ライフサイエンスコーパス: sustained release

1 r) and corticosterone (100-mg pellet, 3-week sustained-release).

2 n exciting rational engineering strategy for sustained release.

3 a and none are able to provide controlled or sustained release.

4 ork materials with potential applications in sustained release.

5 provided by the microspheres together with a sustained release.

6 ascular injectable drug delivery systems for sustained release.

7 6391 patients (81.5%) were taking verapamil sustained release; 4934 (62.9%) were taking trandolapril

8 ated gastric fluids (pH 1.2 and 4); while, a sustained release (77% during 12h) was observed in simul

9 development of particle-based approaches for sustained release after IVT injection.

10 ered in a single infusion, or from a two-day sustained-release alginate implant, produced an antidepr

11 ed an initial fast release, MCM-41, showed a sustained release along the time.

12 d on LDH, the dsRNA does not wash off, shows sustained release and can be detected on sprayed leaves

13 manipulation for delivery systems, providing sustained release and the ability to target specific cel

14 ecdysteroids from local plants, demonstrated sustained release and transgene expression in vivo.

15 ation, whereas ON synapses showed relatively sustained release and weak rectification.

16 saponin resulted in high loading efficiency, sustained release, and catalase preservation against pro

17 The combination of improved tolerability, sustained release, and vascular targeting could potentia

18 from the 3 categories of immediate-release, sustained-release, and no-flush were purchased at health

19 ul as a carrier for therapeutic proteins for sustained release applications.

20 specializations that provide for graded and sustained release are not well-defined.

21 in a PLGA matrix resulted in vivo in a more sustained release as well as a higher amount of drug rel

22 tely 10 min and a succeeding second phase of sustained release, as exhibited by mouse islets.

23 a, supported by a mass action model, suggest sustained release at hair cell afferent fiber synapse is

24 g changes in light intensity into changes in sustained release at the cone ribbon synapse.

25 is loaded into silica nanopollens and shows sustained release behavior, potent antimicrobial activit

26 ransport of nanoparticle carboplatin, with a sustained-release behavior but without any associated sh

27 atment of abdominal fascial incisions with a sustained-release bFGF polymer significantly lowered the

28 sone intravitreal implant (DEX implant) is a sustained-release biodegradable implant approved for tre

29 rect nose-brain delivery of neuropeptides in sustained-release biodegradable nanoparticles (NPs) is a

30 the effects of periodontal treatment with a sustained-release, biodegradable gel containing 8.5% dox

31 e of the following drugs for up to 14 weeks: sustained-release bupropion (239 patients) at a maximal

32 uble-blind, placebo-controlled comparison of sustained-release bupropion (244 subjects), a nicotine p

33 Our aim was to investigate the effect of sustained-release bupropion (amfebutamone) (SR) in promo

34 (mean final dose, 55 mg per day) to receive sustained-release bupropion (at a dose of up to 400 mg p

35 m were randomly assigned either to switch to sustained-release bupropion (N=239), sertraline (N=238),

36 ing citalopram and receive augmentation with sustained-release bupropion (N=279) or buspirone (N=286)

37 l, 6-week trial comparing patients receiving sustained-release bupropion (up to 200 mg b.i.d.) (N=21)

38 tained-release naltrexone 32 mg per day plus sustained-release bupropion 360 mg per day combined in f

39 tained-release naltrexone 16 mg per day plus sustained-release bupropion 360 mg per day combined in f

40 her antidepressant (N=86; sertraline [N=27], sustained-release bupropion [N=28], or extended-release

41 therapy (N=65) or medication (N=117; either sustained-release bupropion [N=56] or buspirone [N=61])

42 Treatment with sustained-release bupropion alone or in combination with

43 were no significant differences between the sustained-release bupropion and placebo groups as measur

44 Augmentation with sustained-release bupropion does have certain advantages

45 smoking with 7 weeks of bupropion treatment, sustained-release bupropion for 12 months delayed smokin

46 upportive group psychotherapy and adjunctive sustained-release bupropion for nicotine addiction in pa

47 f combination treatment with varenicline and sustained-release bupropion for smokers who, based on an

48 The sustained-release bupropion group and the buspirone grou

49 Sustained-release bupropion hydrochloride and nortriptyl

50 Sustained-release bupropion hydrochloride was started at

51 Use of sustained-release bupropion in combination with supporti

52 Augmentation of citalopram with either sustained-release bupropion or buspirone appears to be u

53 -release venlafaxine or an augmentation with sustained-release bupropion or buspirone was provided (l

54 mly assigned to receive either 150 mg/day of sustained-release bupropion or placebo at 6:00 p.m. for

55 The authors compared low-dose sustained-release bupropion with placebo for sexual dysf

56 vely, were 21.3 percent and 25.5 percent for sustained-release bupropion, 17.6 percent and 26.6 perce

57 S-SR-16 response rates were 26.1 percent for sustained-release bupropion, 26.7 percent for sertraline

58 The participants received open-label, sustained-release bupropion, 300 mg/d, for 7 weeks.

59 Sustained-release bupropion, however, was associated wit

60 onditions: nicotine lozenge, nicotine patch, sustained-release bupropion, nicotine patch plus nicotin

61 al (level 1), either a switch to sertraline, sustained-release bupropion, or extended-release venlafa

62 a biodegradable polyanhydride copolymer as a sustained-release carrier.

63 drug delivery, as nanoparticles can provide sustained release, cellular targeting, and even intrinsi

64 e) (pHEMA) hydrogel was developed to achieve sustained release characteristics of antibiotics.

65 ompared the effectiveness of two intraocular sustained-release codrugs in suppressing PVR in a rabbit

66 A sustained-release combination of naltrexone plus bupropi

67 th aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, a

68 ncluding the newly approved aflibercept eye; sustained-release compounds that may allow for fewer inj

69 cent advances have led to the development of sustained-release corticosteroid devices using different

70 rocess to produce polymeric microspheres for sustained-release delivery of protein drugs with preserv

71 lucosamine that has the dual properties of a sustained-release delivery system and a potent adjuvant.

72 Sustained-release devices and suspensions were prepared

73 ch as intravitreal injection and intraocular sustained-release devices facilitate high local angiosta

74 of FDA-approved ranibizumab (Lucentis) and a sustained release dexamethasone implant (Ozurdex), along

75 y pro re nata (PRN) treatment (n = 124) or 1 sustained-release dexamethasone implant followed by PRN

76 fenfluramine (366 patients), investigational sustained-release dexfenfluramine (352 patients), or pla

77 either with Dexfen, with an investigational sustained-release dexfenfluramine (Dexfen SR), or with a

78 fluramine group, 5.8 percent of those in the sustained-release dexfenfluramine group, 5.4 percent of

79 Sustained release drug delivery systems remain a major c

80 ore effective drug delivery systems, such as sustained-release drug implants, to overcome these limit

81 ne therapy, and microparticle or viscous gel sustained-release drug-delivery platforms.

82 er 2/3 to layer 5 synapses were incapable of sustained release during prolonged, complex trains of pr

83 By a novel method of sustained release, E. coli-derived endostatin was admini

84 in the presence of a tumor growth-supporting sustained release estrogen pellet.

85 by a random but time-modulated appearance of sustained release events, which have a high potential to

86 every 4 hours as needed) or morphine (15 mg sustained release every 12 hours and 5 mg every 4 hours

87 study assessed efficacy and safety of oral, sustained-release fampridine in people with ambulatory d

88 aster muscle in mice treated for 4 days with sustained-release FGF-2.

89 To date, most sustained release fibers have been restricted to the del

90 h groups received 100 microg of perivascular sustained-release fibroblast growth factor (FGF)-2 in th

91 Half of the animals received intramuscular sustained-release fibroblast growth factor-2 (FGF-2).

92 Twenty-seven sustained-release fluocinolone acetonide implant (Retise

93 Sustained-release fluocinolone acetonide implant (Retise

94 Retrospective review of 27 consecutive sustained-release fluocinolone acetonide implant (Retise

95 n initial bolus in the 1st week, followed by sustained release for the remaining 3 weeks.

96 double-blind, placebo-controlled trial of a sustained-release form of bupropion for smoking cessatio

97 A sustained-release form of bupropion was effective for sm

98 An injectable sustained-release form of human growth hormone (hGH) was

99 zation, however, have allowed development of sustained-release forms of several therapeutic proteins,

100 t our polymeric microspheres are suitable as sustained release formulation for targeted protein const

101 Sustained release formulation of larger biological molec

102 months old) were treated daily with either a sustained release formulation of MPH or placebo (N=8 per

103 ence; these limitations may be obviated by a sustained release formulation.

104 n in 1952 with the introduction of the first sustained release formulation.

105 The drug is administered as a sustained-release formulation.

106 Improvements in sustained-release formulations and patient-controlled an

107 itors are applied may also be critical, with sustained-release formulations and vaginal ring delivery

108 The initial sustained-release formulations of methylphenidate had re

109 ization and encapsulation, the advantages of sustained-release formulations previously demonstrated f

110 Potassium chloride depolarization caused sustained release from synaptoneurosomes of Abeta(42) as

111 aocular injections of anti-CMV drugs and the sustained-release ganciclovir device are the mainstay of

112 treatment of cytomegalovirus retinitis, the sustained-release ganciclovir implant is more effective

113 Thermo-reversible sustained-release green tea catechin gel was prepared an

114 empt was made to develop a thermo-reversible sustained-release green tea gel and to study its clinica

115 the dexfenfluramine group, P = 0.02 for the sustained-release group).

116 e of abdominal wall incisional hernias using sustained release growth factor therapy.

117 or 100 microg versus placebo) delivered via sustained-release heparin-alginate microcapsules implant

118 Sustained-release IGF-1 pellets were implanted bilateral

119 wering effect of a biodegradable bimatoprost sustained-release implant (Bimatoprost SR).

120 the posterior segment was evaluated, using a sustained-release implant containing gadolinium-DTPA (Gd

121 al implant (DEX implant) is a biodegradable, sustained-release implant that releases dexamethasone fo

122 o-, testosterone-(T), or dihydrotestosterone-sustained release implants, and ovaries were taken for h

123 developing countries where newer options of sustained-release implants and oral valganciclovir are u

124 ions over a 6-month period was 11.7% that of sustained-release implants for unilateral treatment and

125 Because sustained release in darkness is governed by vesicle rep

126 the bulk material with possible utility for sustained release in robust, programmably shapeable mech

127 olubility and bioavailability, and providing sustained release in the GI tract.

128 edication (i.e., brimonidine) formulated for sustained release in the supraciliary space of the eye a

129 DT)-treated steel surfaces demonstrated both sustained release in vitro over 30 days and localized gr

130 teria 1.5 log units the first day and showed sustained release, inhibiting 0.52 and 0.76 log units, r

131 Sustained-release, intraocular implants that deliver gan

132 Sustained-release intravitreal drug implants for posteri

133 osterior segment either via nanoparticles or sustained-release intravitreal implants may supplant rep

134 ncreased cyclic AMP and [Ca2+]i, whereas the sustained release is mediated by a novel wortmannin-sens

135 resumes upon fluid exchange, suggesting that sustained release is possible under flow conditions.

136 lied to a variety of protein drugs requiring sustained release kinetics.

137 isorders significantly improved while taking sustained-release lithium carbonate compared to placebo

138 re) was also lower in the group treated with sustained-release lithium carbonate compared to placebo.

139 with bipolar spectrum disorders; it compares sustained-release lithium carbonate to placebo.

140 blind, placebo-controlled treatment study of sustained-release lithium carbonate.

141 2 completers were rated as responders in the sustained-release lithium group versus five (29%) of 17

142 Sustained-released lithium may be an effective treatment

143 s, an enormous opportunity exists to develop sustained-release, local delivery systems that enable bo

144 ain paclitaxel within the lungs, achieve its sustained release locally, and thereby, improve its effi

145 the best candidate for a passively targeted sustained release lung delivery system.

146 s a vaccine candidate when administered in a sustained-release manner.

147 aded copolymer forms a gel that can act as a sustained-release matrix for drugs.

148 een silk and drug molecules, near-zero order sustained release may be achieved through diffusion- and

149 This depletion of release sites implies that sustained release may be rate limited by vesicle deliver

150 was to investigate the use of an injectable sustained release microparticle formulation of curcumin

151 horoid-RPE in pigmented rats is also true of sustained-release microparticle systems.

152 Extended-release naltrexone, a sustained-release monthly injectable formulation of the

153 chronic treatment with therapeutic doses of sustained release MPH did not have a significant influen

154 in fixed-dose tablets (also known as NB32), sustained-release naltrexone 16 mg per day plus sustaine

155 andomly assigned in a 1:1:1 ratio to receive sustained-release naltrexone 32 mg per day plus sustaine

156 Combination treatment with sustained-release naltrexone and bupropion was developed

157 Conjugation of GIRLRG to a sustained-release nanoparticle drug delivery system yiel

158 t the central-most levels, with increasingly sustained release near the borders.

159 atic toxicity is common with higher doses of sustained-release niacin but rare with immediate-release

160 Over-the-counter sustained-release niacin contains free nicotinic acid, b

161 g for immediate-release niacin, 502.6 mg for sustained-release niacin, and 0 for no-flush niacin.

162 e purpose of this study was to assess if the sustained release of 4% doxycycline through a bioabsorba

163 lymer implants and RF ablation shows uniform sustained release of 5-FU for 48 hours at least 8 mm fro

164 3-day BRB breakdown corresponded to a total sustained release of 7.42 +/- 0.54 microg/ml of VEGF.

165 This was achieved after a total sustained release of 7.42 +/- 0.54 microg/ml of VEGF.

166 Although the first report of sustained release of a microencapsulated protein was mor

167 material that exhibits stable, near-linear, sustained release of a model hydrophilic protein (e.g.,

168 Here, we report on the encapsulation and sustained release of a model hydrophobic drug (dexametha

169 as adjuvants or immunomodulators, allow for sustained release of antigen, enable single dose deliver

170 ze the design of lipodisks, for example, for sustained release of antimicrobial peptides in therapeut

171 from Alternaria alternata evoked a rapid and sustained release of ATP with greater efficacy observed

172 While the sustained release of bFGF was up to 3.0-fold more potent

173 onalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorph

174 d force generation and muscle size caused by sustained release of BMP-4 suggests that myogenic signal

175 A-LL37 NP) promotes wound closure due to the sustained release of both LL37 and lactate.

176 Gel matrix enabled sustained release of both oAd and DCs while preserving t

177 timulating factor (GM-CSF) (oAd) and DCs for sustained release of both therapeutics.

178 The second phase consisted of a sustained release of calcium from the vacuole via the ca

179 rug delivery system that produces a slow and sustained release of chemotherapeutic agent, has recentl

180 ed as Safe (GRAS) materials that can provide sustained release of corticosteroids to prevent corneal

181 -NPs could be internalized in the DCs with a sustained release of CsA to the culture medium, suppress

182 This activity is responsible for the sustained release of dopamine necessary for the proper f

183 pamine into synaptic vesicles and regulating sustained release of dopamine.

184 EG5K-Fmoc-VE2/DOX mixed micelles showed more sustained release of DOX in comparison to the counterpar

185 The sustained release of Doxo from Doxo-PLA NCs was achieved

186 The cyclosporine implants showed sustained release of drug over time with in vitro assays

187 ery devices offers an effective strategy for sustained release of drugs with immediate applicability

188 hese locations, and subsequently maintaining sustained release of drugs.

189 m a subsecond abrupt burst release to a slow sustained release of encapsulant over many minutes.

190 These findings suggest that pSNL induced a sustained release of endogenous prodynorphin-derived opi

191 represents an efficient, tunable method for sustained release of gene vectors to the vasculature.

192 es neurons in the inferior olive, leading to sustained release of glutamate at climbing fiber synapse

193 nt against devastating diseases by providing sustained release of high concentrations of therapeutic

194 and characterized the effects of a local and sustained release of human rIL-12 (rhIL-12) from biodegr

195 This study shows that the sustained release of IGF-1 can enhance tissue formation

196 The sustained release of IL-12 from the microspheres was sup

197 mors and can be reactivated by the local and sustained release of IL-12 to proliferate and secrete IF

198 ion of transplanted cancer cells and provide sustained release of immunomodulators.

199 nt homing to lymph nodes can be modulated by sustained release of inflammatory signals and adjuvants

200 icity in synchrony with a photoinitiated and sustained release of inhibitors that suppress tumour reg

201 o primary s.c. tumors to achieve a local and sustained release of interleukin 12 (IL-12), granulocyte

202 ontact of T cells and the paAPCs and require sustained release of low levels of IL-2.

203 P2Y(2)R) agonist UTP stimulates a strong and sustained release of LTA from WT but not P2Y(2)R(-/-) SM

204 ring hydrogel scaffold was developed for the sustained release of macromolecules to enhance the diffe

205 cle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly suppressin

206 en cultured in vitro, donor bags also showed sustained release of MMP-2 and -9.

207 TGF-beta2 also induced sustained release of MMP-2 and -9.

208 applications that require encapsulation and sustained release of molecules in aqueous environments.

209 of the IHC ribbon synapses not only enables sustained release of neurotransmitter but also imposes t

210 Sustained release of neurotransmitter depends upon the r

211 signal graded changes in light intensity via sustained release of neurotransmitter.

212 HNA but not ADO alone caused a prolonged and sustained release of nitric oxide as measured by direct

213 g molecule in cardiovascular system, and the sustained release of NO by endothelial cells plays a vit

214 Sustained release of NO may account for improved perform

215 A) nanoparticles loaded with SA-2 provided a sustained release of NO over days, improved aqueous stab

216 middle dot) donor NOR-1, which provides more sustained release of NO( small middle dot) persisting at

217 n-alpha ganglion cell to have a near-maximal sustained release of only approximately two quanta synap

218 stomach and intestinal simulation, showed a sustained release of PAs from PLA-NPs.

219 termined that the thioether linkage provided sustained release of peptide over 72h.

220 Coupled with the sustained release of physiological amounts of osteoinduc

221 engineering tissues by the incorporation and sustained release of plasmids encoding tissue-inductive

222 isk factors, prolonged glial activation, and sustained release of pro-inflammatory mediators in glauc

223 ults show that brief oxidative stress causes sustained release of protein factors from VSMC that can

224 biodegradable polymeric microspheres for the sustained release of proteinaceous drugs.

225 MSC osteogenic differentiation in vitro and sustained release of PRP alone on a fracture defect mode

226 Sustained release of PRP along with BMP2-modified MSCs c

227 Sustained release of PRP and BMP2 demonstrated significa

228 irst study to examine the combined effect of sustained release of PRP from alginate beads on BMP2-mod

229 summary, quininib-HA microneedles allow for sustained release of quininib; are safe in vivo and quin

230 onstrated the capability of nanoemulsions in sustained release of resveratrol from dialysis bags comp

231 ride-ester) (SA-PAE) provides controlled and sustained release of salicylic acid (SA) that locally re

232 The effect of sustained release of SDF-1 from PPCN (PPCN+SDF-1) versus

233 In conclusion, sustained release of SDF-1 from PPCN is a promising and

234 goal of this research was to assess whether sustained release of SDF-1, a chemokine that promotes en

235 ve vasculitis both induced a significant and sustained release of sFlt1 from monocytes, whereas anti-

236 This results in sustained release of soluble tumor necrosis factor alpha

237 er cells through endocytosis and demonstrate sustained release of the active agent, resulting in the

238 The DDCs showed cell uptake and sustained release of the bound drugs in conditions mimic

239 f Dex within the beaded structure results in sustained release of the drug over the period of 28days.

240 Targeted CONs showed sustained release of the drug to the cancer cells throug

241 and biological conditions providing a slow, sustained release of the exceptionally potent free drug.

242 mer films were fabricated for the controlled sustained release of the Ga- or Zn-complexes, using an i

243 We tested whether local, sustained release of the neurotrophic factor neurotrophi

244 vealed an effective bactericidal profile and sustained release of the parent antibiotic over time.

245 The latter accordingly resulted in a more sustained release of the volatile, trans-2-hexenal, from

246 iciency (ca. 46-56%), could be prepared, and sustained release of their entrapped cargoes have been d

247 Sustained release of therapeutic levels of 9-cis-retinoi

248 platforms that facilitate the localized and sustained release of therapeutics.

249 ration in rats showed extended stability and sustained release of these ligands.

250 nd bryostatin 1 (but not UCN-01) resulted in sustained release of tumor necrosis factor (TNF) alpha;

251 ibrin (PRF) is a platelet concentrate having sustained release of various growth factors with regener

252 In this study, we hypothesize that local sustained release of vascular endothelial growth factor

253 ent can be removed from a population through sustained release of wild-type insects.

254 Reproducible, sustained releases of both dexamethasone and solid dispe

255 to Tat for a few minutes was sufficient for sustained releases of cytokines for several hours.

256 The resulting hydrogel provides sustained-release of protein for more than a week.

257 e randomly assigned to either CAS (verapamil sustained release) or NCAS (atenolol).

258 , atenolol, captopril, clonidine, diltiazem (sustained release), or prazosin.

259 INVEST were randomly assigned to a verapamil sustained-release- or atenolol-based strategy; blood pre

260 In addition to sustained release oral medication, the transdermal patch

261 heir pain medication than those who received sustained-release oral forms of morphine (P = .035).

262 fied with transdermal fentanyl compared with sustained-release oral forms of morphine.

263 vel polymeric platform that provides steady, sustained release over a range of precise doses.

264 o its increased retention in tissues and its sustained release over time.

265 The drug release showed sustained release pattern noted up to 24h.

266 Sustained-release pellets, releasing 500 nanograms/day o

267 tered interleukin 12 (IL-12) encapsulated in sustained-release polymer microspheres significantly enh

268 X) 40, a non-biodegradable, non-inflammatory sustained-release polymer.

269 -vinyl acetate (ELVAX), a non-biodegradable, sustained-release polymer.

270 To assess the effect of a sustained-release preparation of bone morphogenetic prot

271 What effect sustained-release preparations and newer calcium antagon

272 des a new approach that can be combined with sustained-release preparations to optimize delivery of a

273 Moreover, curcumin exhibited sustained release profile from crosslinked nanogels in s

274 The niosomes had sustained release profile in the simulated gastric and i

275 iding a low complement activation as well as sustained release profile with high tunability.

276 e polypill showed the intended immediate and sustained release profiles based upon the active/excipie

277 double-blind four-period crossover study of sustained-release ranolazine 500, 1,000, or 1,500 mg, or

278 nicline tartrate and bupropion hydrochloride sustained-release (SR) on neurobiological targets relate

279 were assigned randomly to either a verapamil sustained-release (SR)- or an atenolol-based strategy fo

280 However, the use of intravitreal of sustained-released steroid had not been mentioned to dat

281 X) for 1 week and an injectable intravitreal sustained-release suspension releasing 5-FU and triamcin

282 day 8, to determine the effectiveness of the sustained release system.

283 r delivery of an anti-VEGF molecule within a sustained-release system, showing protection in a pre-cl

284 ) focused on developing oral and transdermal sustained release systems and establishing controlled dr

285 Various sustained release technologies were considered, and base

286 we demonstrate that nanoformulating 1K1 for sustained release temporally alters downstream signaling

287 es tethered to the ribbon provide a pool for sustained release that is typically fivefold greater tha

288 d increase in glycerol secretion followed by sustained release that was 40% higher than basal concent

289 ed as a comparison group 3,825 recipients of sustained-release theophylline.

290 Furthermore, layer 5 to layer 5 synapses sustained release throughout the duration of prolonged,

291 tenolol/hydrochlorothiazide or verapamil-SR (sustained release)/trandolapril in INVEST (INternational

292 f these novel nanotherapeutics toward future sustained release treatments via administration directly

293 oof of principle that intranasal delivery of sustained-release TRH-NPs may be neuroprotective and can

294 or proteins) allowing for formulations with sustained release tuned by the tube end-stoppers for hou

295 Vaccination with a sustained-release vehicle to enhance vaccination efficac

296 Sustained release was demonstrated, and drug loading cor

297 e of lamellar bone area for intermittent and sustained release was higher than that for the control g

298 easure of their ability to be formulated for sustained release, was determined using RP-HPLC at neutr

299 ddition, hydrogel delivery, which mimics low sustained release, was equally effective as gavage for B

300 vide a large pool of releasable vesicles for sustained release, while minimizing spontaneous release