ライフサイエンスコーパス: sustain

1 very was remarkably common if support can be sustained.

2 Importantly, this mutation was able to sustain 15% of wild-type transport activity, when the ca

3 -glass laminated devices are reported, which sustain 80% of their "post burn-in" efficiency over 3400

4 s permanent DNA editing with an indefinitely sustained 95 % decrease in protein expression.

5 s prospectively used to guide treatment, 533 sustained ACS (excluding acute ST-segment-elevation myoc

6 us retrovirus HERV-K could both initiate and sustain activation of the immune system and cause vascul

7 transient regulation of AMPK targets, unlike sustained activation by low glucose.

8 Persistence of this pathway would lead to sustained activation of direct-pathway T cells, arguably

9 y provoking a cellular state of "ER stress." Sustained activation of ER stress sensors endows maligna

10 g have inferred value coding upon temporally sustained activity during the period of reward consumpti

11 xpressed, IL-18 expression was increased and sustained after stimulation of TLRs.

12 inases (SFK) and focal adhesion kinase (FAK) sustain AKT and MAPK pathway signaling under continuous

13 but forest elephants in Central Africa have sustained alarming losses in the last decade [1].

14 k is capable of independently generating the sustained alpha seen in propofol, which may then be rela

15 8.4%) sustained an incident MOF, 1579 (2.3%) sustained an incident hip fracture, and 8998 (13.1%) die

16 dian, 6.7 years) of observation, 5750 (8.4%) sustained an incident MOF, 1579 (2.3%) sustained an inci

17 ar-old woman developed new-onset depression, sustained an unexplained fall, and started walking cauti

18 weighted prevalence, 25.6%), with more women sustaining an injury than men (868 [27.1%] vs 562 [23.7%

19 tage mesothelioma, silencing of p16/Ink4a is sustained and deletion of p19/Arf is detected, recapitul

20 and the transition from oscillatory to more sustained and prolonged Ca(2+) increases.

21 Rac1 signaling is required for the rapid and sustained antidepressant effects of GLYX-13.

22 0% of known HIV-positive individuals receive sustained antiretroviral therapy (ART), and 90% of indiv

23 d directly, does not appear to independently sustain appreciable long-lived charge generation.

24 trichloroethene, trichloroethene removal was sustained at >99.6%.

25 rol group at 3 months, and improvements were sustained at 9 months (mean differences, 1.1 units [CI,

26 e energy, substantial oscillator strength is sustained at the singlet-triplet degeneracy point.

27 , slows both receptor desensitization during sustained ATP application and receptor deactivation afte

28 arate days, craving, withdrawal, affect, and sustained attention were measured after overnight abstin

29 This group showed an opposing sustained attentional disengagement.

30 Additionally, protective TLR ligands induce sustained augmentation of phagocyte metabolism and antim

31 gy is known, the mechanisms that promote and sustain autophagy are less well defined.

32 s would be expected to include mechanisms to sustain B vitamin supply under demanding circumstances.

33 tant metabolic effectors under conditions of sustained BAT activation and highlight the relevance of

34 gest that CCR2 deficiency does not provide a sustained benefit and that Ly6C(low) MPs may contribute

35 Sustained benefits in glycemia were not identified follo

36 after 2 to 3 years of tamoxifen can lead to sustained benefits in terms of reduction of disease recu

37 the beta cell, indicating that acquiring and sustaining beta cell identity and function requires not

38 mplex dynamic of mutational waves, which was sustained beyond passage 100.

39 affinity for HSA (</=2 muM) showed high and sustained blood-pool activity and reduced uptake in the

40 a widely consumed nutrient can paradoxically sustain brain starvation signals, and identify a biologi

41 tment suggests that the effect seen might be sustained, but this needs to be confirmed at the 18 mont

42 focus of Cdc42*GTP which is thought to self sustain by recruiting a complex containing Cla4, a Cdc42

43 In summary, basal transmission can be sustained by glycolysis, but strong presynaptic demands

44 This protection is sustained by heme-hemopexin complexes in biological flui

45 nflationary" epitopes whose responses can be sustained by infected nonhematopoietic cells.

46 Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine tri

47 I into stromal lamellae in plants, similarly sustained by long-distance diffusion of electron carrier

48 r with D. mccartyi strain BAV1 were actively sustained by providing acetylene as the electron donor a

49 ittle throughout the year and appeared to be sustained by recently fixed C from the atmosphere (<60 y

50 Although LTM is sustained by structural synaptic plasticity, how synapse

51 Tropical forest productivity is sustained by the cycling of nutrients through decomposin

52 CD8(+) T cells require sustained Ca(2+) signaling for inflammatory cytokine pro

53 sm suggests that stony corals may be able to sustain calcification even under lower pH conditions tha

54 tion of Doc2B - inhibition of release during sustained calcium elevations - depends on an overlapping

55 f renal allograft injury, when severe and/or sustained, can result in chronic histological damage of

56 ns thought to initiate tumor development and sustain cancer growth.

57 ys for oxidation and ROS generation, thereby sustaining cancer cell survival in hypoxia.

58 n, brain natriuretic peptide expression, and sustained capillarization.

59 brogated hypertrophic response and decreases sustained cardiac function, but the cardiomyocyte-specif

60 74), and these differences were abrogated by sustained CD274 blockade.

61 ty and telomerase is further up-regulated to sustain cell proliferation.

62 vovirus minute virus of mice (MVM) induces a sustained cellular DNA damage response (DDR) which the v

63 tion program and strategies to implement and sustain change in practice.

64 o, indicate the commensal microbiota induces sustained changes in RANKL-mediated osteoclastogenesis.

65 irst 10 seconds, with many short rather than sustained changes.

66 (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of ca

67 ti-PD-1 therapy and could be identified by a sustained coexpression of PD-1 and TIGIT receptors.

68 the global tuberculosis community to make a sustained commitment to tuberculosis transmission scienc

69 The sustained common Cd response of the two accessions was d

70 Sustained contacts result in long-lasting calcium activi

71 Sustained control has resulted in reduced malaria transm

72 We explore the proposal that for sustained cooperation, guilty repair needs to override a

73 at solve the free-rider problem-critical for sustaining cooperation as a viable strategy-emerge later

74 at the MD may be required for amplifying and sustaining cortical representations under different beha

75 ing of clinical symptoms and may result in a sustained decline in lung function.

76 The sustained decrease in binding may reflect prolonged mGlu

77 In the RYGB cohort, large, sustained decreases occurred for treatment of metabolic

78 om the UK Biobank to identify healthy-weight-sustaining density environments.

79 on and postmarital residence rules encourage sustained directional movement between speech communitie

80 for the chemotactic gradient responsible for sustained directionality.

81 Our results show how NFkappaB sustains diverse cancer phenotypes via distinct classica

82 que, cardiac-restricted compartment to allow sustained drug penetration into the myocardium.

83 In vitro study showed more sustained drug release of CM-AL-containing scaffolds tha

84 tial of utilizing the pericardial space as a sustained drug-eluting reservoir through the application

85 ng-agent immunosuppression has a low rate of sustained, drug-free remissions, <10%/year.

86 e because of their exquisite specificity and sustained duration of inhibition.

87 These effects occurred without a sustained effect on the FEV1.

88 Memory T cells sustain effector T-cell production while self-renewing i

89 ed sensory input, can result in profound and sustained effects on neural responses to predictable sen

90 ne compound, 3ch, showed particularly marked sustained effects, with a reversal t1/2 > 6 hours and cl

91 results show that PENFS with Neuro-Stim has sustained efficacy for abdominal pain-related functional

92 A sustained effort to develop and share diagnostic methods

93 Although there has been a sustained effort to reconstruct the dynamics of the phos

94 dly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking r

95 and P-tau-T-tau ratios show more robust and sustained elevations among patients with chronic TBI.

96 ce of SOS1/EPS8/ABI1 complex is critical for sustained EMT traits of ovarian cancer cells.

97 pstream of AMPK, failed to activate AMPK and sustain energy homeostasis and resulted in apoptosis.

98 approach allows to assess the danger of self-sustained epidemics from any viral sequence data.

99 e unfolded protein response, associated with sustained ER stress.

100 es not exacerbate SV endocytosis but impairs sustained exocytosis in MB neurons and alters specific m

101 Short-term IL-33 treatment in mice led to sustained expansion of IL-33 receptor-positive kidney IL

102 ylation due to an inability of the mutant to sustain expression of ICP0.

103 ells and regeneration tracks, and failure to sustain expression of repair cell markers, including Shh

104 moted gene expression program, including the sustained expression of Ets transcription factors such a

105 Infused NK cells showed sustained expression of most activating receptors, upreg

106 ore intricate, but were surely essential for sustaining far-from-equilibrium chemical dynamics, given

107 , interlocutor identity was represented in a sustained fashion throughout the different stages of lan

108 cles fail to generate enough muscle cells to sustain fetal myofiber growth.

109 Together, our data suggest a model in which sustained FGF signaling acts to suppress cardiomyocyte p

110 ters, we accurately explain the sensor-level sustained field amplitude, demonstrating that slow chang

111 nsists of sensitizing rod bipolar cells by a sustained GABAergic input originating from a population

112 of transgene-positive functional T cells and sustained gene marking in myeloid and B-cell lineages up

113 In this paper, we report sustained glycolytic oscillations in single cells withou

114 n lestaurtinib-treated patients who achieved sustained greater than 85% FLT3 inhibition.

115 erpin ideologies and actions that ultimately sustain group-based hierarchy.

116 Sustained growth in dichloromethane would therefore offs

117 Sustained GSK3 activity in GSK3(S/A) knock-in mice repor

118 xceeded 100 IU/dL in 88% of patients and was sustained >100 IU/dL after 4 hours in 72% of subjects.

119 plenic ferroportin was increased probably to sustain hematopoiesis.

120 HBV functional cure is sustained hepatitis B surface antigen loss and anti-HBs

121 We propose that sustained high catecholamine concentrations observed in

122 reduced pumping to prevent clogging, whereas sustained high sedimentation caused an increase in respi

123 e and near-complete N removal accompanied by sustained high-rate, high-yield N2O production with part

124 Both sustaining higher and achieving relatively increased lev

125 silience in sex-changing fish, many of which sustain highly valued and vulnerable fisheries worldwide

126 this strategy, 12.8% of postmenopausal women sustained hip fractures in their remaining life (no scre

127 m Hg and was further divided into masked and sustained hypertension.

128 We infer rapid and sustained ice-sheet retreat driven by MICI, commencing a

129 lecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironme

130 All schedules elicited sustained immune responses up to M36.

131 of average post-transplant eGFR will require sustained improvement in immunosuppression and other asp

132 CCR2 deficiency does not provide sustained improvement of muscular dystrophy in mdx(5cv)

133 stance following verum acupuncture predicted sustained improvements in symptom severity at 3-month fo

134 tor-derived factor IX coagulant activity was sustained in all the participants, with a mean (+/-SD) s

135 have been described, yet how these cells are sustained in chronically inflamed tissues remains unclea

136 mocytes undergoing positive selection and is sustained in immature single-positive thymocytes, despit

137 and show that these improvements are largely sustained in real data.

138 as to determine the types of ocular injuries sustained in the earthquake in Nepal and its management

139 Currently, sustained in vivo delivery of active bone morphogenetic

140 nd the proportion of patients who achieved a sustained increase in hemoglobin (>/=0.75 g/dl over any

141 vaccines and the need for a booster dose to sustain individual protection against invasive meningoco

142 a4, but not IFN-lambda3, caused a strong and sustained induction of SOCS1 and refractoriness to furth

143 Inappropriately sustained inflammation is a hallmark of chronic ischemic

144 mproved behavioral performance and increased sustained inhibitory control-related activation for both

145 ick skin types IV, VI, and VI demonstrated a sustained interrater reliability, with an ICC of 0.93 (9

146 In subjects with DME, sustained intraocular delivery of FAc slows development

147 dicate that OCT4 expression is sufficient to sustain intrinsic signaling in a LIF-independent manner

148 l Institute of Mental Health (NIMH) has made sustained investments in the development of genomic reso

149 ecifically because tDCS is diffuse, weak and sustained it can boost connectivity between co-active br

150 ve triggered the atmospheric escape that now sustains its giant exosphere.

151 les in the spindle must be able to apply and sustain large forces to maintain spindle integrity.

152 Mechanical ventilation is used to sustain life in patients with acute respiratory failure.

153 She lost consciousness in shock and sustained life-threatening injuries.

154 in a sequencing batch reactor by maintaining sustained limiting extant nitrite and dissolved oxygen c

155 Sustained locking of deep brain stimulation to a particu

156 ress synaptic transmission and are unable to sustain long-term potentiation (LTP).

157 dren >/=3 years of age from LPV/r to EFV are sustained long-term.

158 erturbations can alter membrane structure to sustain LS functionality at the air-liquid interface.

159 coglycolide) (PLGA) was developed that shows sustained maintenance of plasma drug concentrations and

160 n Earth's geologic history by ubiquitous and sustained massive eruption of lava, forming several enor

161 Because low-level sustained microglia activation can lead to abnormal resp

162 ntial participants were identified as having sustained minor injury by the combination of three stand

163 With Dox, there was a sustained, modest decrease in LVEF over the follow-up du

164 AATP terminated 39 of 69 (59% adjusted) sustained monomorphic VT in the fast VT zone, 509 of 590

165 ) at 35 C (fully charged within 100 s) and sustain more than 10,000 cycles with capacity fade of on

166 Sepsis triggers more severe and sustained muscle fiber atrophy in limb muscles when comp

167 Moreover, we found that PUM1/2 sustain myeloid leukemic cell growth.

168 These materials can sustain nanoscale pores in their rigid lattices and due

169 A possible explanation for the sustained neuronal injury is that the neurotoxic HIV-1 r

170 In arterial SMCs, CXCR4 sustained normal vascular reactivity and contractile res

171 1 mutations result in ligand-independent and sustained NOTCH1-receptor signaling, which translates in

172 Dust provides ecosystem-sustaining nutrients to landscapes underlain by intensiv

173 These findings suggest that the sustained occurrence of psychedelic phenomenology consti

174 ke of carbon and heat, nutrient resupply for sustaining oceanic biological production, and the melt r

175 the development of therapies to maximize and sustain opioid analgesic efficacy.

176 onia is a movement disorder characterized by sustained or intermittent muscle contractions and its pa

177 Little is known about the sustained or slowly reversible form(s) of NPQ and whethe

178 The Nod1 x 2(-/-) T cells had sustained p53 expression that was associated with downre

179 ientific, MA) displaying more controlled and sustained paclitaxel delivery promise to improve the cli

180 degree of non-genetic individuality to shape sustained patterns of behavior across the population.

181 ned the duration of Ca(2+) response during a sustained phase.

182 Finally, sustained phosphorylation of RIPK1 intermediate domain a

183 f cerebrospinal fluid (CSF) viral rebound or sustained plasma and CSF viremia during treatment.

184 In human scalp EEG recordings, both sustained potentials and alpha-band oscillations are pre

185 TFH cells supported the sustained production of IgE antibody in vivo in the abse

186 mmon hallmark cellular phenotypes, including sustained proliferation, suppression of cell death, and

187 of [Ca(2+) ]i initiates CICR from nj-SR and sustains propagation of CICR to the cell centre.

188 -signal mechanism has likely evolved to both sustain protective immunity and avoid autoantibody produ

189 in these dopaminergic neurons, thus enabling sustained protein consumption.

190 ant for cytoplasmic NAD(+) regeneration that sustains rapid glucose breakdown through glycolysis.

191 A 12 mumol h(-1) sustained rate of H2 production was maintained during il

192 inning on day 3 after infection, experienced sustained rebound plasma viraemia when treatment was int

193 d, 407 children (56%) and 347 children (53%) sustained recovery in the intervention and control group

194 well as to identify factors associated with sustained recovery.Of 1383 children who returned for the

195 nced chronic kidney disease was defined by a sustained reduction in eGFR less than 30 mL/min/1.73 m2

196 atory mediator arginase-1 (P = 0.005), and a sustained reduction in skin redness (P = 0.02), correlat

197 Sustained refibrillation was successful in fewer ranolaz

198 lied to a variety of protein drugs requiring sustained release kinetics.

199 biodegradable polymeric microspheres for the sustained release of proteinaceous drugs.

200 Moreover, curcumin exhibited sustained release profile from crosslinked nanogels in s

201 wering effect of a biodegradable bimatoprost sustained-release implant (Bimatoprost SR).

202 The resulting hydrogel provides sustained-release of protein for more than a week.

203 The sustained response of neutralizing antibody correlated t

204 vely for observed dipole-like Ve patterns in sustained responses to monaural tones with frequencies >

205 ing prevalent barriers to timely linkage and sustained retention in HIV care in Mozambique.

206 risk for death by 1 year compared with early sustained reversal.

207 erving reinforcement-related signals used to sustain reward-maximization.

208 However, sustained scientific investigation has not yet provided

209 (both sexes) using concurrent EEG-fMRI and a sustained selective listening task, in which one out of

210 changes in synaptic efficacy, combined with sustained sensory input, can result in profound and sust

211 ing aerobic exercise interventions; that is, sustained sessions of moderate intensity.

212 at SMAD2 recruits multiple co-factors during sustained signaling to shape the downstream transcriptio

213 ed no decrease of PINK1 protein levels but a sustained, significant reduction in kinase activity.

214 ntaining interneurons, suggesting that their sustained silencing could be causally involved in the de

215 lar degeneration (AMD) on short out-loud and sustained silent reading speeds, and reading comprehensi

216 h a plasma release half-life of 21h achieved sustained SN-38 exposure in blood, above the target conc

217 unctions of RNA molecules are dependent upon sustained specific three-dimensional (3D) structures of

218 ed-loop cavitation controlling paradigm that sustains stable cavitation while suppressing inertial ca

219 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the prolifer

220 idence for dilation of the hP2X7R channel on sustained stimulation with ATP(4).

221 sensory processing is that neurons adapt to sustained stimuli by reducing their response over time.

222 ear-zero (ENZ) behavior while simultaneously sustaining stopped light energy bands which contain mult

223 Our results show that synaptic scaling sustains strength of the respiratory motor output follow

224 larval California newts (Taricha torosa) to sustained stressful conditions while longitudinally quan

225 tors play a crucial role in initializing and sustaining successful parasitism.

226 stroke, post-ischaemic tPA treatment led to sustained suppression of regulatory T cells in the blood

227 anism of replication stress tolerance, which sustains survival of BRCA2-deficient cells and can be ex

228 lated E14.5 SCN and most show reliable, self-sustained, synchronized rhythms in the E15.5 SCN.

229 suggesting that Themis might be important to sustain TCR signals during these key developmental proce

230 all RFs, high evoked firing rates (FRs), and sustained temporal responses, whereas the dSC is enriche

231 (MR(4.5), BCR-ABL1 </=0.0032%, n = 16), and sustained TFR (BCR-ABL1 undetectable following cessation

232 may provide an important source of oxygen to sustain the cardiomyocyte during extended ischemia.

233 this consortium and act as public goods that sustain the community.

234 ain could produce a sodium gradient that may sustain the energetic demands required for its rapid mul

235 endgame activities to permanently secure and sustain the enormous gains of polio eradication forever.

236 ability to reverse translational shutoff and sustain the expression of other IFN inhibitors encoded b

237 hanced uptake of hexoses also contributes to sustain the increased activity of respiratory metabolism

238 lasma membrane channels is also necessary to sustain the oscillations over longer times.

239 ung antigen-presenting cell (APC) types that sustain the self-renewal of TH17 cells.

240 ymmetric division of mammalian stem cells to sustain the stem cell pool.

241 Double ATP injections sustained the activation of phospho-STAT3 and GAP43, whi

242 d remarkably low collagen solubilization and sustained the bulk elastic properties over 12 mo.

243 prolonged blocking period in early 2016 that sustained the extreme Arctic warming.

244 none were using protective eyewear when they sustained the eye trauma.

245 sing adeno-associated virus vectors robustly sustained the rescue of rod function and preserved retin

246 ice does play a causal role in promoting and sustaining the evolution of stratified societies by main

247 s, the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals.

248 alled baleen to capture enough small prey to sustain their enormous size [1].

249 deaths following planned withdrawal of life-sustaining therapy, 54.0% (n = 760) were medically suita

250 KAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies.

251 therapeutic value in patients whose cancers sustain this mutation.

252 f some species as model experimental systems sustained this effort.

253 epresentations of environmental stimuli that sustain through the interval between stimulus and outcom

254 The off-time reduction was sustained throughout the open-label phase (-126.3 minute

255 thus unveil a global physical mechanism that sustains tissue separation independently of the biochemi

256 These benefits are sustained to 1 year and support the "real-world" effecti

257 hus in early-start patients the efficacy was sustained to month 48.

258 olving nonhuman primates, and responses were sustained to week 48.

259 Fb, generating a positive feedback loop that sustains transcription.

260 enables high-level stable gene transfer and sustained transgene expression in multiple primary human

261 population immunity to transmission and will sustain transmission as long as they do not attain high

262 f understanding patient preferences for life-sustaining treatment is well described for individual cl

263 Delivering effective and sustained treatments to the invasive GBM cells intermixe

264 HSD2), which otherwise inactivates cortisol, sustaining tumor cortisol concentrations to stimulate GR

265 We show that the galactic winds sustain turbulence in the 10-kiloparsec-scale environmen

266 inflammation and pathogen's control through sustaining type I IFN signaling in DCs.

267 cted at the expense of neuronal number under sustained undernourishment during the development of the

268 leting clinical trials and, in some studies, sustained unresponsiveness.

269 specifically associated with acquisition of sustained unresponsiveness.

270 after extubation was common in ICU patients, sustained until hospital discharge in the majority of af

271 rticles elicited more pulmonary specific and sustained vasodilation in SUGEN-5416/hypoxia-induced PAH

272 veloped over lifetime in 166 patients (19%), sustained ventricular tachyarrhythmias in 17 (2%), and p

273 ts was defined as appropriate ICD therapy or sustained ventricular tachyarrhythmias.

274 th (FHSD), syncope, atrial fibrillation, non-sustained ventricular tachycardia (nsVT), maximum left v

275 One hundred percent achieved a sustained viral response by 12 weeks after therapy, and

276 e oil that can be absorbed from moderate and sustained virgin olive oil consumption, is a strong inhi

277 Pre-treatment predictors of sustained virologic response (SVR) at 24 weeks following

278 High sustained virologic response (SVR) rates have been obser

279 thnicity were associated with lower rates of sustained virologic response (SVR) to interferon-based t

280 ce interval [CI], .33-.57) and attainment of sustained virologic response (SVR) were associated with

281 ral agents are associated with high rates of sustained virologic response (SVR), generally exceeding

282 d treatment, and 119 (91% of initiators) had sustained virologic response (SVR).

283 The primary endpoint was sustained virologic response 12 weeks after treatment (S

284 dpoint was the percentage of patients with a sustained virologic response 12 weeks after treatment (S

285 ts with chronic HCV infection who achieved a sustained virologic response after 12 weeks of treatment

286 epatitis C virus (HCV) and who do not have a sustained virologic response after treatment with regime

287 One hundred percent of patients exhibited sustained virologic response at week 12 after the end of

288 quantifiable HCV RNA 12 weeks posttreatment (sustained virological response 12 weeks after completion

289 d with pibrentasvir, has shown high rates of sustained virological response in phase 2 and 3 studies.

290 o the utility of patients post-LT, treatment sustained virological response rates, LT costs, and base

291 ue of patients in fibrosis stages F0-F3 post-sustained virological response, and in the transition pr

292 , 145 patients (99%, 95% CI 98-100) achieved sustained virological response, with one (1%) relapse at

293 completing 12 weeks of follow-up achieved a sustained virological response.

294 circumscribed social anxiety patients showed sustained visuocortical facilitation to aversive facial

295 recombinant virus (rLBNSE-IL-7) were able to sustain VNA levels much longer than those elicited by th

296 action time, and firing rate associated with sustained voluntary contractions.

297 ents in obesity-related comorbid disease and sustained weight loss over a 5-year period.

298 However, the recent finding of sustained weight reduction in response to systemic admin

299 IL-15 equally sustains wild-type and Il7ra(-/-) ILC survival in vitro

300 important feed-forward mechanism to achieve sustained Wnt/beta-catenin signaling.