ライフサイエンスコーパス: sustained expression

1 n of MAPK phosphatase-1 (MKP-1) mRNA and its sustained expression.

2 r of advantages, including the potential for sustained expression.

3 moter and/or insertion site are critical for sustained expression.

4 lizing antibodies dramatically inhibited the sustained expression (6-24 h) of collagenase-1 mRNA, whe

5 in multipotent CNS progenitor cells but also sustained expression and proneural functions in the form

6 skeletal muscle and are capable of achieving sustained expression and systemic delivery of a therapeu

7 ed in the heart after tissue injury, and its sustained expression can contribute to the development o

8 -encoded sensors, which contributes to their sustained expression during the G(1)-S transition.

9 specifically binds to IL13Ralpha2 to provide sustained expression, effective anti-GBM cytotoxicity, a

10 lpha(1)-antitrypsin (hAAT) gene, resulted in sustained expression for longer than 10 months with negl

11 deno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a larg

12 in previous studies to have upregulated and sustained expression in a biofilm, both in vitro and in

13 m sequence from the K6a gene fails to direct sustained expression in any adult tissue, including thos

14 The third phase is characterized by high and sustained expression in the adult cerebellum and dorsal

15 ecific expression in muscle progenitors, and sustained expression in the differentiated musculatures.

16 In contrast, Sox7-sustained expression in the earliest committed hematopoi

17 ucleus at embryonic day 18 (E18), areas with sustained expression into adulthood.

18 ion of an F.IX transgene in mouse liver, but sustained expression is critically dependent on the choi

19 -beta stimulates Foxp3 expression, for which sustained expression is then associated with acquisition

20 dministration of AAV2/8 vector have achieved sustained expression of 10% and 26% of normal levels of

21 sis in transgenic Arabidopsis lines detected sustained expression of a large MLA1-dependent gene clus

22 least in part, chromatin remodeling to allow sustained expression of a large number of genes critical

23 tissue levels of HIV and does not result in sustained expression of a previously silent quasi specie

24 ocuments that a local immune response limits sustained expression of a secreted protein in muscle gen

25 f sequential controls critical to robust and sustained expression of a target mRNA.

26 effective agents for the direct delivery and sustained expression of a transgene in several tissues,

27 thophysiological changes associated with the sustained expression of abnormal pain.

28 tivating factor), has been implicated in the sustained expression of amyloidogenic SAA under chronic

29 regulator EZH2 at serine 21, leading to the sustained expression of antiapoptotic genes, including I

30 :CD21 and either cytokine alone; and 4) BAFF-sustained expression of antiapoptotic Mcl-1 within repli

31 us-induced chromosomal DNA fragmentation and sustained expression of apoptogenic p53 and IL-1beta con

32 Thus, sustained expression of Aurora-B induces tetraploidy, wh

33 Early and sustained expression of autophagy-related proteins in th

34 The mechanism of sustained expression of autoreactive RF B cells in norma

35 Sustained expression of B-cell lymphoma 6 causes maligna

36 In contrast, sustained expression of Bcl-2 in transgenic mice by a me

37 Sustained expression of beta-catenin results in the gene

38 xpression cassette into the human genome for sustained expression of beta-globin.

39 We demonstrate that sustained expression of both Ephrin-A3 and novel EFNA3 l

40 Additionally, we show that sustained expression of C/EBPalpha in these LIP-expressi

41 Upon sustained expression of Cas9 and appropriately chosen gu

42 Sustained expression of CBX7 in EC cells confers a growt

43 t during BCG infection, the inflammation and sustained expression of CCL19 result in the recruitment,

44 saccharide (LPS) and interferon (IFN) induce sustained expression of CD154 on liver-derived macrophag

45 imp-1-deficient CD8(+) T cells resulted from sustained expression of CD25 and CD27 and persistent cyt

46 Induction of B7-1 (CD80) and increased or sustained expression of CD44H, ICAM-1 (CD54), and B7-2 (

47 ic reticulum stress caused a much higher and sustained expression of CHOP protein.

48 ze molecular and cellular changes induced by sustained expression of ciliary neurotrophic factor (CNT

49 We demonstrated that sustained expression of constitutively active stathmin d

50 cts geminin from degradation in G1, allowing sustained expression of core pluripotency factors.

51 Alveolar macrophages exhibited sustained expression of cosignaling molecule CD86 in iNO

52 Therefore, our data demonstrated that sustained expression of CXCL12 by MSCs in the primary tu

53 CNS was consistent with their recruitment by sustained expression of CXCR3 ligands during viral persi

54 Sustained expression of CXCR4 was maintained on synovial

55 , Wnt5A expression was also required for the sustained expression of CXCR4.

56 Induction of c-Jun results in sustained expression of cyclin A in the nonadherent stat

57 in cdk1 protein levels, and an elevated and sustained expression of cyclin B1.

58 Mechanistically, sustained expression of cyclin D3 was found to be regula

59 of cycling lymphoblasts was associated with sustained expression of cyclooxygenase 2 (COX-2), the ra

60 acteristics of immature enterocytes, notably sustained expression of cytokeratin and alkaline phospha

61 ponses of coronary SMCs were associated with sustained expression of differentiation markers (alpha-s

62 Sustained expression of dma-1 was found only in the elab

63 ervated striatum of the 6-OHDA-lesioned rat, sustained expression of each enzyme and effective produc

64 Sustained expression of each of these individual signali

65 mediate aspects of beta-selection including sustained expression of early growth response (Egr) gene

66 Notably, sustained expression of EBF in Pax5-/- hematopoietic pro

67 f miR-17 approximately 92, we show here that sustained expression of endogenous miR-17 approximately

68 moted gene expression program, including the sustained expression of Ets transcription factors such a

69 Complementary studies showed that sustained expression of exogenous MKP-3 inhibited palyto

70 tor IX (FIX) into skeletal muscle results in sustained expression of F.IX at levels sufficient to cor

71 proved adenoviral vectors for high levels of sustained expression of factor VIII in mice, stable ther

72 gency granulopoiesis, we found increased and sustained expression of Fap1 and Gas2 in bone marrow mye

73 Two naive HB dogs showed sustained expression of FIX-Padua with an 8- to 12-fold

74 tosis, and this protection corresponded with sustained expression of FLIP.

75 nt accumulation of many viral lytic RNAs and sustained expression of four previously described latenc

76 Aire(+) mTECs; responsiveness to RANKL; and sustained expression of FoxN1, Aire, and tissue-restrict

77 D, which could substantially be prevented by sustained expression of FoxO1 in beta-cells.

78 g a potential role of TNFR2 in promoting the sustained expression of Foxp3.

79 y cells induced by IL-25 are associated with sustained expression of GATA-3, c-MAF, and JunB in an IL

80 H11 delayed differentiation characterized by sustained expression of Gata2, Il1rl1, and Csf2rb, a phe

81 n this study, we report that STAT5CA induced sustained expression of genes controlling tissue homing,

82 erocysts or hormogonia resulted in rapid and sustained expression of genes required for utilization o

83 such repressor identified to date, and that sustained expression of Gfi-1B blocks IL-6-induced G1 ar

84 iPSCs without off-target inserts resulted in sustained expression of gp91(phox) and substantially res

85 Sustained expression of green fluorescent protein (GFP),

86 The requirement for a selective and sustained expression of growth factors during the early

87 Sustained expression of hFVIII at physiologic levels (10

88 t that tolerance to hFVIII can be induced by sustained expression of hFVIII in a mouse model.

89 Here we report sustained expression of hFVIII in immunocompetent mice u

90 ctor encoding polysialyltransferase leads to sustained expression of high levels of PSA.

91 Sustained expression of Hnf6 also results in downregulat

92 (PGRP-LC), is required for the induction and sustained expression of homeostatic synaptic plasticity.

93 In fact, sustained expression of Hox D3 in vivo on the chick chor

94 Here we show that sustained expression of Hoxa3 in diabetic-derived BMD Gr

95 Sustained expression of Hoxa3 in vivo in db wounds reduc

96 We have previously shown that sustained expression of Hoxa3 reduces the excessive numb

97 Moreover, sustained expression of HoxD10 impaired endothelial cell

98 miR156 promotes sustained expression of HS-responsive genes and is criti

99 The sustained expression of I-FABP transcripts in the villar

100 nscription of the IFN-gamma gene in B cells, sustained expression of IFN-gamma and T-bet by B cells i

101 Sustained expression of IFN-gamma protein by effector T

102 Together, these data suggest that the sustained expression of IFN-gammaR2 inhibits Th1 differe

103 Moreover, sustained expression of IK17-EGFP effectively prevented

104 persistence is associated with an early and sustained expression of IL-10 by lung leukocytes.

105 Pneumonia induced sustained expression of IL-10 mRNA and protein in lungs,

106 Th17 cells required TGF-beta for sustained expression of IL-17F and IL-17A.

107 ced IL-12p40 production was accompanied by a sustained expression of IL-23p19, but not IL-12p35, resu

108 coding IL-4 into the hippocampus resulted in sustained expression of IL-4, reduced astro/microgliosis

109 ntly, using IL6 knockout mice, we found that sustained expression of IL6 in the salivary gland long a

110 However, Egr-1 does contribute to the sustained expression of inflammatory mediators and to th

111 It is defined by poor effector function, sustained expression of inhibitory receptors and a trans

112 Indeed, sustained expression of intact sarcoglycan-sarcospan com

113 cfu of Streptococcus pneumoniae resulted in sustained expression of interleukin (IL)-6 mRNA in lungs

114 Sustained expression of KLF2 reduced and deficiency of K

115 xclusively in the endothelium, we found that sustained expression of KLF4 promotes ineffective angiog

116 through a novel signaling cascade involving sustained expression of Kruppel-like factor 4 (KLF4), a

117 Either transient or sustained expression of KSHV-GPCR activated both Rac1 an

118 the central nervous system (CNS) often have sustained expression of labile genes, including angiogen

119 duction of preexisting host signal cascades, sustained expression of latency-associated genes, transi

120 duction of preexisting host signal cascades, sustained expression of latency-associated genes, transi

121 ver is repopulated by human hepatocytes, and sustained expression of lentiviral vector transduced gen

122 y epithelium, and perk deletion inhibits the sustained expression of lipogenic enzymes FAS, ACL, and

123 We show here that sustained expression of Lmx1a and Lmx1b is required for

124 th the MC amplicon exhibited higher and more sustained expression of luciferase than those injected w

125 Sustained expression of lymphotoxin-like inducible prote

126 To determine if sustained expression of Mect1-Maml2 is required for tumo

127 nts after its internalization and promotes a sustained expression of MHC class I/peptide complexes in

128 Nevertheless, sustained expression of MICA by tumors can also elicit N

129 transcription factor CREB dependent, and the sustained expression of miR-132/-212 was responsible for

130 growth of TAL1-positive T-ALL cells and that sustained expression of miR-223 partially rescues T-ALL

131 Infused NK cells showed sustained expression of most activating receptors, upreg

132 d Isl1/Onecut1-bound enhancers contribute to sustained expression of motor neuron effector genes, dem

133 Enhanced cell survival and sustained expression of multiple oncogenic proteins down

134 P125A substitution (P125A-endostatin) showed sustained expression of mutant endostatin.

135 We show that sustained expression of mutant p53 is required to mainta

136 AAV-D76A in adult Ldlr null mice resulted in sustained expression of myostatin pro-peptide in the liv

137 e cells from passages (P) 1 to P6, whereas a sustained expression of nestin and PAX6 was observed thr

138 gfp) transgenic mice, we observed robust and sustained expression of Nrp2 in the SM compartments of t

139 These data demonstrate that local, sustained expression of NT-3 will support axonal plastic

140 lial cell proliferation and an increased and sustained expression of nuclear p53 in the hormone-treat

141 Sustained expression of Olig2 is counterintuitive becaus

142 There is sustained expression of osteoclast-promoting factors, RA

143 During chronic or allergic inflammation, sustained expression of P-selectin on the endothelial ce

144 aired cell proliferation in association with sustained expression of p27(Kip1) and decreased expressi

145 There was a uniform and sustained expression of p53 protein as well as a strong

146 table nucleotide analog ATPgammaS stimulated sustained expression of PAI-1 and MCP-1 in vitro, wherea

147 Functionally, sustained expression of Pax3 proteins inhibited myogenic

148 infection was associated with increased and sustained expression of PD-1 on lung lymphocytes, includ

149 hosphatase activity in vitro and resulted in sustained expression of PhoP-dependent mRNAs in vivo.

150 n 2.6 x 10(11) vg/kg body weight resulted in sustained expression of plasma ADAMTS13 activity at ther

151 Additionally, Isl1 was required for the sustained expression of Pou4f2, suggesting that Isl1 pos

152 actors is linked to the SA-induced onset and sustained expression of PR-1.

153 ess distinctive patterns of genes, including sustained expression of programmed cell death protein 1

154 Sustained expression of prohibitin in intestinal epithel

155 Consequently, sustained expression of proinflammatory cytokines from t

156 on of the pathophysiological consequences of sustained expression of proinflammatory mediators in pre

157 to our knowledge, that bacteria can promote sustained expression of proliferating cell nuclear Ag an

158 Abundant, sustained expression of prosurvival Mcl-1 is an importan

159 er technology is very efficient in achieving sustained expression of proteins in vivo, we examined th

160 long 5' UTRs via EIF4A1 suppression leads to sustained expression of proteins involved in respiration

161 Sustained expression of RAGE and its ligand S100B was ob

162 Sustained expression of RAGE by critical target cells, i

163 Sustained expression of RBPMS2 inhibits the expression o

164 ected to nonneural cell types did we observe sustained expression of reactivated tumor suppressors an

165 the most common strategy employed to provide sustained expression of RNAi effectors.

166 In this study, we show that sustained expression of Runx2 modulates Cbfbeta-smooth m

167 6 production but instead was associated with sustained expression of several antiapoptotic members of

168 Functionally, sustained expression of SIRT3 decreases membrane potenti

169 thermore, our data demonstrate that the mere sustained expression of Sox7 is sufficient to completely

170 bit functional properties of CAFs, including sustained expression of stromal-derived factor-1 (SDF-1)

171 Depletion of JMJD2b or sustained expression of SUV39H1 delays the repair of HC

172 distinguishes between rapid induction versus sustained expression of synaptic homeostasis and disting

173 Finally, both the rapid induction and the sustained expression of synaptic homeostasis are blocked

174 nction is required postembryonically for the sustained expression of synaptic homeostasis.

175 red high levels of FoxM1 protein to overcome sustained expression of the alternative reading frame tu

176 Here we show sustained expression of the antiangiogenic factors angio

177 f B lymphoblasts with IL-4 and IL-5 elicited sustained expression of the beta-chain and promoted secr

178 removal of doxycycline led to pronounced and sustained expression of the caMKKs and dnMKKs.

179 uous exposure of macrophages to IL-10 caused sustained expression of the chemokine receptors CCR1 and

180 er toxicity that would otherwise result from sustained expression of the copper transport genes.

181 of BMSSC-Ts was correlated with a higher and sustained expression of the early pre-osteogenic stem ce

182 TBI triggered sustained expression of the ER stress marker proteins in

183 Sustained expression of the estrogen receptor-alpha (ESR

184 G-repeats in the FMR1 mRNA, also resulted in sustained expression of the FMR1 gene in AZA-treated cel

185 Sustained expression of the histone demethylase, KDM2B (

186 cient to account for the rapid induction and sustained expression of the homeostatic change in vesicl

187 Presentation by these migrants sustained expression of the IL-2 receptor and promoted d

188 cells in chronic infections and cancer have sustained expression of the inhibitory receptor programm

189 duction of preexisting host signal cascades; sustained expression of the latency-associated open read

190 s oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival,

191 Sustained expression of the MYC transgene culminated in

192 With inhibitory signals diminished and sustained expression of the positive factors SHH and VEG

193 chwann cell genes (Id2, c-Jun, and p75), and sustained expression of the promyelinating Schwann cell

194 AP itself was proteolyzed by CatL, promoting sustained expression of the protease during podocyte inj

195 Intra-amniotic IL-1beta also induced the sustained expression of the surfactant proteins in the l

196 Sustained expression of the transcription factor Foxp3,

197 hes will require efficient gene delivery and sustained expression of the transgene in recipients.

198 e been several reports over the past year of sustained expression of therapeutic levels of clotting f

199 BDNF mRNA in stg/stg mice demonstrates that sustained expression of this neurotrophin is not require

200 mechanism distinct from that regulating the sustained expression of this proteinase in activated mac

201 no-associated virus (rAAV) vectors allow for sustained expression of transgene products from mouse li

202 nscription factor, NeuroD1, is necessary for sustained expression of TRbeta2 in immature cone photore

203 infection, and induced the most dramatic and sustained expression of type I interferons and inflammat

204 from ovarian HB-EGF deficiency is a cause of sustained expression of uterine amphiregulin before the

205 However, sustained expression of WT MMP-8 by breast cancer cells

206 file, deficient activation of NF-kappaB, and sustained expression of zDC and CCR2.

207 Finally, sustained expressions of c-Fos in GM3 KO MEFs were shown

208 e of cleaved caspase-1 in cells by day 1 and sustained expression until day 7 after radiation.

209 A rapid and sustained expression was noted in most amygdaloid and hy