ライフサイエンスコーパス: swap

1 bly through a process referred to as 'domain swapping'.

2 arm domain and GF domain in each monomer are swapped).

3 e N terminus domain of two adjacent monomers swap.

4 complexes following the intracellular domain swap.

5 main to first unfold, then refold via domain swap.

6 -alpha1AT polymerizes by a C-terminal domain swap.

7 alent murine locus, corresponding to a locus swap.

8 tifacts, including missing tissue and tissue swaps.

9 erse case study, input/output variables were swapped.

10 rticle [1] some of the additional files were swapped.

11 intracellular domains (N1ICD and N2ICD) were swapped.

12 near-isogenic lines with the VRN-A1 alleles swapped.

13 from the monomer and does not require domain-swapping.

14 mutations do not significantly affect domain swapping.

15 lding, stability, and dimerization by domain swapping.

16 ge conformational change required for domain swapping.

17 a new crystal form showing important domain swapping.

18 rovides a prime exemplar of bona fide domain-swapping.

19 can form oligomers without undergoing domain-swapping.

20 ithin each subunit without undergoing domain swapping.

21 taneously dimerise through C-terminal strand swapping.

22 rms a dimer through three-dimensional domain swapping (3DDS) by swapping helices alpha6-alpha8 betwee

23 SWAP-70 controls Cer accumulation through the regulation

24 cells, and highlights the important role of SWAP-70 in Cer dynamics in dendritic cells.

25 nd biochemical assays to analyze the role of SWAP-70 in lipid dynamics.

26 SWAP-70 was required for regulating the increase and loc

27 ested a role of switch-activated protein 70 (SWAP-70) in lipid raft formation of dendritic cells.

28 stabilized in a native-like trimeric form by swapping a domain from BG505 Env to 4-2.J41 Env.

29 ts that hinder DNA-binding (R53H) and domain swapping (A39P), using size-exclusion chromatography, ci

30 Domain-swap analysis showed that the non-Pd localization is als

31 Further promoter allele swap analysis under fermentation conditions confirmed th

32 Deletion and domain-swapping analysis identified that the C-terminal extensi

33 mutation, L68Q, increases the rate of domain-swapping and causes a fatal amyloid disease, hereditary

34 lts reveal structural determinants of domain swapping and raise the possibility that a single ion cha

35 ica molecule by sequential mutagenesis using swapping and site-directed mutagenesis, which identified

36 l molecule is used to trigger protein domain swapping and subsequent activation of biological functio

37 oped Conpair, a tool for detection of sample swaps and cross-individual contamination in whole-genome

38 tiscale method to accelerate the rate of the swaps and reach the so-called infinite-swap limit that i

39 the binding affinities between the selected SwAps and VSV and to determine the coefficient of switch

40 h) domain using engineered glycans, sequence swaps, and single point mutations in this domain.

41 SNAC-linked precursors and present a domain swapping approach to reprogramming these enzymes for pep

42 ans of mice were evaluated using a novel pup-swapping approach.

43 Third, by P4H promoter and protein swapping approaches, we show that P4H2 and P4H13 have in

44 bunits that interlock in an elaborate domain-swapped architecture and is encircled by an outer strand

45 the physical mechanisms that lead to domain swapping are poorly understood.

46 SwAps are controlled-affinity aptamers, which have been

47 These swaps are typically attempted every few MD steps and acc

48 eric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains.

49 es primarily contained (56)Fe or (57)Fe were swapped at birth such that each nursed on milk containin

50 ts voltage-sensor domain adopts a non-domain-swapped attachment to the pore and contacts the cytoplas

51 work alignment that uses extremely efficient swap-based local search, mutation and crossover operatio

52 7SK HP1 highlights an original mechanism of swapping bases, which could represent a possible '7SK si

53 nning residues 1-15 (1) preceding the domain-swapped Bcl-2-like domains.

54 t feature of the tetramer interface, a helix swapped between dimers, implies transient association.

55 ric beta tubulins with native tail sequences swapped between isotypes.

56 thm were used to identify residues that when swapped between mGluR1 and mGluR4 increased the potency

57 a helix-swapped homodimer wherein helix 1 is swapped between monomers.

58 In a modified CTD dimer, MHR is swapped between monomers.

59 eptual states emerge when the two images are swapped between the eyes multiple times per second; (iii

60 nd transmission within the same device, thus swapping between the cases R --> 1, A --> 1, and T --> 1

61 we demonstrate coherent optomechanical state swapping between two spatially and frequency separated r

62 Hybrid VLP binding with surface loop swapping between types indicated the essential roles of

63 To investigate this, we created domain swaps between the close homologs Gpa2 and Rx1, which con

64 ing residues from one Hox protein to another swapped binding specificities in vitro and gene regulati

65 correlate with their contribution to domain swapping, but it did correlate with their importance for

66 Credit Default Swaps (CDS) spreads should reflect default risk of the u

67 It utilizes a VP2 'domain swap' characteristic of insect picorna-like viruses, and

68 Using alphaS/betaS domain-swapped chimera constructs and single residue substituti

69 n paralogues was assessed using the sequence swap (chimera) approach.

70 f 140 sequence modifications, including loop-swap chimeras and single-residue mutations distributed t

71 lysialylation, we created a series of domain swap chimeras with sequences from neuropilin-1, a protei

72 DEP domain swapping confers directional bias on signaling, and the

73 This experimentally elusive domain-swapped conformation is likely to be responsible for the

74 ge strain between domains can promote domain swapping, consistent with experimental observations for

75 general strategy to prevent TCR mispairing: swapping constant domains between the alpha and beta cha

76 e was found to feature a trans-linked domain swap, converting an intramolecular disulfide to intermol

77 a new oligomeric arrangement, with a domain-swapped, cross-armed conformation for the protomers in t

78 c and kinetic characterization of the domain-swapped CTD dimer in solution.

79 apsid assembly by conformational trapping of swapped CTD dimers.

80 section of the dimerization interface in MHR-swapped CTD may also facilitate the design of anti-HIV c

81 Swapping cyclases between cyanobacteria and purple photo

82 hase boundaries, anti-site point defects and swap defects.

83 Domain swapping depends nonmonotonically on the protein concent

84 ks-willingness (at least 50% of the time) to swap devices or attend the clinic for a change in SNR--w

85 ain (ENH), we had instead generated a domain-swapped dimer (ENH_DsD).

86 Whatever the case, the MHR-swapped dimer does provide a novel target for the develo

87 GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hind

88 TrkAIg2 domain crystallizes as a beta-strand-swapped dimer in the absence of NGF, occluding the bindi

89 rmore, each three-helix bundle in the domain-swapped dimer is a structural homolog of MYB-like domain

90 RapZ self-associates into a domain swapped dimer of dimers, and in vivo data support the im

91 ructures at 1.7-2.0 A resolution of a domain-swapped dimer of yeast iso-1-cytochrome c with the deter

92 tion in the hinge loop of the ENH_DsD domain-swapped dimer relative to monomeric ENH.

93 reveals that FOXP3 can form a stable domain-swapped dimer to bridge DNA in the absence of cofactors,

94 One potential competing state, the domain-swapped dimer, is especially compelling because it is of

95 ize the monomer and stabilize an off-pathway swapped dimer, preventing productive pore formation.

96 s a conformational switch, from monomeric to swapped dimer, to trigger DIX-dependent polymerization a

97 electron pathway through a potential domain-swapped dimer.

98 of its C terminus shows an elongated domain-swapped dimer.

99 ric unit arranged to form an intimate domain-swapped dimer.

100 formation toward an unproductive off-pathway swapped-dimer state.

101 in two distinct trans conformations: strand-swap dimers and X-dimers.

102 interconversion between X-dimers and strand-swap dimers, and the cadherin structures that form ideal

103 as they shuttle between X-dimers and strand-swap dimers; pulling on this conformation induces a tors

104 isation, cystatins populate stable 3D domain-swapped dimers both in vitro and in vivo that represent

105 that enables FoxP2 and FoxP3 to form domain-swapped dimers capable of bridging two DNA molecules in

106 ly on the protein concentration, with domain-swapped dimers occurring at intermediate concentrations

107 nput structure and that, in contrast, domain-swapped dimers would exhibit increased backbone flexibil

108 dentify sequence mutations leading to domain-swapped dimers.

109 uring conditions, CysC forms inactive domain-swapped dimers.

110 Swapping doc-1 and doc-2 alleles from different communic

111 The trimers in an open conformation swap domains with each other.

112 k for the rational reengineering of NRPSs by swapping domains handling different substrates to genera

113 When paired, domain-swapped (ds)TCRs assemble with CD3, express on the cell

114 e human-to-mouse low-affinity FcgammaR locus swap engendered hFcgammaRIIA/IIB/IIIA/IIIB expression in

115 The neural model explains both swap errors and response variability as results of decod

116 The results suggest that swap errors are considerably more prevalent than previou

117 sion, and found a strong correlation between swap errors occurring in spatial and nonspatial report.

118 Second, responses are corrupted by "swap errors", in which a different item from the memory

119 ding failure in this task is associated with swap errors, in which observers report an item other tha

120 n the probe feature dimension as a source of swap errors.

121 nd inhibitor functions of SBT3PP in a domain-swap experiment indicated that they are mediated by diff

122 Here we present a free-space entanglement-swapping experiment between the Canary Islands of La Pal

123 s an inhibitor of cell division in a species-swapping experiment.

124 This was further corroborated by domain swapping experiment.

125 ed to high affinity EWS binding and sequence swap experiments between target and non-target demonstra

126 Protein domain-swap experiments identify a region including the STAR do

127 opus, which are further supported by residue-swapping experiments involving the L1 loop of CENP-A.

128 N-terminal deletions and swapping experiments of SEIPIN1 and 3 revealed that this

129 Domain swapping experiments showed that the RIPK4 kinase domain

130 rate models for these structures with domain-swapped features, fully consistent with the available da

131 t in conversion from a domain-swapped to non-swapped fold.

132 to receive evidence-based dietetic advice to swap foods for similar, but healthier, choices and incre

133 al riboswitches, we show that Spinach can be swapped for the expression platform of various riboswitc

134 bly mechanism by monomer addition and domain swapping for the oligomeric species of DeltaN6-beta2m.

135 that the N-terminal DNA-binding domains are swapped, forming a dimer, and four dimers are assembled

136 that switching between monomeric and domain-swapped forms may regulate DNA selectivity of TEAD prote

137 Among fifteen sequenced SwAps, four have exhibited high affinity to VSV and abil

138 non-parametric (NP) methods, which estimate swap frequency and feature variability with fewer prior

139 via transfer by TSG-6 and that HCs could be swapped from the bikunin PG and its free CS chain to HA.

140 This leads us to extend the theory of domain-swapping from the level of monomeric subunits and multim

141 In addition, combining ET identified swaps from mGluR4 with one identified by computational d

142 We show that highly reliable special swap gate is achievable by different detuning.

143 monstrate a CNOT (controlled-NOT) gate and a SWAP gate.

144 By swapping gene promoters, we show that Arabidopsis KAI2 a

145 n elongated helix, resulting in a novel site-swapped globin fold made up of helices A-E, hence the di

146 Propagated domain-swapping has been proposed as the mechanism by which Cys

147 While no evidence for MHR swapping has been provided by structural models of retro

148 Swapping has important implications for the mechanism of

149 bundles connected by a long, curved pair of swapped helical domains.

150 three-dimensional domain swapping (3DDS) by swapping helices alpha6-alpha8 between two monomers.

151 tramer, revealing the importance of a domain-swapped hinge region for formation of higher order oligo

152 ture of the DeltaL1 TEAD DBD reveals a helix-swapped homodimer wherein helix 1 is swapped between mon

153 mone receptor 1 (MCHR1), and splicing factor SWAP homolog (SFRS8)] was associated with the degree of

154 uman PKR (hPKR) and regulatory/kinase domain swap human-rat chimeric PKRs to assess the contributions

155 fibrils, contradicting the propagated domain-swapping hypothesis.

156 and a target protein that undergoes a domain swap in response to binding of the triggering ligand.

157 to the active site cysteine induces a domain swap in Ube2T that leads to cyclic trimerization organiz

158 These methods also identify which items are swapped in for targets: when the target item is cued by

159 types in these clusters, most of which were swapped in from existing cellular processes and subseque

160 They are instead extensively swapped in the holoenzyme, such that one cycle of cataly

161 ogenies and supports a possible role for env swapping in allowing cross-species transmissions across

162 ition experiments, we propose x-y coordinate swapping in conventional linear regression.

163 stressed the biological relevance of domain swapping in FoxP, as several disease-causing mutations h

164 Our results suggest that domain swapping in FoxP1 is at least partially linked to monome

165 mental tests of quantum science.Entanglement swapping in high dimensions requires large numbers of en

166 Domain swapping in proteins is an important mechanism of functi

167 ional coarse-grained model of protein domain swapping in the cytoplasm.

168 /AC413/rAmy variants with C-terminal residue swaps indicated that the C-terminal sCT/rAmy residue ide

169 Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein f

170 The Solar Wind Around Pluto (SWAP) instrument revealed an interaction region confined

171 These include highly interdigitated domain-swapping interactions between the winged-helix folds and

172 vealed some energetic hotspots at the domain-swapped interface.

173 nt regions of membrane cofactor protein were swapped into decay-accelerating factor.

174 al activation by using chimeric ligands with swapped intracellular domains (ICDs), demonstrated that

175 ork of intermolecular contacts, and a domain-swap involving the two N-terminal helices and C-terminal

176 d to stabilize a subset of configurations by swapping ion pairs across the protein-protein interface.

177 interaction, hotspots grafting with CDR loop swapping is an attractive route to the rational design o

178 Runaway domain swapping is proposed as a mechanism for folded proteins

179 Domain swapping is the process by which identical proteins exch

180 ermolecular chain reaction similar to domain swapping, is the most probable mechanism of aggregate pr

181 ng pairs of bats flying over a water surface swapped leader-follower roles and performed chases or co

182 This ion swap led to enzyme inactivation while retaining high-aff

183 f the swaps and reach the so-called infinite-swap limit that is known to optimize sampling efficiency

184 rved that nucleation precursors are particle-swapping loops rather than newly generated structural de

185 To overcome this, entanglement swapping may be used to generate remote quantum correlat

186 a beta4A-beta5A beta-hairpin runaway domain swap mechanism for antithrombin polymerization.

187 Dsc1 and Dsc2 show binding through a strand-swap mechanism similar to that of homophilic classical c

188 d into an inactive complex through a partner swapping mechanism.

189 Exon swap mice that express only P1- or only P2-HNF4alpha hav

190 Fkh1- and Fkh2-domain-swap-minus (dsm) mutations are functional as transcripti

191 l model to predict the propensity for domain-swapped misfolding of multidomain proteins.

192 propensity of a given fold to undergo domain-swapped misfolding?

193 ities of multidomain proteins to form domain-swapped misfolds, where data is available.

194 ative crystal structure analyses and residue-swapping mutagenesis to investigate whether this determi

195 -terminal domains of TcdB012 and TcdB027 are swapped, neutralization experiments suggest that the ami

196 We propose that swapping NLSs among terminase subunits is a regulatory m

197 rent implementation of REMD in which (i) the swaps obey a continuous-time Markov jump process impleme

198 ive to each other as a result of this strand swapping, obliterating the putative PG-binding groove se

199 simulations of the model reveal that domain swapping occurs at intermediate temperatures, whereas fo

200 anti-symmetric states, and thus entanglement swapping occurs for several thousand pairs of spatial li

201 " mechanism that enables a phospho-triggered swap of protein partners by Raf Kinase Inhibitory Protei

202 similar MsexD3 and MsexD2 demonstrated that swapping of a single amino acid in the fatty acyl substr

203 se results suggest a mechanism that involves swapping of an intramotif salt bridge, i.e. R-E2 to R-E1

204 harging almost always involves ion exchange (swapping of co-ions for counter-ions), and rarely occurs

205 at allows real-time detection of rupture and swapping of complete secondary-structure elements in glo

206 Our results show that domain swapping of FoxP1 occurs at micromolar protein concentra

207 Thus, the ability of filoviruses to tolerate swapping of GP can be used for identification of neutral

208 V expressing a fluorescent protein tolerated swapping of GP with counterparts from heterologous filov

209 Swapping of lysine 41 with glutamate 42 maintains the vo

210 Here we demonstrate entanglement swapping of multiple orbital angular momentum states of

211 Here the authors demonstrate entanglement swapping of multiple spatial modes of light simultaneous

212 Here, Weaver et al. demonstrate coherent swapping of optomechanical states between two separate r

213 Swapping of plastomes between the three different genomi

214 Here we show that systematic swapping of pre-existing variation in a subfamily of pla

215 We observe frequent swapping of strong and weak promoters in the context of

216 Removal or swapping of the BAM domains demonstrates that the BAM7 B

217 ating the ability of filoviruses to tolerate swapping of the envelope protein.

218 Swapping of the LCMV Z NTD into the nonpathogenic Pichin

219 PaMTH1 forms a tight dimer through swapping of the N termini.

220 3 is a dimer at pH 4.1 that is stabilized by swapping of the N-terminal arms, a feature not previousl

221 -shaped nonamers held together by N-terminal swapping of the pro-peptides.

222 A remarkable swapping of the S1 and S1' pocket between structurally r

223 ural basis for these differences, reciprocal swaps of yeast and human Top1 domains were engineered in

224 within SRCR domain 5, or replacement (domain swap) of SRCR domain 5 with a synthesized exon encoding

225 These non-swapped oligomers are identical in secondary structure t

226 The non-swapped oligomers likely represent a dead-end offshoot o

227 Swapping only four amino acids is necessary and sufficie

228 127-nt fragment encompassing improved PSs is swapped onto the RNA otherwise lacking CP recognition mo

229 Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and por

230 if DNA samples from a cohort are mislabeled, swapped, or contaminated or if they include unintended i

231 The inactivating mutations become 'swapped out' in the dimer, increasing nuclease and ribos

232 parallel at different temperatures that are swapped periodically.

233 ns of shade-induced changes in leaf shape by swapping plants between light treatments.

234 We also found that swapping PLB N and C termini with those from SLN caused

235 and interactive, visual detection of sample swaps, poor sequencing quality, and other indicators of

236 Phe of the DFG motif on the activation loop swap positions, resulting in the formation of a new allo

237 Swapped-promoter experiments clarify the presence of dis

238 ectively, and each human-rat chimeric domain-swapped protein showed intermediate levels of inhibition

239 3D domain-swapping proteins form multimers by unfolding and then s

240 al two-state model described for most domain-swapping proteins, whereas the A39P mutant follows a two

241 complete protein unfolding as do most domain-swapping proteins.

242 lly favored, in contrast to classical domain-swapping proteins.

243 vents, we also showed the feasibility of the swapping protocol in a long-distance scenario, where the

244 To assess the content of such HL-chain swapped reaction products with high sensitivity, we deve

245 onomer, which may dramatically slow down the swapping reaction.

246 CysC mutant, V57N, stabilized against domain-swapping, readily forms fibrils, contradicting the propa

247 n a manner dependent on the conserved domain-swapping region, strongly suggestive of homodimer format

248 We found that removal of the strand-swapped regions (TolR(60-133)) exposes cryptic PG bindin

249 on of an entangled state, i.e., entanglement swapping, representing the central resource to relay ent

250 Site-directed mutagenesis that swapped residue 153 between UGT89A2 from Col-0 and C24 r

251 Such a loop2 swap restored activation of the N-truncation Orai1 mutan

252 Interspecies gene swaps result in phenotypically normal divisions with the

253 ison of the isolated RH domain with a domain swapped RH dimer that reveals several intrinsically dest

254 g a salient feature of the dimeric 3D domain-swapped structure.

255 is for antagonist selectivity and mutational swap studies confirmed this hypothesis.

256 hat phospholipid binding results in a domain-swapped symmetric MV dimer via a quasi-equivalent interf

257 cy is further demonstrated experimentally by swapping synonymous codons in a yeast transgene.

258 ge on the so-called three-dimensional domain-swapped systems is reexamined in the context of the wide

259 Here we offer switchable aptamers (SwAps) that have been developed to solve this problem an

260 number of paired examples, (b) if they would swap the worse for the better SNR (e.g., their current d

261 s mEos2-A69T and Dendra2-T69A, we completely swapped the blinking behaviors of mEos2 and Dendra2, two

262 We have swapped the individual regions between different OST pro

263 Previous studies have shown that swapping the AD1 in TRPV1 with the cognate from the TRPV

264 Swapping the C terminus alone was not sufficient for thi

265 cage introduces a new piece to the system by swapping the closed form with the open form in the solid

266 By swapping the entry glycoproteins of two alphaherpesvirus

267 ctively sensitive to zolpidem by genetically swapping the gamma2I77 subunits with gamma2F77 subunits.

268 relieved and redirected to miR-15 targets by swapping the miRNA tropism of the virus.

269 Swapping the prodomain fragments between fly and human r

270 ate into a superposition involving partially swapping the qubit states.

271 The mutational analysis of swapping the residues at the +2 and +3 positions between

272 dies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in fa

273 The two parallel beta-sheets have swapped their last beta-strands giving a novel sheet top

274 activity can be transferred from h2 to h1 by swapping their hinge and CH1 domains, and substitution o

275 ues will reduce G3 discrimination by RF2, we swapped these residues between E. coli RF1 and RF2 by si

276 Swapping this improved region into the wild-type STNV1 s

277 be used to determine species identity, were swapped to generate a Saccharomyces synXII strain that w

278 coded by the S RNA segment (NP and GPC) were swapped to generate rLCMV/TransS.

279 TRPV6 can result in conversion from a domain-swapped to non-swapped fold.

280 es of deletions, point mutations, and domain swaps to identify a 12-residue region (residues Gln-62-L

281 ing and pore domains to produce a non-domain-swapped transmembrane architecture, which appears to be

282 meric DEP to Frizzled followed by DEP domain swapping triggered by its high local concentration upon

283 Moreover, swapping two hydrophobic residues between these D-sites

284 We observed that the probability of swapping two items strongly correlated with the items' s

285 propose and explore the concept of "pathway swapping," using yeast glycolysis as the experimental mo

286 By swapping Val (V63) with Phe, AtPOT1bOB1 gained the capac

287 The swap variant showed WT-like FVIII and FVIIIa stability,

288 ic communication by investigating FVIIa loop swap variants containing the 170 loop of trypsin that di

289 t the ability to manipulate viral tropism by swapping viral surface proteins.

290 and C-terminal domains of different GCPs are swapped, we show that the N-terminal domains define the

291 affinity measurements, domain deletion, and swapping, we show that Spc110 and Mzt1 bind to distinct

292 These SwAps were developed in the presence of Ca(2+) and Mg(2+

293 combinations are compatible, and (iii) gene swaps were likely a key to evolution of chemical diversi

294 meric BACs, in which two TERT promoters were swapped, were also generated.

295 can oligomerize by three-dimensional domain swapping, whereby structural elements are exchanged betw

296 meric pseudovirions with inter-genotype loop swaps which demonstrated that the L1 domains recognised

297 nd the transmembrane segments are not domain swapped, which suggest an alternative mechanism of volta

298 he same time, HSV and PRV homologs cannot be swapped, which suggests that in addition to a conserved

299 he functionally important B- and T-loops are swapped with respect to their size.

300 presented together with insights into domain swapping within eukaryotic thioesterases for substrate r