking women have previously identified six susceptibility loci associated with lung cancer risk.

80 ation studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson's Disease

81 and 83,943 male controls) to identify novel susceptibility loci associated with PCa risk.

82 (GWAS) have identified thousands of germline susceptibility loci associated with risk for cancer as w

83 04 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595

84 This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31.

85 P<5.0 x 10(-8)) evidence of 4 additional CHD susceptibility loci at 4q31.22 (rs1400558, upstream of E

86 We also identified two novel susceptibility loci at 5q15 near ERAP2 (rs7705093; OR =

87 rited susceptibility to BCP-ALL, identifying susceptibility loci at 7p12.2, 9p21.3, 10q21.2, and 14q1

88 Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(

89 We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 x

90 ,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 x 1

91 We identified 4 susceptibility loci at genome-wide significance: rs58923

92 ween the immune system, psoriasis-associated susceptibility loci, autoantigens, and multiple environm

93 y is unexplained, indicating that additional susceptibility loci await identification.

94 e frequencies at these and other established susceptibility loci (BMI1, PIP4K2A, and CEBPE) and found

95 d IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci

96 reveals that several diseases share multiple susceptibility loci, but there are many nuances.

97 ested in mapping common and uncommon disease susceptibility loci by focusing on output linking correl

98 ng to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have pr

99 or which the goal is to discover new genetic susceptibility loci by leveraging G-E interaction when p

100 eth cells associated with particular genetic susceptibility loci can be used to define specific subty

101 genetic basis of the disease, the identified susceptibility loci can only account for a small portion

102 ts at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1

103 We use examples of four T2DM susceptibility loci (CDKAL1, MTNR1B, SLC30A8 and PAM) to

104 Many disease susceptibility loci colocalize with DNA regulatory eleme

105 These new TGCT susceptibility loci contain biologically plausible genes

106 -associated loci, suggesting that additional susceptibility loci exist.

107 some 19p13.11 (p = 1.0 x 10(-11) ) as shared susceptibility loci for ALS and FTD-TDP.

108 This meta-analysis discovered 19 susceptibility loci for Alzheimer's disease in populatio

109 vances have been made in identifying genetic susceptibility loci for autoimmune diseases, but evidenc

110 s have driven the discovery of more than 300 susceptibility loci for autoimmune diseases.

111 High-penetrance susceptibility loci for breast cancer usually result fro

112 To search for additional genetic susceptibility loci for breast cancer, here we perform a

113 To identify functional susceptibility loci for breast cancer, we interrogated t

114 East Asian women to search for novel genetic susceptibility loci for breast cancer.

115 The recent identification of over 60 susceptibility loci for CAD confirms not only the import

116 d with lupus, potentially harboring distinct susceptibility loci for CCLE.

117 We discuss genetic susceptibility loci for CD and how these affect Paneth c

118 ation studies (GWAS) have identified several susceptibility loci for childhood acute lymphoblastic le

119 Several susceptibility loci for classical Hodgkin lymphoma have

120 a good alternative method to detect disease susceptibility loci for clinic genomic data.

121 ion studies (GWASs) have identified multiple susceptibility loci for colorectal cancer, but much of h

122 To identify additional susceptibility loci for colorectal cancer, here we perfo

123 ociation Studies (GWAS) have identified many susceptibility loci for common diseases, they only expla

124 Most susceptibility loci for complex dermatologic diseases fa

125 ssociation studies (GWAS) have revealed many susceptibility loci for complex genetic diseases.

126 wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) i

127 gulatory elements that colocalize with known susceptibility loci for coronary artery disease (CARDIoG

128 Genetic susceptibility loci for Crohn's disease (CD) are numerou

129 We discover 16 susceptibility loci for CTS with p < 5 x 10(-8).

130 ome-wide association study (GWAS) identified susceptibility loci for dengue shock syndrome (DSS) at M

131 ieve the large sample sizes needed to detect susceptibility loci for depression.

132 We identified nine new susceptibility loci for different EOC histotypes: six fo

133 ngle nucleotide polymorphisms (SNPs) at four susceptibility loci for diffuse large B-cell lymphoma (D

134 We report two susceptibility loci for DLB at genome-wide significance,

135 To identify genetic susceptibility loci for DLBCL, we conducted a meta-analy

136 In humans, these genes reside in susceptibility loci for epilepsy, and, in flies, we obse

137 ociation studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC),

138 nduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.

139 vious candidate gene studies suggested a few susceptibility loci for food allergy, but no study inves

140 Conclusion: We identified six susceptibility loci for gallstone disease.

141 ) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14.

142 nal candidate-gene annotation for 37 disease susceptibility loci for human atherosclerotic disease th

143 city, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predic

144 nochip genotyping array expand the number of susceptibility loci for IBD in Caucasians to 163, but th

145 We correlated these regions with susceptibility loci for IBD.

146 tion studies (GWAS) have identified multiple susceptibility loci for immunoglobulin A nephropathy (Ig

147 ommon variants in genomic regions containing susceptibility loci for inflammatory bowel disease and c

148 Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, most

149 Major susceptibility loci for islet autoantibodies are separat

150 and to investigate relationships with known susceptibility loci for kidney function and lipids.

151 (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, pr

152 To identify genetic susceptibility loci for MacTel, we performed a genome-wi

153 ubstantially increases the number of genetic susceptibility loci for NSCLP and provides important ins

154 ome-wide interaction study to identify novel susceptibility loci for occupational exposure to biologi

155 ermine whether the identified genes are true susceptibility loci for occupational exposures and wheth

156 udies (GWAS) have identified multiple common susceptibility loci for pancreatic cancer.

157 idence for SMAP1, B3GAT2, and RIMS1 as novel susceptibility loci for pediatric VTE and warrant future

158 STAT4, IL10, and CCR1-CCR3 were significant susceptibility loci for PFAPA, suggesting that the patho

159 We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12

160 dies (GWAS) have identified >100 independent susceptibility loci for prostate cancer, including the h

161 in UC patients with the aim of detecting new susceptibility loci for PSC.

162 ve facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA).

163 the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human can

164 ion studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been condu

165 tion (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT

166 We conducted a meta-analysis to identify new susceptibility loci for testicular germ cell tumor (TGCT

167 ighted SNP-scores were built involving known susceptibility loci for the aforementioned traits (53, 7

168 IoGRAM and METASTROKE, are ongoing to reveal susceptibility loci for their underlying disease-atheros

169 studies (GWAS) have identified more than 20 susceptibility loci for these conditions.

170 To identify additional susceptibility loci for this common cancer, we conducted

171 To identify further susceptibility loci for this common, complex skin diseas

172 Known genetic susceptibility loci for type 2 diabetes (T2D) explain on

173 studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most

174 to the CF disease-causing gene) and at four susceptibility loci for type 2 diabetes in the general p

175 To identify susceptibility loci for visceral leishmaniasis, we under

176 To conclude, we identified 16 novel susceptibility loci for VTE; for some loci, the associat

177 hort of 1,481 individuals and identified two susceptibility loci: for lobar ICH, chromosomal region 1

178 h as discoveries of large numbers of disease susceptibility loci from genome-wide association studies

179 r risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, a

180 dies have had limited success in identifying susceptibility loci, genome-wide association studies (GW

181 Subsequently, the search for susceptibility loci has been reinvigorated by the use of

182 lay between lifestyle risk factors and these susceptibility loci has not been fully elucidated.

183 mewide association studies, over 50 vitiligo susceptibility loci have been discovered.

184 While numerous genetic susceptibility loci have been identified for clinical Al

185 Over 40 susceptibility loci have been identified for type 1 diab

186 More than 200 susceptibility loci have been identified in populations

187 ory skin disorder for which multiple genetic susceptibility loci have been identified, but few resolv

188 Although several lung cancer susceptibility loci have been identified, much of the he

189 cing dyslipidemia and currently; 157 genetic susceptibility loci have been reported to be associated

190 Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of

191 Thirteen common susceptibility loci have been reproducibly associated wi

192 have identified common risk variants in >100 susceptibility loci; however, the contribution of rare v

193 mer's disease, with the identification of 40 susceptibility loci; however, this does not equate to th

194 Additional susceptibility loci identified at genome-wide significan

195 Susceptibility loci identified by GWAS generally account

196 ion to prioritize candidate genes in disease susceptibility loci identified by GWAS.

197 In addition to susceptibility loci identified in genome-wide associatio

198 tion of genes causing beta cell failure from susceptibility loci identified in type 2 diabetes genome

199 Intriguingly, two PBC susceptibility loci identified through genome-wide assoc

200 tudy, we aimed to investigate whether the OA susceptibility loci identified to date are functioning a

201 eritability for PsA, the majority of genetic susceptibility loci identified to date are shared with p

202 ntribution to prostate cancer, with over 100 susceptibility loci identified to date that can explain

203 MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls

204 to investigate established RA, IBD, and T1D susceptibility loci in AD.

205 olism (VTE) and identified a number of novel susceptibility loci in adults.

206 substantially increased the number of known susceptibility loci in Alzheimer's disease to 40.

207 e we identified a role for nine genes in IBD susceptibility loci in antibacterial autophagy and chara

208 We recently identified ten novel SLE susceptibility loci in Asians and uncovered several addi

209 sing the Immunochip to determine whether IBD susceptibility loci in Caucasians also affect risk in AA

210 Here we map common genetic susceptibility loci in European ancestry women for the N

211 ing regulatory biofeatures at 17 known HGSOC susceptibility loci in FTSECs (P = 3.8 x 10(-30)), OSECs

212 s have been reproducibly identified as major susceptibility loci in large-scale genome-wide associati

213 rches the NHGRI-EBI GWAS Catalog to identify susceptibility loci in linkage disequilibrium (LD) with

214 (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry.

215 NXB, and ERBB3, which had been identified as susceptibility loci in previous genome-wide association

216 nd Behcet's disease and exploring additional susceptibility loci in the human leukocyte antigen (HLA)

217 We identify four novel inguinal hernia susceptibility loci in the regions of EFEMP1, WT1, EBF2

218 have not previously been identified as TGCT susceptibility loci in these GWA scans, demonstrating th

219 discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 a

220 diovascular phenotypes, we identify novel AD susceptibility loci, including 2 genome-wide significant

221 s of this study identify three candidate LSL susceptibility loci, including one that appears to be as

222 We have mapped 43 susceptibility loci, including ten new associations.

223 additive interactions between smoking and 12 susceptibility loci, individually and combined as a poly

224 50-IL13 and IL4), and 12q13 (STAT6) as major susceptibility loci influencing the regulation of total

225 cellular structure affected by schizophrenia susceptibility loci is the actin cytoskeleton, an organe

226 spite the large number of identified disease-susceptibility loci, it is not known which loci influenc

227 n linkage disequilibrium might be unreported susceptibility loci located in the epidermis differentia

228 determine whether, similarly, common cancer susceptibility loci map to genes that have altered frequ

229 A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14

230 A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1

231 o date, but the identification of additional susceptibility loci might be important to enhance our un

232 studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally

233 pots were enriched in breast cancer germline susceptibility loci (odds ratio (OR) = 4.28) and breast-

234 addition to PLG, the currently known shared susceptibility loci of CAD and periodontitis, ANRIL and

235 Several susceptibility loci of differentiated thyroid cancer (DT

236 , including SLC25A39 and SLC25A40, reside in susceptibility loci of severe forms of epilepsy.

237 ned interactions between smoking and obesity susceptibility loci on BMI.

238 he additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) r

239 In addition to revealing two new TGCT susceptibility loci, our results continue to support the

240 Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus uniqu

241 We identified 32 novel susceptibility loci (P < 5.0 x 10(-8)), 15 of which show

242 Furthermore, among 21 breast cancer susceptibility loci previously established in European p

243 In gene regions harboring known susceptibility loci, Primo performs conditional associat

244 These susceptibility loci provide deeper insight into the path

245 We describe six new susceptibility loci reaching a genome-wide threshold of

246 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P

247 hisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide a

248 These observations suggest that OA susceptibility loci regulate the level of DNA methylatio

249 ty and function of the causal genes in these susceptibility loci remain, however, elusive.

250 diabetes predisposition at most established susceptibility loci remains poorly understood.

251 These two studies identified 27 and 29 susceptibility loci, respectively.

252 Ultimately, we identified a NSCL/P susceptibility loci (rs17095681 at 10q25.3, intron of SH

253 Two GVHD susceptibility loci (rs17114803 and rs17114808) within t

254 ormatics using all 82 loci revealed that SLE susceptibility loci share many gene regulatory features,

255 nforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries.

256 -DR2 and HLA-DR3, two well established lupus susceptibility loci, showed evidence of association with

257 ar germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding prot

258 To identify susceptibility loci specific to ER-negative disease, we

259 dies (GWAS) in PSC have detected a number of susceptibility loci that also show associations in UC an

260 ion (ITC-SIS, for short) to detect important susceptibility loci that are associated with the polycys

261 and we discover novel etiologically relevant susceptibility loci that are invisible to standard singl

262 y identified four novel diabetic nephropathy susceptibility loci that have subsequently been shown to

263 ically analyze chromatin-interactions at IBD susceptibility loci that localize to regulatory DNA.

264 , our integrated analyses highlight a set of susceptibility loci that might subserve a shared molecul

265 and progression of DR, the identification of susceptibility loci through candidate gene approaches, l

266 ction of heritability, discovery of vitiligo susceptibility loci through candidate gene, genomewide l

267 f colorectal cancer (CRC) have identified 23 susceptibility loci thus far.

268 renal cell cancer (RCC) have identified four susceptibility loci thus far.

269 We identified 19 susceptibility loci to be significantly associated with

270 WAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33.

271 thnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethni

272 studies have identified not only hundreds of susceptibility loci to immune-mediated diseases but also

273 cts demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunit

274 nt with previous genetic mapping of teratoma susceptibility loci to the region containing Gfra1.

275 Known susceptibility loci together can only explain about 6-8%

276 sequencing and targeted resequencing of IBD susceptibility loci), transcriptome information generate

277 T1D studies and examined to identify new T1D susceptibility loci using molecular inversion probe sequ

278 NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SE

279 ide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease

280 ly, the aggregated effect of all 170 disease susceptibility loci was not associated with disease prog

281 k score quantifying the risk across multiple susceptibility loci was strongly associated with CC risk

282 To identify new susceptibility loci, we carried out a genetic study of m

283 To identify additional CLL susceptibility loci, we conducted a GWAS and performed a

284 To identify additional BCP-ALL susceptibility loci, we conducted a GWAS and performed a

285 To identify additional FL susceptibility loci, we conducted a large-scale two-stag

286 To identify new glioma susceptibility loci, we conducted a meta-analysis of fou

287 To identify novel CRC susceptibility loci, we conducted a new GWAS and perform

288 To identify additional CLL susceptibility loci, we conducted the largest meta-analy

289 tter understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,6

290 To further discover new susceptibility loci, we imputed data from four GWAS of A

291 In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11

292 To identify new susceptibility loci, we performed a meta-analysis of 11

293 To identify new susceptibility loci, we performed meta-analysis on genom

294 gle nucleotide polymorphisms (SNPs) at these susceptibility loci were associated with diabetic nephro

295 Twenty-three new susceptibility loci were identified at association P < 5

296 Twenty-three new prostate cancer susceptibility loci were identified at genome-wide signi

297 Four novel susceptibility loci were identified with genome-wide sig

298 After adjusting for these factors, 100 susceptibility loci were identified.

299 n the allele frequencies and effect sizes of susceptibility loci, which we use to interpret the volum

300 We increased the number of susceptibility loci with genome-wide significant associa